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* ''WesternAnimation/EdEddNEddy'': [[VideoGame/TYTheTasmanianTiger Andy]], [[WesternAnimation/BabyLooneyTunes Daffy Duck]], and [[Anime/MobileSuitGundamSeed Miguel Aiman]] (or, alternatively, [[Manga/CardcaptorSakura Kero, Julian and Tori]]) have tons of misadventures in their cul-de-sac. The other denizens on the cul-de-sac are [[Manga/RanmaOneHalf Hinako Ninomiya]], Andy's bratty sister; [[WesternAnimation/DragonTales Wheezie]], a JerkJock; [[Literature/ShakuganNoShana Shana]] ([[TheOtherDarrin who depending on the episode is also]] [[VideoGame/LeagueOfLegends Sona]], [[Manga/{{InuYasha}} Jakotsu]] or [[VideoGame/PuyoPuyo Feli]]), a DumbBlonde; [[Manga/DragonBallZ Goku]], a FunnyForeigner; and [[Series/OnceUponATime Doc]], who has a NotSoImaginaryFriend [[note]]Jimmy's voice actor Keenan Christensen doesn't have any other known roles[[/note]]. There's also a TerribleTrio consisting of [[Manga/RanmaOneHalf Tsukasa]] (sometimes [[VideoGame/Persona4 Chie Satonaka]]), [[Toys/{{Bionicle}} Roodaka]], and [[Manga/{{InuYasha}} Kagura]], who all have crushes on the main trio. [[WesternAnimation/MyLittlePonyFriendshipIsMagic Igneous Rock]] is Miguel Aiman's mysterious older brother.
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* ''WesternAnimation/EdEddNEddy'': [[VideoGame/TYTheTasmanianTiger Andy]], [[WesternAnimation/BabyLooneyTunes Daffy Duck]], and [[Anime/MobileSuitGundamSeed Miguel Aiman]] (or, alternatively, [[Manga/CardcaptorSakura Kero, Julian and Tori]]) have tons of misadventures in their cul-de-sac. The other denizens on the cul-de-sac are [[Manga/RanmaOneHalf Hinako Ninomiya]], [[Anime/NightWarriorsDarkstalkersRevenge Felicia]], Andy's bratty sister; [[WesternAnimation/DragonTales Wheezie]], a JerkJock; [[Literature/ShakuganNoShana Shana]] ([[TheOtherDarrin who depending on the episode is also]] [[VideoGame/LeagueOfLegends Sona]], [[Manga/{{InuYasha}} Jakotsu]] or [[VideoGame/PuyoPuyo Feli]]), a DumbBlonde; [[Manga/DragonBallZ Goku]], a FunnyForeigner; and [[Series/OnceUponATime Doc]], who has a NotSoImaginaryFriend [[note]]Jimmy's voice actor Keenan Christensen doesn't have any other known roles[[/note]]. There's also a TerribleTrio consisting of [[Manga/RanmaOneHalf Tsukasa]] (sometimes [[VideoGame/Persona4 Chie Satonaka]]), [[Toys/{{Bionicle}} Roodaka]], and [[Manga/{{InuYasha}} Kagura]], who all have crushes on the main trio. [[WesternAnimation/MyLittlePonyFriendshipIsMagic Igneous Rock]] is Miguel Aiman's mysterious older brother.
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* ''WesternAnimation/DaBoomCrew'': [[WesternAnimation/CarlSquared Jamie James]], [[Film/BigMommasHouse Trent Pierce]], [[WesternAnimation/CaptainFlamingo Lizbeth Zaragoza]] and [[WesternAnimation/MissSpidersSunnyPatchFriends Dragon]] are four kids that created a homemade video game, which causes a power surge to throw them inside of their game. They embark on a quest to find their missing game cartridges and stop the villain [[Series/NewAttitude Lamarr]] from taking control of the cosmos.
* ''WesternAnimation/DanVs'': [[WesternAnimation/StrokerAndHoop Double Wide]] takes his friend [[Series/TheKidsInTheHall Hecubus]] (as well as Hecubus' wife [[Series/CriminalMinds Emily Prentiss]]) to get revenge on what had wronged him in the past. It rarely ends well for him. [[WesternAnimation/TheFairlyOddParents Cupid]] is a NewAgeRetroHippie.
* ''WesternAnimation/DangerRangers'': In a WorldOfFunnyAnimals, [[WesternAnimation/GIJoeARealAmericanHero Sci-Fi]], [[VideoGame/SlyCooperThievesInTime Carmelita Montoya Fox]], [[VideoGame/RatchetAndClank2002 Chairman Drek]], [[WesternAnimation/TimeSquad Larry 3000]], [[WesternAnimation/TeenageMutantNinjaTurtles1987 Raphael]], and [[VideoGame/SaintsRowTheThird Monica Hughes]] educate children about the importance of safety while dealing with anyone and anything that threatens their safety. [[Series/TalesFromTheCrypt The Crypt Keeper]] is their clumsy robot companion and [[WesternAnimation/CowAndChicken the Red Guy]] ([[WesternAnimation/ABugsLife Manny]] in the original pilot) is their artificial intelligence.
* ''WesternAnimation/DanielTigersNeighborhood'': WesternAnimation/MikeTheKnight (later [[WesternAnimation/PJMasks Night Ninja]] and then [[WesternAnimation/PawPatrol Rubble]]) lives in the Neighborhood of Make-Believe with his parents [[WesternAnimation/{{Roboroach}} Reg Roach]] and [[WesternAnimation/WildKratts Koki]], his little sister [[WesternAnimation/CreativeGalaxy Epiphany]], and his grandfather [[WesternAnimation/{{Redwall}} Shadow]]. His friends include [[Series/MaxAndShred Juliet]] (daughter of [[Series/AmericanGothic2016 Dana]]), [[WesternAnimation/MyBigBigFriend Lili]] (later WesternAnimation/{{Elinor|WondersWhy}}) (daughter of [[Series/TheJaneShow Jane Black]] and [[WesternAnimation/TrailerParkBoysTheAnimatedSeries Clont]]), [[WesternAnimation/SuperWhy Littlest Pig]] (nephew of [[WesternAnimation/TimeWarpTrio Uncle Joe]]), [[WesternAnimation/SuperWhy Whyatt]] ([[WesternAnimation/{{Sixteen}} Coach Halder]] and [[WesternAnimation/StickinAround Stella Stickler]]'s youngest son and [[Series/TheBestYears Rich Powell]]'s little brother), and [[WesternAnimation/AbbyHatcher Mo]] (daughter of [[Series/InstantStar Portia Quincy]], granddaughter of [[WesternAnimation/{{Babar}} Madame]], and older sister of [[Franchise/{{Peanuts}} Rerun]] and [[WesternAnimation/{{Grojband}} Laney Penn]]).
* ''WesternAnimation/DannyPhantom'': [[WesternAnimation/{{Freakazoid}} Dexter Douglas]] is a ghost powered superhero. His best friends [[WesternAnimation/AvatarTheLastAirbender Azula]] and [[WesternAnimation/{{Recess}} Vince]] help him out along the way. His parents [[Franchise/WinnieThePooh Kanga]] and [[WesternAnimation/{{Catscratch}} Gordon]] are ghost hunters while his sister [[Anime/DigimonAdventure Sora Takenouchi]] [[IJustWantToBeNormal just wants to be a normal person]]. He is also taught by [[WesternAnimation/TeenTitans2003 Slade]], and has a crush on the resident AlphaBitch [[WesternAnimation/JusticeLeague Hawkgirl]]. Dexter's enemies include [[Series/{{Roseanne}} Leon Carp]], WesternAnimation/{{Bubsy}}, [[WesternAnimation/KungFuPandaLegendsOfAwesomeness Temutai]], WesternAnimation/JohnnyTest, [[WesternAnimation/ThePowerpuffGirls Bubbles]], [[WesternAnimation/TheSpectacularSpiderMan Doctor Octopus]], [[Toys/{{Bionicle}} Mata Nui]], [[WesternAnimation/BatmanTheBraveAndTheBold Huntress]], and [[Series/{{Frasier}} Roz Doyle]].
** In an alternate future, Dexter grows up to become [[Series/DoctorWho The Master]], which [[Film/KillBill Bill]] tries to prevent.
** In the ChristmasEpisode, Dexter is trapped in a poem by [[WesternAnimation/TheLegoMovie Batman]].
* ''WesternAnimation/DarkwingDuck'': {{WesternAnimation/Cat|Dog}} is an egotistical crime fighter who is joined in his adventures by his adopted daughter [[WesternAnimation/AaahhRealMonsters Oblina]] and his pilot sidekick [[Film/TheGodfather Luca Brasi]]. He clashes with such supervillains as crime lord [[WesternAnimation/TheWildThornberrys Nigel Thornberry]] (including his henchmen [[Franchise/{{Transformers}} Shrapnel]] and [[WesternAnimation/DextersLaboratory Mandark]]), film-directing criminal [[WesternAnimation/TheLittleMermaid1989 King Triton]], metal-mouthed [[WesternAnimation/PinkyAndTheBrain Pinky]], electrical menace [[WesternAnimation/TheSimpsons Krusty the Klown]], salesman-turned-hydrokinetic [[WesternAnimation/SpiderManTheAnimatedSeries Nick Fury]], plant-loving scientist [[WesternAnimation/{{Barnyard}} Pig]], crazed toymaker [[WesternAnimation/{{Rugrats}} Drew Pickles]], and his archnemesis doppelganger, Franchise/WinnieThePooh. He also romances reformed criminal [[WesternAnimation/DannyPhantom Maddie Fenton]] and occasionally clashes with rival superhero [[WesternAnimation/TheSmurfs1981 Greedy Smurf]]. Cat's next-door neighbors include [[WesternAnimation/TazMania the Tazmanian Devil]], his wife [[WesternAnimation/PepperAnn Aunt Janie Diggety]], their bratty son [[WesternAnimation/GoofTroop Max Goof]], and their younger son [[WesternAnimation/TotallySpies Alex]], who also knows Cat's secret identity and helps him and his friends.
* ''WesternAnimation/DaveTheBarbarian'': While the king and queen are away, Udrogoth is being ruled and protected by [[WesternAnimation/TinyToonAdventures Montana Max]], his sword [[Series/{{Seinfeld}} Estelle Costanza]], his sisters [[WesternAnimation/{{Animaniacs}} Dot Warner]] and [[Literature/TheMagicSchoolBus Keesha]], his uncle [[WesternAnimation/DannyPhantom Skulker]], and his pet dragon [[WesternAnimation/{{Aladdin}} Abu]]. Their most fearsome enemy is the Dark Lord WesternAnimation/{{Freakazoid}}. Their adventures are narrated by [[WesternAnimation/CodenameKidsNextDoor Mr. Boss]].
** In one episode, [[Music/{{Metallica}} James Hetfield, Lars Ulrich]], and [[WesternAnimation/{{Rugrats}} Charlotte Pickles]] teach Abu how to be a real dragon.
** In an award-winning episode, [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Billy]] attempts to take over Udrogoth by time travel.
* ''WesternAnimation/TheDayMyButtWentPsycho'': [[WesternAnimation/{{Wishfart}} Dez]] and his buddy [[WesternAnimation/TheAdventuresOfSamAndMaxFreelancePolice Max]] go on misadventures with [[WesternAnimation/NumbChucks Quills]] (daughter of [[WesternAnimation/{{Wayside}} Principal Kidswatter]]) fighting butt-themed villainy, namely [[WesternAnimation/DanielTigersNeighborhood Dad Tiger]] and his henchmen [[WesternAnimation/RocketMonkeys Wally]] and [[WesternAnimation/{{Spliced}} Entree]]. Dez lives with his grandmother [[Anime/{{Bakugan}} Runo Misaki]].
* ''Franchise/DCAnimatedUniverse''
** ''WesternAnimation/BatmanTheAnimatedSeries'': [[WesternAnimation/TheVentureBrothers Captain Sunshine]] is a crime fighter. [[WesternAnimation/AvatarTheLastAirbender Fire Lord Ozai]] is an insane criminal mastermind and a MonsterClown. Sunshine often fights crime with [[WesternAnimation/DefendersOfTheEarth Rick Gordon]]. [[Series/LittleHouseOnThePrairie Laura Ingalls Wilder]] (later [[WesternAnimation/DrawnTogether Princess Clara]]) is a young female superhero, while [[Series/{{Smallville}} Lionel Luthor]] is a PunchClockVillain who suffers greatly from ChronicVillainy. Other villains include [[Series/{{Maude}} Bea Arthur's daughter]], [[Film/AnimalHouse Dean Wormer]], [[Film/BrokenArrow1950 Cochise]], [[Series/NightCourt Bull the Bailiff]], [[Franchise/PlanetOfTheApes Cornelius]], [[WesternAnimation/TeenTitans2003 Slade]], and [[Film/PhantomOfTheParadise Swan]], among others.
** ''WesternAnimation/SupermanTheAnimatedSeries'': [[Series/{{Wings}} Joe Hackett]] is the Man of Steel, who is sent to Earth by his parents [[Film/HappyGilmore Shooter McGavin]] and [[Series/Charmed1998 Patty Halliwell]], and after being adopted by real-life couple [[Series/{{Mash}} B.J. Hunnicutt]] and [[Series/{{Coach}} Christine Armstrong Fox]], grows up to become a journalist at a major metropolitan newspaper, where he's friendly rivals with [[Series/DesperateHousewives Katherine Mayfair]], working for [[WesternAnimation/BatmanTheAnimatedSeries The Ventriloquist]]. But as the near-invincible Man of Steel, he has many enemies, including [[WesternAnimation/AvatarTheLastAirbender Long Feng]], [[VideoGame/SplinterCell Sam Fisher]], [[WesternAnimation/{{Hercules}} Zeus]], [[Film/AClockworkOrange Alex DeLarge]], [[WesternAnimation/{{Aladdin}} Iago]], Film/TankGirl, [[Film/TheFifthElement General Munro]], and Film/{{Harold|AndMaude}}; but he has quite a few allies like [[Series/TheNanny Maggie Sheffield]], [[Series/TilDeath Joy Stark]] and police officers [[Film/BladeRunner Zhora]] and [[Film/BigDaddy Lenny Koufax]]. [[WesternAnimation/MegasXLR R.E.G.I.S. Mark V]] and [[Series/EverybodyLovesRaymond Robert Barone]] have recurring roles as heroes and villains.
** ''WesternAnimation/BatmanBeyond'': TwentyMinutesIntoTheFuture, after his father [[Series/FamilyTies Steven Keaton]] is killed by [[VideoGame/DevilMayCry2 Arius]], [[WesternAnimation/KimPossible Ron Stoppable]] swipes a costume from Sunshine in order to get revenge. [[VideoGame/StarcraftII Selendis]] later learns his secret. [[WesternAnimation/{{Futurama}} Amy Wong]] is his girlfriend. [[Film/AustinPowers Scott Evil]] is a JerkJock rival.
*** "Dead Man's Hand": Ron falls for [[Series/TheWonderYears Karen Arnold]], not knowing she's part of a gang led by [[Film/OnHerMajestysSecretService James Bond]].
*** "Meltdown": Sick of his decaying body, Arius turns to Dr. [[Franchise/{{Terminator}} Sarah Connor]] for a solution. She proposes making a new body, and tests the procedure on Sunshine's old nemesis, [[Series/StarTrekTheOriginalSeries Kang]], who has been in hiding for decades, and decides to make amends after all these years.
*** "A Touch of Curare": District attorney [[Film/StarTrekIITheWrathOfKhan Captain Terrell]] has been targeted for assassination by [[VideoGame/KingdomHeartsII Vivi Ornitier]], and Commissioner [[Film/{{Grease}} Betty Rizzo]], the former Batgirl, tries to protect him, being unamused by Ron's work.
*** "Disappearing Inque": Feeling unappreciated at his job, [[Film/MysteryMen The Shoveler]] breaks [[WesternAnimation/TheWildThornberrys Gillian Gibson]] out of her icy prison, and she wants vengeance against Ron and Sunshine.
*** "Ascension": As Arius' condition worsens, he calls upon his son [[Film/ThePrincessBride Westley]] for help, but Westley has other plans for his father.
*** "Earth Mover": One of Ron's classmates, [[Series/SabrinaTheTeenageWitch Valerie Birkhead]], learns from his foster father the truth about what actually happened to her father, [[Film/StarTrekTheMotionPicture Willard Decker]].
*** "The Call": Ron teams up with the other heroes of the future, including [[WesternAnimation/TheIronGiant Kent Mansley]], [[WesternAnimation/KingOfTheHill Connie Souphanousinphone]], [[Series/{{Wings}} Alex Lambert]], [[WesternAnimation/TheLittleMermaid1989 Ariel]], [[Series/HowIMetYourMother James Stinson]], and [[WesternAnimation/TeenTitans2003 Robotman]], but discovers one of them might be a traitor.
*** "Final Cut": [[Film/MuppetTreasureIsland Long John Silver]] threatens to blow up Gotham unless Ron helps him stop Vivi Ornitier.
*** "Sneak Peek": [[Film/ThisIsSpinalTap David St. Hubbins]] is a shady tabloid host who uncovers the secret identities of Ron and Sunshine.
** ''WesternAnimation/StaticShock'': [[WesternAnimation/{{Futurama}} Hermes Conrad]] gains superpowers after a freak accident and must keep them secret from his father, [[WesternAnimation/TransformersPrime Bulkhead]]. Later, his buddy [[WesternAnimation/AGoofyMovie Max Goof]] gets his own powers.
*** Alternately, [[WesternAnimation/TheWeekenders Tino and Carver]] receive their own superpowers.
** ''WesternAnimation/TheZetaProject'': [[Series/TheDrewCareyShow Oswald Harvey]] is a peaceful robot who is searching for his hard to find creator with his buddy, [[WesternAnimation/MegasXLR Kiva's Ancestor]]. He's pursued by several government agents, including [[Series/That70sShow Red Foreman]], [[WesternAnimation/JusticeLeague The Flash]], [[WesternAnimation/CodenameKidsNextDoor Numbuh 3]], and later [[Series/SunsetBeach Virginia Harrison]], who signs on after Numbuh 3 quits.
** ''WesternAnimation/JusticeLeague'': Joe Hackett (now [[VideoGame/FinalFantasyVII Sephiroth]]), Captain Sunshine, [[WesternAnimation/JackieChanAdventures Viper]], [[Series/{{Smallville}} Lex Luthor]], [[WesternAnimation/AvatarTheLastAirbender Earth King Kuei]], [[VideoGame/MarvelVSCapcom3 She-Hulk]], and [[Series/{{Alias}} Marcus Dixon]] join forces to become a superhero team, in a bid to protect the world from the likes of villains such as [[WesternAnimation/AvatarTheLastAirbender Long Feng, Fire Lord Ozai]], [[Film/SinCity Senator Roark]], WesternAnimation/{{Aladdin}}, and the fearsome [[VideoGame/SplinterCell Sam Fisher]].
** ''WesternAnimation/JusticeLeagueUnlimited'': The ranks of the above superhero team immensely grows, with other heroes such as archer [[Series/GeneralHospital Scotty Baldwin]], Sephiroth's cousin [[Series/TheNanny Maggie Sheffield]], radioactive military man [[VideoGame/BatmanArkhamCity Deadshot]], shrinking scientist [[Series/{{Scrubs}} Dr. Cox]], conspiracy theorist [[Series/StarTrekEnterprise Commander Shran]], animal-themed heroine [[Series/{{Firefly}} Zoe Washburne]], modern-day cowboy [[Series/{{Firefly}} Malcolm Reynolds]], blundering glory-hound [[Series/{{Southland}} Detective Russell Clarke]] (and his robot companion [[WesternAnimation/{{Futurama}} Philip J. Fry]]) and the great magician [[VideoGame/UltimateSpiderMan2005 Silver Sable]], among many others. A government-sanctioned body headed by [[Film/{{Avatar}} Moat]], staffed with people such as [[Film/SpiderManTrilogy J. Jonah Jameson]] and [[Series/SixFeetUnder Dr. Bernard Chenowith]], and funded by Long Feng aim to control them, believing them to be too powerful to be left unchecked.
* ''WesternAnimation/TheDeep2015'': [[WesternAnimation/{{Ninjago}} Kai]], his sister [[WesternAnimation/DinoTrux Skya]], and their parents [[Series/NinjaTurtlesTheNextMutation Leonardo]] and [[WesternAnimation/EdEddNEddy Marie Kanker]] explore the ocean and unravel its mysteries. The family's archenemies are the pirate [[WesternAnimation/XMenEvolution Blob]], his two kids WesternAnimation/MartinMystery and [[WesternAnimation/LoliRock Iris]], and his first mate [[Anime/DeathNote Ryuk]].
* ''WesternAnimation/DeathstrokeKnightsAndDragons'': [[Film/FantasticFour2005 The Thing]] is a mercenary who must rescue his mute son [[VideoGame/RiverCityGirls Yamada]] when [[Anime/LoveLive Rin Hoshizora]], [[spoiler:the Thing's ''other'' kid]], kidnaps him. [[Series/RizzoliAndIsles Maura Isles]] is the Thing's ex-wife, [[Series/{{Krypton}} General Zod]] is the Thing's friend, and [[VideoGame/TransformersRiseOfTheDarkSpark Drift]] is the reason Isles and the Thing are divorced and Yamada is mute.
* ''WesternAnimation/DefendersOfTheEarth'': After his wife [[WesternAnimation/BatmanTheAnimatedSeries Poison Ivy]] is killed, [[WesternAnimation/GaltarAndTheGoldenLance Galtar]] and his son [[Franchise/DCAnimatedUniverse Dick Grayson]] join forces with [[Film/FridayThe13thPartVIIIJasonTakesManhattan Charles McCulloch]], [[WesternAnimation/TeenageMutantNinjaTurtles1987 Master Splinter]], and [[WesternAnimation/TheTransformers Blaster]] and their successors to defeat the tyrannical [[WesternAnimation/DarkwingDuck Agent Grizzlikof]]
* ''WesternAnimation/DelilahAndJulius'': [[Anime/LoveLive Honoka Kousaka]] and [[WesternAnimation/{{Detentionaire}} Camillio Martinez]] are a pair of secret agents who fight international crime while training at a top-secret spy academy.
* ''WesternAnimation/{{Detention}}'': PerkyGoth [[WesternAnimation/TeenTitans2003 Raven]], conspiracy theorist [[WesternAnimation/{{Futurama}} Philip J. Fry]], the comic book geek head writer of the show, perpetually angry [[Series/Reno911 Deputy Garcia]], identical twins [[Literature/{{Twitches}} Artemis and Apolla DuBaer]], and the eternally peppy [[WesternAnimation/CharlottesWeb Fern]] are a group of kids trying (and failing) to stay out of getting detention from P.E. teacher [[WesternAnimation/DuckTales1987 Mrs. Crackshell]].
* ''WesternAnimation/{{Detentionaire}}'': [[WesternAnimation/MyLittlePonyMakeYourMark Rocky]] ([[WesternAnimation/EverAfterHigh Daring Charming]] in the pilot) is framed for a prank and gets detention for a full year as a result. His friends [[WesternAnimation/DelilahAndJulius Julius Chevalier]], [[WesternAnimation/WinstonSteinburgerAndSirDudleyDingDong Sir Dudley Ding Dong]], and [[Anime/{{Bakugan}} Shun Kazami]] help him find the culprit while avoiding the principal [[WesternAnimation/JimmyTwoShoes Lucius Heinous VII]]. [[WesternAnimation/{{Grossology}} Abby Archer]] is a journalist for the school news program (co-host of [[WesternAnimation/ScaredySquirrel Paddy]]) and Rocky's love interest. The ones who framed Rocky are [[Series/MurdochMysteries Dr. Julia Ogden]] and [[WesternAnimation/ChopChopNinja Magic Master]]. [[Series/ToddAndTheBookOfPureEvil Hannah B. Williams]] is the BetaBitch to [[WesternAnimation/GrowingUpCreepie Creepie Creecher]], whose mother [[WesternAnimation/JacobTwoTwo Renee Ratelle]] is head of the school parents' council secretly working with [[WesternAnimation/RocketMonkeys Gus]]. Nose-picking outcast [[WesternAnimation/TotalDramaPresentsTheRidonculousRace Crimson]] later becomes a core member of Rocky's circle of friends. Notable students at Rocky's school include skater [[WesternAnimation/{{Sixteen}} Jude Lizowski]]; rocker [[WesternAnimation/{{Braceface}} Adam Spitz]]; math nerds [[WesternAnimation/{{Grojband}} Corey Riffin]], [[WesternAnimation/{{Pelswick}} Julie Smockford]] (who later dates Dudley), and [[WesternAnimation/AtomicPuppet Pauline Bell]]; and hearthrob [[Anime/MetalFightBeyblade Gingka Hagane]]. Also, the school mascot is [[WesternAnimation/SevenLittleMonsters Five]], [[WesternAnimation/RudolphTheRedNosedReindeer1964 Hermey the Elf]] is a magician, and the old principal was [[WesternAnimation/DNAce Mendel]].
* ''WesternAnimation/DexHamiltonAlienEntomologist'': [[WesternAnimation/MarvinTheTapDancingHorse Fast-Talking Jack]], [[WesternAnimation/InspectorGadget2015 Talon]], [[WesternAnimation/{{Sidekick}} Vana Glama]], and [[WesternAnimation/TotalDrama Noah]] are a team of scientists who study and capture extraterrestrial insects that are attacking Earth in the year 3000 while also protecting them from [[WesternAnimation/HotelTransylvaniaTheSeries Aunt Lydia]].
* ''WesternAnimation/DextersLaboratory'': [[WesternAnimation/{{Rugrats}} Chuckie Finster]] (later [[WesternAnimation/{{Chalkzone}} Snap]]) is a child genius whose parents are [[WesternAnimation/TinyToonAdventures Fifi La Fume]] and WesternAnimation/JohnnyBravo, and whose older sister is [[WesternAnimation/{{Archer}} Uta]]. He frequently fights with his rival [[Film/{{Grease}} Eugene Felnic]] and has a pet monkey named [[Franchise/{{Transformers}} Megatron]], who is actually a superhero. Chuckie/Snap's best friend at school is [[WesternAnimation/CampLazlo Mr. Slinkman]] and his teacher is [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Goddard]]. Uta's best friends are [[WesternAnimation/MuchaLucha Snow Pea]] and [[WesternAnimation/{{Rugrats}} Lil DeVille]]. Eugene's younger sibling is [[Film/SesameStreetPresentsFollowThatBird Donny Dodo]] and his parents are [[WesternAnimation/JakeAndTheNeverlandPirates Mr. Smee]] and [[WesternAnimation/HeyArnold Miriam Pataki]], while his pet duck is [[WesternAnimation/{{Aladdin}} Abu]]. Uta has an imaginary friend named [[WesternAnimation/ATrollInCentralPark Stanley the Troll]]. In one episode, Chuckie tries seducing his babysitter [[WesternAnimation/DannyPhantom Maddie Fenton]] (whose boyfriend is [[WesternAnimation/ThePenguinsOfMadagascar Kowalski]]). [[VideoGame/MetalGearSolid Grey Fox]] is the mascot of the local SuckECheeses along with his two sidekicks [[WesternAnimation/{{CatDog}} Cliff]] and [[VideoGame/TakAndThePowerOfJuju Party Juju]]. Chuckie also idolizes a bodybuilder named [[WesternAnimation/TeenageMutantNinjaTurtles2012 Shredder]], while Uta and her friends idolize a pony named [[Film/SpaceJam Lola Bunny]].
** One ShowWithinAShow has three superheroes, WesternAnimation/SpongeBobSquarePants, [[WesternAnimation/PinkyandTheBrain Pinky]], and [[Franchise/ScoobyDoo Fred Jones]], living together. Fred watches a puppet show starring [[WesternAnimation/{{Animaniacs}} Yakko]] and [[WesternAnimation/RockosModernLife Heffer]].
** Another segment involves Megatron being summoned by [[WesternAnimation/TheSpectacularSpiderMan Martha Connors]] to fight villains like [[WesternAnimation/SupermanTheAnimatedSeries Lobo]], [[VideoGame/GodOfWarIII Perses the Lava Titan]], [[Main/ProfessionalWrestling "Macho Man" Randy Savage]], [[WesternAnimation/TheBatman Temblor]], and [[Film/TeamAmericaWorldPolice Alec Baldwin]].
* ''ComicBook/{{Diabolik}}'': [[WesternAnimation/MyDadTheRockStar Rock Zilla]] is a master thief who along with his partner [[WesternAnimation/{{Sixteen}} Jen Masterson]] pursue vengeance against Rock's brother [[WesternAnimation/GetEd Anthony Ol' Skool]] for framing him for the murder for his adoptive father [[VideoGame/ResidentEvil2 Brian Irons]] - all while being pursued by the detective [[WesternAnimation/TheAvengersUnitedTheyStand Edwin Jarvis]].
* ''WesternAnimation/DiGataDefenders'': The host of ''Series/TheBachelorette Canada'', [[Film/{{Superbad}} Becca]], [[WesternAnimation/TotalDrama Geoff]], and his sister [[WesternAnimation/{{Cyberchase}} Creech]] defend the world of [=RaDos=] from the evil Order of Infinis, which is led by [[WesternAnimation/XMenTheAnimatedSeries Cable]] and his lieutenants, [[WesternAnimation/JaneAndTheDragon King Caradoc]], [[WesternAnimation/{{Sidekick}} Master XOX]], and [[WesternAnimation/{{Wishfart}} Fireball Cat]] as they seek to free a SealedEvilInACan. Our heroes are helped out by a rogue named [[Anime/DeathNote Hirokazu Ukita]] and mentored by [[Film/{{Cube}} Quentin]]. In Season 2, [[Film/CheaperByTheDozen2003 Kenneth Murtaugh]] joins the heroes' team to help them battle a returning evil, while [[Series/TrailerParkBoys Officer Erica Miller]] joins the villains as a representative for the new threat.
* ''WesternAnimation/{{Dilbert}}'': [[Series/GettingOn Richard James]] is stuck in a dead-end office job under [[Film/TheNuttyProfessor1996 Dean Richmond]]. His co-workers are [[Series/MadAboutYou a TV host]], [[WesternAnimation/TheSimpsons Francine]], [[WesternAnimation/RockosModernLife Heffer Wolfe]], and [[Series/EvenStevens Coach Tugnut]]. He lives with his mother, [[Series/TheNewNormal Frances Bartholomew]], and his pets, [[Film/TheDictator Mr. Ogden]], [[WesternAnimation/InspectorGadget Chief Quimby]], and [[WesternAnimation/AdventureTime the Ice King]]. Dean's secretary is [[WesternAnimation/TheSimpsons Agnes Skinner]], WesternAnimation/{{Duckman}} is the company's Human Resources director, and [[WesternAnimation/{{Futurama}} Calculon]] is the world's smartest garbageman.
* ''WesternAnimation/{{Dinosaucers}}'': [[WesternAnimation/FlyingRhinoJuniorHigh Principal Mulligan]], [[WesternAnimation/{{Babar}} Cornelius]], [[WesternAnimation/TheRaccoons Cedric Sneer]], [[Series/Goosebumps1995 Cal]], [[WesternAnimation/MonsterForce Niles Lupon]], [[WesternAnimation/COPS1988 Mayor Davis]], [[Film/TommyBoy Mr. Brady]], and [[Manga/CardcaptorSakura Yelan Li]] are a team of heroic dinosaurs who battle a team of evil dinosaurs made up of [[WesternAnimation/LittleBear Father Bear]], [[WesternAnimation/{{Madeline}} Miss Clavell]], [[Anime/{{Bakugan}} Naga]], [[WesternAnimation/RoliePolieOlie Pappy Polie]], [[Film/{{Hannibal}} Asst. Mayor Benny Holcombe]], [[WesternAnimation/TheAdventuresOfSuperMarioBros3 Big Mouth Koopa]], [[WesternAnimation/BlazingDragons Sir Hotbreath]], and [[WesternAnimation/SuperMarioWorld Oogtar]]. Helping the heroes out are a team of humans made up of [[Series/InstantStar Stuart Harrison]], [[WesternAnimation/{{Popples}} Bonnie]], [[Series/TheEdisonTwins Smitty]], and WesternAnimation/{{Donkey Kong|Country}}.
* ''WesternAnimation/{{Dinotrux}}'': [[Anime/DragonBallZ Dende]] and [[WesternAnimation/BeingIan Ian Kelley]] are two friends who live in a world of dinosaur-machine hybrids, including [[WesternAnimation/EdEddNEddy Ed]], [[WesternAnimation/MyLittlePonyFriendshipIsMagic Applejack]], [[Toys/{{Bionicle}} Toa Matau]], [[Series/CornerGas Hank Yarbo]], [[WesternAnimation/Thundercats2011 Panthera]], and [[WesternAnimation/ClassOfTheTitans Odie]]. Together, they defend their home from [[WesternAnimation/{{Reboot}} Matrix]] and [[WesternAnimation/GuardiansOfTheGalaxy2015 Rocket Raccoon]].
* ''WesternAnimation/{{Disenchantment}}'': [[Series/BroadCity Abbi Abrams]], princess of Dreamland, goes on adventures with [[Series/TheEricAndreShow Eric Andre]] and [[Series/Reno911 the Milkshake Man]]. Her father [[WesternAnimation/{{Futurama}} Bender is currently married to Mom]], whose child (Abbi's step-sibling) is [[WesternAnimation/DaveTheBarbarian Fang]]. Bender's court includes [[Film/OfficeSpace Michael Bolton]], [[WesternAnimation/TheCritic Orson Welles]], WesternAnimation/{{Doug}}, [[WesternAnimation/ThomasAndFriends the Troublesome Trucks]], and [[Series/TheMightyBoosh Vince Noir]]. Abbi's mother and Bender's first wife was [[Series/{{Catastrophe}} Sharon Morris]].
* ''WesternAnimation/DMynaLeagues'': [[Anime/MobileSuitGundamSeed Kira Yamato]], [[WesternAnimation/{{Supernoobs}} Jennifer Shope]], [[WesternAnimation/BeastWars Inferno]], [[Series/StargateSG1 Janet Frasier]], [[Anime/ZatchBell Professor Takamine]], [[Anime/DragonBallZ Nappa]], [[WesternAnimation/LeagueOfSuperEvil Voltar]], and [[WesternAnimation/BabyLooneyTunes Baby Sylvester]] are members of a minor league baseball team owned by [[WesternAnimation/LibertysKids Henri LeFevbre]]. They are antagonized by [[Toys/{{Bionicle}} Turaga Dume]] and his minions [[WesternAnimation/WhatsWithAndy Andy Larkin]] and [[WesternAnimation/{{Ninjago}} Pythor]], who seek to buy their stadium and demolish it.
* ''WesternAnimation/DNAce'': [[Anime/{{Bakugan}} Masquerade]] and [[WesternAnimation/{{Wishfart}} Finnuala O'Thugg]] meet an immortal talking squirrel named [[WesternAnimation/{{Grossology}} Lance Boil]], who gives Masquerade the power to create creatures via LegoGenetics to defend a superpowered meteor from Finnuala's brother WesternAnimation/{{Fangbone}}.
* ''WesternAnimation/DogCity'' (animated segments): [[Series/{{Copper}} Captain Ciaran Joseph Sullivan]], [[WesternAnimation/TheRaccoons Nicole Raccoon]], and [[WesternAnimation/CarlSquared Carl Crashman]] investigate crimes and solve mysteries. They primarily deal with the crime lord [[WesternAnimation/DonkeyKongCountry Kutlass]] and his henchmen [[WesternAnimation/{{Franklin}} Mr. Owl]], [[WesternAnimation/{{Babar}} Pompadour]], [[WesternAnimation/AlmostNakedAnimals Octo]], and [[WesternAnimation/MyLittlePonyFriendshipIsMagic Rarity]], as well as the evil baron [[WesternAnimation/TheAdventuresOfTintin1991 Thomson]] and the thief [[WesternAnimation/TheBatman Batman]]. WesternAnimation/{{Beetlejuice}} is the mayor of their city, with [[WesternAnimation/{{Dinosaucers}} Terrible Dactyl]] as his aide; [[WesternAnimation/ThePowerpuffGirls1998 Bubbles]] is Nicole's niece; and [[WesternAnimation/XMenTheAnimatedSeries Beast]] is a watchman.
* ''WesternAnimation/DonkeyKongCountry'': [[VideoGame/TrueCrimeNewYorkCity President Hamilton]] and [[WesternAnimation/SuperMarioWorld Yoshi]] are the heroes of Kongo Bongo Island and the protectors of the [[{{MacGuffin}} Crystal Coconut]]. Living alongside them are their mentor [[WesternAnimation/BlazingDragons King Allfire]], [[Film/ShortCircuit2 Bones]], [[Series/LifeWithDerek Nora McDonald]], [[WesternAnimation/TotallySpies G.L.A.D.I.S.]], and [[WesternAnimation/{{Franklin}} Mr. Bear]]. They are frequently antagonized by [[WesternAnimation/TheBerenstainBears Papa Q. Bear]], his henchmen [[WesternAnimation/{{Cyberchase}} Buzz]] and [[WesternAnimation/CampLakebottom Armand]], and a gang of pirates consisting of [[WesternAnimation/XMenTheAnimatedSeries Morph]], [[WesternAnimation/TheSuperMarioBrosSuperShow Toad]], and [[WesternAnimation/MyLittlePonyFriendshipIsMagic Cranky Doodle Donkey]].
* ''WesternAnimation/DorgVanDango'': [[WesternAnimation/DinosaurTrain Buddy]] befriends a group of magical beings made up of [[WesternAnimation/{{Grossology}} Lab Rat]], [[Literature/ShakuganNoShana Shana]], [[Film/DiaryOfAWimpyKid Coach Malone]], and [[WesternAnimation/LoliRock Iris]].
* ''WesternAnimation/{{Dot}}'': [[WesternAnimation/PawPatrol The second Skye]] is the tech-savvy daughter of [[WesternAnimation/{{Grojband}} Mina Beff]] and [[WesternAnimation/{{Sixteen}} Jonesy Garcia]].
* ''WesternAnimation/{{Doug}}'': [[WesternAnimation/TheLooneyTunesShow Elmer Fudd]] writes in his journal about life in Bluffington. His sister is DramaQueen [[Literature/BecauseOfWinnDixie Gertrude the Parrot]]. He has a crush on [[Series/OrangeIsTheNewBlack Yoga Jones]], his principal is [[WesternAnimation/ThunderCats1985 Alluro]], the school bully is [[WesternAnimation/{{Futurama}} Richard Nixon's Head]], and the new mayor is [[Film/{{Tootsie}} Rita Marshall]]. Additionally, [[WesternAnimation/MyLittlePonyTheMovie1986 Baby Lickety-Split]] is one of the students as Bluffington Elementary[[note]]She also happens to have a similar last name to the town where the show takes place.[[/note]].
* ''WesternAnimation/DrDimensionpants'': [[WesternAnimation/EdEddNEddy Edd]] finds a pair of magic pants that turn him into a superhero with the power to save dimensions. He is guided in his adventures by Anime/{{InuYasha}}.
* ''WesternAnimation/{{Dragamonz}}'': [[Anime/MetalFightBeyblade Gingka Hagane]], [[WesternAnimation/TheDayMyButtWentPsycho Zack Freeman]], and [[WesternAnimation/DanielTigersNeighborhood Mom Tiger]] guard a magic crystal from [[WesternAnimation/TotalDramaRama Chef Hatchet]] and his henchman WesternAnimation/JimmyTwoShoes.
* ''WesternAnimation/DragonBooster'': WesternAnimation/{{Captain N|TheGameMaster}}, [[WesternAnimation/EdEddNEddy Kevin]], [[Animation/{{Pucca}} Abyo]], [[WesternAnimation/BeastWars Optimus Primal]], [[Anime/TransformersCybertron Thundercracker]], [[WesternAnimation/ObanStarRacers Ondai]], [[Manga/DeathNote Shingo Midou]], and half of the cast of ''Anime/MegaManNTWarrior'' race horseback on [[CallARabbitASmeerp dragons]] (really {{dinosaurs|AreDragons}}).
* ''WesternAnimation/DragonHunters'': [[WesternAnimation/{{Wunschpunsch}} Maurizio di Mauro]] and [[WesternAnimation/WinxClub Darkar]] hunt dragons, and live in an inn run by [[WesternAnimation/{{Arthur}} Jane Read]].
* ''WesternAnimation/TheDragonPrince'': [[WesternAnimation/AvatarTheLastAirbender Sokka]], prince of the Kingdom of Katolis, discovers the egg of the legendary Dragon Prince, and along with his half-brother and an elf, he must return it to the land of Xadia to restore peace to the world.
* ''WesternAnimation/DragonTales'': [[WesternAnimation/YakkityYak Lemony]] and [[WesternAnimation/{{Reboot}} Enzo 00]] discover a magical dragon scale after moving into their new home and use it to go on adventures in Dragon Land. The dragons they befriend include GentleGiant [[WesternAnimation/IronManArmoredAdventures Killer Shrike]], ShrinkingViolet [[Anime/{{Hamtaro}} Bijou]], and ConjoinedTwins [[VideoGame/SengokuBasara Irdene]] and [[WesternAnimation/MyLittlePonyFriendshipIsMagic the Great and Powerful Trixie]], as well as their CoolTeacher [[Literature/ShakuganNoShana Sydonay]]. Later on, their cousin[[note]]Aida Ortega, Enrique's voice actress, has no other known credits.[[/note]] [[TheSixthRanger joins the group]].
* ''WesternAnimation/DrawnTogether'': VideoGame/CrashBandicoot, [[WesternAnimation/BatmanTheAnimatedSeries Batgirl]], [[WesternAnimation/TransformersAnimated Blackarachnia]], [[WesternAnimation/ThePowerpuffGirls Bubbles]], [[WesternAnimation/{{TMNT}} Leonardo]], [[WesternAnimation/FamilyGuy Death]], [[Series/Reno911 Steve Marmella]], and [[Film/SouthlandTales Sheena Gee]] are picked to live in a house together on a TV reality show.
* ''WesternAnimation/{{Duckman}}'': [[Series/{{Seinfeld}} George Constanza]] works as a private detective with [[WesternAnimation/AaahhRealMonsters the Gromble]]. His family consists of [[Film/NationalLampoonsEuropeanVacation Audrey Griswold]], [[WesternAnimation/ThePowerpuffGirls Buttercup]], [[Film/ThreeMenAndABaby Sylvia Bennington]], and Music/FrankZappa's son. [[WesternAnimation/TheWildThornberrys Nigel Thornberry]] is his archenemy and [[WesternAnimation/AnAmericanTail Tony Toponi]] is his office assistant.
* ''WesternAnimation/DuckDodgers'': [[VideoGame/SpiderManFriendOrFoe Dr. Octopus]] and his eager young cadet Anime/LupinIII save the world from [[WesternAnimation/{{Rugrats}} Grandpa Lou Pickles]] and his queen [[Film/TrueLies Juno Skinner]]. He works for [[VideoGame/NoMoreHeroes Dr. Peace]], and is constantly annoyed by rival hero [[Series/{{Seinfeld}} J. Peterman]]. [[Series/StarTrekTheNextGeneration Worf]] is every single {{Mook|s}}.
* ''WesternAnimation/DuckTales1987'': [[Film/TheTimeMachine1960 David Filby]] goes globe-trotting for treasure with his grandnephews [[WesternAnimation/TheSimpsons Martin Prince]], [[WesternAnimation/TheBraveLittleToasterGoesToMars Robbie]], and [[WesternAnimation/MuppetBabies1984 Baby Gonzo]] (and sometimes [[WesternAnimation/WaitTillYourFatherGetsHome Irma Boyle]]'s granddaughter WesternAnimation/StrawberryShortcake). The cave duck [[Franchise/ScoobyDoo Fred Jones]] moves in with the family in Season 2, while [[Series/LoisAndClark the older H.G. Wells]] works for Filby as both his accountant and armored security guard. Occasional antagonists include [[WesternAnimation/TheTownSantaForgot Santa Claus]], [[WesternAnimation/{{CatDog}} Cat]], and [[WesternAnimation/RockyAndBullwinkle Natasha Fatale]].
** ''WesternAnimation/DuckTalesTheMovieTreasureOfTheLostLamp'': David, Martin, Rapsheeba, Gonzo, Strawberry Shortcake, and [[VideoGame/SamAndMaxFreelancePolice a different Santa Claus]] search for a lost treasure, which contains a lamp housing the genie known as [[WesternAnimation/TheAddamsFamily1992 Uncle Fester]]. [[Film/TheAddamsFamily Another Uncle Fester]] wants to enslave the first Fester, and is assisted by his bumbling sidekick [[Film/{{Fletch}} Frank Walker]].
** ''WesternAnimation/DuckTales2017'': [[Series/DoctorWho The Tenth Doctor]] goes globe-trotting for treasure with his grandnephews [[Series/{{Community}} Abed Nadir]], [[Film/SonicTheHedgehog2020 Sonic the Hedgehog]], and [[WesternAnimation/WeBareBears Panda]] (and occasionally [[Series/TheNeighbors Jackie Joyner-Kersee]]'s granddaughter [[WesternAnimation/StevenUniverse Sadie Miller]]). Recurring antagonists include [[WesternAnimation/WanderOverYonder Lord Hater]], [[Series/SiliconValley Nelson "Big Head" Bighetti]], [[Film/BeautifulCreatures Aunt Del]], [[Series/DoctorWho Donna Noble]], and her niece, [[Series/OrangeIsTheNewBlack Brooke Soso]], and [[Series/{{Fringe}} Phillip Broyles]], as well as [[WesternAnimation/{{Recess}} Miss Finster]], [[Series/TheGoodPlace Shawn, and Tahani Al-Jamil]]. The show also delves into what happened to [[spoiler: Ten's missing niece, [[WesternAnimation/DanVs Elise]].]]
** ''WesternAnimation/QuackPack'': The boys become [[WesternAnimation/TheOblongs Beth Oblong]], [[WesternAnimation/KingOfTheHill Bobby Hill]], and [[WesternAnimation/ChalkZone Rudy Tabootie]] as they move back in with [[WesternAnimation/TheRealGhostbusters the Mayor of Morrisville]] and [[WesternAnimation/DextersLaboratory Dexter's mom]].
** ''WesternAnimation/LegendOfTheThreeCaballeros'': The Morrisville mayor, [[WesternAnimation/MuppetBabies2018 Baby Fozzie]], and [[Series/JaneTheVirgin Rogelio de la Vega]] move into a cabana together. They travel around the world and come into conflict with [[Series/ThirdRockFromTheSun Officer Don]] and [[WesternAnimation/LiloAndStitch Captain Gantu]]. The goddess [[WesternAnimation/TUFFPuppy Kitty Katswell]], {{Cloudcuckoolander}} caretaker [[WesternAnimation/TheAvengersEarthsMightiestHeroes Mr. Fantastic]], and Dexter's mom's (now [[WesternAnimation/{{Animaniacs}} Dot Warner's]]) nieces [[WebAnimation/HanazukiFullOfTreasures Hanazuki]], [[WesternAnimation/TheBuzzOnMaggie Maggie Pesky]], and [[WesternAnimation/AdventureTime Flame Princess]] aid the trio.
* ''WesternAnimation/DudeThatsMyGhost'': [[WesternAnimation/{{Hilda}} Alfur Aldric]] is an aspiring filmmaker who befriends the ghost of a rock star named Music/{{Beardyman}}.
* ''WesternAnimation/DudleyDoRight'': [[WesternAnimation/RockyAndBullwinkle Bullwinkle J. Moose]] must save his girlfriend [[WesternAnimation/TheSmurfs1981 Jokey Smurf]] from [[WesternAnimation/PeterPan Captain Hook]].
* ''WesternAnimation/DumbAndDumber'': [[WesternAnimation/{{Gargoyles}} Jackal and Broadway]] get into wacky misadventures together.
* ''WesternAnimation/TheDumbBunnies'': [[VideoGame/MegaManLegends Teisel Bonne]] and [[WesternAnimation/XMenTheAnimatedSeries Famine]] are a very stupid couple with a very stupid child[[note]]Dustin Lauzon, voice of Baby Bunny, has no other credits[[/note]]. Their uppity neighbors are [[WesternAnimation/JimmyTwoShoes Samy Garvin]] and [[WesternAnimation/{{Mysticons}} Queen Goodfey]], whose daughter is [[WesternAnimation/RoliePolieOlie Polie Pi]]; [[WesternAnimation/RescueHeroes Billy Blazes]] is the local conman; and Teisel's boss is [[Film/{{Meatballs}} Larry 'Fink' Finkelstein]]. Their misadventures are narrated by [[Series/TheRedGreenShow Buzz Sherwood]].
* ''WesternAnimation/{{Duncanville}}'': [[WesternAnimation/TheMightyB Bessie Higgenbottom]] is an ordinary teenager whose family is made up of her mother [[Series/ParksAndRecreation Leslie Knope]], her father [[Series/ModernFamily Phil Dunphy]], her sister [[WesternAnimation/TheLegoBatmanMovie Poison Ivy]], and her adopted sister [[Series/Stargirl2020 Tigress]]. Her friends are [[WesternAnimation/OurCartoonPresident Ben Carson]], [[Series/MakingHistory Chris]], and [[WesternAnimation/TrollsWorldTour Clampers Buttonwillow]], and [[Series/TheOfficeUS Karen Filippelli]] is her crush. [[Series/{{Dickinson}} Death]] is her CoolTeacher.
* ''WesternAnimation/DungeonsAndDragons1983'': [[Series/CharlesInCharge Buddy Lembeck]] the Ranger, [[WesternAnimation/MisterT Spike]] the Barbarian, [[Series/EightIsEnough Nicholas Bradford]] the Magician, [[WesternAnimation/DarkwingDuck Honker Muddlefoot]] the Thief, [[Series/HappyDays Ralph Malph]] the Cavalier, and an acrobat are youngsters trapped in a world of sorcery. With guidance from the mysterious [[Anime/LittleNemoAdventuresInSlumberland Oompe]] and the unicorn [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Goddard]], they must find a way back to their world while running afoul of the evil wizard [[Franchise/{{Transformers}} Optimus Prime]], his demonic henchman [[WesternAnimation/TheIncredibleHulk1982 Hulk]], and the dragon [[WesternAnimation/{{Futurama}} Nibbler]].
!!E
* ''WesternAnimation/EarthwormJim'': [[WesternAnimation/TheSimpsons Groundskeeper Willie]] is a worm in a superhero suit accompanied by WesternAnimation/JohnnyBravo. They fight villains like [[WesternAnimation/ThePowerpuffGirls Fuzzy Lumpkins]], [[WesternAnimation/TheLionKingIISimbasPride Zazu]], [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Ms. Fowl]], and [[WesternAnimation/{{ChalkZone}} Skrawl]]. They are also helped out by [[WesternAnimation/TheSuperheroSquadShow Dr. Doom]] and Willie's love interest is [[WesternAnimation/DannyPhantom Maddie Fenton]].
* ''WesternAnimation/{{Eckhart}}'': [[Literature/EmilyOfNewMoon Ilse Burnley]] and [[WesternAnimation/DiGataDefenders Melosa]] live in a mouse colony on Prince Edward Island. The colony's bumbling evil leader is [[WesternAnimation/XMenTheAnimatedSeries Sabretooth]].
* ''WesternAnimation/EdEddNEddy'': [[VideoGame/TYTheTasmanianTiger Andy]], [[WesternAnimation/BabyLooneyTunes Daffy Duck]], and [[Anime/MobileSuitGundamSeed Miguel Aiman]] (or, alternatively, [[Manga/CardcaptorSakura Kero, Julian and Tori]]) have tons of misadventures in their cul-de-sac. The other denizens on the cul-de-sac are [[Manga/RanmaOneHalf Hinako Ninomiya]], Andy's bratty sister; [[WesternAnimation/DragonTales Wheezie]], a JerkJock; [[Literature/ShakuganNoShana Shana]] ([[TheOtherDarrin who depending on the episode is also]] [[VideoGame/LeagueOfLegends Sona]], [[Manga/{{InuYasha}} Jakotsu]] or [[VideoGame/PuyoPuyo Feli]]), a DumbBlonde; [[Manga/DragonBallZ Goku]], a FunnyForeigner; and [[Series/OnceUponATime Doc]], who has a NotSoImaginaryFriend [[note]]Jimmy's voice actor Keenan Christensen doesn't have any other known roles[[/note]]. There's also a TerribleTrio consisting of [[Manga/RanmaOneHalf Tsukasa]] (sometimes [[VideoGame/Persona4 Chie Satonaka]]), [[Toys/{{Bionicle}} Roodaka]], and [[Manga/{{InuYasha}} Kagura]], who all have crushes on the main trio. [[WesternAnimation/MyLittlePonyFriendshipIsMagic Igneous Rock]] is Miguel Aiman's mysterious older brother.
* ''WesternAnimation/EdgarAndEllen'': '''[[WesternAnimation/MyLittlePonyFriendshipIsMagic The Great and Powerful Trixie]]''' and [[Manga/{{Inuyasha}} Shippo]] are a pair of troublemaking CreepyTwins.
* ''WesternAnimation/EekTheCat'': WesternAnimation/MadJackThePirate is a friendly housecat who lives with his owners [[WesternAnimation/TinyToonAdventures Buster Bunny]] and [[WesternAnimation/ThePowerpuffGirls Buttercup]]. Mad Jack's girlfriend is [[Music/{{Whitesnake}} the chick from "Here I Go Again"]].
** ''The Terrible Thunderlizards'': One of the show's creators, [[WesternAnimation/WhatACartoonShow Yuckie Duck]], and [[Series/BeverlyHills90210 Brandon Walsh]] (later [[Film/TeenageMutantNinjaTurtles1990 Donatello]]) are dispatched by [[Series/That70sShow Red Foreman]] to eliminate the world's two humans, [[WesternAnimation/MyLittlePonyAndFriends Spike]] and [[WesternAnimation/DanVs Dan]].
* ''WesternAnimation/ElinorWondersWhy'': [[WesternAnimation/XavierRiddleAndTheSecretMuseum Amelia Earhart]], [[Film/TheBananaSplitsMovie Zoe]], and [[WesternAnimation/TotalDramaRama Cody]] ask questions about the world around them.
* ''WesternAnimation/EllaTheElephant'': [[WesternAnimation/DanielTigersNeighborhood Miss Elaina]] has adventures on Elephant Island with her friends [[WesternAnimation/ThreeAmigonauts Herby]], [[WesternAnimation/PawPatrol Rubble]], and [[Series/FallingSkies Constance]].
* ''WesternAnimation/ElliotMoose'' (animated segments): [[Series/RadioFreeRoscoe Ray Brennan]] is a young moose who goes on adventures with his friends [[WesternAnimation/AngelaAnaconda Nanette Manoir]], [[Series/DegrassiTheNextGeneration Shannon]], [[WesternAnimation/LittleBear Owl]], [[Film/{{Meatballs}} Larry 'Fink' Finkelstein]], and [[Series/{{Wilbur}} Wilbur the Calf]]. They are antagonized by [[WesternAnimation/StickinAround Russell]].
* ''WesternAnimation/EndangeredSpecies2015'': [[WesternAnimation/MyLittlePonyFriendshipIsMagic Rarity]], [[WesternAnimation/LeagueOfSuperEvil Doktor Frogg]], and [[WesternAnimation/EdEddNEddy Edd]] all live together in a tree stump.
* ''WesternAnimation/TheEpicTalesOfCaptainUnderpants'': [[WesternAnimation/TheChickenSquad Coop]] and [[WesternAnimation/BubbleGuppies Gil]] are mischief-making best friends who hypnotize their principal, [[WesternAnimation/BlazeAndTheMonsterMachines Pickle]], into becoming a superhero. Along for the ride are the InsufferableGenius [[WesternAnimation/BigCityGreens Carlos]], TheAce [[WesternAnimation/StevenUniverse Sapphire]], AlphaBitch [[VideoGame/SuperSmashBrosUltimate Viridi]], MellowFellow [[WesternAnimation/HomeAdventuresWithTipAndOh Apple]], ButtMonkey [[WesternAnimation/MickeyMouseMixedUpAdventures Elray Thunderboom]], and GentleGiant [[WesternAnimation/DangerAndEggs Tyronius]].
* ''WesternAnimation/ErkyPerky'': [[WesternAnimation/{{Redakai}} Zylus]] and [[WesternAnimation/TotalDramaPresentsTheRidonculousRace Dwayne]] are two bugs whose peaceful life on a hot dog stand comes to a sudden end when they end up in a sterile suburban kitchen.
* ''WesternAnimation/EsmeAndRoy'': [[Series/OddSquad Ms. O]] is a little girl who is best friends with a monster named [[WesternAnimation/ClangInvasion Rivet]].
* ''WesternAnimation/ExtremeGhostbusters'': [[VideoGame/LollipopChainsaw Juliet Starling]], [[WesternAnimation/AnAmericanTail Tony Toponi]], [[WesternAnimation/JusticeLeague Snapper Carr]], [[Series/TheFreshPrinceOfBelAir Carlton Banks]], and [[WesternAnimation/TheBatman Batman]] are five youths trained by [[WesternAnimation/InspectorGadget Chief Quimby]] to catch ghosts, like their lovable sidekick [[WesternAnimation/{{Futurama}} Dr. Zoidberg]].
!!F
* ''WesternAnimation/FIsForFamily'': [[Series/BreakingBad Patrick Kuby]] is the short-tempered head of a 60s suburban family made of his wife [[Film/JurassicPark Dr. Ellie Sattler]] and his three children, who are [[Film/AlvinAndTheChipmunks Alvin]], an ''Series/AmericanIdol'' performer, and [[Anime/ZatchBell Zatch]]. Their next-door neighbor is [[Film/TheHitchhikersGuideToTheGalaxy2005 President Zaphod Beeblebrox]].
* ''WesternAnimation/TheFairlyOddParents'': [[WesternAnimation/Ben10 Ben Tennyson]] (originally [[WesternAnimation/SouthPark Wendy Testaburger]]) is a buck-toothed kid who is ignored by his parents, [[WesternAnimation/TheSpectacularSpiderMan J. Jonah Jameson]] and [[WesternAnimation/TheSecretSaturdays Dr. Miranda Grey]], and bullied by an evil, ill-tempered teenager named [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Mandy]]. He gets through the day by making wishes to his fairy godparents, [[Manga/FistOfTheNorthStar Rei]] and [[WesternAnimation/OneHundredAndOneDalmatiansIIPatchsLondonAdventure Cruella de Vil]] (whose evil counterparts are [[Anime/DinoZaurs Dark Dragon]] and [[WesternAnimation/{{Amphibia}} Valeriana]]), [[BeCarefulWhatYouWishFor though they don't always work out as he hoped]]. WesternAnimation/{{Rocko|sModernLife}}, Ben's teacher, frequently tries to capture the fairies, [[WesternAnimation/IceAgeTheMeltdown Fast Tony]] is a superhero that Ben idolizes (whose ArchEnemy is [[WesternAnimation/{{Cars}} Jay Limo]]), Mandy's little sister [[WesternAnimation/CodenameKidsNextDoor Lizzie Devine]] is crushing on Ben, [[Film/RobinsonCrusoeOnMars Colonel Dan McReady]] (later WesternAnimation/JohnnyBravo) is a cat-themed superhero, and [[WesternAnimation/CampLazlo Lazlo]] is a StalkerWithACrush towards Cruella. Ben also likes to hang out with his friends [[Series/TheCosbyShow Nelson Tibideaux]], {{Series/Malcolm|InTheMiddle}} (later [[WesternAnimation/AGoofyMovie Max Goof]]), [[WesternAnimation/StarWarsTheCloneWars Captain Rex]], and [[WesternAnimation/StevenUniverse Lion]], and is frequently visited by [[TheAhnold a muscular German fairy]] named [[Film/TeamAmericaWorldPolice Spotswoode]], who later marries [[WesternAnimation/FostersHomeForImaginaryFriends Frankie Foster]]. He has a crush on popular girl [[WesternAnimation/{{Rugrats}} Kimi Finster]], who is friends with another popular girl that has a secret crush on Ben, [[WesternAnimation/TheLoudHouse Lola Loud]], who also happens to be a ButtMonkey. [[WesternAnimation/TeenTitans2003 Raven]] and [[WesternAnimation/WhateverHappenedToRobotJones Shannon]] are the snobby rich class presidents. [[WesternAnimation/{{Animaniacs}} Yakko Warner]] is an alien that Ben befriends. [[WesternAnimation/MyGymPartnersAMonkey Jake Spidermonkey]] is another fairy who works on Valentine's Day. [[VideoGame/CrashBandicoot Crunch Bandicoot]] is an AffablyEvil supervillain. [[Film/TheMask Dr. Neuman]] and [[Film/FerrisBuellersDayOff the economics teacher]] are recurring villains who believe everything should be dull and boring. [[WesternAnimation/{{Aladdin}} Iago]] is a psycho dentist, whose son is [[WesternAnimation/{{Cyberchase}} Digit]]. [[WesternAnimation/TheLifeAndTimesOfJuniperLee Monroe]] is the next door neighbor that Jameson hates. Rocko lives with his parent [[WesternAnimation/CatDog Winslow Oddfellow]]. [[WesternAnimation/EvilConCarne Major Doctor Ghastly]] is the school principal and [[WesternAnimation/ElTigreTheAdventuresOfMannyRivera Puma Loco]] is the town mayor. [[WesternAnimation/TimeSquad Buck Tuddrussel]] and [[WesternAnimation/HiHiPuffyAmiYumi Yumi Yoshimura]] work at a daycare run by [[WesternAnimation/DannyPhantom Dash Baxter]]. Ben also likes to watch a TV show starring [[Anime/DigimonFrontier Mercurymon]]. In the sixth season, Rei and Cruella have a baby named [[WesternAnimation/ThePowerpuffGirls1998 Bubbles]], whose evil counterpart is [[WesternAnimation/{{Unikitty}} Master Frown]]. Ben later gets a pet named [[WesternAnimation/TuffPuppy Snaptrap]], and in season 10, Ben has to share Cruella and Rei with [[Anime/{{FLCL}} Haruko Haruhara]].
* ''WesternAnimation/FamilyGuy'': [[Series/TheOrville Ed Mercer]], [[Series/GilmoreGirls Drella]], [[Franchise/MassEffect Joker]], [[Series/That70sShow Jackie Burkhart]] (formerly [[WesternAnimation/TheWildThornberrys Eliza Thornberry]] and [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]] when singing), [[Film/AMillionWaysToDieInTheWest Albert Stark]], and [[WesternAnimation/{{Sing}} Mike]] all live under one roof. [[Series/{{Scrubs}} A urologist]], [[Film/HellboyIITheGoldenArmy Johann Krauss]], and WesternAnimation/{{Buzz Lightyear|OfStarCommand}} are Ed's drinking buddies. [[Franchise/StarWars Princess Leia]] is Ed's current boss (his former boss [[WesternAnimation/HappyFeet Nestor]] choked on a dinner roll), [[Film/NeverBeenKissed Josie Grossie]] is Mike's (or Albert's?) ex, [[Film/BrideOfChucky Tiffany]] is Buzz's wife, [[Series/MySoCalledLife Danielle Chase]] is an AlphaBitch who torments Jackie, and Series/{{Batman|1966}} was the mayor of their town.
** ''WesternAnimation/TheClevelandShow'': The urologist moves out of Quahog with his son [[VideoGame/CrashBandicoot Crunch Bandicoot]]. He marries his highschool sweetheart [[Series/NipTuck Michelle Landau]], whose two kids are [[Series/GilmoreGirls Ed]] and [[Film/BigMommasHouse Sherry Pierce]] (later [[Series/TheParentHood Zazia Peterson]]). Film/{{Ted}} (later [[WesternAnimation/{{Animaniacs}} Wakko Warner]]) is his neighbor.
* ''WesternAnimation/FanboyAndChumChum'': Two kids, [[Series/SixFeetUnder Patrick]] and [[VideoGame/MetalGearSolid4GunsOfThePatriots Raging Raven]], dress like superheroes and have adventures along with a wizard named [[Film/SonOfTheMask Tim Avery]], an {{otaku}} named [[Series/AllMyChildren Leo du Pres]], and a bully named WesternAnimation/JohnnyBravo. They're the biggest fanboys of a superhero named [[WesternAnimation/TransformersAnimated Prowl]].
* ''WesternAnimation/{{Fangbone}}'': [[Series/TheStanleyDynamic Luke Stanley]] is sent from Skullbania to Earth by [[WesternAnimation/{{Spliced}} Mister Smarty Smarts]] with [[WesternAnimation/DiGataDefenders Brackus]]' magic toe to keep it out of his hands. On Earth, Luke befriends [[WesternAnimation/TopWing Speedy]], who helps him fight Brackus' monsters. Speedy's mother is [[WesternAnimation/{{Sixteen}} Nikki Wong]]; their teacher is [[WesternAnimation/GeorgeShrinks Perdita Shrinks]]; and the principal is [[WesternAnimation/{{Freaktown}} Lord Cuddles the Fluffy]]. [[WesternAnimation/CampLakebottom Suzi]] is a thief who helps them out sometimes, while WesternAnimation/MarvinTheTapDancingHorse is Luke's chieftain. Luke and Speedy's friends/classmates are [[WesternAnimation/{{Wayside}} Maurecia]], [[WesternAnimation/{{Sidekick}} Kitty Ko]], [[WesternAnimation/{{Detentionaire}} Jenny Jergens]], [[WesternAnimation/HeroElementary Benny Bubbles]], [[WesternAnimation/JaneAndTheDragon Prince Cuthbert]], and [[WesternAnimation/WinstonSteinburgerAndSirDudleyDingDong Hampton]]. In the final episode, [[spoiler:Brackus' magic toe]] is revealed to be sapient and speaks in the voice of [[WesternAnimation/JacobTwoTwo Renee Ratelle]].
* ''WesternAnimation/{{Fangface}}'': [[Franchise/{{Transformers}} Megatron]] is a teenage werewolf.
* ''WesternAnimation/FantasticFourTheAnimatedSeries'': [[WesternAnimation/RubySpearsSuperman Superman]], [[WesternAnimation/SpongebobSquarepants Pearl Krabs]], [[Series/BeverlyHills90210 David Silver]] (later [[WesternAnimation/MyLifeAsATeenageRobot Sheldon Lee]]), and WesternAnimation/CoolMcCool are a superhero team battling against the evil [[VideoGame/TheCurseOfMonkeyIsland Wally B. Feed]] (later [[VideoGame/DeadSpace3 Jacob Danik]]).
** ''WesternAnimation/FantasticFourWorldsGreatestHeroes'': [[Anime/MobileSuitGundam Gihren Zabi]], [[Series/BattlestarGalactica2003 Paulla Schaffer]], [[WesternAnimation/TotalDrama Topher]], and [[Anime/DragonBallZ Majin Buu]] are a team of superheroes who do battle against [[WesternAnimation/{{Reboot}} Enzo Matrix]].
* ''WesternAnimation/FantasticMax'': [[WesternAnimation/DinkTheLittleDinosaur Shyler]] goes on adventures in outer space with his alien doll [[WesternAnimation/TheSimpsons Ralph Wiggum]] and his RobotMaid [[VideoGame/Spyro2RiptosRage Ripto]].
* ''WesternAnimation/FastAndFuriousSpyRacers'': [[Franchise/MarvelRising Inferno]], cousin of Film/{{Riddick}}, is recruited into a goverment agency, under the command of [[Theatre/{{Hamilton}} Angelica Schuyler]], with his friends/crew [[WesternAnimation/GlitchTechs Mitch Williams]], [[WesternAnimation/CarmenSandiego Julia Argent]], and [[WesternAnimation/ElenaOfAvalor Gabriel Núñez]] to stop an organization known as {{SH1FT3R}}, led by [[Series/TheResident Devon Pravesh]], and his crew [[Series/AmericanVandal Mackenzie Wagner]] and [[WesternAnimation/PhineasAndFerb Vanessa Doofenshmirtz]]. Who is searching for something called the "skeleton key" to avenge his parents, who were killed by [[Film/BorisAndNatasha Boris Badenov]].
** Season 2: Following Devon arrest. The crew is sent to Rio to uncover a secret weapon, and find Mackenzie, who had joined the agency but disappeared investigating the secret weapon. And find that the weapon is a mind control gas made by [[Manga/ScienceFellInLoveSoITriedToProveIt Ayame Himuro]], a daughter of a crime family.
** Season 3: After being freed by Boris, Ayame, alongside fellow prisoner [[Film/BabyDriver JD]], is recruited to help set up a WeatherControlMachine. Leading the crew, now joined by Mackenzie, to stop them in the Sahara.
** Season 4: Blamed for a crime they didn't commit. The crew and Angelica flees to Mexico to clear their names and find the perpetrator, while being hunted down by Wrestling/BigShow. And find out the mastermind is [[WesternAnimation/VictorAndValentino Don Julio Jalapeño]], a former agent who intends to flood the city in lava.
* ''WesternAnimation/FatherOfThePride'': [[WesternAnimation/MonstersInc Sulley]] is a lion in a Las Vegas show starring [[WesternAnimation/CaptainZedAndTheZeeZone Captain Zed]] and [[WesternAnimation/{{Futurama}} Scruffy the Janitor]] and lives with his family consisting of [[Series/CurbYourEnthusiasm Cheryl David]], [[WesternAnimation/TheWildThornberrys Debbie Thornberry]], [[Film/SpyKids Juni Cortez]], and [[Series/TwoAndAHalfMen Marty Pepper]]. His best friend is [[VideoGame/{{Halo}} Marine Sergeant Banks]]. [[WesternAnimation/{{Mulan}} Mushu]] guest starred in one episode.
* ''WesternAnimation/{{Fillmore}}'': [[Series/ThatsSoRaven Eddie Thomas]] and [[WesternAnimation/TeenTitans2003 Raven]] fight crime in middle school for Jr. Commissioner [[Series/SaturdayNightLive Jasper Hahn]] and Principal [[Series/JustShootMe Nina Van Horn]], as do [[WesternAnimation/{{Futurama}} Amy Wong]] and [[Series/TheAdventuresOfPeteAndPete Little Pete]]. [[Music/TenaciousD Kyle Gass]], [[WesternAnimation/KimPossible Duff Killigan]], [[Series/BuffyTheVampireSlayer Rupert Giles]] (Miss Collins' father), [[Series/TwoAndAHalfMen Evelyn Harper]] and [[Series/{{Survivor}} Jeff Probst]] also work at the school, and Eddie's parents are [[Series/TwentyOneJumpStreet Judy Hoffs]] and [[Series/{{CSI}} Warrick Brown]].
** Among those involved in their cases: [[Film/RoboCop1987 Clarence Boddicker]], [[Series/TheOfficeUS Michael Scott]], [[Series/JoanOfArcadia Adam Rove]], WesternAnimation/{{Jimmy Neutron|BoyGenius}}, [[WesternAnimation/AmericanDad Hayley Smith]], [[Series/Flight29Down Taylor Hagan]], [[{{Series/Heroes}} Claire Bennet]], [[Series/That70sShow Midge Pinciotti]], [[Series/TerminatorTheSarahConnorChronicles John Connor]], WesternAnimation/{{Lilo|AndStitch}}, [[Film/TheLordOfTheRings Gimli]], [[WesternAnimation/HeyArnold Helga G. Pataki]], [[WesternAnimation/BatmanTheBraveAndTheBold Wildcat]], [[Series/TheSecretLifeOfTheAmericanTeenager Madison Cooperstein]], [[Series/TheDrewCareyShow Mimi]], [[Series/TheWestWing Annabeth Schott]], [[WesternAnimation/PhineasAndFerb the artist formerly known as Lindana]], Series/{{Malcolm|InTheMiddle}}, [[WesternAnimation/{{WITCH}} Miranda]], [[Series/DrakeAndJosh Josh]], and [[WesternAnimation/JohnnyBravo Little Suzy]].
* ''WesternAnimation/FinalSpace'':
** (Season 1): A man spends 5 years in space prison, slowly losing his sanity. Along the way, he befriends WesternAnimation/SpongeBobSquarePants, an alien cat man and his son [[WesternAnimation/Invincible2021 Mark]], and eventual love interest [[Film/SonicTheHedgehog2020 Pretzel Lady]]. Together, they must stop [[WesternAnimation/DuckTales2017 Scrooge McDuck]] from destroying Earth. Also, [[WesternAnimation/TeenTitans2003 Slade]] is the main character's father.
** (Season 2): The space man and his friends are back! Joining them on their adventure are [[WesternAnimation/TheLegoBatmanMovie the Riddler]]'s adopted children [[Manga/AttackOnTitan Sasha Braus]] and [[WesternAnimation/{{Trolls}} Cooper]]. Our hero's mother [[VideoGame/{{Uncharted}} Chloe Frazer]] may have ulterior motives, but the BigBad of it all is [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Irwin]].
* ''WesternAnimation/FishHooks'': [[Series/CoryInTheHouse Cory Baxter]], [[WesternAnimation/AdventureTime the Earl of Lemongrab]], and [[Series/{{Jonas}} Stella Malone]] are three fish attending school. [[WesternAnimation/{{Chowder}} Gazpacho]] is their MisterSeahorse teacher, and [[WesternAnimation/ThePenguinsOfMadagascar Rico]] is a JerkJock.
* ''WesternAnimation/TheFlintstones'': [[WesternAnimation/LadyAndTheTramp Boris]] and [[WesternAnimation/TheJetsons Rosie]] are HappilyMarried and so are their neighbors WesternAnimation/BugsBunny and [[Series/PetticoatJunction Kate Bradley]]. Boris and Bugs work for [[WesternAnimation/SecretSquirrel Chief Winchley]] and know an alien named [[Film/ThePinkPantherStrikesAgain Professor Auguste Balls]], and Bugs and Kate adopt super strong [[WesternAnimation/YogiBear Ranger Smith]] after Rosie gives birth to [[WesternAnimation/SecretSquirrel Winsome Witch]]. WesternAnimation/PorkyPig is Boris and Rosie's pet dinosaur.
* ''WesternAnimation/FlyingRhinoJuniorHigh'': [[WesternAnimation/StickinAround Bradley]], [[WesternAnimation/JohnCallahansQuads Franny]], WesternAnimation/GeorgeShrinks, and his sister [[WesternAnimation/LittleBear Duck]] have adventures in their middle school, which is warped by [[WesternAnimation/{{Cyberchase}} Dr. Marbles]] and his hench-rat [[Anime/SailorMoon Artemis]]. The kids' teacher is [[Film/GingerSnaps Nurse Ferry]], the principal is [[WesternAnimation/TheRaccoons Bert Raccoon]], and the janitor is [[WesternAnimation/XMenTheAnimatedSeries Quicksilver]].
* ''WesternAnimation/FostersHomeForImaginaryFriends'': [[Franchise/KingdomHearts Pence]] sends his imaginary friend, [[VideoGame/{{Overwatch}} Reaper]], to a foster home where they meet other imaginary friends like WesternAnimation/SamuraiJack, [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Nick Dean]], [[WesternAnimation/{{CatDog}} Dog]], [[WesternAnimation/MyGymPartnersAMonkey Ingrid Giraffe]], and [[WesternAnimation/StarWarsTheCloneWars Yoda]]. [[WesternAnimation/MyLifeAsATeenageRobot Nora Wakeman]] is the home's founder and owner while the manager (and her granddaughter) is [[WesternAnimation/AvatarTheLastAirbender Azula]]. [[WesternAnimation/HiHiPuffyAmiYumi Yumi Yoshimura]] is Pence's mother and his BigBrotherBully is [[VideoGame/TalesOfSymphonia Presea Combatir]]. Later seasons add characters like [[VideoGame/BatmanArkhamCity Catwoman]], [[WesternAnimation/StaticShock Virgil Hawkins]], and [[WesternAnimation/MuchaLucha The Flea]].
* ''[[Series/FraggleRock Fraggle Rock: The Animated Series]]'': [[WesternAnimation/TeenageMutantNinjaTurtles1987 Michelangelo]], [[WesternAnimation/TheLooneyTunesShow Porky Pig]], [[WesternAnimation/MickeyMouseClubhouse Toodles]], [[VideoGame/Persona5 Shinya Oda]], and [[Literature/{{Kanokon}} Kota Oyamada]] are five Fraggles who live together in the caverns of Fraggle Rock. They are often sent letters by Mikey's uncle [[WesternAnimation/SpiderManTheAnimatedSeries the Thing]] and antagonized by [[WesternAnimation/TheTick a cab driver]] and his parents [[WesternAnimation/{{Jabberjaw}} Shelly]] and [[WesternAnimation/SpongeBobSquarePants Painty the Pirate]].
* ''Literature/{{Franklin}}'': [[Series/SchittsCreek Patrick Brewer]] (later [[WesternAnimation/{{Committed}} Nicholas Larson]]) is a turtle whose parents are [[WesternAnimation/BeastWars Rhinox]] and [[Series/Goosebumps1995 Penelope Benson]]. His friends include [[Series/RoadToAvonlea Duffy Dean]] (later [[WesternAnimation/{{Redwall}} Brome]] and then [[WesternAnimation/JacobTwoTwo Noah]]) the bear, [[WesternAnimation/StickinAround Melody]] the beaver, [[WesternAnimation/PippiLongstocking Annika Settergren]] (later [[Series/TheLine Emma]]) the goose, [[WesternAnimation/RoliePolieOlie Spaceboy]] (later [[WesternAnimation/MissSpidersSunnyPatchFriends Dragon]]) the rabbit, [[WesternAnimation/NoddysToylandAdventures Boobull]] (later WesternAnimation/ElliotMoose and then WesternAnimation/{{Peep|AndTheBigWideWorld}}) the fox, [[WesternAnimation/AngelaAnaconda Nanette Manoir]] the badger, [[WesternAnimation/MaggieAndTheFerociousBeast Maggie]] the snail, [[WesternAnimation/{{Cyberchase}} Inez]] the skunk, [[WesternAnimation/MetaJets Johnny Miller]] the raccoon, and [[Film/LetMeCallYouSweetheart Robin McGrath]] the otter (who moves away and becomes [[WesternAnimation/DelilahAndJulius Delilah Devonshire]]). His teacher is [[WesternAnimation/TheAdventuresOfSuperMarioBros3 Cheatsy Koopa]] the owl, his grandmother is [[WesternAnimation/RudolphTheRedNosedReindeer1964 Dolly]], and his neighbors include [[Anime/BakutenShootBeyblade Mr. Dickenson]] the mole and [[Series/SlingsAndArrows May Silverstone]] the muskrat. Later, he gets a baby sister named [[WesternAnimation/GeorgeShrinks Becky Lopez]]. Narrated by [[Series/LifeWithBoys Grandma Helen]], later [[Series/WindAtMyBack May Bailey]], and then [[WesternAnimation/CareBears1980s Wish Bear]].
* ''WesternAnimation/FrannysFeet'': [[WesternAnimation/JoJosCircus Maya]] (who becomes [[WesternAnimation/JaneAndTheDragon Jane Turnkey]] when singing) tries on shoes that take her to different places while hanging at the shoe repair store of her grandfather [[WesternAnimation/XMenTheAnimatedSeries Beast]].
* ''WesternAnimation/{{Freakazoid}}'': [[WesternAnimation/DannyPhantom Danny Fenton]] is a nerd who can transform into a zany superhero named [[WesternAnimation/DaveTheBarbarian Dark Lord Chuckles]]. He fights supervillains like [[WesternAnimation/BatmanTheAnimatedSeries Ra's al Ghul]], [[WesternAnimation/KimPossible Señor Senior, Sr.]], WesternAnimation/JohnnyBravo, [[WesternAnimation/DextersLaboratory Dexter's Dad]] (who'll tie you up if you say his name), [[VideoGame/BatmanArkhamCity Hugo Strange]], [[VideoGame/MarvelUltimateAlliance the (second) Mighty Thor]], [[Film/MuppetTreasureIsland Long John Silver]], and [[WesternAnimation/TinyToonAdventures Babs Bunny]]. In his free time, Chuckles often hangs out with [[WesternAnimation/SpiderManTheAnimatedSeries J. Jonah Jameson]].
* ''WesternAnimation/{{Freaktown}}'': [[WesternAnimation/WorldOfQuest Prince Nestor]] lives in a town for monsters surrounded by a SugarBowl ruled by [[WesternAnimation/TotalDramaPresentsTheRidonculousRace Josee]] and her minions [[WesternAnimation/WinstonSteinburgerAndSirDudleyDingDong Hampton]], [[WesternAnimation/{{Sixteen}} Ron the Rent-A-Cop]], and [[WesternAnimation/FlyingRhinoJuniorHigh Earl P. Sidebottom]], who seek to cutify the town. His pals are [[WesternAnimation/{{Stoked}} No-Pants Lance]] and [[WesternAnimation/JuliusJr Ping]].
* ''WesternAnimation/FreakyStories'': [[WesternAnimation/TheAdventuresOfSuperMarioBros3 Cheatsy Koopa]] and [[Series/PuppetsWhoKill Dan Barlow]] tell spooky stories at a diner staffed by [[WesternAnimation/CareBears1980s Birthday Bear]].
* ''WesternAnimation/FreeWilly: The Animated Series'': [[WesternAnimation/{{Detentionaire}} Biffy Goldstein]] discovers he has the power to speak to animals and befriends an orca named [[WesternAnimation/{{Babar}} Uncle Arthur]].
* ''WesternAnimation/FrogAndToad'': [[WesternAnimation/BlazeAndTheMonsterMachines Crusher and Pickle]] are two amphibians living out their daily lives.
* ''WesternAnimation/FuggetAboutIt'': [[Film/SawII Gus]] is a New York mobster who moves to Canada under witness protection alongside his wife [[WesternAnimation/{{Cyberchase}} Matt]], uncle [[Film/CinderellaMan Father Roddick]], and kids [[WesternAnimation/AlmostNakedAnimals Bunny]], [[Series/BigWolfOnCampus Merton Dingle]], and [[WesternAnimation/TimothyGoesToSchool Grace]]. The RCMP agent [[Film/{{Hollywoodland}} Det. Doug Johnson]] oversees their safety.
* ''WesternAnimation/{{Funpak}}'':
** ''Coolman'': [[WesternAnimation/PawPatrol Cap'n Turbot]] fantasizes about life as his beatnik alter ego. [[WesternAnimation/TotalDrama Courtney]] is his coworker and love interest.
** ''Harold Rosenbaum: Chartered Accountant Extreme'': [[Series/TheRedGreenShow Ranger Gord]], with the help of his secretary [[Series/MadeInCanada Veronica Miller]] and KidSidekick [[WesternAnimation/{{Rupert}} Rupert Bear]], uses his accounting skills to thwart [[WesternAnimation/FlyingRhinoJuniorHigh Raticus]]' evil plot to destroy the city. [[WesternAnimation/XMenTheAnimatedSeries Cyclops]] narrates his adventures.
** ''The Manly Bee'': [[WesternAnimation/XMenTheAnimatedSeries Gambit]] is an OldSuperhero who is brought out of retirement to fight crime once more. [[WesternAnimation/DanielTigersNeighborhood X the Owl]] narrates his adventures.
** ''Martini & Meatballs'': [[WesternAnimation/AngelaAnaconda Mrs. Brinks]] and [[WesternAnimation/AtomicBetty Sparky]] have surreal adventures together.
** ''WesternAnimation/RottingHills'': [[Anime/BakutenShootBeyblade Julia]] and her parents [[WesternAnimation/{{Braceface}} Maria Wong]] and [[WesternAnimation/JacobTwoTwo Principal I.M. Greedyguts]] move to a town populated by zombies, where Julia befriends [[Anime/SailorMoon Shingo Tsukino]].
* ''WesternAnimation/{{Futurama}}'': [[Advertising/MAndMs The Red M&M]] is unfrozen a millennium into the future, and then goes to work for a space courier crew run by his descendant WesternAnimation/WoodyWoodpecker that includes [[Series/MarriedWithChildren Peg Bundy]], [[VideoGame/GearsOfWar Marcus Fenix]], [[WesternAnimation/BatmanBeyond Dana Tan]], [[WesternAnimation/TheRenAndStimpyShow Stimpy]], and [[WesternAnimation/StarWarsTheCloneWars Kit Fisto]]. WesternAnimation/{{Doug}} is a space general who wants to sleep with Peg, and his BeleagueredAssistant is [[WesternAnimation/PinkyAndTheBrain The Brain]]. We also have [[WesternAnimation/HeyArnold Grandma Gertie]] as a CorruptCorporateExecutive, [[WesternAnimation/CampLazlo Scoutmaster Lumpus]] as Red's older brother, [[WesternAnimation/{{Rugrats}} Phil DeVille]] as Woody's clone and son, WesternAnimation/{{Jabberjaw}} as Peg Bundy's pet alien (who is actually a super intelligent protector of the universe), and [[Film/OfficeSpace Michael Bolton]] as a janitor.
* ''WesternAnimation/TheFutureIsWild'': [[WesternAnimation/TotalDrama Staci]] is assigned by her father [[WesternAnimation/XMenTheAnimatedSeries Professor X]] to explore future environments. She is joined by [[Series/DegrassiTheNextGeneration Derek Haig]], WesternAnimation/{{Fangbone}}, Emily[[note]]Miranda Jones has no other credits[[/note]], and TeamPet [[WesternAnimation/PippiLongstocking Mr. Nilsson]].
----
* ''WesternAnimation/DaBoomCrew'': [[WesternAnimation/CarlSquared Jamie James]], [[Film/BigMommasHouse Trent Pierce]], [[WesternAnimation/CaptainFlamingo Lizbeth Zaragoza]] and [[WesternAnimation/MissSpidersSunnyPatchFriends Dragon]] are four kids that created a homemade video game, which causes a power surge to throw them inside of their game. They embark on a quest to find their missing game cartridges and stop the villain [[Series/NewAttitude Lamarr]] from taking control of the cosmos.
* ''WesternAnimation/DanVs'': [[WesternAnimation/StrokerAndHoop Double Wide]] takes his friend [[Series/TheKidsInTheHall Hecubus]] (as well as Hecubus' wife [[Series/CriminalMinds Emily Prentiss]]) to get revenge on what had wronged him in the past. It rarely ends well for him. [[WesternAnimation/TheFairlyOddParents Cupid]] is a NewAgeRetroHippie.
* ''WesternAnimation/DangerRangers'': In a WorldOfFunnyAnimals, [[WesternAnimation/GIJoeARealAmericanHero Sci-Fi]], [[VideoGame/SlyCooperThievesInTime Carmelita Montoya Fox]], [[VideoGame/RatchetAndClank2002 Chairman Drek]], [[WesternAnimation/TimeSquad Larry 3000]], [[WesternAnimation/TeenageMutantNinjaTurtles1987 Raphael]], and [[VideoGame/SaintsRowTheThird Monica Hughes]] educate children about the importance of safety while dealing with anyone and anything that threatens their safety. [[Series/TalesFromTheCrypt The Crypt Keeper]] is their clumsy robot companion and [[WesternAnimation/CowAndChicken the Red Guy]] ([[WesternAnimation/ABugsLife Manny]] in the original pilot) is their artificial intelligence.
* ''WesternAnimation/DanielTigersNeighborhood'': WesternAnimation/MikeTheKnight (later [[WesternAnimation/PJMasks Night Ninja]] and then [[WesternAnimation/PawPatrol Rubble]]) lives in the Neighborhood of Make-Believe with his parents [[WesternAnimation/{{Roboroach}} Reg Roach]] and [[WesternAnimation/WildKratts Koki]], his little sister [[WesternAnimation/CreativeGalaxy Epiphany]], and his grandfather [[WesternAnimation/{{Redwall}} Shadow]]. His friends include [[Series/MaxAndShred Juliet]] (daughter of [[Series/AmericanGothic2016 Dana]]), [[WesternAnimation/MyBigBigFriend Lili]] (later WesternAnimation/{{Elinor|WondersWhy}}) (daughter of [[Series/TheJaneShow Jane Black]] and [[WesternAnimation/TrailerParkBoysTheAnimatedSeries Clont]]), [[WesternAnimation/SuperWhy Littlest Pig]] (nephew of [[WesternAnimation/TimeWarpTrio Uncle Joe]]), [[WesternAnimation/SuperWhy Whyatt]] ([[WesternAnimation/{{Sixteen}} Coach Halder]] and [[WesternAnimation/StickinAround Stella Stickler]]'s youngest son and [[Series/TheBestYears Rich Powell]]'s little brother), and [[WesternAnimation/AbbyHatcher Mo]] (daughter of [[Series/InstantStar Portia Quincy]], granddaughter of [[WesternAnimation/{{Babar}} Madame]], and older sister of [[Franchise/{{Peanuts}} Rerun]] and [[WesternAnimation/{{Grojband}} Laney Penn]]).
* ''WesternAnimation/DannyPhantom'': [[WesternAnimation/{{Freakazoid}} Dexter Douglas]] is a ghost powered superhero. His best friends [[WesternAnimation/AvatarTheLastAirbender Azula]] and [[WesternAnimation/{{Recess}} Vince]] help him out along the way. His parents [[Franchise/WinnieThePooh Kanga]] and [[WesternAnimation/{{Catscratch}} Gordon]] are ghost hunters while his sister [[Anime/DigimonAdventure Sora Takenouchi]] [[IJustWantToBeNormal just wants to be a normal person]]. He is also taught by [[WesternAnimation/TeenTitans2003 Slade]], and has a crush on the resident AlphaBitch [[WesternAnimation/JusticeLeague Hawkgirl]]. Dexter's enemies include [[Series/{{Roseanne}} Leon Carp]], WesternAnimation/{{Bubsy}}, [[WesternAnimation/KungFuPandaLegendsOfAwesomeness Temutai]], WesternAnimation/JohnnyTest, [[WesternAnimation/ThePowerpuffGirls Bubbles]], [[WesternAnimation/TheSpectacularSpiderMan Doctor Octopus]], [[Toys/{{Bionicle}} Mata Nui]], [[WesternAnimation/BatmanTheBraveAndTheBold Huntress]], and [[Series/{{Frasier}} Roz Doyle]].
** In an alternate future, Dexter grows up to become [[Series/DoctorWho The Master]], which [[Film/KillBill Bill]] tries to prevent.
** In the ChristmasEpisode, Dexter is trapped in a poem by [[WesternAnimation/TheLegoMovie Batman]].
* ''WesternAnimation/DarkwingDuck'': {{WesternAnimation/Cat|Dog}} is an egotistical crime fighter who is joined in his adventures by his adopted daughter [[WesternAnimation/AaahhRealMonsters Oblina]] and his pilot sidekick [[Film/TheGodfather Luca Brasi]]. He clashes with such supervillains as crime lord [[WesternAnimation/TheWildThornberrys Nigel Thornberry]] (including his henchmen [[Franchise/{{Transformers}} Shrapnel]] and [[WesternAnimation/DextersLaboratory Mandark]]), film-directing criminal [[WesternAnimation/TheLittleMermaid1989 King Triton]], metal-mouthed [[WesternAnimation/PinkyAndTheBrain Pinky]], electrical menace [[WesternAnimation/TheSimpsons Krusty the Klown]], salesman-turned-hydrokinetic [[WesternAnimation/SpiderManTheAnimatedSeries Nick Fury]], plant-loving scientist [[WesternAnimation/{{Barnyard}} Pig]], crazed toymaker [[WesternAnimation/{{Rugrats}} Drew Pickles]], and his archnemesis doppelganger, Franchise/WinnieThePooh. He also romances reformed criminal [[WesternAnimation/DannyPhantom Maddie Fenton]] and occasionally clashes with rival superhero [[WesternAnimation/TheSmurfs1981 Greedy Smurf]]. Cat's next-door neighbors include [[WesternAnimation/TazMania the Tazmanian Devil]], his wife [[WesternAnimation/PepperAnn Aunt Janie Diggety]], their bratty son [[WesternAnimation/GoofTroop Max Goof]], and their younger son [[WesternAnimation/TotallySpies Alex]], who also knows Cat's secret identity and helps him and his friends.
* ''WesternAnimation/DaveTheBarbarian'': While the king and queen are away, Udrogoth is being ruled and protected by [[WesternAnimation/TinyToonAdventures Montana Max]], his sword [[Series/{{Seinfeld}} Estelle Costanza]], his sisters [[WesternAnimation/{{Animaniacs}} Dot Warner]] and [[Literature/TheMagicSchoolBus Keesha]], his uncle [[WesternAnimation/DannyPhantom Skulker]], and his pet dragon [[WesternAnimation/{{Aladdin}} Abu]]. Their most fearsome enemy is the Dark Lord WesternAnimation/{{Freakazoid}}. Their adventures are narrated by [[WesternAnimation/CodenameKidsNextDoor Mr. Boss]].
** In one episode, [[Music/{{Metallica}} James Hetfield, Lars Ulrich]], and [[WesternAnimation/{{Rugrats}} Charlotte Pickles]] teach Abu how to be a real dragon.
** In an award-winning episode, [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Billy]] attempts to take over Udrogoth by time travel.
* ''WesternAnimation/TheDayMyButtWentPsycho'': [[WesternAnimation/{{Wishfart}} Dez]] and his buddy [[WesternAnimation/TheAdventuresOfSamAndMaxFreelancePolice Max]] go on misadventures with [[WesternAnimation/NumbChucks Quills]] (daughter of [[WesternAnimation/{{Wayside}} Principal Kidswatter]]) fighting butt-themed villainy, namely [[WesternAnimation/DanielTigersNeighborhood Dad Tiger]] and his henchmen [[WesternAnimation/RocketMonkeys Wally]] and [[WesternAnimation/{{Spliced}} Entree]]. Dez lives with his grandmother [[Anime/{{Bakugan}} Runo Misaki]].
* ''Franchise/DCAnimatedUniverse''
** ''WesternAnimation/BatmanTheAnimatedSeries'': [[WesternAnimation/TheVentureBrothers Captain Sunshine]] is a crime fighter. [[WesternAnimation/AvatarTheLastAirbender Fire Lord Ozai]] is an insane criminal mastermind and a MonsterClown. Sunshine often fights crime with [[WesternAnimation/DefendersOfTheEarth Rick Gordon]]. [[Series/LittleHouseOnThePrairie Laura Ingalls Wilder]] (later [[WesternAnimation/DrawnTogether Princess Clara]]) is a young female superhero, while [[Series/{{Smallville}} Lionel Luthor]] is a PunchClockVillain who suffers greatly from ChronicVillainy. Other villains include [[Series/{{Maude}} Bea Arthur's daughter]], [[Film/AnimalHouse Dean Wormer]], [[Film/BrokenArrow1950 Cochise]], [[Series/NightCourt Bull the Bailiff]], [[Franchise/PlanetOfTheApes Cornelius]], [[WesternAnimation/TeenTitans2003 Slade]], and [[Film/PhantomOfTheParadise Swan]], among others.
** ''WesternAnimation/SupermanTheAnimatedSeries'': [[Series/{{Wings}} Joe Hackett]] is the Man of Steel, who is sent to Earth by his parents [[Film/HappyGilmore Shooter McGavin]] and [[Series/Charmed1998 Patty Halliwell]], and after being adopted by real-life couple [[Series/{{Mash}} B.J. Hunnicutt]] and [[Series/{{Coach}} Christine Armstrong Fox]], grows up to become a journalist at a major metropolitan newspaper, where he's friendly rivals with [[Series/DesperateHousewives Katherine Mayfair]], working for [[WesternAnimation/BatmanTheAnimatedSeries The Ventriloquist]]. But as the near-invincible Man of Steel, he has many enemies, including [[WesternAnimation/AvatarTheLastAirbender Long Feng]], [[VideoGame/SplinterCell Sam Fisher]], [[WesternAnimation/{{Hercules}} Zeus]], [[Film/AClockworkOrange Alex DeLarge]], [[WesternAnimation/{{Aladdin}} Iago]], Film/TankGirl, [[Film/TheFifthElement General Munro]], and Film/{{Harold|AndMaude}}; but he has quite a few allies like [[Series/TheNanny Maggie Sheffield]], [[Series/TilDeath Joy Stark]] and police officers [[Film/BladeRunner Zhora]] and [[Film/BigDaddy Lenny Koufax]]. [[WesternAnimation/MegasXLR R.E.G.I.S. Mark V]] and [[Series/EverybodyLovesRaymond Robert Barone]] have recurring roles as heroes and villains.
** ''WesternAnimation/BatmanBeyond'': TwentyMinutesIntoTheFuture, after his father [[Series/FamilyTies Steven Keaton]] is killed by [[VideoGame/DevilMayCry2 Arius]], [[WesternAnimation/KimPossible Ron Stoppable]] swipes a costume from Sunshine in order to get revenge. [[VideoGame/StarcraftII Selendis]] later learns his secret. [[WesternAnimation/{{Futurama}} Amy Wong]] is his girlfriend. [[Film/AustinPowers Scott Evil]] is a JerkJock rival.
*** "Dead Man's Hand": Ron falls for [[Series/TheWonderYears Karen Arnold]], not knowing she's part of a gang led by [[Film/OnHerMajestysSecretService James Bond]].
*** "Meltdown": Sick of his decaying body, Arius turns to Dr. [[Franchise/{{Terminator}} Sarah Connor]] for a solution. She proposes making a new body, and tests the procedure on Sunshine's old nemesis, [[Series/StarTrekTheOriginalSeries Kang]], who has been in hiding for decades, and decides to make amends after all these years.
*** "A Touch of Curare": District attorney [[Film/StarTrekIITheWrathOfKhan Captain Terrell]] has been targeted for assassination by [[VideoGame/KingdomHeartsII Vivi Ornitier]], and Commissioner [[Film/{{Grease}} Betty Rizzo]], the former Batgirl, tries to protect him, being unamused by Ron's work.
*** "Disappearing Inque": Feeling unappreciated at his job, [[Film/MysteryMen The Shoveler]] breaks [[WesternAnimation/TheWildThornberrys Gillian Gibson]] out of her icy prison, and she wants vengeance against Ron and Sunshine.
*** "Ascension": As Arius' condition worsens, he calls upon his son [[Film/ThePrincessBride Westley]] for help, but Westley has other plans for his father.
*** "Earth Mover": One of Ron's classmates, [[Series/SabrinaTheTeenageWitch Valerie Birkhead]], learns from his foster father the truth about what actually happened to her father, [[Film/StarTrekTheMotionPicture Willard Decker]].
*** "The Call": Ron teams up with the other heroes of the future, including [[WesternAnimation/TheIronGiant Kent Mansley]], [[WesternAnimation/KingOfTheHill Connie Souphanousinphone]], [[Series/{{Wings}} Alex Lambert]], [[WesternAnimation/TheLittleMermaid1989 Ariel]], [[Series/HowIMetYourMother James Stinson]], and [[WesternAnimation/TeenTitans2003 Robotman]], but discovers one of them might be a traitor.
*** "Final Cut": [[Film/MuppetTreasureIsland Long John Silver]] threatens to blow up Gotham unless Ron helps him stop Vivi Ornitier.
*** "Sneak Peek": [[Film/ThisIsSpinalTap David St. Hubbins]] is a shady tabloid host who uncovers the secret identities of Ron and Sunshine.
** ''WesternAnimation/StaticShock'': [[WesternAnimation/{{Futurama}} Hermes Conrad]] gains superpowers after a freak accident and must keep them secret from his father, [[WesternAnimation/TransformersPrime Bulkhead]]. Later, his buddy [[WesternAnimation/AGoofyMovie Max Goof]] gets his own powers.
*** Alternately, [[WesternAnimation/TheWeekenders Tino and Carver]] receive their own superpowers.
** ''WesternAnimation/TheZetaProject'': [[Series/TheDrewCareyShow Oswald Harvey]] is a peaceful robot who is searching for his hard to find creator with his buddy, [[WesternAnimation/MegasXLR Kiva's Ancestor]]. He's pursued by several government agents, including [[Series/That70sShow Red Foreman]], [[WesternAnimation/JusticeLeague The Flash]], [[WesternAnimation/CodenameKidsNextDoor Numbuh 3]], and later [[Series/SunsetBeach Virginia Harrison]], who signs on after Numbuh 3 quits.
** ''WesternAnimation/JusticeLeague'': Joe Hackett (now [[VideoGame/FinalFantasyVII Sephiroth]]), Captain Sunshine, [[WesternAnimation/JackieChanAdventures Viper]], [[Series/{{Smallville}} Lex Luthor]], [[WesternAnimation/AvatarTheLastAirbender Earth King Kuei]], [[VideoGame/MarvelVSCapcom3 She-Hulk]], and [[Series/{{Alias}} Marcus Dixon]] join forces to become a superhero team, in a bid to protect the world from the likes of villains such as [[WesternAnimation/AvatarTheLastAirbender Long Feng, Fire Lord Ozai]], [[Film/SinCity Senator Roark]], WesternAnimation/{{Aladdin}}, and the fearsome [[VideoGame/SplinterCell Sam Fisher]].
** ''WesternAnimation/JusticeLeagueUnlimited'': The ranks of the above superhero team immensely grows, with other heroes such as archer [[Series/GeneralHospital Scotty Baldwin]], Sephiroth's cousin [[Series/TheNanny Maggie Sheffield]], radioactive military man [[VideoGame/BatmanArkhamCity Deadshot]], shrinking scientist [[Series/{{Scrubs}} Dr. Cox]], conspiracy theorist [[Series/StarTrekEnterprise Commander Shran]], animal-themed heroine [[Series/{{Firefly}} Zoe Washburne]], modern-day cowboy [[Series/{{Firefly}} Malcolm Reynolds]], blundering glory-hound [[Series/{{Southland}} Detective Russell Clarke]] (and his robot companion [[WesternAnimation/{{Futurama}} Philip J. Fry]]) and the great magician [[VideoGame/UltimateSpiderMan2005 Silver Sable]], among many others. A government-sanctioned body headed by [[Film/{{Avatar}} Moat]], staffed with people such as [[Film/SpiderManTrilogy J. Jonah Jameson]] and [[Series/SixFeetUnder Dr. Bernard Chenowith]], and funded by Long Feng aim to control them, believing them to be too powerful to be left unchecked.
* ''WesternAnimation/TheDeep2015'': [[WesternAnimation/{{Ninjago}} Kai]], his sister [[WesternAnimation/DinoTrux Skya]], and their parents [[Series/NinjaTurtlesTheNextMutation Leonardo]] and [[WesternAnimation/EdEddNEddy Marie Kanker]] explore the ocean and unravel its mysteries. The family's archenemies are the pirate [[WesternAnimation/XMenEvolution Blob]], his two kids WesternAnimation/MartinMystery and [[WesternAnimation/LoliRock Iris]], and his first mate [[Anime/DeathNote Ryuk]].
* ''WesternAnimation/DeathstrokeKnightsAndDragons'': [[Film/FantasticFour2005 The Thing]] is a mercenary who must rescue his mute son [[VideoGame/RiverCityGirls Yamada]] when [[Anime/LoveLive Rin Hoshizora]], [[spoiler:the Thing's ''other'' kid]], kidnaps him. [[Series/RizzoliAndIsles Maura Isles]] is the Thing's ex-wife, [[Series/{{Krypton}} General Zod]] is the Thing's friend, and [[VideoGame/TransformersRiseOfTheDarkSpark Drift]] is the reason Isles and the Thing are divorced and Yamada is mute.
* ''WesternAnimation/DefendersOfTheEarth'': After his wife [[WesternAnimation/BatmanTheAnimatedSeries Poison Ivy]] is killed, [[WesternAnimation/GaltarAndTheGoldenLance Galtar]] and his son [[Franchise/DCAnimatedUniverse Dick Grayson]] join forces with [[Film/FridayThe13thPartVIIIJasonTakesManhattan Charles McCulloch]], [[WesternAnimation/TeenageMutantNinjaTurtles1987 Master Splinter]], and [[WesternAnimation/TheTransformers Blaster]] and their successors to defeat the tyrannical [[WesternAnimation/DarkwingDuck Agent Grizzlikof]]
* ''WesternAnimation/DelilahAndJulius'': [[Anime/LoveLive Honoka Kousaka]] and [[WesternAnimation/{{Detentionaire}} Camillio Martinez]] are a pair of secret agents who fight international crime while training at a top-secret spy academy.
* ''WesternAnimation/{{Detention}}'': PerkyGoth [[WesternAnimation/TeenTitans2003 Raven]], conspiracy theorist [[WesternAnimation/{{Futurama}} Philip J. Fry]], the comic book geek head writer of the show, perpetually angry [[Series/Reno911 Deputy Garcia]], identical twins [[Literature/{{Twitches}} Artemis and Apolla DuBaer]], and the eternally peppy [[WesternAnimation/CharlottesWeb Fern]] are a group of kids trying (and failing) to stay out of getting detention from P.E. teacher [[WesternAnimation/DuckTales1987 Mrs. Crackshell]].
* ''WesternAnimation/{{Detentionaire}}'': [[WesternAnimation/MyLittlePonyMakeYourMark Rocky]] ([[WesternAnimation/EverAfterHigh Daring Charming]] in the pilot) is framed for a prank and gets detention for a full year as a result. His friends [[WesternAnimation/DelilahAndJulius Julius Chevalier]], [[WesternAnimation/WinstonSteinburgerAndSirDudleyDingDong Sir Dudley Ding Dong]], and [[Anime/{{Bakugan}} Shun Kazami]] help him find the culprit while avoiding the principal [[WesternAnimation/JimmyTwoShoes Lucius Heinous VII]]. [[WesternAnimation/{{Grossology}} Abby Archer]] is a journalist for the school news program (co-host of [[WesternAnimation/ScaredySquirrel Paddy]]) and Rocky's love interest. The ones who framed Rocky are [[Series/MurdochMysteries Dr. Julia Ogden]] and [[WesternAnimation/ChopChopNinja Magic Master]]. [[Series/ToddAndTheBookOfPureEvil Hannah B. Williams]] is the BetaBitch to [[WesternAnimation/GrowingUpCreepie Creepie Creecher]], whose mother [[WesternAnimation/JacobTwoTwo Renee Ratelle]] is head of the school parents' council secretly working with [[WesternAnimation/RocketMonkeys Gus]]. Nose-picking outcast [[WesternAnimation/TotalDramaPresentsTheRidonculousRace Crimson]] later becomes a core member of Rocky's circle of friends. Notable students at Rocky's school include skater [[WesternAnimation/{{Sixteen}} Jude Lizowski]]; rocker [[WesternAnimation/{{Braceface}} Adam Spitz]]; math nerds [[WesternAnimation/{{Grojband}} Corey Riffin]], [[WesternAnimation/{{Pelswick}} Julie Smockford]] (who later dates Dudley), and [[WesternAnimation/AtomicPuppet Pauline Bell]]; and hearthrob [[Anime/MetalFightBeyblade Gingka Hagane]]. Also, the school mascot is [[WesternAnimation/SevenLittleMonsters Five]], [[WesternAnimation/RudolphTheRedNosedReindeer1964 Hermey the Elf]] is a magician, and the old principal was [[WesternAnimation/DNAce Mendel]].
* ''WesternAnimation/DexHamiltonAlienEntomologist'': [[WesternAnimation/MarvinTheTapDancingHorse Fast-Talking Jack]], [[WesternAnimation/InspectorGadget2015 Talon]], [[WesternAnimation/{{Sidekick}} Vana Glama]], and [[WesternAnimation/TotalDrama Noah]] are a team of scientists who study and capture extraterrestrial insects that are attacking Earth in the year 3000 while also protecting them from [[WesternAnimation/HotelTransylvaniaTheSeries Aunt Lydia]].
* ''WesternAnimation/DextersLaboratory'': [[WesternAnimation/{{Rugrats}} Chuckie Finster]] (later [[WesternAnimation/{{Chalkzone}} Snap]]) is a child genius whose parents are [[WesternAnimation/TinyToonAdventures Fifi La Fume]] and WesternAnimation/JohnnyBravo, and whose older sister is [[WesternAnimation/{{Archer}} Uta]]. He frequently fights with his rival [[Film/{{Grease}} Eugene Felnic]] and has a pet monkey named [[Franchise/{{Transformers}} Megatron]], who is actually a superhero. Chuckie/Snap's best friend at school is [[WesternAnimation/CampLazlo Mr. Slinkman]] and his teacher is [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Goddard]]. Uta's best friends are [[WesternAnimation/MuchaLucha Snow Pea]] and [[WesternAnimation/{{Rugrats}} Lil DeVille]]. Eugene's younger sibling is [[Film/SesameStreetPresentsFollowThatBird Donny Dodo]] and his parents are [[WesternAnimation/JakeAndTheNeverlandPirates Mr. Smee]] and [[WesternAnimation/HeyArnold Miriam Pataki]], while his pet duck is [[WesternAnimation/{{Aladdin}} Abu]]. Uta has an imaginary friend named [[WesternAnimation/ATrollInCentralPark Stanley the Troll]]. In one episode, Chuckie tries seducing his babysitter [[WesternAnimation/DannyPhantom Maddie Fenton]] (whose boyfriend is [[WesternAnimation/ThePenguinsOfMadagascar Kowalski]]). [[VideoGame/MetalGearSolid Grey Fox]] is the mascot of the local SuckECheeses along with his two sidekicks [[WesternAnimation/{{CatDog}} Cliff]] and [[VideoGame/TakAndThePowerOfJuju Party Juju]]. Chuckie also idolizes a bodybuilder named [[WesternAnimation/TeenageMutantNinjaTurtles2012 Shredder]], while Uta and her friends idolize a pony named [[Film/SpaceJam Lola Bunny]].
** One ShowWithinAShow has three superheroes, WesternAnimation/SpongeBobSquarePants, [[WesternAnimation/PinkyandTheBrain Pinky]], and [[Franchise/ScoobyDoo Fred Jones]], living together. Fred watches a puppet show starring [[WesternAnimation/{{Animaniacs}} Yakko]] and [[WesternAnimation/RockosModernLife Heffer]].
** Another segment involves Megatron being summoned by [[WesternAnimation/TheSpectacularSpiderMan Martha Connors]] to fight villains like [[WesternAnimation/SupermanTheAnimatedSeries Lobo]], [[VideoGame/GodOfWarIII Perses the Lava Titan]], [[Main/ProfessionalWrestling "Macho Man" Randy Savage]], [[WesternAnimation/TheBatman Temblor]], and [[Film/TeamAmericaWorldPolice Alec Baldwin]].
* ''ComicBook/{{Diabolik}}'': [[WesternAnimation/MyDadTheRockStar Rock Zilla]] is a master thief who along with his partner [[WesternAnimation/{{Sixteen}} Jen Masterson]] pursue vengeance against Rock's brother [[WesternAnimation/GetEd Anthony Ol' Skool]] for framing him for the murder for his adoptive father [[VideoGame/ResidentEvil2 Brian Irons]] - all while being pursued by the detective [[WesternAnimation/TheAvengersUnitedTheyStand Edwin Jarvis]].
* ''WesternAnimation/DiGataDefenders'': The host of ''Series/TheBachelorette Canada'', [[Film/{{Superbad}} Becca]], [[WesternAnimation/TotalDrama Geoff]], and his sister [[WesternAnimation/{{Cyberchase}} Creech]] defend the world of [=RaDos=] from the evil Order of Infinis, which is led by [[WesternAnimation/XMenTheAnimatedSeries Cable]] and his lieutenants, [[WesternAnimation/JaneAndTheDragon King Caradoc]], [[WesternAnimation/{{Sidekick}} Master XOX]], and [[WesternAnimation/{{Wishfart}} Fireball Cat]] as they seek to free a SealedEvilInACan. Our heroes are helped out by a rogue named [[Anime/DeathNote Hirokazu Ukita]] and mentored by [[Film/{{Cube}} Quentin]]. In Season 2, [[Film/CheaperByTheDozen2003 Kenneth Murtaugh]] joins the heroes' team to help them battle a returning evil, while [[Series/TrailerParkBoys Officer Erica Miller]] joins the villains as a representative for the new threat.
* ''WesternAnimation/{{Dilbert}}'': [[Series/GettingOn Richard James]] is stuck in a dead-end office job under [[Film/TheNuttyProfessor1996 Dean Richmond]]. His co-workers are [[Series/MadAboutYou a TV host]], [[WesternAnimation/TheSimpsons Francine]], [[WesternAnimation/RockosModernLife Heffer Wolfe]], and [[Series/EvenStevens Coach Tugnut]]. He lives with his mother, [[Series/TheNewNormal Frances Bartholomew]], and his pets, [[Film/TheDictator Mr. Ogden]], [[WesternAnimation/InspectorGadget Chief Quimby]], and [[WesternAnimation/AdventureTime the Ice King]]. Dean's secretary is [[WesternAnimation/TheSimpsons Agnes Skinner]], WesternAnimation/{{Duckman}} is the company's Human Resources director, and [[WesternAnimation/{{Futurama}} Calculon]] is the world's smartest garbageman.
* ''WesternAnimation/{{Dinosaucers}}'': [[WesternAnimation/FlyingRhinoJuniorHigh Principal Mulligan]], [[WesternAnimation/{{Babar}} Cornelius]], [[WesternAnimation/TheRaccoons Cedric Sneer]], [[Series/Goosebumps1995 Cal]], [[WesternAnimation/MonsterForce Niles Lupon]], [[WesternAnimation/COPS1988 Mayor Davis]], [[Film/TommyBoy Mr. Brady]], and [[Manga/CardcaptorSakura Yelan Li]] are a team of heroic dinosaurs who battle a team of evil dinosaurs made up of [[WesternAnimation/LittleBear Father Bear]], [[WesternAnimation/{{Madeline}} Miss Clavell]], [[Anime/{{Bakugan}} Naga]], [[WesternAnimation/RoliePolieOlie Pappy Polie]], [[Film/{{Hannibal}} Asst. Mayor Benny Holcombe]], [[WesternAnimation/TheAdventuresOfSuperMarioBros3 Big Mouth Koopa]], [[WesternAnimation/BlazingDragons Sir Hotbreath]], and [[WesternAnimation/SuperMarioWorld Oogtar]]. Helping the heroes out are a team of humans made up of [[Series/InstantStar Stuart Harrison]], [[WesternAnimation/{{Popples}} Bonnie]], [[Series/TheEdisonTwins Smitty]], and WesternAnimation/{{Donkey Kong|Country}}.
* ''WesternAnimation/{{Dinotrux}}'': [[Anime/DragonBallZ Dende]] and [[WesternAnimation/BeingIan Ian Kelley]] are two friends who live in a world of dinosaur-machine hybrids, including [[WesternAnimation/EdEddNEddy Ed]], [[WesternAnimation/MyLittlePonyFriendshipIsMagic Applejack]], [[Toys/{{Bionicle}} Toa Matau]], [[Series/CornerGas Hank Yarbo]], [[WesternAnimation/Thundercats2011 Panthera]], and [[WesternAnimation/ClassOfTheTitans Odie]]. Together, they defend their home from [[WesternAnimation/{{Reboot}} Matrix]] and [[WesternAnimation/GuardiansOfTheGalaxy2015 Rocket Raccoon]].
* ''WesternAnimation/{{Disenchantment}}'': [[Series/BroadCity Abbi Abrams]], princess of Dreamland, goes on adventures with [[Series/TheEricAndreShow Eric Andre]] and [[Series/Reno911 the Milkshake Man]]. Her father [[WesternAnimation/{{Futurama}} Bender is currently married to Mom]], whose child (Abbi's step-sibling) is [[WesternAnimation/DaveTheBarbarian Fang]]. Bender's court includes [[Film/OfficeSpace Michael Bolton]], [[WesternAnimation/TheCritic Orson Welles]], WesternAnimation/{{Doug}}, [[WesternAnimation/ThomasAndFriends the Troublesome Trucks]], and [[Series/TheMightyBoosh Vince Noir]]. Abbi's mother and Bender's first wife was [[Series/{{Catastrophe}} Sharon Morris]].
* ''WesternAnimation/DMynaLeagues'': [[Anime/MobileSuitGundamSeed Kira Yamato]], [[WesternAnimation/{{Supernoobs}} Jennifer Shope]], [[WesternAnimation/BeastWars Inferno]], [[Series/StargateSG1 Janet Frasier]], [[Anime/ZatchBell Professor Takamine]], [[Anime/DragonBallZ Nappa]], [[WesternAnimation/LeagueOfSuperEvil Voltar]], and [[WesternAnimation/BabyLooneyTunes Baby Sylvester]] are members of a minor league baseball team owned by [[WesternAnimation/LibertysKids Henri LeFevbre]]. They are antagonized by [[Toys/{{Bionicle}} Turaga Dume]] and his minions [[WesternAnimation/WhatsWithAndy Andy Larkin]] and [[WesternAnimation/{{Ninjago}} Pythor]], who seek to buy their stadium and demolish it.
* ''WesternAnimation/DNAce'': [[Anime/{{Bakugan}} Masquerade]] and [[WesternAnimation/{{Wishfart}} Finnuala O'Thugg]] meet an immortal talking squirrel named [[WesternAnimation/{{Grossology}} Lance Boil]], who gives Masquerade the power to create creatures via LegoGenetics to defend a superpowered meteor from Finnuala's brother WesternAnimation/{{Fangbone}}.
* ''WesternAnimation/DogCity'' (animated segments): [[Series/{{Copper}} Captain Ciaran Joseph Sullivan]], [[WesternAnimation/TheRaccoons Nicole Raccoon]], and [[WesternAnimation/CarlSquared Carl Crashman]] investigate crimes and solve mysteries. They primarily deal with the crime lord [[WesternAnimation/DonkeyKongCountry Kutlass]] and his henchmen [[WesternAnimation/{{Franklin}} Mr. Owl]], [[WesternAnimation/{{Babar}} Pompadour]], [[WesternAnimation/AlmostNakedAnimals Octo]], and [[WesternAnimation/MyLittlePonyFriendshipIsMagic Rarity]], as well as the evil baron [[WesternAnimation/TheAdventuresOfTintin1991 Thomson]] and the thief [[WesternAnimation/TheBatman Batman]]. WesternAnimation/{{Beetlejuice}} is the mayor of their city, with [[WesternAnimation/{{Dinosaucers}} Terrible Dactyl]] as his aide; [[WesternAnimation/ThePowerpuffGirls1998 Bubbles]] is Nicole's niece; and [[WesternAnimation/XMenTheAnimatedSeries Beast]] is a watchman.
* ''WesternAnimation/DonkeyKongCountry'': [[VideoGame/TrueCrimeNewYorkCity President Hamilton]] and [[WesternAnimation/SuperMarioWorld Yoshi]] are the heroes of Kongo Bongo Island and the protectors of the [[{{MacGuffin}} Crystal Coconut]]. Living alongside them are their mentor [[WesternAnimation/BlazingDragons King Allfire]], [[Film/ShortCircuit2 Bones]], [[Series/LifeWithDerek Nora McDonald]], [[WesternAnimation/TotallySpies G.L.A.D.I.S.]], and [[WesternAnimation/{{Franklin}} Mr. Bear]]. They are frequently antagonized by [[WesternAnimation/TheBerenstainBears Papa Q. Bear]], his henchmen [[WesternAnimation/{{Cyberchase}} Buzz]] and [[WesternAnimation/CampLakebottom Armand]], and a gang of pirates consisting of [[WesternAnimation/XMenTheAnimatedSeries Morph]], [[WesternAnimation/TheSuperMarioBrosSuperShow Toad]], and [[WesternAnimation/MyLittlePonyFriendshipIsMagic Cranky Doodle Donkey]].
* ''WesternAnimation/DorgVanDango'': [[WesternAnimation/DinosaurTrain Buddy]] befriends a group of magical beings made up of [[WesternAnimation/{{Grossology}} Lab Rat]], [[Literature/ShakuganNoShana Shana]], [[Film/DiaryOfAWimpyKid Coach Malone]], and [[WesternAnimation/LoliRock Iris]].
* ''WesternAnimation/{{Dot}}'': [[WesternAnimation/PawPatrol The second Skye]] is the tech-savvy daughter of [[WesternAnimation/{{Grojband}} Mina Beff]] and [[WesternAnimation/{{Sixteen}} Jonesy Garcia]].
* ''WesternAnimation/{{Doug}}'': [[WesternAnimation/TheLooneyTunesShow Elmer Fudd]] writes in his journal about life in Bluffington. His sister is DramaQueen [[Literature/BecauseOfWinnDixie Gertrude the Parrot]]. He has a crush on [[Series/OrangeIsTheNewBlack Yoga Jones]], his principal is [[WesternAnimation/ThunderCats1985 Alluro]], the school bully is [[WesternAnimation/{{Futurama}} Richard Nixon's Head]], and the new mayor is [[Film/{{Tootsie}} Rita Marshall]]. Additionally, [[WesternAnimation/MyLittlePonyTheMovie1986 Baby Lickety-Split]] is one of the students as Bluffington Elementary[[note]]She also happens to have a similar last name to the town where the show takes place.[[/note]].
* ''WesternAnimation/DrDimensionpants'': [[WesternAnimation/EdEddNEddy Edd]] finds a pair of magic pants that turn him into a superhero with the power to save dimensions. He is guided in his adventures by Anime/{{InuYasha}}.
* ''WesternAnimation/{{Dragamonz}}'': [[Anime/MetalFightBeyblade Gingka Hagane]], [[WesternAnimation/TheDayMyButtWentPsycho Zack Freeman]], and [[WesternAnimation/DanielTigersNeighborhood Mom Tiger]] guard a magic crystal from [[WesternAnimation/TotalDramaRama Chef Hatchet]] and his henchman WesternAnimation/JimmyTwoShoes.
* ''WesternAnimation/DragonBooster'': WesternAnimation/{{Captain N|TheGameMaster}}, [[WesternAnimation/EdEddNEddy Kevin]], [[Animation/{{Pucca}} Abyo]], [[WesternAnimation/BeastWars Optimus Primal]], [[Anime/TransformersCybertron Thundercracker]], [[WesternAnimation/ObanStarRacers Ondai]], [[Manga/DeathNote Shingo Midou]], and half of the cast of ''Anime/MegaManNTWarrior'' race horseback on [[CallARabbitASmeerp dragons]] (really {{dinosaurs|AreDragons}}).
* ''WesternAnimation/DragonHunters'': [[WesternAnimation/{{Wunschpunsch}} Maurizio di Mauro]] and [[WesternAnimation/WinxClub Darkar]] hunt dragons, and live in an inn run by [[WesternAnimation/{{Arthur}} Jane Read]].
* ''WesternAnimation/TheDragonPrince'': [[WesternAnimation/AvatarTheLastAirbender Sokka]], prince of the Kingdom of Katolis, discovers the egg of the legendary Dragon Prince, and along with his half-brother and an elf, he must return it to the land of Xadia to restore peace to the world.
* ''WesternAnimation/DragonTales'': [[WesternAnimation/YakkityYak Lemony]] and [[WesternAnimation/{{Reboot}} Enzo 00]] discover a magical dragon scale after moving into their new home and use it to go on adventures in Dragon Land. The dragons they befriend include GentleGiant [[WesternAnimation/IronManArmoredAdventures Killer Shrike]], ShrinkingViolet [[Anime/{{Hamtaro}} Bijou]], and ConjoinedTwins [[VideoGame/SengokuBasara Irdene]] and [[WesternAnimation/MyLittlePonyFriendshipIsMagic the Great and Powerful Trixie]], as well as their CoolTeacher [[Literature/ShakuganNoShana Sydonay]]. Later on, their cousin[[note]]Aida Ortega, Enrique's voice actress, has no other known credits.[[/note]] [[TheSixthRanger joins the group]].
* ''WesternAnimation/DrawnTogether'': VideoGame/CrashBandicoot, [[WesternAnimation/BatmanTheAnimatedSeries Batgirl]], [[WesternAnimation/TransformersAnimated Blackarachnia]], [[WesternAnimation/ThePowerpuffGirls Bubbles]], [[WesternAnimation/{{TMNT}} Leonardo]], [[WesternAnimation/FamilyGuy Death]], [[Series/Reno911 Steve Marmella]], and [[Film/SouthlandTales Sheena Gee]] are picked to live in a house together on a TV reality show.
* ''WesternAnimation/{{Duckman}}'': [[Series/{{Seinfeld}} George Constanza]] works as a private detective with [[WesternAnimation/AaahhRealMonsters the Gromble]]. His family consists of [[Film/NationalLampoonsEuropeanVacation Audrey Griswold]], [[WesternAnimation/ThePowerpuffGirls Buttercup]], [[Film/ThreeMenAndABaby Sylvia Bennington]], and Music/FrankZappa's son. [[WesternAnimation/TheWildThornberrys Nigel Thornberry]] is his archenemy and [[WesternAnimation/AnAmericanTail Tony Toponi]] is his office assistant.
* ''WesternAnimation/DuckDodgers'': [[VideoGame/SpiderManFriendOrFoe Dr. Octopus]] and his eager young cadet Anime/LupinIII save the world from [[WesternAnimation/{{Rugrats}} Grandpa Lou Pickles]] and his queen [[Film/TrueLies Juno Skinner]]. He works for [[VideoGame/NoMoreHeroes Dr. Peace]], and is constantly annoyed by rival hero [[Series/{{Seinfeld}} J. Peterman]]. [[Series/StarTrekTheNextGeneration Worf]] is every single {{Mook|s}}.
* ''WesternAnimation/DuckTales1987'': [[Film/TheTimeMachine1960 David Filby]] goes globe-trotting for treasure with his grandnephews [[WesternAnimation/TheSimpsons Martin Prince]], [[WesternAnimation/TheBraveLittleToasterGoesToMars Robbie]], and [[WesternAnimation/MuppetBabies1984 Baby Gonzo]] (and sometimes [[WesternAnimation/WaitTillYourFatherGetsHome Irma Boyle]]'s granddaughter WesternAnimation/StrawberryShortcake). The cave duck [[Franchise/ScoobyDoo Fred Jones]] moves in with the family in Season 2, while [[Series/LoisAndClark the older H.G. Wells]] works for Filby as both his accountant and armored security guard. Occasional antagonists include [[WesternAnimation/TheTownSantaForgot Santa Claus]], [[WesternAnimation/{{CatDog}} Cat]], and [[WesternAnimation/RockyAndBullwinkle Natasha Fatale]].
** ''WesternAnimation/DuckTalesTheMovieTreasureOfTheLostLamp'': David, Martin, Rapsheeba, Gonzo, Strawberry Shortcake, and [[VideoGame/SamAndMaxFreelancePolice a different Santa Claus]] search for a lost treasure, which contains a lamp housing the genie known as [[WesternAnimation/TheAddamsFamily1992 Uncle Fester]]. [[Film/TheAddamsFamily Another Uncle Fester]] wants to enslave the first Fester, and is assisted by his bumbling sidekick [[Film/{{Fletch}} Frank Walker]].
** ''WesternAnimation/DuckTales2017'': [[Series/DoctorWho The Tenth Doctor]] goes globe-trotting for treasure with his grandnephews [[Series/{{Community}} Abed Nadir]], [[Film/SonicTheHedgehog2020 Sonic the Hedgehog]], and [[WesternAnimation/WeBareBears Panda]] (and occasionally [[Series/TheNeighbors Jackie Joyner-Kersee]]'s granddaughter [[WesternAnimation/StevenUniverse Sadie Miller]]). Recurring antagonists include [[WesternAnimation/WanderOverYonder Lord Hater]], [[Series/SiliconValley Nelson "Big Head" Bighetti]], [[Film/BeautifulCreatures Aunt Del]], [[Series/DoctorWho Donna Noble]], and her niece, [[Series/OrangeIsTheNewBlack Brooke Soso]], and [[Series/{{Fringe}} Phillip Broyles]], as well as [[WesternAnimation/{{Recess}} Miss Finster]], [[Series/TheGoodPlace Shawn, and Tahani Al-Jamil]]. The show also delves into what happened to [[spoiler: Ten's missing niece, [[WesternAnimation/DanVs Elise]].]]
** ''WesternAnimation/QuackPack'': The boys become [[WesternAnimation/TheOblongs Beth Oblong]], [[WesternAnimation/KingOfTheHill Bobby Hill]], and [[WesternAnimation/ChalkZone Rudy Tabootie]] as they move back in with [[WesternAnimation/TheRealGhostbusters the Mayor of Morrisville]] and [[WesternAnimation/DextersLaboratory Dexter's mom]].
** ''WesternAnimation/LegendOfTheThreeCaballeros'': The Morrisville mayor, [[WesternAnimation/MuppetBabies2018 Baby Fozzie]], and [[Series/JaneTheVirgin Rogelio de la Vega]] move into a cabana together. They travel around the world and come into conflict with [[Series/ThirdRockFromTheSun Officer Don]] and [[WesternAnimation/LiloAndStitch Captain Gantu]]. The goddess [[WesternAnimation/TUFFPuppy Kitty Katswell]], {{Cloudcuckoolander}} caretaker [[WesternAnimation/TheAvengersEarthsMightiestHeroes Mr. Fantastic]], and Dexter's mom's (now [[WesternAnimation/{{Animaniacs}} Dot Warner's]]) nieces [[WebAnimation/HanazukiFullOfTreasures Hanazuki]], [[WesternAnimation/TheBuzzOnMaggie Maggie Pesky]], and [[WesternAnimation/AdventureTime Flame Princess]] aid the trio.
* ''WesternAnimation/DudeThatsMyGhost'': [[WesternAnimation/{{Hilda}} Alfur Aldric]] is an aspiring filmmaker who befriends the ghost of a rock star named Music/{{Beardyman}}.
* ''WesternAnimation/DudleyDoRight'': [[WesternAnimation/RockyAndBullwinkle Bullwinkle J. Moose]] must save his girlfriend [[WesternAnimation/TheSmurfs1981 Jokey Smurf]] from [[WesternAnimation/PeterPan Captain Hook]].
* ''WesternAnimation/DumbAndDumber'': [[WesternAnimation/{{Gargoyles}} Jackal and Broadway]] get into wacky misadventures together.
* ''WesternAnimation/TheDumbBunnies'': [[VideoGame/MegaManLegends Teisel Bonne]] and [[WesternAnimation/XMenTheAnimatedSeries Famine]] are a very stupid couple with a very stupid child[[note]]Dustin Lauzon, voice of Baby Bunny, has no other credits[[/note]]. Their uppity neighbors are [[WesternAnimation/JimmyTwoShoes Samy Garvin]] and [[WesternAnimation/{{Mysticons}} Queen Goodfey]], whose daughter is [[WesternAnimation/RoliePolieOlie Polie Pi]]; [[WesternAnimation/RescueHeroes Billy Blazes]] is the local conman; and Teisel's boss is [[Film/{{Meatballs}} Larry 'Fink' Finkelstein]]. Their misadventures are narrated by [[Series/TheRedGreenShow Buzz Sherwood]].
* ''WesternAnimation/{{Duncanville}}'': [[WesternAnimation/TheMightyB Bessie Higgenbottom]] is an ordinary teenager whose family is made up of her mother [[Series/ParksAndRecreation Leslie Knope]], her father [[Series/ModernFamily Phil Dunphy]], her sister [[WesternAnimation/TheLegoBatmanMovie Poison Ivy]], and her adopted sister [[Series/Stargirl2020 Tigress]]. Her friends are [[WesternAnimation/OurCartoonPresident Ben Carson]], [[Series/MakingHistory Chris]], and [[WesternAnimation/TrollsWorldTour Clampers Buttonwillow]], and [[Series/TheOfficeUS Karen Filippelli]] is her crush. [[Series/{{Dickinson}} Death]] is her CoolTeacher.
* ''WesternAnimation/DungeonsAndDragons1983'': [[Series/CharlesInCharge Buddy Lembeck]] the Ranger, [[WesternAnimation/MisterT Spike]] the Barbarian, [[Series/EightIsEnough Nicholas Bradford]] the Magician, [[WesternAnimation/DarkwingDuck Honker Muddlefoot]] the Thief, [[Series/HappyDays Ralph Malph]] the Cavalier, and an acrobat are youngsters trapped in a world of sorcery. With guidance from the mysterious [[Anime/LittleNemoAdventuresInSlumberland Oompe]] and the unicorn [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Goddard]], they must find a way back to their world while running afoul of the evil wizard [[Franchise/{{Transformers}} Optimus Prime]], his demonic henchman [[WesternAnimation/TheIncredibleHulk1982 Hulk]], and the dragon [[WesternAnimation/{{Futurama}} Nibbler]].
!!E
* ''WesternAnimation/EarthwormJim'': [[WesternAnimation/TheSimpsons Groundskeeper Willie]] is a worm in a superhero suit accompanied by WesternAnimation/JohnnyBravo. They fight villains like [[WesternAnimation/ThePowerpuffGirls Fuzzy Lumpkins]], [[WesternAnimation/TheLionKingIISimbasPride Zazu]], [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Ms. Fowl]], and [[WesternAnimation/{{ChalkZone}} Skrawl]]. They are also helped out by [[WesternAnimation/TheSuperheroSquadShow Dr. Doom]] and Willie's love interest is [[WesternAnimation/DannyPhantom Maddie Fenton]].
* ''WesternAnimation/{{Eckhart}}'': [[Literature/EmilyOfNewMoon Ilse Burnley]] and [[WesternAnimation/DiGataDefenders Melosa]] live in a mouse colony on Prince Edward Island. The colony's bumbling evil leader is [[WesternAnimation/XMenTheAnimatedSeries Sabretooth]].
* ''WesternAnimation/EdEddNEddy'': [[VideoGame/TYTheTasmanianTiger Andy]], [[WesternAnimation/BabyLooneyTunes Daffy Duck]], and [[Anime/MobileSuitGundamSeed Miguel Aiman]] (or, alternatively, [[Manga/CardcaptorSakura Kero, Julian and Tori]]) have tons of misadventures in their cul-de-sac. The other denizens on the cul-de-sac are [[Manga/RanmaOneHalf Hinako Ninomiya]], Andy's bratty sister; [[WesternAnimation/DragonTales Wheezie]], a JerkJock; [[Literature/ShakuganNoShana Shana]] ([[TheOtherDarrin who depending on the episode is also]] [[VideoGame/LeagueOfLegends Sona]], [[Manga/{{InuYasha}} Jakotsu]] or [[VideoGame/PuyoPuyo Feli]]), a DumbBlonde; [[Manga/DragonBallZ Goku]], a FunnyForeigner; and [[Series/OnceUponATime Doc]], who has a NotSoImaginaryFriend [[note]]Jimmy's voice actor Keenan Christensen doesn't have any other known roles[[/note]]. There's also a TerribleTrio consisting of [[Manga/RanmaOneHalf Tsukasa]] (sometimes [[VideoGame/Persona4 Chie Satonaka]]), [[Toys/{{Bionicle}} Roodaka]], and [[Manga/{{InuYasha}} Kagura]], who all have crushes on the main trio. [[WesternAnimation/MyLittlePonyFriendshipIsMagic Igneous Rock]] is Miguel Aiman's mysterious older brother.
* ''WesternAnimation/EdgarAndEllen'': '''[[WesternAnimation/MyLittlePonyFriendshipIsMagic The Great and Powerful Trixie]]''' and [[Manga/{{Inuyasha}} Shippo]] are a pair of troublemaking CreepyTwins.
* ''WesternAnimation/EekTheCat'': WesternAnimation/MadJackThePirate is a friendly housecat who lives with his owners [[WesternAnimation/TinyToonAdventures Buster Bunny]] and [[WesternAnimation/ThePowerpuffGirls Buttercup]]. Mad Jack's girlfriend is [[Music/{{Whitesnake}} the chick from "Here I Go Again"]].
** ''The Terrible Thunderlizards'': One of the show's creators, [[WesternAnimation/WhatACartoonShow Yuckie Duck]], and [[Series/BeverlyHills90210 Brandon Walsh]] (later [[Film/TeenageMutantNinjaTurtles1990 Donatello]]) are dispatched by [[Series/That70sShow Red Foreman]] to eliminate the world's two humans, [[WesternAnimation/MyLittlePonyAndFriends Spike]] and [[WesternAnimation/DanVs Dan]].
* ''WesternAnimation/ElinorWondersWhy'': [[WesternAnimation/XavierRiddleAndTheSecretMuseum Amelia Earhart]], [[Film/TheBananaSplitsMovie Zoe]], and [[WesternAnimation/TotalDramaRama Cody]] ask questions about the world around them.
* ''WesternAnimation/EllaTheElephant'': [[WesternAnimation/DanielTigersNeighborhood Miss Elaina]] has adventures on Elephant Island with her friends [[WesternAnimation/ThreeAmigonauts Herby]], [[WesternAnimation/PawPatrol Rubble]], and [[Series/FallingSkies Constance]].
* ''WesternAnimation/ElliotMoose'' (animated segments): [[Series/RadioFreeRoscoe Ray Brennan]] is a young moose who goes on adventures with his friends [[WesternAnimation/AngelaAnaconda Nanette Manoir]], [[Series/DegrassiTheNextGeneration Shannon]], [[WesternAnimation/LittleBear Owl]], [[Film/{{Meatballs}} Larry 'Fink' Finkelstein]], and [[Series/{{Wilbur}} Wilbur the Calf]]. They are antagonized by [[WesternAnimation/StickinAround Russell]].
* ''WesternAnimation/EndangeredSpecies2015'': [[WesternAnimation/MyLittlePonyFriendshipIsMagic Rarity]], [[WesternAnimation/LeagueOfSuperEvil Doktor Frogg]], and [[WesternAnimation/EdEddNEddy Edd]] all live together in a tree stump.
* ''WesternAnimation/TheEpicTalesOfCaptainUnderpants'': [[WesternAnimation/TheChickenSquad Coop]] and [[WesternAnimation/BubbleGuppies Gil]] are mischief-making best friends who hypnotize their principal, [[WesternAnimation/BlazeAndTheMonsterMachines Pickle]], into becoming a superhero. Along for the ride are the InsufferableGenius [[WesternAnimation/BigCityGreens Carlos]], TheAce [[WesternAnimation/StevenUniverse Sapphire]], AlphaBitch [[VideoGame/SuperSmashBrosUltimate Viridi]], MellowFellow [[WesternAnimation/HomeAdventuresWithTipAndOh Apple]], ButtMonkey [[WesternAnimation/MickeyMouseMixedUpAdventures Elray Thunderboom]], and GentleGiant [[WesternAnimation/DangerAndEggs Tyronius]].
* ''WesternAnimation/ErkyPerky'': [[WesternAnimation/{{Redakai}} Zylus]] and [[WesternAnimation/TotalDramaPresentsTheRidonculousRace Dwayne]] are two bugs whose peaceful life on a hot dog stand comes to a sudden end when they end up in a sterile suburban kitchen.
* ''WesternAnimation/EsmeAndRoy'': [[Series/OddSquad Ms. O]] is a little girl who is best friends with a monster named [[WesternAnimation/ClangInvasion Rivet]].
* ''WesternAnimation/ExtremeGhostbusters'': [[VideoGame/LollipopChainsaw Juliet Starling]], [[WesternAnimation/AnAmericanTail Tony Toponi]], [[WesternAnimation/JusticeLeague Snapper Carr]], [[Series/TheFreshPrinceOfBelAir Carlton Banks]], and [[WesternAnimation/TheBatman Batman]] are five youths trained by [[WesternAnimation/InspectorGadget Chief Quimby]] to catch ghosts, like their lovable sidekick [[WesternAnimation/{{Futurama}} Dr. Zoidberg]].
!!F
* ''WesternAnimation/FIsForFamily'': [[Series/BreakingBad Patrick Kuby]] is the short-tempered head of a 60s suburban family made of his wife [[Film/JurassicPark Dr. Ellie Sattler]] and his three children, who are [[Film/AlvinAndTheChipmunks Alvin]], an ''Series/AmericanIdol'' performer, and [[Anime/ZatchBell Zatch]]. Their next-door neighbor is [[Film/TheHitchhikersGuideToTheGalaxy2005 President Zaphod Beeblebrox]].
* ''WesternAnimation/TheFairlyOddParents'': [[WesternAnimation/Ben10 Ben Tennyson]] (originally [[WesternAnimation/SouthPark Wendy Testaburger]]) is a buck-toothed kid who is ignored by his parents, [[WesternAnimation/TheSpectacularSpiderMan J. Jonah Jameson]] and [[WesternAnimation/TheSecretSaturdays Dr. Miranda Grey]], and bullied by an evil, ill-tempered teenager named [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Mandy]]. He gets through the day by making wishes to his fairy godparents, [[Manga/FistOfTheNorthStar Rei]] and [[WesternAnimation/OneHundredAndOneDalmatiansIIPatchsLondonAdventure Cruella de Vil]] (whose evil counterparts are [[Anime/DinoZaurs Dark Dragon]] and [[WesternAnimation/{{Amphibia}} Valeriana]]), [[BeCarefulWhatYouWishFor though they don't always work out as he hoped]]. WesternAnimation/{{Rocko|sModernLife}}, Ben's teacher, frequently tries to capture the fairies, [[WesternAnimation/IceAgeTheMeltdown Fast Tony]] is a superhero that Ben idolizes (whose ArchEnemy is [[WesternAnimation/{{Cars}} Jay Limo]]), Mandy's little sister [[WesternAnimation/CodenameKidsNextDoor Lizzie Devine]] is crushing on Ben, [[Film/RobinsonCrusoeOnMars Colonel Dan McReady]] (later WesternAnimation/JohnnyBravo) is a cat-themed superhero, and [[WesternAnimation/CampLazlo Lazlo]] is a StalkerWithACrush towards Cruella. Ben also likes to hang out with his friends [[Series/TheCosbyShow Nelson Tibideaux]], {{Series/Malcolm|InTheMiddle}} (later [[WesternAnimation/AGoofyMovie Max Goof]]), [[WesternAnimation/StarWarsTheCloneWars Captain Rex]], and [[WesternAnimation/StevenUniverse Lion]], and is frequently visited by [[TheAhnold a muscular German fairy]] named [[Film/TeamAmericaWorldPolice Spotswoode]], who later marries [[WesternAnimation/FostersHomeForImaginaryFriends Frankie Foster]]. He has a crush on popular girl [[WesternAnimation/{{Rugrats}} Kimi Finster]], who is friends with another popular girl that has a secret crush on Ben, [[WesternAnimation/TheLoudHouse Lola Loud]], who also happens to be a ButtMonkey. [[WesternAnimation/TeenTitans2003 Raven]] and [[WesternAnimation/WhateverHappenedToRobotJones Shannon]] are the snobby rich class presidents. [[WesternAnimation/{{Animaniacs}} Yakko Warner]] is an alien that Ben befriends. [[WesternAnimation/MyGymPartnersAMonkey Jake Spidermonkey]] is another fairy who works on Valentine's Day. [[VideoGame/CrashBandicoot Crunch Bandicoot]] is an AffablyEvil supervillain. [[Film/TheMask Dr. Neuman]] and [[Film/FerrisBuellersDayOff the economics teacher]] are recurring villains who believe everything should be dull and boring. [[WesternAnimation/{{Aladdin}} Iago]] is a psycho dentist, whose son is [[WesternAnimation/{{Cyberchase}} Digit]]. [[WesternAnimation/TheLifeAndTimesOfJuniperLee Monroe]] is the next door neighbor that Jameson hates. Rocko lives with his parent [[WesternAnimation/CatDog Winslow Oddfellow]]. [[WesternAnimation/EvilConCarne Major Doctor Ghastly]] is the school principal and [[WesternAnimation/ElTigreTheAdventuresOfMannyRivera Puma Loco]] is the town mayor. [[WesternAnimation/TimeSquad Buck Tuddrussel]] and [[WesternAnimation/HiHiPuffyAmiYumi Yumi Yoshimura]] work at a daycare run by [[WesternAnimation/DannyPhantom Dash Baxter]]. Ben also likes to watch a TV show starring [[Anime/DigimonFrontier Mercurymon]]. In the sixth season, Rei and Cruella have a baby named [[WesternAnimation/ThePowerpuffGirls1998 Bubbles]], whose evil counterpart is [[WesternAnimation/{{Unikitty}} Master Frown]]. Ben later gets a pet named [[WesternAnimation/TuffPuppy Snaptrap]], and in season 10, Ben has to share Cruella and Rei with [[Anime/{{FLCL}} Haruko Haruhara]].
* ''WesternAnimation/FamilyGuy'': [[Series/TheOrville Ed Mercer]], [[Series/GilmoreGirls Drella]], [[Franchise/MassEffect Joker]], [[Series/That70sShow Jackie Burkhart]] (formerly [[WesternAnimation/TheWildThornberrys Eliza Thornberry]] and [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]] when singing), [[Film/AMillionWaysToDieInTheWest Albert Stark]], and [[WesternAnimation/{{Sing}} Mike]] all live under one roof. [[Series/{{Scrubs}} A urologist]], [[Film/HellboyIITheGoldenArmy Johann Krauss]], and WesternAnimation/{{Buzz Lightyear|OfStarCommand}} are Ed's drinking buddies. [[Franchise/StarWars Princess Leia]] is Ed's current boss (his former boss [[WesternAnimation/HappyFeet Nestor]] choked on a dinner roll), [[Film/NeverBeenKissed Josie Grossie]] is Mike's (or Albert's?) ex, [[Film/BrideOfChucky Tiffany]] is Buzz's wife, [[Series/MySoCalledLife Danielle Chase]] is an AlphaBitch who torments Jackie, and Series/{{Batman|1966}} was the mayor of their town.
** ''WesternAnimation/TheClevelandShow'': The urologist moves out of Quahog with his son [[VideoGame/CrashBandicoot Crunch Bandicoot]]. He marries his highschool sweetheart [[Series/NipTuck Michelle Landau]], whose two kids are [[Series/GilmoreGirls Ed]] and [[Film/BigMommasHouse Sherry Pierce]] (later [[Series/TheParentHood Zazia Peterson]]). Film/{{Ted}} (later [[WesternAnimation/{{Animaniacs}} Wakko Warner]]) is his neighbor.
* ''WesternAnimation/FanboyAndChumChum'': Two kids, [[Series/SixFeetUnder Patrick]] and [[VideoGame/MetalGearSolid4GunsOfThePatriots Raging Raven]], dress like superheroes and have adventures along with a wizard named [[Film/SonOfTheMask Tim Avery]], an {{otaku}} named [[Series/AllMyChildren Leo du Pres]], and a bully named WesternAnimation/JohnnyBravo. They're the biggest fanboys of a superhero named [[WesternAnimation/TransformersAnimated Prowl]].
* ''WesternAnimation/{{Fangbone}}'': [[Series/TheStanleyDynamic Luke Stanley]] is sent from Skullbania to Earth by [[WesternAnimation/{{Spliced}} Mister Smarty Smarts]] with [[WesternAnimation/DiGataDefenders Brackus]]' magic toe to keep it out of his hands. On Earth, Luke befriends [[WesternAnimation/TopWing Speedy]], who helps him fight Brackus' monsters. Speedy's mother is [[WesternAnimation/{{Sixteen}} Nikki Wong]]; their teacher is [[WesternAnimation/GeorgeShrinks Perdita Shrinks]]; and the principal is [[WesternAnimation/{{Freaktown}} Lord Cuddles the Fluffy]]. [[WesternAnimation/CampLakebottom Suzi]] is a thief who helps them out sometimes, while WesternAnimation/MarvinTheTapDancingHorse is Luke's chieftain. Luke and Speedy's friends/classmates are [[WesternAnimation/{{Wayside}} Maurecia]], [[WesternAnimation/{{Sidekick}} Kitty Ko]], [[WesternAnimation/{{Detentionaire}} Jenny Jergens]], [[WesternAnimation/HeroElementary Benny Bubbles]], [[WesternAnimation/JaneAndTheDragon Prince Cuthbert]], and [[WesternAnimation/WinstonSteinburgerAndSirDudleyDingDong Hampton]]. In the final episode, [[spoiler:Brackus' magic toe]] is revealed to be sapient and speaks in the voice of [[WesternAnimation/JacobTwoTwo Renee Ratelle]].
* ''WesternAnimation/{{Fangface}}'': [[Franchise/{{Transformers}} Megatron]] is a teenage werewolf.
* ''WesternAnimation/FantasticFourTheAnimatedSeries'': [[WesternAnimation/RubySpearsSuperman Superman]], [[WesternAnimation/SpongebobSquarepants Pearl Krabs]], [[Series/BeverlyHills90210 David Silver]] (later [[WesternAnimation/MyLifeAsATeenageRobot Sheldon Lee]]), and WesternAnimation/CoolMcCool are a superhero team battling against the evil [[VideoGame/TheCurseOfMonkeyIsland Wally B. Feed]] (later [[VideoGame/DeadSpace3 Jacob Danik]]).
** ''WesternAnimation/FantasticFourWorldsGreatestHeroes'': [[Anime/MobileSuitGundam Gihren Zabi]], [[Series/BattlestarGalactica2003 Paulla Schaffer]], [[WesternAnimation/TotalDrama Topher]], and [[Anime/DragonBallZ Majin Buu]] are a team of superheroes who do battle against [[WesternAnimation/{{Reboot}} Enzo Matrix]].
* ''WesternAnimation/FantasticMax'': [[WesternAnimation/DinkTheLittleDinosaur Shyler]] goes on adventures in outer space with his alien doll [[WesternAnimation/TheSimpsons Ralph Wiggum]] and his RobotMaid [[VideoGame/Spyro2RiptosRage Ripto]].
* ''WesternAnimation/FastAndFuriousSpyRacers'': [[Franchise/MarvelRising Inferno]], cousin of Film/{{Riddick}}, is recruited into a goverment agency, under the command of [[Theatre/{{Hamilton}} Angelica Schuyler]], with his friends/crew [[WesternAnimation/GlitchTechs Mitch Williams]], [[WesternAnimation/CarmenSandiego Julia Argent]], and [[WesternAnimation/ElenaOfAvalor Gabriel Núñez]] to stop an organization known as {{SH1FT3R}}, led by [[Series/TheResident Devon Pravesh]], and his crew [[Series/AmericanVandal Mackenzie Wagner]] and [[WesternAnimation/PhineasAndFerb Vanessa Doofenshmirtz]]. Who is searching for something called the "skeleton key" to avenge his parents, who were killed by [[Film/BorisAndNatasha Boris Badenov]].
** Season 2: Following Devon arrest. The crew is sent to Rio to uncover a secret weapon, and find Mackenzie, who had joined the agency but disappeared investigating the secret weapon. And find that the weapon is a mind control gas made by [[Manga/ScienceFellInLoveSoITriedToProveIt Ayame Himuro]], a daughter of a crime family.
** Season 3: After being freed by Boris, Ayame, alongside fellow prisoner [[Film/BabyDriver JD]], is recruited to help set up a WeatherControlMachine. Leading the crew, now joined by Mackenzie, to stop them in the Sahara.
** Season 4: Blamed for a crime they didn't commit. The crew and Angelica flees to Mexico to clear their names and find the perpetrator, while being hunted down by Wrestling/BigShow. And find out the mastermind is [[WesternAnimation/VictorAndValentino Don Julio Jalapeño]], a former agent who intends to flood the city in lava.
* ''WesternAnimation/FatherOfThePride'': [[WesternAnimation/MonstersInc Sulley]] is a lion in a Las Vegas show starring [[WesternAnimation/CaptainZedAndTheZeeZone Captain Zed]] and [[WesternAnimation/{{Futurama}} Scruffy the Janitor]] and lives with his family consisting of [[Series/CurbYourEnthusiasm Cheryl David]], [[WesternAnimation/TheWildThornberrys Debbie Thornberry]], [[Film/SpyKids Juni Cortez]], and [[Series/TwoAndAHalfMen Marty Pepper]]. His best friend is [[VideoGame/{{Halo}} Marine Sergeant Banks]]. [[WesternAnimation/{{Mulan}} Mushu]] guest starred in one episode.
* ''WesternAnimation/{{Fillmore}}'': [[Series/ThatsSoRaven Eddie Thomas]] and [[WesternAnimation/TeenTitans2003 Raven]] fight crime in middle school for Jr. Commissioner [[Series/SaturdayNightLive Jasper Hahn]] and Principal [[Series/JustShootMe Nina Van Horn]], as do [[WesternAnimation/{{Futurama}} Amy Wong]] and [[Series/TheAdventuresOfPeteAndPete Little Pete]]. [[Music/TenaciousD Kyle Gass]], [[WesternAnimation/KimPossible Duff Killigan]], [[Series/BuffyTheVampireSlayer Rupert Giles]] (Miss Collins' father), [[Series/TwoAndAHalfMen Evelyn Harper]] and [[Series/{{Survivor}} Jeff Probst]] also work at the school, and Eddie's parents are [[Series/TwentyOneJumpStreet Judy Hoffs]] and [[Series/{{CSI}} Warrick Brown]].
** Among those involved in their cases: [[Film/RoboCop1987 Clarence Boddicker]], [[Series/TheOfficeUS Michael Scott]], [[Series/JoanOfArcadia Adam Rove]], WesternAnimation/{{Jimmy Neutron|BoyGenius}}, [[WesternAnimation/AmericanDad Hayley Smith]], [[Series/Flight29Down Taylor Hagan]], [[{{Series/Heroes}} Claire Bennet]], [[Series/That70sShow Midge Pinciotti]], [[Series/TerminatorTheSarahConnorChronicles John Connor]], WesternAnimation/{{Lilo|AndStitch}}, [[Film/TheLordOfTheRings Gimli]], [[WesternAnimation/HeyArnold Helga G. Pataki]], [[WesternAnimation/BatmanTheBraveAndTheBold Wildcat]], [[Series/TheSecretLifeOfTheAmericanTeenager Madison Cooperstein]], [[Series/TheDrewCareyShow Mimi]], [[Series/TheWestWing Annabeth Schott]], [[WesternAnimation/PhineasAndFerb the artist formerly known as Lindana]], Series/{{Malcolm|InTheMiddle}}, [[WesternAnimation/{{WITCH}} Miranda]], [[Series/DrakeAndJosh Josh]], and [[WesternAnimation/JohnnyBravo Little Suzy]].
* ''WesternAnimation/FinalSpace'':
** (Season 1): A man spends 5 years in space prison, slowly losing his sanity. Along the way, he befriends WesternAnimation/SpongeBobSquarePants, an alien cat man and his son [[WesternAnimation/Invincible2021 Mark]], and eventual love interest [[Film/SonicTheHedgehog2020 Pretzel Lady]]. Together, they must stop [[WesternAnimation/DuckTales2017 Scrooge McDuck]] from destroying Earth. Also, [[WesternAnimation/TeenTitans2003 Slade]] is the main character's father.
** (Season 2): The space man and his friends are back! Joining them on their adventure are [[WesternAnimation/TheLegoBatmanMovie the Riddler]]'s adopted children [[Manga/AttackOnTitan Sasha Braus]] and [[WesternAnimation/{{Trolls}} Cooper]]. Our hero's mother [[VideoGame/{{Uncharted}} Chloe Frazer]] may have ulterior motives, but the BigBad of it all is [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Irwin]].
* ''WesternAnimation/FishHooks'': [[Series/CoryInTheHouse Cory Baxter]], [[WesternAnimation/AdventureTime the Earl of Lemongrab]], and [[Series/{{Jonas}} Stella Malone]] are three fish attending school. [[WesternAnimation/{{Chowder}} Gazpacho]] is their MisterSeahorse teacher, and [[WesternAnimation/ThePenguinsOfMadagascar Rico]] is a JerkJock.
* ''WesternAnimation/TheFlintstones'': [[WesternAnimation/LadyAndTheTramp Boris]] and [[WesternAnimation/TheJetsons Rosie]] are HappilyMarried and so are their neighbors WesternAnimation/BugsBunny and [[Series/PetticoatJunction Kate Bradley]]. Boris and Bugs work for [[WesternAnimation/SecretSquirrel Chief Winchley]] and know an alien named [[Film/ThePinkPantherStrikesAgain Professor Auguste Balls]], and Bugs and Kate adopt super strong [[WesternAnimation/YogiBear Ranger Smith]] after Rosie gives birth to [[WesternAnimation/SecretSquirrel Winsome Witch]]. WesternAnimation/PorkyPig is Boris and Rosie's pet dinosaur.
* ''WesternAnimation/FlyingRhinoJuniorHigh'': [[WesternAnimation/StickinAround Bradley]], [[WesternAnimation/JohnCallahansQuads Franny]], WesternAnimation/GeorgeShrinks, and his sister [[WesternAnimation/LittleBear Duck]] have adventures in their middle school, which is warped by [[WesternAnimation/{{Cyberchase}} Dr. Marbles]] and his hench-rat [[Anime/SailorMoon Artemis]]. The kids' teacher is [[Film/GingerSnaps Nurse Ferry]], the principal is [[WesternAnimation/TheRaccoons Bert Raccoon]], and the janitor is [[WesternAnimation/XMenTheAnimatedSeries Quicksilver]].
* ''WesternAnimation/FostersHomeForImaginaryFriends'': [[Franchise/KingdomHearts Pence]] sends his imaginary friend, [[VideoGame/{{Overwatch}} Reaper]], to a foster home where they meet other imaginary friends like WesternAnimation/SamuraiJack, [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Nick Dean]], [[WesternAnimation/{{CatDog}} Dog]], [[WesternAnimation/MyGymPartnersAMonkey Ingrid Giraffe]], and [[WesternAnimation/StarWarsTheCloneWars Yoda]]. [[WesternAnimation/MyLifeAsATeenageRobot Nora Wakeman]] is the home's founder and owner while the manager (and her granddaughter) is [[WesternAnimation/AvatarTheLastAirbender Azula]]. [[WesternAnimation/HiHiPuffyAmiYumi Yumi Yoshimura]] is Pence's mother and his BigBrotherBully is [[VideoGame/TalesOfSymphonia Presea Combatir]]. Later seasons add characters like [[VideoGame/BatmanArkhamCity Catwoman]], [[WesternAnimation/StaticShock Virgil Hawkins]], and [[WesternAnimation/MuchaLucha The Flea]].
* ''[[Series/FraggleRock Fraggle Rock: The Animated Series]]'': [[WesternAnimation/TeenageMutantNinjaTurtles1987 Michelangelo]], [[WesternAnimation/TheLooneyTunesShow Porky Pig]], [[WesternAnimation/MickeyMouseClubhouse Toodles]], [[VideoGame/Persona5 Shinya Oda]], and [[Literature/{{Kanokon}} Kota Oyamada]] are five Fraggles who live together in the caverns of Fraggle Rock. They are often sent letters by Mikey's uncle [[WesternAnimation/SpiderManTheAnimatedSeries the Thing]] and antagonized by [[WesternAnimation/TheTick a cab driver]] and his parents [[WesternAnimation/{{Jabberjaw}} Shelly]] and [[WesternAnimation/SpongeBobSquarePants Painty the Pirate]].
* ''Literature/{{Franklin}}'': [[Series/SchittsCreek Patrick Brewer]] (later [[WesternAnimation/{{Committed}} Nicholas Larson]]) is a turtle whose parents are [[WesternAnimation/BeastWars Rhinox]] and [[Series/Goosebumps1995 Penelope Benson]]. His friends include [[Series/RoadToAvonlea Duffy Dean]] (later [[WesternAnimation/{{Redwall}} Brome]] and then [[WesternAnimation/JacobTwoTwo Noah]]) the bear, [[WesternAnimation/StickinAround Melody]] the beaver, [[WesternAnimation/PippiLongstocking Annika Settergren]] (later [[Series/TheLine Emma]]) the goose, [[WesternAnimation/RoliePolieOlie Spaceboy]] (later [[WesternAnimation/MissSpidersSunnyPatchFriends Dragon]]) the rabbit, [[WesternAnimation/NoddysToylandAdventures Boobull]] (later WesternAnimation/ElliotMoose and then WesternAnimation/{{Peep|AndTheBigWideWorld}}) the fox, [[WesternAnimation/AngelaAnaconda Nanette Manoir]] the badger, [[WesternAnimation/MaggieAndTheFerociousBeast Maggie]] the snail, [[WesternAnimation/{{Cyberchase}} Inez]] the skunk, [[WesternAnimation/MetaJets Johnny Miller]] the raccoon, and [[Film/LetMeCallYouSweetheart Robin McGrath]] the otter (who moves away and becomes [[WesternAnimation/DelilahAndJulius Delilah Devonshire]]). His teacher is [[WesternAnimation/TheAdventuresOfSuperMarioBros3 Cheatsy Koopa]] the owl, his grandmother is [[WesternAnimation/RudolphTheRedNosedReindeer1964 Dolly]], and his neighbors include [[Anime/BakutenShootBeyblade Mr. Dickenson]] the mole and [[Series/SlingsAndArrows May Silverstone]] the muskrat. Later, he gets a baby sister named [[WesternAnimation/GeorgeShrinks Becky Lopez]]. Narrated by [[Series/LifeWithBoys Grandma Helen]], later [[Series/WindAtMyBack May Bailey]], and then [[WesternAnimation/CareBears1980s Wish Bear]].
* ''WesternAnimation/FrannysFeet'': [[WesternAnimation/JoJosCircus Maya]] (who becomes [[WesternAnimation/JaneAndTheDragon Jane Turnkey]] when singing) tries on shoes that take her to different places while hanging at the shoe repair store of her grandfather [[WesternAnimation/XMenTheAnimatedSeries Beast]].
* ''WesternAnimation/{{Freakazoid}}'': [[WesternAnimation/DannyPhantom Danny Fenton]] is a nerd who can transform into a zany superhero named [[WesternAnimation/DaveTheBarbarian Dark Lord Chuckles]]. He fights supervillains like [[WesternAnimation/BatmanTheAnimatedSeries Ra's al Ghul]], [[WesternAnimation/KimPossible Señor Senior, Sr.]], WesternAnimation/JohnnyBravo, [[WesternAnimation/DextersLaboratory Dexter's Dad]] (who'll tie you up if you say his name), [[VideoGame/BatmanArkhamCity Hugo Strange]], [[VideoGame/MarvelUltimateAlliance the (second) Mighty Thor]], [[Film/MuppetTreasureIsland Long John Silver]], and [[WesternAnimation/TinyToonAdventures Babs Bunny]]. In his free time, Chuckles often hangs out with [[WesternAnimation/SpiderManTheAnimatedSeries J. Jonah Jameson]].
* ''WesternAnimation/{{Freaktown}}'': [[WesternAnimation/WorldOfQuest Prince Nestor]] lives in a town for monsters surrounded by a SugarBowl ruled by [[WesternAnimation/TotalDramaPresentsTheRidonculousRace Josee]] and her minions [[WesternAnimation/WinstonSteinburgerAndSirDudleyDingDong Hampton]], [[WesternAnimation/{{Sixteen}} Ron the Rent-A-Cop]], and [[WesternAnimation/FlyingRhinoJuniorHigh Earl P. Sidebottom]], who seek to cutify the town. His pals are [[WesternAnimation/{{Stoked}} No-Pants Lance]] and [[WesternAnimation/JuliusJr Ping]].
* ''WesternAnimation/FreakyStories'': [[WesternAnimation/TheAdventuresOfSuperMarioBros3 Cheatsy Koopa]] and [[Series/PuppetsWhoKill Dan Barlow]] tell spooky stories at a diner staffed by [[WesternAnimation/CareBears1980s Birthday Bear]].
* ''WesternAnimation/FreeWilly: The Animated Series'': [[WesternAnimation/{{Detentionaire}} Biffy Goldstein]] discovers he has the power to speak to animals and befriends an orca named [[WesternAnimation/{{Babar}} Uncle Arthur]].
* ''WesternAnimation/FrogAndToad'': [[WesternAnimation/BlazeAndTheMonsterMachines Crusher and Pickle]] are two amphibians living out their daily lives.
* ''WesternAnimation/FuggetAboutIt'': [[Film/SawII Gus]] is a New York mobster who moves to Canada under witness protection alongside his wife [[WesternAnimation/{{Cyberchase}} Matt]], uncle [[Film/CinderellaMan Father Roddick]], and kids [[WesternAnimation/AlmostNakedAnimals Bunny]], [[Series/BigWolfOnCampus Merton Dingle]], and [[WesternAnimation/TimothyGoesToSchool Grace]]. The RCMP agent [[Film/{{Hollywoodland}} Det. Doug Johnson]] oversees their safety.
* ''WesternAnimation/{{Funpak}}'':
** ''Coolman'': [[WesternAnimation/PawPatrol Cap'n Turbot]] fantasizes about life as his beatnik alter ego. [[WesternAnimation/TotalDrama Courtney]] is his coworker and love interest.
** ''Harold Rosenbaum: Chartered Accountant Extreme'': [[Series/TheRedGreenShow Ranger Gord]], with the help of his secretary [[Series/MadeInCanada Veronica Miller]] and KidSidekick [[WesternAnimation/{{Rupert}} Rupert Bear]], uses his accounting skills to thwart [[WesternAnimation/FlyingRhinoJuniorHigh Raticus]]' evil plot to destroy the city. [[WesternAnimation/XMenTheAnimatedSeries Cyclops]] narrates his adventures.
** ''The Manly Bee'': [[WesternAnimation/XMenTheAnimatedSeries Gambit]] is an OldSuperhero who is brought out of retirement to fight crime once more. [[WesternAnimation/DanielTigersNeighborhood X the Owl]] narrates his adventures.
** ''Martini & Meatballs'': [[WesternAnimation/AngelaAnaconda Mrs. Brinks]] and [[WesternAnimation/AtomicBetty Sparky]] have surreal adventures together.
** ''WesternAnimation/RottingHills'': [[Anime/BakutenShootBeyblade Julia]] and her parents [[WesternAnimation/{{Braceface}} Maria Wong]] and [[WesternAnimation/JacobTwoTwo Principal I.M. Greedyguts]] move to a town populated by zombies, where Julia befriends [[Anime/SailorMoon Shingo Tsukino]].
* ''WesternAnimation/{{Futurama}}'': [[Advertising/MAndMs The Red M&M]] is unfrozen a millennium into the future, and then goes to work for a space courier crew run by his descendant WesternAnimation/WoodyWoodpecker that includes [[Series/MarriedWithChildren Peg Bundy]], [[VideoGame/GearsOfWar Marcus Fenix]], [[WesternAnimation/BatmanBeyond Dana Tan]], [[WesternAnimation/TheRenAndStimpyShow Stimpy]], and [[WesternAnimation/StarWarsTheCloneWars Kit Fisto]]. WesternAnimation/{{Doug}} is a space general who wants to sleep with Peg, and his BeleagueredAssistant is [[WesternAnimation/PinkyAndTheBrain The Brain]]. We also have [[WesternAnimation/HeyArnold Grandma Gertie]] as a CorruptCorporateExecutive, [[WesternAnimation/CampLazlo Scoutmaster Lumpus]] as Red's older brother, [[WesternAnimation/{{Rugrats}} Phil DeVille]] as Woody's clone and son, WesternAnimation/{{Jabberjaw}} as Peg Bundy's pet alien (who is actually a super intelligent protector of the universe), and [[Film/OfficeSpace Michael Bolton]] as a janitor.
* ''WesternAnimation/TheFutureIsWild'': [[WesternAnimation/TotalDrama Staci]] is assigned by her father [[WesternAnimation/XMenTheAnimatedSeries Professor X]] to explore future environments. She is joined by [[Series/DegrassiTheNextGeneration Derek Haig]], WesternAnimation/{{Fangbone}}, Emily[[note]]Miranda Jones has no other credits[[/note]], and TeamPet [[WesternAnimation/PippiLongstocking Mr. Nilsson]].
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