History ShoutOut / FiendFolio

** Another enemy, this time in the corpse, known as Fingore, is a zombie that points at Isaac and tries to grab him. Fingore resembles the Unstoppable Nevadean Champion himself, [[MonsterClown Tricky]]. They also use sounds from the Grunts, further hammering in the reference.

* A vertical [=2x1=] layout in the Womb is labeled "[[WebVideo/MinecraftWithGadget My deduction skills as a detective tell me he has quite possibly never - ]]" (the last part, "had sex.", is cut off.)

** Speaking of ''VideoGame/NuclearThrone'', There's also a secret joke option called Popo Modo, that spawns IDPD units, as well as Fish [[DepartmentOfRedundancyDepartment From Nuclear Throne]][[note]]Yes, thats its full name[[/note]], and also IDPD Gary.

** Speaking of trading card games, [[TabletopGame/{{Pokemon}} Energy Cards]] can be found and, like Pot of Greed, have their respective card back, they can also be found more often via the Energy Searcher trinket

* An enemy encountered in the Mausoleum is Shi, whose name and design references [[VideoGame/{{SpookysJumpscareMansion}} Specimen 4]]. Thankfully, this one can't vore you like the original Specimen 4, otherwise this would be grounds for a DemonicSpider.

** Speaking of ''VideoGame/NuclearThrone'', There's also a secret joke option called Popo Modo, that spawns IDPD units, as well as Fish [[DepartmentOfRedundancyDepartment From Nuclear Throne]][[note]]Yes, thats its full name[[/note]], and also [[TheLastOfTheseIsNotLikeTheOthers IDPD Gary]]

** The Ascent-only enemies known as the Mag Gapers, Mag Horfs, and Mag Clotties were all named after the Mag Agents, with all four of them being stronger and larger versions of standard foes in their series (Gapers, Horfs, and Clotties for ''[=TBoI=]'', Agents for ''Madness Combat'').

** The Ascent-only enemy known as the Mag Gaper was named after the Mag Agents, with both being stronger and larger versions of standard foes in their series (Gapers for ''[=TBoI=]'', Agents for ''Madness Combat'').

** The Fiend Soda is based on Crit-A-Cola, also from ''Team Fortress 2''. Its FlavorText, "Critical spit", likely references the "CRITICAL SHIT" meme.

** Speaking of dueling card games, [[TabletopGame/{{Pokemon}} Energy Cards]] can be found and, like Pot of Greed, have their respective card back, they can also be found more often via the Energy Searcher trinket

** Speaking of dueling card games, [[Franchise/{{Pokemon}} Energy Cards]] can be found and, like Pot of Greed, have their respective card back, they can also be found more often via the Energy Searcher trinket

* The Pot of Greed card comes directly from the ''Franchise/YuGiOh'' franchise, complete with the same card back, text description, and effect (it spawns two cards, like a weaker Ancient Recall).

* The Reheated Pizza item, when used on most characters, changes their head to be a mirror image of Peppino, the main protagonist of ''VideoGame/PizzaTower''. Equipping the item on Fiend and The Bastard turns their heads into The Noise and Fake Peppino respectively, two bosses from the same game.

* When Golem picks up Technology, his face cracks open on one side, revealing a ''Franchise/{{Terminator}}'' skull inside

* The 2.8 Spitshine update adds the [[VideoGame/EarthBound1994 Fuzzy Pickle]] trinket, which gives Isaac a small stat boost for every ShoutOut item he has.

* The Black Moon item serves as a reference to [[Franchise/NeonGenesisEvangelion Lilith]], as it not only gives Isaac a mask like the one she wears, but its activated aura spawns a red cross, not unlike the one she is crucified on.

* When Golem picks up Technology, his face cracks open on one side, revealing a ''Film/{{Terminator}}'' skull inside

* One of the two new horsemen featured in the mod, Pollution, is named after one of the modern-day horsemen featured in ''Literature/GoodOmens''.

* Meltdown, the Modern Horseman of Burning Basement, looks like a combination of War and [[VideoGame/NuclearThrone Melting]]