History Main / ManOfKryptonite

** [[{{Cyborg}} Metallo]], who first appeared in ''ComicBook/ActionComics #252: ComicBook/TheSupergirlFromKrypton1959'', has a Kryptonite heart that allows him to serve as a walking delivery system for Superman's main weakness. In fact, of all the Kryptonite powered foes Superman has faced, Metallo is easily the most enduring and popular, likely due to the fact that he backs up his FlawExploitation with actual physical power--even without the Kryptonite he's still a SuperStrength and NighInvulnerable killing machine.

** Logan is always at a severe disadvantage when up against a mutant who can manipulate metal like Magneto (The movies being explicit about it), because of his adamantium skeleton. In fact, Magneto singlehandedly kicked off Ol' Canucklehead's entire years-long Bone Claw/Feral arc after violently divorcing Logan from his adamantium in ''ComicBook/FatalAttractionsMarvelComics''

* ''Literature/EpithetErased'': Lorelai (who acts as the BigBad of the first book, ''[[Literature/EpithetErasedPrisonOfPlastic Prison of Plastic]]''), can use her epithet, Augment, to create "[[PocketDimension Dream Bubbles]]" in which she can do nearly anything she wants. Her sister Molly, whose epithet is Dumb, can nullify this, letting her create holes in the Dream Bubble, erase the constructed creatures of these worlds, and NoSell any attack Lorelai might try to use against her. Because of this, [[FoolishSiblingResponsibleSibling Molly feels that it is her duty to clean up after the messes Lorelai creates with her epithet]].

* In ''Literature/HighSchoolDXD'', Samael is also known as the Dragon Eater. His body exudes a poison that is deadly to any dragon or any being connected to dragons. Not even dragon gods like Ophis and Great Red are immune.

* ''Toys/{{BIONICLE}}'': While it's never relevant to the main storyline, side stories mention that Toa of Iron ''do'' exist, and would theoretically be this in a world of Bio-mechanical lifeforms who are all partially-metal; they'd ''really'' be dangerous to the series villains, the Makuta, however; since the Makuta are a race of [[PureEnergyBeing Pure Energy Beings]] who can't survive long outside their air-tight suits of armor, the first thing they did upon their species-wide FaceHeelTurn (after massacring their members who were opposed to the idea anyway) was to start a genocide campaign against Toa of Iron for being the biggest threat to their plans.

* ''Toys/{{BIONICLE}}'': While it's never relevant to the main storyline, side stories mention that Toa of Iron ''do'' exist, and would theoretically be this in a world of Bio-mechanical lifeforms who are all partially-metal; they'd ''really'' be dangerous to the series villains, the Makuta, however; since the Makuta are a race of [[PureEngergyBeing Pure Energy Beings]] who can't survive long outside their air-tight suits of armor, the first thing they did upon their species-wide FaceHeelTurn (after massacring their members who were opposed to the idea anyway) was to start a genocide campaign against Toa of Iron for being the biggest threat to their plans.

* Creator/WillWight: In [[https://drive.google.com/file/d/1rMiBzAh2XpR8g-rEz8Yi1BO7zhP6E7AL/view Deathmatch 2,]] [[GodEmperor The Emperor]] from ''Literature/TheElderEmpire'' is set against [[AnthropomorphicPersonifications the Incarnations]] from ''Literature/TheTravelersGate''. The Incarnations are nigh-{{Physical God}}s that are pure expressions of specific virtues and elements, while the Emperor has a god-tier {{empathy}} ability and experience fighting {{Cosmic Horror}}s. He takes them apart like he was given the script in advance.

* ''LightNovel/FateRequiem'': Erice Utsumi fights by [[BloodyMurder animating her blood]]. Her blood is highly toxic to Servants and can absorb and dissolve their spirits, making her well suited to killing Servants. Servants who are Divine Spirits like Nzambi are immune to the poison, but the blood can still injure them.

* ''LightNovel/ACertainMagicalIndex'' and ''Manga/ACertainScientificRailgun'':

* In ''LightNovel/HighSchoolDXD'', Samael is also known as the Dragon Eater. His body exudes a poison that is deadly to any dragon or any being connected to dragons. Not even dragon gods like Ophis and Great Red are immune.

* Shalltear Bloodfallen from ''LightNovel/Overlord2012'' is an undead (immune to instant death effects) that with specialties in holy magic and can cast fire spells (which the undead are weak to) and a class build that works wonders against spellcasters. Ainz wonders if she was specifically designed to kill him. [[spoiler:When they fight while she's BrainwashedAndCrazy, he only wins because he knows almost all her tricks and thus plans out his attack ''before'' fighting her.]]
** ''Anime/IsekaiQuartet'' takes it several steps further with...'''''[[LightNovel/KonoSuba Aqua]]'''''. Yes, ''[[TheLoad that Aqua]]''. Even though she's a DeconstructedCharacterArchetype of the trope, she's still a PhysicalGoddess who's specialty is purifying and destroying evil spirits and undead, in other words, beings that are in Ainz's and Shalltear's category. Her weakest spell is potent enough to cause Ainz to scream in terrible pain and Shalltear to pass out either from shock or splash damage, and she is able to move freely in his [[TimeStandsStill Time Stop]] spell, which is a 10th level spell. And while his Despair Aura can cause even Level 100 Floor Guardians to tremble in terror, it has no effect on her whatsoever. Needless to say, Ainz treads very carefully around her because he knows that she can very easily kill him despite being a total idiot.

* Franchise/YuGiOh:

* ''Franchise/{{Batman}}'', who was revealed to have records of strengths and weaknesses of his teammates in the ''Franchise/JusticeLeagueOfAmerica'' (and possibly other members of the superhero community), thus knowing the countermeasures for when a hero should go rogue.

* ''Franchise/GreenLantern'':

** The Batman Who Laughs to Batman. He's an evil Batman with ComicBook/TheJoker's personality. He can think like Batman to predict and counter whatever he tries, while Batman can't predict him because he has the Joker's ConfusionFu.

** The Drowned to Aquaman and ComicBook/{{Mera}}. She, like Black Manta, has several anti-Atlantean weapons and devices. She can also instantly pollute water and control it. The pollution prevents other hydrokinetics like Mera from controlling it and it transforms any sea life into monsters under her control.
** The Merciless to Franchise/WonderWoman. He wields the Helmet of Ares, which can counter her divine powers.
** The Murder Machine to ComicBook/{{Cyborg}}. He can interface with and control any technology, including Cyborg's robot parts.

* Comicbook/{{Dazzler}} is one to anybody with sonic attacks, since she can absorb any sound and convert it to [[LightEmUp light]]. Basically, the louder you are, the stronger she gets.

* ''Franchise/TheFlash'':

** In the ComicBook/{{New 52}}, the Rogues got upgraded from tech-using baddies to outright metahumans (at first). In order to give him a new edge against the Flash, one of Captain Cold's new powers allows him to create a field of inertia around him that drastically dampens the Flash's speed.
*** Even before this Captain Cold's Cold Gun was shown to be especially effective on the Flash, as coldness is based on atoms being still (IE, not moving), so his gun's icing effect is really just a side-effect of its actual purpose: Stopping movement. Ergo, it's often shown that a blast from the cold gun is enough to render a speedster drained of their speed (often only for a few seconds, but for a man as smart as Leonard Snart, that's all he needs). Strangely, unlike most KryptoniteFactor weaknesses, this isn't as well-exploited as others.

* Comicbook/IronMan to anyone with ShockAndAwe powers, since he can just absorb it and get a temporary power boost. As well, Tony has developed numerous "Buster" armors to battle certain foes. Nine times out of ten, though, he severely underestimates them, especially the Hulk.
* In Creator/StanLee's ''The Last Comicbook/FantasticFour Story'', Earth is threatened by the Cosmic Tribunal, a bunch of aliens with vast PsychicPowers. Reed sics a race of literally ''mindless'' alien monsters on them (implied by John Romita Jr.'s art to be the Mindless Ones from ''Comicbook/DoctorStrange),'' and the monsters mop the floor with them until Reed calls them off out of pity.

* Franchise/MarvelUniverse demon Nightmare fears one being above all others: the monster Gulgol, who never sleeps and is therefore utterly beyond Nightmare's dream-manipulation powers.

* In Marvel there were a couple of heroes being living weaknesses for a vampire. One are [[ComicBook/TheMightyThor Asgardians]] -- Dracula once found hard way their blood gives a temporary power boost but with devastating side-effects. The other is ComicBook/{{Runaways}} member, Karolina Dean, whose blood is basically a liquid solar energy -- a vampire who once tried to bite her got obliterated from the inside.

* ''Franchise/SpiderMan'':

* ComicBook/{{Wolverine}}
** Logan is always at a severe disadvantage when up against a mutant who can manipulate metal like ComicBook/{{Magneto}} (The movies being explicit about it), because of his adamantium skeleton. In fact, Magneto singlehandedly kicked off Ol' Canucklehead's entire years-long Bone Claw/Feral arc after violently divorcing Logan from his adamantium in ''ComicBook/FatalAttractionsMarvelComics''

* This is the reason why, in the film, Blackheart can easily toss around the ''Film/GhostRider''. Blackheart is stronger and can NoSell everything the Rider would throw at him, including the deadly Penance Stare. [[spoiler:The only reason Ghost Rider was able to best his foe was when Blackheart absorbed a thousand or so corrupt souls, completely removing his immunity to the Stare, and turning it into a weakness a thousandfold.]]

** Logan is always at a severe disadvantage when up against a mutant who can manipulate metal like ComicBook/{{Magneto}} (The movies being explicit about it), because of his adamantium skeleton.

** In "Escaping Expulsion", [[Characters/TheOwlHouseAmityBlight Amity]]'s skill in Abomination magic allows her to easily overwhelm both Abomi-tons by manipulating their body mass.

** Blackbeard's Dark-Dark Devil Fruit power counters other Devil Fruit users in general, as they can't use their ability as long as Blackbeard maintains physical contact with them.

[[caption-width-right:350:What's the matter, guy? You're looking a little '''green''' at the gills.]]

* The third volume of ''Literature/MyVampireOlderSisterAndZombieLittleSister'' begins with Satori having been [[BalefulPolymorph involuntarily transformed]] into a giant, mobile garlic. This makes him a natural enemy to vampires...who are also the first set of antagonists.

* ''ComicBook/IncredibleHulk'': X-Ray of the U-Foes can shoot off "anti-gamma radiation", which can depower or outright kill the Hulk. Fortunately, X-Ray's not terribly bright, so he doesn't have much of a chance to utilize this.

* ''Anime/SenkiZesshoSymphogear'': Noise, which are the series' most recurring {{Mook}} monsters, usually end up as cannon fodder to annoy the Adapters (aka the Symphogear users) and are easily killed by them. However, Noise are extremely deadly to anyone who doesn't wear a Symphogear, as just merely touching a Noise would disintegrate humans to ashes, and Noises cannot be killed by normal weapons either. Genjuurou, the captain of the Symphogear division, is much stronger than any of the Adapters and can defeat all of them easily, as well some of the [[Big Bad]]s. But since the enemies keep an army of Noise around, it's too dangerous for Genjuurou to fight, hence why he usually stays in the command room. To keep him out of the battlefield, even after all the Noise are sealed away at the end of the second season, the third season introduces a new kind of Noise, Alca-Noise, which are created by alchemy and are as deadly as the normal Noise. Alca-Noise remain a staple for the rest of the series, so neither Genjuurou nor Ogawa are allowed to fight alongside the girls most of the time.