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* ''Film/GodzillaKingOfTheMonsters2019'': [[Characters/MonsterVerseEmmaRussell Emma Russell]]. Grief over her son's death gradually drove her to a {{sanity slippage}}, [[spoiler:deciding that the best way to "honor" his memory is to [[WellIntentionedExtremist forcibly save the world]] whilst [[{{Doublethink}} creating a million repeats of the incident that killed him]]]]. It's also implied, particularly in a deleted scene and the novelization, that Mark's abandonment of Emma and Madison amid their {{grief induced split}} was a contributing factor [[spoiler:in Emma's fall from grace]], because he proved in Emma's eyes that he couldn't be relied on when Emma and Madison needed him most of all.
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* ''Film/GodzillaKingOfTheMonsters2019'': [[Characters/MonsterVerseEmmaRussell [[Characters/MonsterVerseEcoTerrorists Emma Russell]]. Grief over her son's death gradually drove her to a {{sanity slippage}}, [[spoiler:deciding that the best way to "honor" his memory is to [[WellIntentionedExtremist forcibly save the world]] whilst [[{{Doublethink}} creating a million repeats of the incident that killed him]]]]. It's also implied, particularly in a deleted scene and the novelization, that Mark's abandonment of Emma and Madison amid their {{grief induced split}} was a contributing factor [[spoiler:in Emma's fall from grace]], because he proved in Emma's eyes that he couldn't be relied on when Emma and Madison needed him most of all.
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* ''WesternAnimation/InfinityTrain'': Simon wasn't that stable to begin with, but he really starts to lose it after he traps Grace in a tape of her memories. When she escapes and confronts him in the final episode, he's become even more manic and paranoid, and he finally loses that last little scrap of sanity he had when he knocks her off the train and thinks he's killed her.
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* ''WesternAnimation/InfinityTrain'': Simon wasn't that stable to begin with, but he really starts to lose it after he traps Grace in a tape of her memories. memories and takes control of the Apex in her absence. When she escapes and confronts him in the final episode, he's it's clear that losing his closest friend has caused him to become even more manic and paranoid, paranoid than he was before, and he finally loses that last little scrap of sanity he had when he knocks her off the train and thinks he's killed her.
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* ''Series/{{Monk}}'': The titular detective's back-story is that his wife had been killed by a car bomb prior to the series. Although he'd always had OCD and multiple phobias, he had a full-on psychotic break when Trudy died, was stripped of his badge, and didn't leave his house for three years. At the time of the pilot, he's just getting back into his work, only now he's a private detective/consultant for the San Francisco PD. He's desperate to be reinstated, but his lingering issues cause his former captain to have serious doubts about his ability to perform in dangerous situations. Case in point, one perp gets away by climbing back down a fire-escape that Monk is clinging to half-way up because he's petrified of heights and froze in place while chasing the guy.
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* Simon Laurent in ''WesternAnimation/InfinityTrain'' wasn't that stable to begin with, but he really starts to lose it after he traps Grace in a tape of her memories. When she comes back and confronts him in the final episode, he's become even more manic and paranoid, and he finally loses that last little scrap of sanity when he throws her off the train and thinks he's killed her.
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* ''WesternAnimation/InfinityTrain'': Simon Laurent in ''WesternAnimation/InfinityTrain'' wasn't that stable to begin with, but he really starts to lose it after he traps Grace in a tape of her memories. When she comes back escapes and confronts him in the final episode, he's become even more manic and paranoid, and he finally loses that last little scrap of sanity he had when he throws knocks her off the train and thinks he's killed her.
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* Simon Laurent in ''WesternAnimation/InfinityTrain'' completely plays this trope straight after he goes insane and snaps harder than ever before when he thinks he's killed his best friend and possible crush, Grace, by kicking her off of the train into the wheels.
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* Simon Laurent in ''WesternAnimation/InfinityTrain'' completely plays this trope straight wasn't that stable to begin with, but he really starts to lose it after he goes insane traps Grace in a tape of her memories. When she comes back and snaps harder than ever before confronts him in the final episode, he's become even more manic and paranoid, and he finally loses that last little scrap of sanity when he throws her off the train and thinks he's killed his best friend and possible crush, Grace, by kicking her off of the train into the wheels.her.
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* An interesting case occurs with the Doctor in ''Series/DoctorWho''; only on two occasions has he been shown without a companion or a companion surrogate for an extended period of time, and in both cases, it resulted in a more unhinged and dangerous Doctor.
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* An interesting case occurs with the Doctor in ''Series/DoctorWho''; only on two three occasions has he been shown without a companion or a companion surrogate for an extended period of time, and in both cases, each case, it resulted in a more unhinged and dangerous Doctor.
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** A third time in [[Recap/DoctorWhoS35E11HeavenSent "Heaven Sent"]]/[[Recap/DoctorWhoS35E12HellBent "Hell Bent"]] when his companion Clara dies. She lampshades it, telling him, "You're going to be alone now, and you're very bad at that." The Doctor is sent into a mechanical castle where he is left alone with his grief for [[spoiler: four and a half ''billion'' years]]. By the time he finally escapes, he is completely off the rails and ready to face down everything from a gunship to the Lord President of Gallifrey, kill a fellow Time Lord, and endanger the very existence of all of space and time in order to get Clara back.
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* ''Series/{{Forever|2014}}'': Seen in the flashback of "Punk Is Dead." When Abigail left Henry, saying she needed a little time to think, Henry became convinced something had happened to her when three months went by with no word. By the time Abe visited him several months after that, Henry had fallen apart completely, his apartment a MessOfWoe housing a StringTheory StalkerShrine trying to track her down. It's also implied Henry has been [[DrowningMySorrows drowning his sorrows]], both by Abe having to pull him off the floor and put him to bed, and by Abe commenting in the pilot that Henry quit drinking 28 years before.
