Edward Cole
- Played by Jack Nicholson
Character Death: Dies in the end of his cancer.
Carter Chambers
- Played by Morgan Freeman
Posthumous Narrator: Was narrating the film after his death.
Thomas/Matthew
- Played by Sean Hayes
Virginia Chambers
- Played by Beverly Todd
Dr. Hollins
- Played by Rob Morrow
Roger Chambers
- Played by Alfonso Freeman
Angelica
- Played by Rowena King