History TearJerker / AmericanDad

* Klaus on the brink of tears after Roger rudely tells him that he's not a pet because nobody loves him on ''Stan's Best Friend''.

* The flashback of Roger's most memorable moments on "Naked to the Limit: One More Time" when it looks as if Roger is going back to his home planet.

* ''National Treasure 4: Baby Franny: She's Doing Well: The Hole Story'' puts a horrifyingly depressing new light on all the previous Francine-centric episodes where she either tries to find a career or some new form of fulfillment beyond what she has. Because she was saved from a well when she was younger, and a firefighter died [[spoiler: though not really]] so she could live, Francine's previous attempts at jobs and careers were all to prove that her life really was worth saving. She's felt that she's done nothing with her life, meaning that firefighter died for nothing and it's on her head.
* Steve's dream about him and Simon in "Choosy Wives Choose Smith". He just wanted Simon to love him.
* Barry being forced to kill Rosie the calf.
* For some, Stan's death in the end of the episode "Hot Water".

* Barry being forced to kill Rosie the calf.

* Barry being forced to kill (and ''eat'') Rosie the calf.

* Steve's dream about him and Simon in "Choosy Wives Choose Smith". He just wanted Simon to love him.

* Steve's dream about him and Simon in "Choosy Wives Choose Smith".

* ''National Treasure 4: Baby Franny: She's Doing Well: The Hole Story'' puts a horrifyingly depressing new light on all the previous Francine-centric episodes where she either tries to find a career or some new form of fulfillment beyond what she has. Because she was saved from a well when she was younger, and a firefighter died [[spoiler: though not really]] so she could live, Francine's previous attempts at jobs and careers were all to prove that her life really was worth saving. She's felt that she's done nothing with her life, meaning that firefighter died for nothing and it's on her head.

* The subplot with Lindsay dying from staph infection after breaking her leg in soccer on "Adventures In Hayley-Sitting"

* "Man in the Moonbounce", where Stan has fun for the first time in his life, then breaks down sobbing over the loss of his childhood.

* The subplot with Lindsay in "Adventures In Hayley-Sitting"

* Klaus on the brink of tears after Roger rudely tells him that he's not a pet because nobody loves him on ''Stan's Best Friend''.

* Stan not winning the respect of his neighbors in "I Can't Stan You". Sure he is a jerkass but he just [[JerkassWoobie wants to]] [[IJustWantToBeLoved be loved]].

* Stan and Hayley's relationship. "Stannie Get Your Gun" showed that they were once the best of friends who loved each other and now their political views [[WeUsedToBeFriends turned them into mortal enemies.]] Sure Stan's an a-hole, [[JerkassWoobie but he just wants those happy days back.]]
-->'''Stan:''' By morning she'll be back in her bed wearing her footsie pajamas and sucking on her ''[[Disney/TheLionKing Lion King]]'' blankie.
-->'''Francine:''' But she got rid of those things years ago.
-->'''Stan:''' ''(points to his head)'' Not in here.
* This brief moment from "Pulling Double Booty" when Hayley is outlining her three-way with Stan (posing as his body double) and a waitress.

* "Weiner of Our Discontent", when Roger realizes that he was sent to Earth as a crash test dummy and not on some important mission and goes through a month-long depression (though it can be argued that Roger deserved it because of his rude behavior before discovering his true intentions of being put on Earth).

* Stan not winning the respect of his neighbors in ''I Can't Stan You''. Sure he is a jerkass but he just [[JerkassWoobie wants to be beloved]].

* The subplot from "Delorean Story-an" parodying ''TheTortoiseAndTheHare''.

* ''Stan's Best Friend'': The story of how young Stan was forced to kill his dog because he thought he had a terminal disease ([[spoiler:Turns out it was because his mom was moving into an apartment that didn't allow dogs or cats. Rabbits, however, were only allowed on a case-by-case basis]]). Even Stan said the story was so sad, that he wasn't going to undercut the flashback with a joke.

* "Man in the Moonbounce", where Stan has fun for the first time in his life and cries about not having a real childhood.

* ''Stan's Best Friend'' the entire freaking episode.

* "Weiner of Our Discontent", when Roger realizes that he was sent to Earth as a crash test dummy and not on some important mission and goes through a month-long depression (though it can be argued that Roger deserved it because of his rude behavior before discovering his true intentions of being put on Earth)..

* This brief moment from "Pulling Double Booty" when Hayley is outlining her three-way with Bill (Stan's body double) and a waitress.

-->'''Stan:''' By morning she'll be back in her bed wearing her footsie pajamas and sucking on her ''[[TheLionKing Lion King]]'' blankie.

* Stan being DrivenToSuicide in "Every Which Way But Lose", saying that he's a big fat loser who doesn't deserve to live because he lost one game in life.

* "Stan's Best Friend". Just..."Stan's Best Friend".
* Stan realizing he wasn't there for Steve's big moments in "Virtual In-Stanity"
* Teddy Bonkers from "Haylias".
* Stan and Hayley's relationship. "Stannie Get Your Gun" showed that they were once the best of friends who loved each other and now their political views [[WeUsedToBeFriends turned them into mortal enemies.]] Sure Stan's an asshole, [[JerkassWoobie but he just wants those happy days back.]]

* This brief moment from "Pulling Double Booty".

-->'''Stan:''' ''(tearing up)'' You used to watch ''SesameStreet''.
* "Weiner of Our Discontent", when Roger realizes that he was sent to Earth as a crash test dummy and not on some important mission.
* Roger's abuse in "A.T.: The Abusive Terrestrial", especially his song.
** His song is downright ''heartbreaking'' if you've lost a friend, or have grown apart from one.
* Francine facing the facts that Steve is growing up and moving on in "Iced, Iced Babies".
* Stan's getting anorexia in "The American Dad After School Special".
* "Man in the Moonbounce", where Stan has fun for the first time in his life and cries about not having a real childhood. Later, Stan gets sent to jail and Steve has to do all the chores, turning him into a cranky, old-looking man.
* Stan being DrivenToSuicide in "Every Which Way But Lose", saying that he's a big fat loser who doesn't deserve to live because he lost one game in life.
* A scene from "Fartbreak Hotel" where Future!Francine, who now has a successful life after abandoning her family, looks in on her old house and sees that her family and moved on and doesn't care she's gone.
* Stan's [[HeroicBSOD near-death experience]] in "Stanny Slickers II: The Legend of Ollie's Gold".
* The ''WhatsEatingGilbertGrape''-esque subplot from "Irregarding Steve". Pretty impressive considering it was done with ''talking squirrels''.
* Francine crying over her family not bonding in "The Vacation Goo".

* The ''WhatsEatingGilbertGrape''-esque subplot from "Irregarding Steve".

* The ''WhatsEatingGilbertGrape''-esque subplot from "Irregarding Steve".

* Stan's [[HeroicBSOD near-death experience]] in "Stanny Slickers II: The Legend of Ollie's Gold".

-->'''Stan:''' By morning she'll be back wearing footsie pajamas, sucking on her ''[[TheLionKing Lion King]]'' blankie.

* Stan and Hayley's relationship. "Stannie Get Your Gun" showed that they were once the best of friends who loved each other and now their political views [[WeUsedToBeFriends turned them into mortal enemies.]] Sure Stan's an asshole, [[JerkassWoobie but he just wants his girl back.]]

* A scene from "Fartbreak Hotel" where Future!Francine, who now has a successful life after abandoning her family, looks in on her old house and sees that her family and moved on and doesn't care she's gone.