History PermanentlyMissableContent / RolePlayingGame

** You can't get the Factory King achievement if you don't defeat Cirno the first time you fight her. Her [[spoiler:fleeing the battle]] doesn't count as a victory for that achievement.

** If, for some reason, you don't take ''The Ranch Owner'' mission at the Hunters' Guild, you'll miss out on some fun NPC dialogue in Mile [[spoiler: because they all drop dead when the Edge opens.]]

*** During [[spoiler: Farts of Future Past]], you're given the option of friending the goons from your backstory on Coonstagram. Fail to do this before you enter your parent's room, and those friends are lost forever, since from then on, you enter the final boss.

** After entering the castle of the Mushroom Kingdom for the first time, you'll enter the main hall where Toad will walk from the castle's entrance towards the throne room. Said main hall contains a Hidden Treasure chest. In order to find it, you'll need to jump and stand on Toad's head, then use the additional height to jump on ''a hidden ledge right above the door'' that he enters. That's where you'll find the hidden chest. You only get one chance at this and the only way to know it's there ([[GuideDangIt other than using a guide]]) is to have the Signal Ring, an accessory which is only available significantly later in the game. However, said accessory only lets you know hidden chests are in any given room, but does nothing to help pinpoint their locations[[labelnote:*]]To clarify, the Signal Ring becomes available after defeating Valentina and Dodo in Nimbus Land in the original SNES game, long after your first visit to the Mushroom Kingdom. It'll be dropped by Croco after finding him in a house within Nimbus Land. However, the Switch remake makes it available much earlier on after completing the Hidden Treasure tutorial in the Mushroom Kingdom shop basement. What's more, Croco will instead drop the Echo Signal Ring in the Switch remake, which ''does'' help pinpoint Hidden Treasure chest locations[[/labelnote]]. The main hall is rather large, so without using a guide, first-time players will be left jumping in every inch of that room looking for a hidden chest that is in a place they not only can't possibly reach any longer, but is in a place they have no idea ''can'' be reached at all. The Switch remake averts this by adding a permanent Toad in the main hall who the player can use to reach the chest at any time after recruiting Mallow. In addition, the dev team went out of their way to [[https://www.mariowiki.com/images/7/70/MKHiddenTreasure.png render the ledge to be clearly visible]], looking nothing like [[https://www.mariowiki.com/images/c/c1/HiddenChest01.png an inconspicuous wall structure as seen in the original SNES game]].
** If you avoid getting caught fewer than three times while hiding behind the curtains in Booster Tower, Booster will reward you with the Amulet. If you ''do'' get caught three times, Booster will challenge you to a fight instead, and you will never be able to get the Amulet. Averted in the Switch remake, where the Amulet has been renamed "Booster's Charm". While it can initially be missable in the same scenario as mentioned for the SNES version, you can acquire it after defeating Booster in a rematch [[PostEndGameContent post-game]].
** Similarly to the Amulet example above, your only shot at obtaining the Feather comes from avoiding Dodo during the segment where you disguise yourself as a statue to get into Nimbus Castle. If Dodo catches you, you will be forced to fight him and he will not drop the Feather. Somewhat averted in the Switch remake. Even if you miss out on the Feather from Dodo, you can now buy one from the treasure hunting Toad in Moleville after reaching Nimbus Land. Keep in mind that it's possible to have ''two'' Feathers in your inventory this time around, as the Feather in Moleville will always be available whether or not you got the original one from Dodo. As such, some players may potentially miss out on having an extra Feather during their playthroughs for the Switch remake.
** In both versions of the game, farming to increase your maximum [[{{Mana}} Flower Points (FP)]] to [[{{Cap}} 99]] isn't a particularly difficult task. However, there are several instances where opportunities to increase FP ''as quickly as possible'' are lost:
*** There are a couple of instances where helping out [=NPCs=] in certain locations at specific times will net you FP-increasing items, such as Flower Tabs (1FP increase), Flower Jars (3FP increase), and Flower Boxes (5FP increase). Miss these chances and you'll won't be able to receive them, such as saving certain Toads in the Mushroom Kingdom during Mack's/Claymorton's attack. In addition, one particular case in Seaside Town relies on dialogue choices you make to Yaridovich/Spearodovich after gaining the fifth Star Piece. Give him the Star Piece right away and you'll receive a Flower Box from the town's elder after the former has been defeated. However, refusals [[TickleTorture cause the elder to be tickled]], downgrading the prize. You'll get a Flower Jar from one refusal and two will get you a Flower Tab, but three refusals or more? All you'll get is a single gold coin.
*** Right after defeating Knife Guy and Grate Guy at Booster Tower, you'll immediately head straight to Booster Hill. Here, you'll have to play a ChaseScene minigame where Mario must catch up to Booster and Peach (the latter is tied up on the former's back) as they all head to Marrymore. If Mario is able to catch up to Peach by jumping on Snifits/Snifsters and barrels, you'll gain a single point of FP each time. Potentially, this can lead to a significant boost in your maximum FP, but it all depends on your skills at the minigame. This is also your ''only'' shot at playing this particular minigame, as it won't happen again during future visits to Booster Hill.

** It's fortunately only a small item that is perfectly fine to miss, but near the beginning there's a part where Toad is walking into the castle. In order to get a certain hidden block, you need to jump onto his head at ''just'' the right moment and use the additional height to jump and hit the hidden block. You only get one chance at this, and the only way to know it's there (other than using a guide) is to have an item that you get significantly later in the game. Which in itself is kind of sadistic because the item only lets you know a hidden chest is in the room, it does nothing to help pinpoint the location. The room is rather large too so without using a guide, you'll be left jumping in every inch of that room looking for a hidden chest that is in a place you not only can't possibly reach any longer, but is in a place you have no idea you even CAN reach because you never do anything like that ever before or ever again. The Switch remake averts this by adding a permanent Toad in that area who the player can use to reach the block at any time after recruiting Mallow.
** Bad Mushrooms are only sold in Seaside Town ''before'' you receive the 5th Star Piece. Once that happens, these mushrooms can never be bought or found anywhere in the game again. Thankfully, they're not as useful as other methods to perform what they do (poisoning enemies), so it's not a huge loss.
** If you avoid getting caught fewer than three times while hiding behind the curtains in Booster Tower, Booster will reward you with the Amulet. If you ''do'' get caught three times, Booster will challenge you to a fight instead, and you will never be able to get the Amulet.
** Similarly to the Amulet example, your only shot at obtaining the Feather comes from avoiding Dodo during the segment where you disguise yourself as a statue to get into Nimbus Castle. If Dodo catches you, you will be forced to fight him, and he will not drop the Feather.

*** Even back in FES, it's easy to forget to confirm that you've taken Elizabeth (or Theodore in Portable) out on a date to obtain key items to fuse certain Personas before the quest's deadline.

** The Rainbow Weapons are the most powerful weapons of the game, and you need to do several steps in order to tame them, such as recruiting Zappa (who hints at these weapons earlier) and talking to Nikki in the S.S Zelbees, after which, if you don't do them, those opportunities are gone, meaning it's impossible to fight all of the 6 Dragons as the Black Dragon can't be fought and the Master Hammer, which you'll need in order to forge these weapons, can't be brought.

** The Rainbow Weapons are the most powerful weapons of the game, and you need to do several steps in order to tame them: recruiting Zappa (who hints at these weapons earlier), talking to Nikki in the S.S Zelbees, after which, if you don't do them, those opportunities are gone, meaning it's impossible to fight the 6 Dragons as the Black Dragon can't be fought and the Master Hammer, which you'll need in order to forge these weapons, can't be brought.

** Say yes to Kid when she first offers to join? Well, you just lost Leena. Answer one or both of the questions she asked earlier wrong? Well, you just lost her best tech.

** ''VideoGame/FinalFantasyIVTheAfterYears'' takes this [[SerialEscalation to the next level]]. Didn't get the needed parts to repair the airship in Rydia's Tale, including two that are dropped by [[GuideDangIt specific enemies which only appear in one deserted room during a specific lunar cycle]] with the same drop rate as the [[ThatOneSidequest PinkTail]]? Sorry, [[spoiler:Calca and Brina will have to be scrapped for replacement parts]]. Lost a battle and didn't reload your save when playing as any of the Eblan Four or picked the wrong dialogue option as Gekkou? Sorry, that ninja is KilledOffForReal. Don't have a party of [[spoiler:Cecil, Ceodore and Rosa]] when [[spoiler: Golbez makes his HeroicSacrifice?]] Sorry, [[KilledOffForReal you can't save him]]. Also, in the final chapter it's possible to permanently kill [[spoiler:brainwashed Shiva and Ramuh]] if you hit them while they're calming down, which is easy to do by accident if you have an action queued up right when the dialogue that tells you to stop attacking them pops up.

*** Many, many materia are missable if you don't pick them up at the first opportunity or miss the wrong sidequest. This includes Comet, Ultima, Morph, W-Item, one of the Enemy Skill Materia, Added Effect, MP Turbo, Steal as Well, MP Absorb, Elemental, Ifrit, Ramuh, Bahamut, Neo Bahamut, Leviathan, and Luck Plus.

*** If Aeris is equipped with any unique items before [[spoiler:her death]], you'll lose them permanently for the rest of the game.

** ROM hacks of Final Fantasy VI:

** In the expansion, if you happen to have kept the Flail, you can also acquire two more heads for said butler to attach, completing the flail, and as you add each head it grows in power, dealing more damage and providing better abilities. Theoretically. The catch? When the final head is added, the Flail begins granting Free Action while it's equipped. That would be fine, except that free action prevents all changes to your movement speed, good or bad. While you're immune to the (by now rather weak) movement-stopping spells like Web and Entangle, you're also "immune" to spells like Haste, and the Boots of Speed. Since both of these are especially useful for melee fighters, who are most likely to be using the flail...Suffice it to say that many experienced players avoid applying the final upgrade, considering the Flail more useful with one head missing. Sadly, once you perform the upgrade (without knowing what the "improved" flail will give) there's no way to downgrade it again other than editing your inventory with an external program or reverting to an earlier save. Since Free Action is a relatively uncommon effect, it's not immediately obvious to many players that they've effectively received a debuff, so they may overwrite their previous saves before realising the problem.

** If you bring a full team to help break Imoen out of Spellhold, and Yoshimo isn't one of them, odds are good you're going to end up leaving one of them in the depths of the Asylum maze without any meaningful way to get them back until the expansion.

** The first game ''VideoGame/GoldenSun1'' doesn't have anything that is technically missable during the game, but once the final credits roll and the file is completed, they cannot play that file anymore. However the sequel, ''VideoGame/GoldenSunTheLostAge'', has extra content, including a bonus dungeon, that is locked unless the player picked up all Djinn and optional items in the first game and then transferred their save file.