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7[[SlidingScaleOfAnthropomorphism Animals with human attributes (or humans with animal attributes)]] are common in fiction, especially in fantasy and science fiction ([[CaptainObvious since they do not exist except in fantastical settings]]). In these sorts of settings, such improbable creatures may be left unexplained, or presumed to be the result of evolution, as humans and other animals are in real life. However, other times the writer of the story justifies their existence by making them the product of deliberate engineering -- usually through scientific means.
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9This trope is about human-like animals or animal-like humans created through science. The motivations behind such a project may vary; perhaps the resulting creatures are created by the military as {{Super Soldier}}s, perhaps they are created by a [[MisanthropeSupreme misanthropic]] scientist trying to replace humanity with animal-people, maybe they are simply the result of [[ForScience pure scientific curiosity]]. In any case, these beings often undergo the same treatment as {{Artificial Intelligence}}s, {{Artificial Human}}s and other scientifically-created life forms -- abuse from [[ScienceIsBad dispassionately cruel scientists]] and [[FantasticRacism prejudiced]] [[HumansAreTheRealMonsters humans]], usually prompting them to [[EscapedFromTheLab Escape from the Lab]] and unite with others of their kind as a SecretProjectRefugeeFamily. Expect a lot of thorny questions about WhatMeasureIsANonHuman.
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11Often the result of [[GeneticEngineeringIsTheNewNuke genetic engineering]], with human and animal genes [[LegoGenetics mixed and matched]] (either [[ArtificialHuman from conception]] or [[ArtificialHybrid later on in their life]]) to create a being with the best of both worlds, a sort of [[HalfHumanHybrid human-animal hybrid]]. A common project for {{Mad Scientist}}s, especially {{Evilutionary Biologist}}s. May be on any point of the SlidingScaleOfAnthropomorphism, from LittleBitBeastly to BeastMan to FunnyAnimal -- however, animals given human intelligence (and maybe the ability to speak) but no other augmentations belong in the UpliftedAnimal sub-trope, not here. As a rule of thumb, if it walks on two legs, it belongs here. If they start out as humans or animals, it's WasOnceAMan and AnthropomorphicTransformation by science respectively.
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13!!Examples:
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16[[folder:Anime & Manga]]
17* [[HalfHumanHybrid Fish-human hybrids]] are a big part of ''Anime/BlueSubmarineNo6'', being the "children" of a MisanthropeSupreme EmperorScientist who intends for them to inherit the Earth in place of humanity.
18* Human-like Chimeras in ''Manga/FullmetalAlchemist'' are made by taking a human being and fusing them with an animal using {{alchemy|IsMagic}}, which in the setting is treated less like magic than [[SufficientlyAnalyzedMagic a science]]. Chimeras need a human base to be capable of speech, though this fact is a state secret.
19* The Beastmen in ''Anime/TengenToppaGurrenLagann'' were engineered by [[EmperorScientist Lordgenome]] to enforce his rule, combining a basic human shape with traits of various animals. For instance, Viral is part cat and part shark. In addition to giving them whatever extra abilities would be useful, they are all sterile, ensuring that they cannot possess Spiral Power, which Lordgenome is trying to suppress.
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22[[folder:Comic Books]]
23* The entire cast of ''ComicBook/AlbedoErmaFelnaEDF'' are sapient and humanoid versions of Earth animals, presumably thanks to [[{{Precursors}} the Creators]] that brought life to their space sector. No one knows who they are or why they decided to put many different races in a single place, and many scientists are trying to find any clue about who they really are. It's eventually revealed that [[spoiler:the Creators were humans, who engineered anthropomorphics for the sole purpose of being guinea pigs for a big, unethical social scientific experiment]].
24* ''Franchise/TheDCU'':
25** One of ComicBook/{{Batman}}'s semi-frequent antagonists is Man-Bat, a formerly human scientist named Kirk Langstrom who [[ProfessorGuineaPig took a serum made from bat DNA to cure his deafness]] and ended up transforming into a [[OurWerebeastsAreDifferent were]]-{{bat|People}} monster. Something similar happened to his wife Francine, who became the She-Bat.
26** The inhabitants of the Wild Land in ''ComicBook/Superboy1994'', who are basically the mainstream universe's counterparts to ''ComicBook/{{Kamandi}}''[='s=] animal people, are eventually revealed to be born from a top-secret genetic research firm called Project [[Literature/TheIslandOfDoctorMoreau Moreau]], which informally named their creations [[HilariousInHindsight "furries"]].
27* The titular ''ComicBook/{{Elephantmen}}'' are human-animal hybrids based on African wildlife (elephants, rhinos, zebras, hippos, crocodiles, giraffes, hyenas), created as {{Super Soldier}}s on behalf of the nations of Northern Africa. The series takes place in the aftermath of a war between said African nations and China, with each side using their own hybrid soldiers -- most of the main characters are Elephantmen trying to integrate into society despite the FantasticRacism against them.
28* ''ComicBook/{{Finder}}'' has a number of humanized animals who were either uplifted by humans or created directly as servants. The ones who get most exploration are the Nyima, uplifted humanoid lions who retain something close to natural lions' social arrangements, with females running society and a single elite male providing sperm to them.
29* ''Franchise/MarvelUniverse'':
30** There are several instances of humans being transformed into animal hybrids through science; like ComicBook/{{Morbius}} (a scientist who accidentally combined himself with [[BatPeople vampire bat DNA]][[note]]though he turned into a mostly human-looking "[[TechnicallyLivingVampire living vampire]]"[[/note]]), [[Characters/SpiderManCentralRoguesGallery the Lizard]] (a scientist who [[ProfessorGuineaPig gave himself]] [[LizardFolk lizard DNA]]), [[Characters/SpiderManRoguesGalleryIToZ Vermin]] (a homeless man given [[RatMen rat DNA]] by a MadScientist), and [[Characters/SubMariner Tiger Shark]] (an athlete given [[SharkMan tiger shark DNA]] by a MadScientist, who himself would later return having spliced himself with starfish DNA and using fish-human hybrids as minions).
31** ComicBook/RocketRaccoon, like many other inhabitants of Halfworld, his home planet, was granted sapience and given a roughly humanoid form by extensive cybernetic and genetic augmentation.
32** ComicBook/TheIncredibleHulk had a couple of run-ins with a [[FaunsAndSatyrs satyr-like]] creature called the Woodgod, who had been genetically engineered by a scientist couple that were later killed defending their creation from an [[TorchesAndPitchforks angry mob]]. The Woodgod later returns, having used the research of his "parents" to make others like him, a race of animal-people he calls the Changelings.
33** The Ani-Mates that the ComicBook/NewMutants meet are a much more sinister example, having been created by a sadistic, deranged creep of a geneticist named the Ani-Mator, who regularly abused his experiments.
34** The New Men are a race of animals [[EvolutionaryLevels "evolved"]] into humanoid form by their master, the High Evolutionary. While some of them, like [[PigMan Sir Porga]], are able to pass for human, many others retain bestial features. In contrast to many other examples, the High Evolutionary is actually rather benevolent ([[HeelFaceRevolvingDoor sometimes]]) and treats his creations with respect.
35* The Blood (later known as Bar Sinister) from ''ComicBook/ShamansTears'' were artificially created human/animal hybrids; each designed to have specific traits from the animal side (wings on the bat hybrid, PrehensileTail and feet on the monkey hybrid, et cetera). The evil corporation that created them felt justified in treating them as possessions as they had a court ruling stating that [[WhatMeasureIsANonHuman they weren't human]] -- merely a higher form of animal -- and therefore [[InhumanableAlienRights do not have human rights]].
36* Many of the {{mutants}} from the ''Franchise/TeenageMutantNinjaTurtles'' franchise are human-animal hybrids created through exposure to MutagenicGoo. Some of them were born as ordinary animals (like the titular Ninja Turtles), while others were born as humans (like their sensei [[RatMen Splinter]], at least in some continuities).
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40* ''Fanfic/Plan7Of9FromOuterSpace'': Gneelix is a chimera (half-man, half-Siberian husky) created by xenograft surgery to settle the harsh polar regions, though he needs a vocalizer-collar to translate his growls and tiny muscular throat movements into speech.
41-->''"I'm not afraid! I have the heart of a lion and the ferocity of a tiger! I'd have the [[Film/TheLordOfTheRingsTheFellowshipOfTheRing eyes of a hawk and the ears of a fox]] too, but [[Literature/TheIslandOfDoctorMoreau Doctor Moreau]] was arrested before he could perform the operation."''
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44[[folder:Films -- Animation]]
45* ''Anime/BagiTheMonsterOfMightyNature'' has (of course) Bagi, a cougar with implanted human DNA and the [[SoleSurvivor only one]] of fifteen genetic prototypes not hunted down and killed after [[EscapedFromTheLab Escaping from the Lab]].
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48[[folder:Films -- Live-Action]]
49* The villain of ''Film/TheAmazingSpiderMan'', the Lizard, is a scientist who has been transformed into a [[LizardFolk reptile-man]] through a serum that uses lizard DNA to re-grow limbs and human tissue. Incidentally, the same genetic technology was used to create the transgenic spider that gave Peter Parker his spider powers.
50* Though ''Film/TheIslandOfDrMoreau1977'' is set in the period when [[Literature/TheIslandOfDoctorMoreau the book]] was written, it updates the methods Moreau uses to create his animal-people, replacing the surgical method of the original novel with a combination of surgery and [[GeneticEngineeringIsTheNewNuke gene therapy]]. Moreau also attempts to change the shipwrecked protagonist into an animal in a reversal of his usual methods, which results in yet another BeastMan.
51* ''Film/TheIslandOfDrMoreau1996'', being a SettingUpdate to the modern day, has Dr. Moreau use [[GeneticEngineeringIsTheNewNuke genetic engineering]] to give animals human traits. In a further departure from the novel, though most of the Beast-Men were originally animals, one of the females gives birth to a hybrid baby, showing that Moreau's modifications breed true.
52* ''Film/IslandOfLostSouls'', being an adaptation of ''The Island of Doctor Moreau'', naturally has this as its premise. As in the novel, the Beast-Men are created by surgically modifying animals into human form, and most of them are [[BeastMan too animalistic to pass for human]]. In a departure from the source material, Moreau succeeds in making an almost entirely human Panther Woman, Lota. Moreau's motivations are also changed; not content to merely make humans out of animals, Moreau now wants to see if his creations can breed with humans.
53* The 1994 film ''Moonchild'' is about the "Moonchild Project", a gene splicing program that mixes human and animal cells to create a new species of {{Super Soldier}}s. The protagonist is their first experiment, a human-wolf hybrid who can shapeshift into a [[OurWerewolvesAreDifferent werewolf]].
54* Shin Kazamatsuri from ''Film/ShinKamenRiderPrologue'' is [[BrokenBase "fondly"]] remembered as the first and ''only'' Kamen Rider that isn't really [[ArtifactTitle masked nor a rider]], but instead a HumanoidAbomination who takes the bug-themed leanings of the Showa-era Kamen Riders to it's logical conclusion. The poor lad was experimented on by his father Dr. Kazmatsuri and his partner Dr. Onizuka, but was unknowingly gene-spliced with Grasshopper DNA. Allowing him to turn into a Grasshopper-monster, with a [[HenshinHero henshin]] that's just pure BodyHorror and poor Shin is [[PainfulTransformation clearly in pain]] throughout the whole TransformationSequence.
55* ''Terror Is A Man'' is a film from the Philippines unofficially based off of ''The Island of Doctor Moreau'', substituting the novel's menagerie of Beast-Men for a single panther-man created via surgery.
56* ''The Twilight People'' is ''another'' unofficial adaptation of ''The Island of Doctor Moreau'', again from the Philippines, with Moreau trying to make a "super race" by combining humans and animals and wanting to experiment on a kidnapped diver, much to his [[MadScientistsBeautifulDaughter daughter's]] consternation.
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59[[folder:Literature]]
60* In ''Literature/AllTomorrows'', some of the post-human species engineered by the [[ScaryDogmaticAliens Qu]] fall into this territory. While they are all technically human, they bear an uncanny resemblance to other Earth mammals, especially the elephant-like Titans, the bat-like Pterosapiens, the dolphin-like Tool Breeders, and the antelope-like Mantelopes.
61* The ani-droids from ''Literature/{{Argo}}'' and ''Literature/AniDroids'' are an unusual example, as they are robots rather than biological creatures. However, they otherwise fit this trope, as they are designed to be anthropomorphs so they can be cute instead of threatening to humans who would otherwise be uncomfortable with them.
62* In the ''Literature/ChildrenOfSteel'' series, a group of genetically-engineered "animorphs" are created by major corporations as [[WeWillUseManualLaborInTheFuture indentured servants]] for humanity's exosolar colonies.
63* Creator/CordwainerSmith's ''Instrumentality of Mankind'' series, set in the distant future, features a [[FantasticUnderclass servant class]] called the Underpeople, who are animals engineered to have human intelligence and a more humanoid form.
64* ''Literature/TheIslandOfDoctorMoreau'', which inspired quite a few of the other examples here, [[UnbuiltTrope does not actually play this trope straight]]. While Moreau's "manimals" are indeed animals given human attributes through science, Moreau is not interested in merely making an anthropomorphic animal; no, his true goal is to essentially ''[[HumanityEnsues transform an animal into a human]]'' through surgery. The manimals are just a stepping stone to this achievement, and even the most human-like of them retain [[RedRightHand a few animal characteristics]] and are [[UncannyValley extremely off-putting]].
65* The titular character of ''Literature/MaximumRide'' and the rest of her Flock are human children spliced with bird DNA, which give them all wings and various superpowers. Their enemies, the Erasers, are artificially created wolf-human hybrids... who also have wings.
66* The titular "Moreaus" from the ''Literature/MoreauSeries'' are genetically-engineered anthropomorphic animals created as {{Super Soldier}}s who are now treated as [[FantasticRacism second-class citizens]].
67* ''Literature/Next2006'' has a few transgenic [[HalfHumanHybrid animal/human hybrids]] in its cast of characters, including Dave, the son of a researcher who manipulated his DNA and a chimpanzee's donated cells.
68* The Pelted from ''Literature/{{Paradox}}'' were created by splicing genes from various animals into human genomes, technically making them a HumanSubspecies (they share 99% of their genome with humans and are capable of interbreeding with them). They were originally designed as servants to humanity but after a number of demands for rights (and a scandal or two where a billionaire got knocked up by her "pet") they left Earth, then returned centuries later to invite humans into their [[TheAlliance Alliance]].
69* The titular Parahumans from ''Literature/ThePrideOfParahumans'' (and its sequel series ''Literature/ParaImperium'') were created as AsteroidMiners after humans wouldn't sign all the legal waivers. Grown from a blend of human and animal genes and printed over [[UnbreakableBones a titanium-alloy skeleton]] in a vat rather than born, they were designed from the cells up for [[SpacePeople life in space]].
70* The plot of ''Literature/SandpaperKiss'' revolves around a group of human-animal hybrids being created in a lab. Their hybrid anatomy makes them prone to disabilities -- Lucy, a human-tiger hybrid, is unable to speak English properly thanks to her feline lips.
71* In ''Literature/SeaOfThePatchworkCats'', a shady black market business kidnaps junkies, strippers, prostitutes and other people who won't be missed or remembered. There they are mutated with animal DNA and have their memories altered for rich men who want exotic sex slaves for themselves.
72* Calatians in ''Literature/TheTowerAndTheFox'' are a fantasy version created by English sorcerers during the Renaissance as a source of [[BloodMagic magically-infused blood]] that wasn't other sorcerers. It's unknown how they were created save that it was a "Great Work" on par with the creation of a land bridge between Britain and North America. [[spoiler:Until the fourth book, when they figure out that it was a mass uplift of assorted animals at the cost of the caster's life.]]
73* The [[OurOrcsAreDifferent trollocs]] in ''Literature/TheWheelOfTime'' are an unconventional example, insofar as they come from a fantasy setting. They were engineered by the [[MadScientist amoral biologist]] Aginor as shock troops for the forces of evil, and all generally look like 8-foot tall, over-muscled humans with the features of various vicious animals, such as bears, lions, hawks et cetera, mixed in. Despite their varied appearance, they all seem to have the same brutish and simplistic instincts.
74* In ''Literature/WitchesAbroad'', the evil Godmother transforms a wolf into a tragic wolf/human hybrid, capable of pretending unconvincingly to be someone's grandmother, simply because that's how [[Literature/LittleRedRidingHood the story]] goes. (Animals [[HumanityEnsues transformed into humans]] start [[TheMindIsAPlaythingOfTheBody thinking a bit like humans]], but still [[MyInstinctsAreShowing have their own nature]] beneath it; the wolf, on the other hand, doesn't know ''what'' it is.)
75* Taura from the ''Literature/VorkosiganSaga'', who's an eight-foot-tall genetically modified SuperSoldier who is only half jokingly described as a "werewolf." Despite her appearance, she's highly intelligent and not particularly bestial in personality at all.
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78[[folder:Live-Action TV]]
79* The X5 series of Transgenics from ''Series/DarkAngel'' were genetically engineered humans designed to be {{Super Soldier}}s for the US government, and many are given animal genes for that purpose. Main character Max is genetically engineered with cat genes (and thus has a [[MatingSeasonMayhem mating cycle]]) but looks entirely human, while other Transgenics like Joshua (a human/dog hybrid and the first Transgenic developed) and Mole (a human/lizard hybrid) look much more animalistic.
80* In the ''Series/DoctorWho'' two-parter "[[Recap/DoctorWhoS29E4DaleksInManhattan Daleks in Manhattan]]"/"[[Recap/DoctorWhoS29E5EvolutionOfTheDaleks Evolution of the Daleks]]", the Daleks turn their captive humans into [[PigMan human-pig hybrids]] and use them for manual labor.
81* ''Series/TheMightyBoosh'': In the episode "Mutants", Dixon Bainbridge becomes a MadScientist and kidnaps humans and zoo animals to splice them together, creating humans-animal hybrids in a quest to [[AGodAmI become a God]]. They're referred to as {{mutants}} and the exact AppliedPhlebotinum involved is not specified, though GratuitousLaboratoryFlasks are involved.
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84[[folder:Tabletop Games]]
85* ''TabletopGame/AfterTheBomb'': As a PostApocalyptic spin-off to ''TabletopGame/TeenageMutantNinjaTurtlesAndOtherStrangeness'', it takes place in a world where the dominant lifeforms are animals that have evolved into [[SlidingScaleOfAnthropomorphism varying degrees]] of human intelligence and appearance. The 2nd edition of the game, which more fully develops itself without tying back to [=TMNT=], establishes that humans were already experimenting in modifying and uplifting animals into human-like forms before the apocalypse, but the widespread rise of the mutant animals is due to the [[GeneticEngineeringIsTheNewNuke bio-engineered gene-modding virus]] that destroyed the world. These "Pre-Crash" examples of the trope are the Chimera strains and the Pleasure Bunny race:
86** Spider-Goats are the descendants of experiments from the 1990s in splicing spider genes into goats to create a docile herd animal that could produce large quantities of spider silk. After the Crash, enough of them survived to become a true-breeding race, which resemble a bizarre combination of a humanoid goat and a humanoid spider, often possessing multiple limbs and/or eyes. Though they tend to be friendly and easy-going, the Empire of Humanity finds them absolutely repulsive and is determined to wipe them out.
87** Pleasure Bunnies were bio-engineered from lab rabbit DNA as a race of [[ServantRace sex-slaves]] prior to the Crash. They are universally drop-dead gorgeous and almost impossible to tell from regular humans (unless they take the optional disadvantage of retaining rabbit ears and/or tails) save for their extremely pale skin, white hair, and [[AnimalEyes pink eyes]]. Their most unique power is their {{pheromones}}, which endow them with the ability to manipulate the emotional states of others and even turn the Pleasure Bunny into a living FantasticDrug.
88** Chameleon Mice descended from early experiments in modifying the genes of mice for various skin-related experiments, such as producing bioluminescence or having transparent skin. Their descendants resemble small, totally hairless, pink-skinned humans who can generate light from their skin, blend into their background like a Hollywood chameleon, or become partially invisible.
89** Shifter Mice are the mutant descendants of mice that were originally bred as a way to artificially enginered "Shifter-Cells", which were basically "gene patches" for ease of genetic splicing. The modern Shifter Mouse is able to [[VoluntaryShapeshifting transform into a near-perfect genetic duplicate of another person]] by consuming a drop of their blood.
90** Porkopolis Flying Pigs descend from a vanity project conducted in pre-Crash Cincinnti, Ohio, where pigs were spliced with bird DNA to create winged, flight-capable pigs and thus bring the city's mascots to life. After the Crash, those flying pigs evolved into humanoids, just like most other animals.
91** Mention is made briefly of an elephant subrace called the Ganeshi, defined by their third eye and innate PsychicPowers, that now rules over a sizable swathe of the Indian subcontinent.
92* ''TabletopGame/BattleTech'': The Magistracy of Canopus is known to have catgirls, mermaids, and a few other human-animal hybrid types, all of which are the result of humans getting voluntary surgical modifications and cybernetic implants. Extreme body modification is not frowned upon there and such people are quite common in the traveling pleasure circuses.
93* The [[Literature/TheIslandOfDoctorMoreau "Moreaus"]] (genetically-engineered [[HalfHumanHybrid human/animal hybrids]]) in ''TabletopGame/D20Modern'''s ''Genetech'' campaign.
94* ''TabletopGame/{{GURPS}}'':
95** Felicia-class bioroids from ''TabletopGame/TranshumanSpace'' are nanite-assembled cat people originally designed as {{Super Soldier}}s and bodyguards, with a version developed after the ban on weaponized bioroids intended more as pilots. While the Felecias are the most common and standardised version, there are also bioroids that resemble other any other kind of animal-person that someone's prepared to pay for.
96** The Tek-Rat in ''TabletopGame/GURPSBioTech'' is a genetically engineered creature that resembles a small rodent with the intelligence and dexterity required to be a starship engineer.
97** Some of the campaign suggestions in ''GURPS Furries'' have furries as human creations, and some of the templates are designed with this in mind.
98* Vectors in ''TabletopGame/HcSvntDracones'' are several species of human-animal hybrid created by [[MegaCorp MarsCo]] shortly before Earth nuked itself in the corporate wars and used to repopulate the solar system.
99* 'TabletopGame/TeenageMutantNinjaTurtlesAndOtherStrangeness'', being inspired by the original [=TMNT=] comics, takes place in a world where science has produced mutagenic compounds that can evolve animals into people, or devolve humans into animals.
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102[[folder:Video Games]]
103* The Therian NPC faction from ''VideoGame/AgeOfWondersPlanetfall'' were once humans before they were experimented on with animal DNA and became animal-human hybrids. They were used in experiments to cure diseases and create superior beings until their first test subject, known as "The Deer", exposed the horrible truth of the experiments. Since the shutdown of these horrid projects, they occupied many planets as refugees, belonging to neither human nor animals and are no longer welcome in society, yet remain positive on life.
104* The Kaka clan in ''Franchise/BlazBlue'' are a race of Beastkin, humanoid animals, that were artificially engineered from the genes of [[FunnyAnimal Jubei]] during the Dark War.
105* In ''VideoGame/{{Cataclysm}}: Dark Days Ahead'', as part of the backstory, American scientists were researching [[LegoGenetics genetic modification]] in order to create {{Super Soldier}}s in case a cold war with China turned hot. Some scientists developed {{Super Serum}}s that grant animal traits, although the Cataclysm prevented widespread usage of them. If you find or recreate the right kind of mutagens, you can become an example of this trope, although [[SuperpowerRussianRoulette it's very risky]].
106* The majority of the cast in the ''VideoGame/CrashBandicoot'' series are this, being once normal animals that were forcibly uplifted by a pair of {{Mad Scientist}}s to serve as their foot soldiers in taking over the world.
107* In the ''VideoGame/DungeonSiege'' expansion ''Legends of Aranna'', the Utraeans had used their magic and scientific knowledge to uplift common lizards and cats into humanoids to be able to serve their empire as slaves. This eventually bites them in the ass as they rise in violent rebellion, all but destroying the once-mighty Utraean Empire. The Zaurask leader even tries to create his own army of uplifted soldiers from crocdiles, though even they quickly rebelled and formed their own society.
108* ''VideoGame/EtrianOdysseyIVLegendsOfTheTitan'': The Sentinels are humanoid animals that were created by humans [[spoiler:as part of the Yggdrasil Project to help restore Earth after a world-ending calamity]].
109* ''VideoGame/InheritTheEarth'' takes place in a seemingly medieval world populated by sentient bipedal animals whose ancestors were uplifted by humanity before a disaster wiped them out. The opening narration states that humans gave them "reaching hands" as well as "thinking minds", and the introductory cinematic shows cave paintings of humanoid animals, so it's likely that they were designed to be humanoid rather than being typical {{Uplifted Animal}}s.
110* The Caninu and Felineko of the ''VideoGame/LittleTailBronx'' universe came into existence after [[spoiler:the Juno information system erased humanity and terraformed the Earth to purify it of their war. The Juno then used the data of all other living organisms to re-seed the planet with new life, eventually mixing in cats and dogs with the human genome through a process of rapid evolution]]. [[https://archive.org/details/solatorobo-supplemental-material-translation-english/Reset%20Information%20From%20Artbook/ A piece of supplementary material]] for ''VideoGame/SolatoroboRedTheHunter'' explains why [[spoiler:cats and dogs were specifically chosen as humanity's successors: Yurlungur, the personality AI that was birthed from Australia's Juno so that it could interact with humans, not only valued the two species for their adaptability to different environments, but the research team she interacted with also took care of some cats and dogs as a way to manage their mental health, which she interpreted as an act of love on their behalf.]]
111* The Stalkers from ''VideoGame/MutantYearZeroRoadToEden'' are [[HalfHumanHybrid half-human, half-animal]] {{Mutants}} who are eventually revealed to be [[spoiler:created as part of Mimir's "Mutant Project" before the apocalypse, intended to grow animal-like humanoids for unknown purposes]].
112* ''VideoGame/{{Utawarerumono}}'': It's implied that [[spoiler:the various LittleBitBeastly races populating the planet actually descend from a vast series of genetic experimentation projects that were undertaken in a hidden underground lab, apparently as part of a project to reclaim the uninhabitable Earth above]].
113* The bestial enemies in ''VideoGame/VivisectorBeastWithin'' are [[HalfHumanHybrid human-animal hybrids]] created as [[SuperSoldier soldiers]] by the renegade geneticist Dr. Morhead.
114* ''VideoGame/{{Xenogears}}'' contains a race of [[BeastMan Beast Men]] called Demihumans, which are revealed to be the result of humanity messing with {{Nanomachines}} in the past after Bishop Stone collects the nanomechanical colony [[RobotGirl Emeralda]] in the Zeboim ruins.
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117[[folder:Webcomics]]
118* The Ferin of ''Webcomic/Aurora2019'' are a fantasy variant of this trope, created by a mysterious mage who would curse people into half-animal beings with enhanced strength and healing abilities but no magic for the slightest reasons. They were treated as monsters at first until people realized they were victims and started treating them better... that is, until they discovered they could have children that would also be Ferin and they were driven out of human settlements due to being seen as an existential threat. They are treated somewhat better now but there is still heavy discrimination, especially for predator Ferin. There are three main types of Ferin with different characteristics:
119** The Unstable Ferin, which were created by the mage when they were less skilled and will shift between a human and animalistic form at random and are viewed as the most dangerous type due to their volatile emotions.
120** The Shifter Ferin, which can voluntarily change from a fully animal form and non-Ferin form which only slight hints to their true natures and are viewed with paranoia as a result.
121** Finally, there are the Hybrid Ferin, which were made when the mage had perfected their curse and appear partially human with animal traits and are the strongest and most resilient of the three.
122* The backstory of ''Webcomic/TheCyantianChronicles'' has the titular Cyantians being created from human and animal DNA by aliens as a ServantRace, and then further modified by another alien race to be superpowered [[BloodSport pit fighters]].
123* The protagonists of ''Webcomic/DNATheWebcomic'' are a group of genetically engineered furry humanoid children, known as Species X, most of which have super powers. They are considered [[WhatMeasureIsANonHuman experiments]] rather than people.
124* Florence Ambrose, the protagonist of ''Webcomic/{{Freefall}}'', is a Bowman's Wolf, part of an experimental breed of red wolves genetically engineered to have humanoid form. They were [[http://freefall.purrsia.com/ff800/fv00710.htm created as]] [[http://freefall.purrsia.com/ff800/fv00711.htm a proof-of-concept]] for the [[UpliftedAnimal uplifting]] of native life on planets inhospitable to Earth life. Technically, the first animals given human traits through genetic engineering in the setting were an army of chimp {{Super Soldier}}s, but they were more traditional {{Uplifted Animal}}s with minimal anatomical modifications, [[spoiler:as evidenced by Dr. Bowman]].
125* The Tarnekis in ''Webcomic/TheKennyChronicles'' are anthropomorphic animals created by pirate scientists for unknown reasons.
126* The hybrids from ''My Life With Fel'' ([[https://mylifewithfel.com/index link here]]) are comprised of [[HalfHumanHybrid a human base spliced with animal DNA]], and were secretly developed by governments such as Hedron (the fictional setting of the story), the United States and China with the purpose of creating super-soldiers with specialized abilities. However, following the election of a new government to Hedron, one which realized that this project was a ''massive'' breach of human rights (indoctrination of humans from birth against their will) and international law (human experimentation without consent or protection), the project was ordered to be scrapped for the sake of preventing a potential PR nightmare, and most of the hybrids were [[ThePurge gunned down by the military]] barring a few dozen that escaped and survived prior to the beginning of the story. Of particular note is that [[OneGenderRace all the successful hybrids are female]], as the augmentation process previously messed with testosterone and made any male hybrids especially violent and unreasonable by comparison.
127* The House of Evolution from ''Webcomic/OnePunchMan'' is a villainous organization consisting of the EvilutionaryBiologist Dr. Genus and his genetically spliced mutant monstrosities, Mosquito Girl being one.
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130[[folder:Web Original]]
131* The eponymous Fox Tayle from ''Literature/TheAdventuresOfFoxTayle'' used to be a normal fox, until he was experimented on by "Project Plume", an initiative run by the shady [=BioCon=] group and funded by the U.S. government to transform animals into lethal soldiers. Now not only is he intelligent and sapient, he can also walk upright and has hand-like paws, essentially making him a FunnyAnimal.
132* In addition to [[UpliftedAnimal provolves]], ''Website/OrionsArm'' has rianths, humans modified with animal genes, and splices, animals modified with human genes. By the 107th century AT the distinction is very blurry and more memetic than genetic, with some splice clades having more human genes than some rianth clades.
133* ''Literature/SpaceBeasts'' has the Humanimals, who were created by humans to serve as slaves. The Humanimals all have [[BeastMan mostly human forms and animalistic heads]], since the scientists who created them nixed the idea of genetically engineering animals to be [[LittleBitBeastly mostly or entirely indistinguishable from humans]] -- after all, if the Humanimals looked too human, they would be accepted as such. They're still pretty humanlike, to the point of being able to interbreed with humans.
134* The Animen from ''Literature/WhateleyUniverse'', who are a genetically engineered, anthropomorphic race of human/animal hybrids originally created as a breeding population for future {{Super Soldier}}s.
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136
137[[folder:Western Animation]]
138* {{Franchise/Batman}} cartoons (aside from the DCAU):
139** Kirk Langstrom appears in ''WesternAnimation/TheBatman'', [[ProfessorGuineaPig becoming the monstrous]] [[BatPeople Man-Bat]] [[IJustWantToBeYou in order to be feared like the Batman]]. In a later episode, a group of three disgruntled college students steal Langstrom's mutagen and splice their genes with {{fox|Folk}}, {{shark|Man}} and [[BirdPeople vulture]] DNA, becoming the animalistic Terrible Trio to wreak havoc on their campus, which motivates Langstrom's HeelFaceTurn.
140** Man-Bat also appears in ''WesternAnimation/BewareTheBatman''. Unlike most versions of the character, Kirk Langstrom wasn't responsible for his own transformation, which was caused by [[MadDoctor Professor Pyg]] and [[FrogMen Mr. Toad]] injecting him with a mutagenic serum before enslaving him with a MindControlDevice. Pyg and Toad also plot to use this serum to create an army of human-animal hybrids, even [[DamselInDistress kidnapping a few random women]] so that Mr. Toad (who's a [[FrogMen humanoid frog]]) can choose to turn one of them into his bride (though this plan is foiled just before Pyg was about to inject "Mrs. Toad").
141* The Franchise/DCAnimatedUniverse features multiple examples of {{mad scientist}}s creating human-animal hybrids (or turning people into them) through genetic splicing:
142** ''WesternAnimation/BatmanTheAnimatedSeries'':
143*** The pilot episode "[[Recap/BatmanTheAnimatedSeriesE1OnLeatherWings On Leather Wings]]" has Man-Bat as its antagonist, the result of Dr. Kirk Langstrom [[ProfessorGuineaPig becoming addicted to a formula for turning people into]] [[BatPeople human-bat hybrids]]. Unlike with most examples, Langstrom can turn from human to Man-Bat and back, essentially making him a [[OurWerebeastsAreDifferent werebat]]. Later in "[[Recap/BatmanTheAnimatedSeriesE45TerrorInTheSky Terror in the Sky]]", Kirk's wife Francine accidentally mutates herself with the Man-Bat formula, causing her to repeatedly and involuntarily transform into a similar werebat monster.
144*** "[[Recap/BatmanTheAnimatedSeriesE42TygerTyger Tyger, Tyger]]" has Dr. Emile Dorian as the antagonist, a geneticist who uses his talents to create various human-animal hybrids, including the ape-man Garth and the [[CatFolk cat-man]] Tygrus. He even goes so far as to turn {{ComicBook/Catwoman}} into a ''literal cat-woman'', intending her to be a mate for Tygrus.
145*** "[[Recap/BatmanTheAnimatedSeriesE43MoonOfTheWolf Moon of the Wolf]]" has an example similar to Man-Bat, with the athlete Anthony Romulus becoming a [[OurWerewolvesAreDifferent werewolf]] after Professor Milo gives him a steroid derivative based on wolf estrogen.
146** ''WesternAnimation/BatmanBeyond'':
147*** "[[Recap/BatmanBeyondS2E3Splicers Splicers]]" has its antagonist Dr. Abel Cuvier running a for-profit splicing clinic, injecting people with animal DNA. When political pressure from anti-splicing activists threatens to criminalize his business, he reacts by sending three of his mutated minions to [[AssassinationAttempt try killing Gotham's district attorney]]. When Batman intervenes, Cuvier splices him with bat DNA, which temporarily turns him into a Man-Bat-like monster.
148*** "[[Recap/BatmanBeyondS3E8E9CurseOfTheKobra Curse of the Kobra]]" features the reptile-worshiping Kobra cult, with many of their members having spliced themselves with snake DNA. Their leader Zander and a few of his henchmen turn themselves into human-dinosaur hybrids before they try to TakeOverTheWorld, and [[StalkerWithACrush Zander]] even attempts to have [[DamselInDistress Max]] spliced against her will to serve as his mate (though Batman stops them before they could do so).
149*** In ''WesternAnimation/BatmanBeyondReturnOfTheJoker'', one of the Jokerz gang members working for the Joker is a hyena splicer named Woof.
150** ''WesternAnimation/JusticeLeague'' has the recurring minor villain {{ComicBook/Cheetah}}, who in this universe was a [[ProfessorGuineaPig geneticist who spliced herself with]] [[CatFolk feline DNA]].
151* The Mutates in ''{{WesternAnimation/Gargoyles}}'' are a group of formerly-human test subjects that were genetically altered by Dr. Sevarius in experiments to create gargoyle-like beings for Xanatos. They were all spliced with bat, cat and electric eel DNA, thus mutating them into {{winged|Humanoid}} [[CatFolk cat-people]] with [[ShockAndAwe electrical powers]] as a result. This technology is later used to transform Wolf of [[QuirkyMinibossSquad the Pack]] into a literal WolfMan.
152* One episode of ''WesternAnimation/GIJoeARealAmericanHero'' has Cobra create a formula to transform people into animal hybrids to use as soldiers. [[WeaksauceWeakness Just one bite of normal meat]] changes them back, however.
153* The ''WesternAnimation/JohnnyBravo'' episode "The Island of Mrs. Morceau" (obviously spoofing ''Literature/TheIslandOfDoctorMoreau'') has Johnny Bravo being tricked into visiting [[MadScientist Dr. Morceau]]'s island laboratory, where she uses him as another test subject in her experiments to turn people into human-animal hybrids. Johnny himself is turned into a hamster-man.
154* The ''WesternAnimation/RoadRovers'' are a group of stray dogs who have been given humanoid form by a mysterious scientist who calls himself "The Master" to fight crime. Unusually, the Road Rovers are able to change from their anthropomorphic forms into regular dogs (through the use of the Master's technology), allowing them to have {{Secret Identit|y}}ies as the pets of various world dignitaries.
155* [[BigBad Dr. Kamikaze]]'s usual M.O. to try and catch the titular ''WesternAnimation/{{Robotboy}}'' is to use his super science know-how to create powerful animal-like monsters, sometimes making them from scratch or just [[UpliftedAnimal uplifting]] his pet animals. One standout event is when he stole Gus' DNA to create animal hybrids with it, due to his TooDumbToLive tendencies making him the perfect person to create fearless and reckless soldiers out of.
156* ''WesternAnimation/TheSimpsons'': In the last segment of "WesternAnimation/TreehouseOfHorror [[Recap/TheSimpsonsS14E1TreehouseOfHorrorXIII XIII]]" ("The Island of Doctor Hibbert", obviously spoofing ''Literature/TheIslandOfDoctorMoreau''), the Simpson family go on vacation to a remote island, where Dr. Hibbert (who now lives there) has become a MadScientist obsessed with genetic engineering. Hibbert turns the Simpsons (along with many other recurring citizens of Springfield) into a wide variety of human-animal hybrids, some more animalistic than others.
157* The ''WesternAnimation/StreetSharks'' are four teenage boys transformed into anthropomorphic sharks by the MadScientist Dr. Paradigm through [[LegoGenetics "gene slamming"]]. Paradigm's goal is to mutate everyone into FishPeople.
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