| 1 | * HarsherInHindsight: The premise of a globally distributed drug turning out to be deadly hasn't aged well since the UsefulNotes/COVID19Pandemic, specifically the paranoia around whether the developed vaccines were safe due to being made relatively quickly. |
| 2 | * InferredHolocaust: No outcome of this game is actually positive. Even the GoldenEnding leaves John and his daughter in a completely dead world, doomed to eventually die of starvation. |
| 3 | * ScrappyMechanic: The author wasn't kidding when he said he wouldn't put a replay feature in... (There is a workaround for this, though, just like in ''VideoGame/OneShot''.) |
| 4 | * EnjoyTheStorySkipTheGame: The gameplay is very simplistic to focus on the deeply tragic and emotional story. |
| 5 | * TooBleakStoppedCaring: Just about everyone is going to die, just about every ending is a {{Downer|Ending}}. |
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