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* Seeing symptoms of AIDS in someone you have slept with multiple times, the realisation that they will have infected you.
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* How many people did [[spoiler: Richie sleep with after becoming infected with HIV]] how many innocent people did he kill?
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* Jill's realisation that all of her friends have slept with each other, in addition to a lot of other men, her entire friend group could be wiped out by a virus that she knows is all too real and there is nothing she can do.
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* Jill's realisation that all of her friends have slept with each other, in addition to a lot of other men, her entire friend group could be wiped out by a virus that she knows is all too real and there is nothing she can do.do.
* By the end of the show, [[spoiler: half of the friend group - Gregory, Colin and Richie]] have lost their life to AIDS.
* By the end of the show, [[spoiler: half of the friend group - Gregory, Colin and Richie]] have lost their life to AIDS.
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* The HIV virus and AIDS, to this day there is no cure, and at the time of the show there is no effective treatment - it's a death sentence.
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* The series portrays the visceral BodyHorror AIDS caused in the 80s before effective drugs and treatments were available.
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* The series portrays the visceral BodyHorror AIDS caused in the 80s before effective drugs and treatments were available.available.
* Jill's realisation that all of her friends have slept with each other, in addition to a lot of other men, her entire friend group could be wiped out by a virus that she knows is all too real and there is nothing she can do.
* Jill's realisation that all of her friends have slept with each other, in addition to a lot of other men, her entire friend group could be wiped out by a virus that she knows is all too real and there is nothing she can do.
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* The nurses, heavily clad in PPE and wearing masks moving Henry's body and sanitizing the bed in a clinical manner in a wide, hollow and cold hospital ward with only the sound of the door forcibly being opened. It has the style and substance of an 80s AIDS PublicServiceAnnouncement and drives home the fear this new seemingly incurable mystery illness caused when it was first identified.
* The series portrays the visceral BodyHorror AIDS caused in the 80s before effective drugs and treatments were available.
* The series portrays the visceral BodyHorror AIDS caused in the 80s before effective drugs and treatments were available.
