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* ''TabletopGame/MagicTheGathering'' averts this in the ''Theros'' block. Pharika, a snake-like goddess associated with poisons, is also the patron of healers due to her pharmaceutical skills. That said, messing with her is [[PoisonousPerson still a bad idea]].
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* ''TabletopGame/MagicTheGathering'' averts ''TabletopGame/MagicTheGathering''
** The Deathtouch mechanic, which causes damage dealt by a creature to instantly kill the recipient, is frequently flavored as poison or venom. It was originally centered on both black cards (not ''necessarily'' evil, but most commonly associated with traditionally "evil" themes) and green cards (which center around [[NatureIsNotNice nature and its natural order]]), but more recently the distribution has shifted in black's favor, cementing it into this trope.
** The Poison mechanic--Certain cards give a player poison counters, and if they have 10 or more, they lose the game. When it was first introduced, it only appeared on a single black card and a single colorless card. For similar reasons to Deathtouch, later appearances also showed up in green. The mechanic remained solely in those two colors until it was associated with the decidedly antagonistic Phyrexians, where Poison was flavored to represent ''[[TheCorruption compleation]]''; all colors now have at least a few poison cards, but they remain most frequent in black and green. Since the downfall of New Phyrexia, poison counters have (at the time of writing) only appeared on one black card: [[https://scryfall.com/card/mkm/98/persuasive-interrogators Persuasive Interrogators]], where the mechanic once again represents outright injecting toxins into your opponent's veins.
** {{Averted|Trope}} in the ''Theros'' block. Pharika, a snake-like goddess associated with poisons, is also the patron of healers due to her pharmaceutical skills. That said, messing with her is [[PoisonousPerson still a bad idea]].
** The Deathtouch mechanic, which causes damage dealt by a creature to instantly kill the recipient, is frequently flavored as poison or venom. It was originally centered on both black cards (not ''necessarily'' evil, but most commonly associated with traditionally "evil" themes) and green cards (which center around [[NatureIsNotNice nature and its natural order]]), but more recently the distribution has shifted in black's favor, cementing it into this trope.
** The Poison mechanic--Certain cards give a player poison counters, and if they have 10 or more, they lose the game. When it was first introduced, it only appeared on a single black card and a single colorless card. For similar reasons to Deathtouch, later appearances also showed up in green. The mechanic remained solely in those two colors until it was associated with the decidedly antagonistic Phyrexians, where Poison was flavored to represent ''[[TheCorruption compleation]]''; all colors now have at least a few poison cards, but they remain most frequent in black and green. Since the downfall of New Phyrexia, poison counters have (at the time of writing) only appeared on one black card: [[https://scryfall.com/card/mkm/98/persuasive-interrogators Persuasive Interrogators]], where the mechanic once again represents outright injecting toxins into your opponent's veins.
** {{Averted|Trope}} in the ''Theros'' block. Pharika, a snake-like goddess associated with poisons, is also the patron of healers due to her pharmaceutical skills. That said, messing with her is [[PoisonousPerson still a bad idea]].
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* ''WebVideo/StampysLovelyWorld'': {{Downplayed|Trope}}. While Stampy and his Helpers use splash potions of poison in certain minigames for non-malevolent purposes, [=HitTheTarget=] and Veeva Dash use it with the intentional purpose of harming others, even actively TamperingWithFoodAndDrink several times with it.
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* ''WebVideo/StampysLovelyWorld'': {{Downplayed|Trope}}. While Stampy and his Helpers use splash potions of poison in certain minigames for non-malevolent purposes, [=HitTheTarget=] and Veeva Dash are the only ones to use it with the intentional purpose of harming others, even actively TamperingWithFoodAndDrink several times with it.
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Crosswicking
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* ''WebAnimation/DCSuperHeroGirls'': Something of an InvokedTrope: this version of ''ComicBook/PoisonIvy'' is a [[AdaptationalHeroism straight-up good guy.]] Likely as a result, people in-universe almost always call her "Ivy" instead of "Poison Ivy", due to the "Poison" part having pretty bad connotations.
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* ''WebAnimation/DCSuperHeroGirls'': Something of an InvokedTrope: this version of ''ComicBook/PoisonIvy'' is a [[AdaptationalHeroism straight-up good guy.]] guy]]. Likely as a result, people in-universe almost always call her "Ivy" instead of "Poison Ivy", due to the "Poison" part having pretty bad connotations.
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* Inverted in ''WebComic/AxeCop'', where using poison to take out bad guys is a favourite tactic of the titular hero, who calls it his "secret attack." Axe Cop seems to have a poison for ''every'' villain he comes across, with some bizarre method to get it into them. The artist notes this trope in his commentary, saying that most people associate poison with treachery and villains, but the author, his six-year old brother, thinks poison is simply a quick, easy, and pragmatic way to take out bad guys.
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* Inverted in ''WebComic/AxeCop'', where using poison to take out bad guys is a favourite tactic of the titular hero, who calls it his "secret attack." Axe Cop seems to have a poison for ''every'' villain he comes across, with some bizarre method to get it into them. The artist notes this trope in his commentary, saying that most people associate poison with treachery and villains, but the author, his six-year old six-year-old brother, thinks poison is simply a quick, easy, and pragmatic way to take out bad guys.
[[folder:Web Videos]]
* ''WebVideo/StampysLovelyWorld'': {{Downplayed|Trope}}. While Stampy and his Helpers use splash potions of poison in certain minigames for non-malevolent purposes, [=HitTheTarget=] and Veeva Dash use it with the intentional purpose of harming others, even actively TamperingWithFoodAndDrink several times with it.
[[/folder]]
* ''WebVideo/StampysLovelyWorld'': {{Downplayed|Trope}}. While Stampy and his Helpers use splash potions of poison in certain minigames for non-malevolent purposes, [=HitTheTarget=] and Veeva Dash use it with the intentional purpose of harming others, even actively TamperingWithFoodAndDrink several times with it.
[[/folder]]
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* Subverted in ''WesternAnimation/KungFuPanda'' with Master Viper, who is venomous, but lacks fangs to deliver the venom, and instead uses kung fu to take down opponents. Averted completely with her father, who uses his fangs as a routine part of his battles until they're shattered by an armor-wearing opponent.
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* Subverted in ''WesternAnimation/KungFuPanda'' ''Franchise/KungFuPanda'' with Master Viper, who is venomous, but lacks fangs to deliver the venom, and instead uses kung fu to take down opponents. Averted completely with her father, who uses his fangs as a routine part of his battles until they're shattered by an armor-wearing opponent.
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* ''Franchise/AceAttorney'': Most of the ''really'' unsympathetic culprits in the game are the ones who use poison. Phoenix also names "poisoning and betrayal" as two crimes he can't forgive, [[spoiler:because his college girlfriend Dahlia betrayed and attempted to poison him]].
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* ''Franchise/AceAttorney'': Most of the ''really'' unsympathetic culprits in the game are the ones who use poison. Phoenix also names "poisoning and betrayal" as two crimes he can't forgive, [[spoiler:because his college girlfriend Dahlia betrayed and attempted to poison him]].
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* The villain in ''Film/TheLostMedallionTheAdventuresOfBillyStone'', Cobra, lives up to his name with his poisonous fingernails that he uses to kill people. Pretty surprising for a kid movie.
