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* This is the premise of ''Manga/AngelHeart'': receiving a heart transplant changes the life of an assassin.

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* This is the premise of ''Manga/AngelHeart'': of ''[[Manga/AngelHeart2001 Angel Heart]]'': receiving a heart transplant changes the life of an assassin.
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* ''Series/BanjunDrama'': Hwi-jae in "Sick Heart" comes up with a heart disease and has to have his heart transplanted. After the surgery, his personality becomes more feminine (feminine meaning [[WomenAreDelicate weak-hearted]]); when he meets Jin, an acquaintance of his donor, he learns that his new heart used to belong to a man named Andy, who was quite feminine in his life.
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* ''Anime/LycorisRecoil'' establishes a few episodes in that one of the lead heroines, Chisato, has an artificial heart and the Alan Institute had replaced her defective birth heart with a state of the art artificial heart. [[spoiler: This heart would have let her live up to and a bit past her eighteenth birthday at most, more than doubling her effective lifespan without it, and when it is sabotaged later in the series it leaves her with two months to live and a major part of the final is trying to retrieve a new, improved artificial heart with a much longer shelf life.]]

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* ''Series/HighwayToHeaven'': Totally reversed in the late Season 2 episode "The Torch," where Everett Soloman, a Nazi death camp survivor whose parents were killed during World War II, is speaking against the growing Neo Nazi movement needs a heart transplant. Meanwhile, one of the Neo Nazi groups, led by Jan Baltic, is determined to silence Soloman and eventually they kill his son. While Baltic and his group -- engaged in a campaign to convince the public that the Holocaust was mere propogandalized fiction -- are planning their next move, his son accidentally sets off a machine gun, mortally wounding Baltic and killing two others. The change of heart comes when Baltic's heart is a biological match for Soloman. The transplant is successful ... but when Soloman learns the heart of his sworn enemy now beats inside him, he suddenly becomes ill and wants to die. While in his coma, Soloman has a dream where he is visited by his son and his parents, convincing him that this literal change of heart came for a reason and that he needs to continue his public speeches before a new Neo Nazi group is able to take root. He agrees and, once well, he resumes his (presumably ultimately successful) public speaking tour.
** In a cruel case of irony, Herschel Bernardi, the actor who played Everett Soloman, died of a heart attack in May 1986, less than six months after this episode was filmed.

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* ''Series/HighwayToHeaven'': Totally reversed in the late Season 2 episode "The Torch," where Everett Soloman, a Nazi death camp survivor whose parents were killed during World War II, is speaking against the growing Neo Nazi movement needs a heart transplant. Meanwhile, one of the Neo Nazi groups, led by Jan Baltic, is determined to silence Soloman and eventually they kill his son. While Baltic and his group -- engaged in a campaign to convince the public that the Holocaust was mere propogandalized fiction -- are planning their next move, his son accidentally sets off a machine gun, mortally wounding Baltic and killing two others. The change of heart comes when Baltic's heart is a biological match for Soloman. The transplant is successful ... but when Soloman learns the heart of his sworn enemy now beats inside him, he suddenly becomes ill and wants to die. While in his coma, Soloman has a dream where he is visited by his son and his parents, convincing him that this literal change of heart came for a reason and that he needs to continue his public speeches before a new Neo Nazi group is able to take root. He agrees and, once well, he resumes his (presumably ultimately successful) public speaking tour.
**
tour. In a cruel case of irony, Herschel Bernardi, the actor who played Everett Soloman, died of a heart attack in May 1986, less than six months after this episode was filmed.



--> '''Antubis''': Out with the old...and in with the new.
--> '''Lawyer''': AAAAAAAAAAAAAAAHHHHHHHHHHHHHHHH!

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--> '''Antubis''': -->'''Antubis:''' Out with the old...old... and in with the new.
--> '''Lawyer''':
new.\\
'''Lawyer:'''
AAAAAAAAAAAAAAAHHHHHHHHHHHHHHHH!



* Played with in an episode of ''Radio/TheRickyGervaisShow''. In the episode, Karl talks about a made-up TV show he came up with called "Look What We Can Do With Science" and has him explaining how he thinks human organs can just be either removed or replaced. He then states that they could replace a person's heart with a pacemaker, but Ricky is quick to point out that [[SubvertedTrope they don't really replace the heart with a pacemaker in real life.]]
* ''Series/StarTrekTheNextGeneration'': In "Samaritan Snare", Captain Picard recounts how he got into a fight with some surly Nausicaans as a youth and got stabbed right through the chest. Now he's got an artificial heart. During a near-death experience in the later episode "Tapestry", he was asked by Q [[SetRightWhatOnceWentWrong if he would like to change that part of his past that lead up to that (and the subsequent malfunction of the artificial heart years later)]]; however, by doing so, [[ForWantOfANail he wound up becoming a person who never developed any guts or took any risks]].
* ''Series/TheTwilightZone1985'': In "Appointment on Route 17", the [[CorruptCorporateExecutive callous businessman]] Tom Bennett begins to act strangely after receiving a heart transplant. He does things that he has never done before such as loosen his tie at the office and have hot dogs on the beach for lunch. At the beach, Tom is immediately attracted to a young woman who seems upset. After driving around for almost an hour the next day, he arrives at a greasy spoon on Route 17 and discovers that the woman, whose name is Mary Jo, is a waitress there. Tom can't explain why he is drawn to Mary Jo but he visits the diner every day in an attempt to bond with her. After a while, she refuses to serve him as she finds his interest in her creepy. Tom eventually learns that she is mourning her recently deceased boyfriend Jamie Adler, who donated his heart after being killed in a car accident. After calling his cardiologist, Tom discovers that it was Jamie's heart that he received. He returns to the diner and tells Mary Jo that he will be waiting for her when she decides that she is ready to date again but doesn't say anything about the heart. The experience also causes Tom to become more ethical in his business practices as he allows a client to set his own price as opposed to charging an exorbitant one as he originally intended.

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* Played with in an episode of ''Radio/TheRickyGervaisShow''. In the episode, Karl talks about a made-up TV show he came up with called "Look What We Can Do With Science" and has him explaining how he thinks human organs can just be either removed or replaced. He then states that they could replace a person's heart with a pacemaker, but Ricky is quick to point out that [[SubvertedTrope they don't really replace the heart with a pacemaker in real life.]]
* ''Series/StarTrekTheNextGeneration'': In "Samaritan Snare", "[[Recap/StarTrekTheNextGenerationS2E17SamaritanSnare Samaritan Snare]]", Captain Picard recounts how he got into a fight with some surly Nausicaans as a youth and got stabbed right through the chest. Now he's got an artificial heart. During a near-death experience in the later episode "Tapestry", "[[Recap/StarTrekTheNextGenerationS6E14Tapestry Tapestry]]", he was asked by Q [[SetRightWhatOnceWentWrong if he would like to change that part of his past that lead led up to that (and the subsequent malfunction of the artificial heart years later)]]; however, by doing so, [[ForWantOfANail he wound up becoming a person who never developed any guts or took any risks]].
risks.
* ''Series/TheTwilightZone1985'': In "Appointment "[[Recap/TheTwilightZone1985S3E15 Appointment on Route 17", 17]]", the [[CorruptCorporateExecutive callous businessman]] Tom Bennett begins to act strangely after receiving a heart transplant. He does things that he has never done before such as loosen his tie at the office and have hot dogs on the beach for lunch. At the beach, Tom is immediately attracted to a young woman who seems upset. After driving around for almost an hour the next day, he arrives at a greasy spoon on Route 17 and discovers that the woman, whose name is Mary Jo, is a waitress there. Tom can't explain why he is drawn to Mary Jo but he visits the diner every day in an attempt to bond with her. After a while, she refuses to serve him as she finds his interest in her creepy. Tom eventually learns that she is mourning her recently deceased boyfriend Jamie Adler, who donated his heart after being killed in a car accident. After calling his cardiologist, Tom discovers that it was Jamie's heart that he received. He returns to the diner and tells Mary Jo that he will be waiting for her when she decides that she is ready to date again but doesn't say anything about the heart. The experience also causes Tom to become more ethical in his business practices as he allows a client to set his own price as opposed to charging an exorbitant one as he originally intended.


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* Played with in an episode of ''Radio/TheRickyGervaisShow''. In the episode, Karl talks about a made-up TV show he came up with called "Look What We Can Do With Science" and has him explaining how he thinks human organs can just be either removed or replaced. He then states that they could replace a person's heart with a pacemaker, but Ricky is quick to point out that [[SubvertedTrope they don't really replace the heart with a pacemaker in real life]].
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* ''{{Manga/Parasyte}}'': Shinichi gets stabbed in the heart, and Migi is forced to replace his heart with a chunk of his own cells. This marks a change in Shinichi's personality, as he becomes cold and emotionless from having to deal with the other parasites. For added symbolism, he also loses the ability to cry.

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* In ''Anime/ScienceNinjaTeamGatchaman'' the Condor has to have his heart replaced.
* Happens in ''Anime/SevenMortalSins'', when [[spoiler:Lucifer switches her heart with Maria's.]]

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* %%* In ''Anime/ScienceNinjaTeamGatchaman'' the Condor has to have his heart replaced.
* %%* Happens in ''Anime/SevenMortalSins'', when [[spoiler:Lucifer switches her heart with Maria's.]]



* In the ''ComicBook/{{Superman}}'' {{Verse}} Metallo has a Kryptonite heart. In various versions he may be a robot, cyborg, or just have an artificial heart.

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* In the ''ComicBook/{{Superman}}'' {{Verse}} Metallo has a Kryptonite heart. In various versions versions, he may be a robot, cyborg, or just have an artificial heart.


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* ''Film/MamasBoy'', an Egyptian comedy about a famous mafia boss who gets seriously injured in a fight and gets transferred to a hospital where he needs an urgent heart transplant. Coincidentally, the mother of an ordinary young man dies in the same hospital and the doctor then decides to transfer her heart to the mafia boss to save him, but he starts acting like a mother towards the young man. HilarityEnsues when the young man, called Jonas, is bewildered by the way the gang leader acts and what he has to do with him as he doesn't know about the heart transplant situation.

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* Occurs in the "Brown Betty" episode of ''Series/{{Fringe}}''.

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* The premise of the KoreanDrama ''Series/BeatingAgain'' revolves around Min-ho, the ruthless, cutthroat investor who takes advantage of the people around him. One day, he has a heart attack and undergoes a heart transplant surgery, and his personality changes dramatically. He's no longer the cruel and cynical man he used to be, as he now became warmer and learned what it is to fall in love.
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Occurs in the "Brown Betty" episode of ''Series/{{Fringe}}''.
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* ''Webcomic/AHeartfeltAndante'':
** Da-ul begins the story a bitter, apathetic youth. When he finds out that his heart donor was a young piano prodigy whose life was cut short by a car accident, he resolves to better himself and become worthy of the heart.
** DiscussedTrope by Da-ul's friend Hyo-seo, who says in Episode 8 that if this were a movie, Da-ul would become a piano genius after getting a pianist's heart.
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* Happens very early in ''Manga/AreaNoKishi'': While Kakeru Aizawa is talented at soccer, he has an inferiority complex over his older brother Suguru who is the top player representing Japan in international U-15 championship, effectively reducing his performances in the field. After [[spoiler:receiving heart transplant from his dead older brother after thei both had an accident, he re-embraces his love for soccer and inherits his brother's spirit.]]

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* Happens very early in ''Manga/AreaNoKishi'': While Kakeru Aizawa is talented at soccer, he has an inferiority complex over his older brother Suguru who is the top player representing Japan in international U-15 championship, effectively reducing his performances in the field. After [[spoiler:receiving heart transplant from his dead older brother after thei they both had an accident, he re-embraces his love for soccer and inherits his brother's spirit.]]

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* A variation in ''Manga/PrincessKnight'' - Princess Sapphire was accidentally given two hearts at birth (shown in the manga as heart symbols). She gives the spoiled Prince Plastic one of them, turning him brave. After she gets the heart back, Plastic's personality change remains.



* A variation in ''Manga/PrincessKnight'' - Princess Sapphire was accidentally given two hearts at birth (shown in the manga as heart symbols). She gives the spoiled Prince Plastic one of them, turning him brave. After she gets the heart back, Plastic's personality change remains.












* In ''Literature/HowlsMovingCastle'' (both the anime and the novel) [[spoiler:Calcifer]] had swallowed [[spoiler:Howl]]'s heart as part of an old contract between them. The ending involves the heart being returned to its original owner, with some improvement of said owner's character.



* In ''Literature/HowlsMovingCastle'' (both the anime and the novel) [[spoiler:Calcifer]] had swallowed [[spoiler:Howl]]'s heart as part of an old contract between them. The ending involves the heart being returned to its original owner, with some improvement of said owner's character.
* Creator/WilhelmHauff's story "The Marble Heart" is a about some giant (or perhaps a [[DealWithTheDevil devil]]) who offers people wealth, but in return, they must have their hearts replaced with marble.



* Creator/WilhelmHauff's story "The Marble Heart" is a about some giant (or perhaps a [[DealWithTheDevil devil]]) who offers people wealth, but in return, they must have their hearts replaced with marble.



* Played with in an episode of ''Radio/TheRickyGervaisShow''. In the episode, Karl talks about a made-up TV show he came up with called "Look What We Can Do With Science" and has him explaining how he thinks human organs can just be either removed or replaced. He then states that they could replace a person's heart with a pacemaker, but Ricky is quick to point out that [[SubvertedTrope they don't really replace the heart with a pacemaker in real life.]]



* Played with in an episode of ''Radio/TheRickyGervaisShow''. In the episode, Karl talks about a made-up TV show he came up with called "Look What We Can Do With Science" and has him explaining how he thinks human organs can just be either removed or replaced. He then states that they could replace a person's heart with a pacemaker, but Ricky is quick to point out that [[SubvertedTrope they don't really replace the heart with a pacemaker in real life.]]















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* In ''VideoGame/DetroitBecomeHuman'', the android Markus is forced to replace his damaged "heart" (actually just the regulator for it) with a new one after being shot and disposed of in a dump. [[spoiler:Later on, in "Battle for Detroit", if Markus is badly wounded while leading a violent revolution, North (if she became Markus' lover) or Simon (if he has a friend-level relationship with Markus) can sacrifice their own regulators to ensure that he survives, in which case they actually refer to the regulators as hearts.]]
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adding Princess Knight example

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* A variation in ''Manga/PrincessKnight'' - Princess Sapphire was accidentally given two hearts at birth (shown in the manga as heart symbols). She gives the spoiled Prince Plastic one of them, turning him brave. After she gets the heart back, Plastic's personality change remains.

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* In ''ComicBook/CreatureTech'', an alien symbiont knocks Dr. Ong unconscious, rips his heart out of his chest, and attaches itself over the hole, serving as a replacement heart.



* In ''ComicBook/CreatureTech'', an alien symbiont knocks Dr. Ong unconscious, rips his heart out of his chest, and attaches itself over the hole, serving as a replacement heart.

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* In ''ComicBook/CreatureTech'', an alien symbiont knocks Dr. Ong unconscious, rips his heart out of his chest, and attaches itself over the hole, serving as a replacement heart.



* In ''Literature/HowlsMovingCastle'' (both the anime and the novel) [[spoiler:Calcifer]] had swallowed [[spoiler:Howl]]'s heart as part of an old contract between them. The ending involves the heart being returned to its original owner, with some improvement of said owner's character.



* One of the older print examples is the TinMan from ''Literature/TheWonderfulWizardOfOz''. Because of the curse on him and the EmergencyTransformation he underwent to survive it, he does not have a proper heart. He wants to ask the Wizard for a replacement so he can return to his girlfriend and become a proper husband for her. He succeeds in his task and gets a [[MagicFeather sawdust and silk one]]. [[spoiler: Too bad his girlfriend was seeing someone else on the side, and got married when he was rusted by the roadside.]]



* In ''Literature/HowlsMovingCastle'' (both the anime and the novel) [[spoiler:Calcifer]] had swallowed [[spoiler:Howl]]'s heart as part of an old contract between them. The ending involves the heart being returned to its original owner, with some improvement of said owner's character.
* Creator/WilhelmHauff's story "The Marble Heart" is a about some giant (or perhaps a [[DealWithTheDevil devil]]) who offers people wealth, but in return, they must have their hearts replaced with marble.
* In the TabletopGame/MagicTheGathering ''Scars of Mirrodin'' block novel, Venser gave his heart to Karn, whose original Heartstone was full of Phyrexian Glistening Oil. This allowed Karn to leave New Phyrexia and begin work in removing their evil once again.



* In the TabletopGame/MagicTheGathering ''Scars of Mirrodin'' block novel, Venser gave his heart to Karn, whose original Heartstone was full of Phyrexian Glistening Oil. This allowed Karn to leave New Phyrexia and begin work in removing their evil once again.
* Creator/WilhelmHauff's story "The Marble Heart" is a about some giant (or perhaps a [[DealWithTheDevil devil]]) who offers people wealth, but in return, they must have their hearts replaced with marble.

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* In One of the TabletopGame/MagicTheGathering ''Scars older print examples is the TinMan from ''Literature/TheWonderfulWizardOfOz''. Because of Mirrodin'' block novel, Venser gave his heart to Karn, whose original Heartstone was full of Phyrexian Glistening Oil. This allowed Karn to leave New Phyrexia the curse on him and begin work in removing their evil once again.
* Creator/WilhelmHauff's story "The Marble Heart" is a about some giant (or perhaps a [[DealWithTheDevil devil]]) who offers people wealth, but in return, they must
the EmergencyTransformation he underwent to survive it, he does not have their hearts replaced with marble.
a proper heart. He wants to ask the Wizard for a replacement so he can return to his girlfriend and become a proper husband for her. He succeeds in his task and gets a [[MagicFeather sawdust and silk one]]. [[spoiler: Too bad his girlfriend was seeing someone else on the side, and got married when he was rusted by the roadside.]]



* In the ''Series/MissionImpossible'' episode "The Miracle", the IMF team convince a hit man that he's had a heart transplant from a priest, and is no longer able to kill, to get him to betray his boss.



* In the ''Series/MissionImpossible'' episode "The Miracle", the IMF team convince a hit man that he's had a heart transplant from a priest, and is no longer able to kill, to get him to betray his boss.



* One mission in the Sega ''TabletopGame/{{Shadowrun}}'' game has you stealing a cybernetic heart in order to save the life of one of your brother's friends, because [[CyberneticsEatYourSoul he's installed so much cyberware on his body that his biological heart can't sustain him anymore.]]


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* One mission in the Sega ''TabletopGame/{{Shadowrun}}'' game has you stealing a cybernetic heart in order to save the life of one of your brother's friends, because [[CyberneticsEatYourSoul he's installed so much cyberware on his body that his biological heart can't sustain him anymore.]]

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* Occurs in the "Brown Betty" episode of ''Series/{{Fringe}}''.



* Occurs in ''Series/KingdomHospital''. A shady, sleazy, overweight lawyer needs a heart transplant. Otto's dog finds a suitable heart, and Antubis transplants it.
--> '''Antubis''': Out with the old...and in with the new.
--> '''Lawyer''': AAAAAAAAAAAAAAAHHHHHHHHHHHHHHHH!



* Occurs in the "Brown Betty" episode of ''Series/{{Fringe}}''.

to:

* Occurs in In the "Brown Betty" ''Series/MissionImpossible'' episode of ''Series/{{Fringe}}''."The Miracle", the IMF team convince a hit man that he's had a heart transplant from a priest, and is no longer able to kill, to get him to betray his boss.



* Played with in an episode of ''Series/TheRickyGervaisShow''. In the episode, Karl talks about a made-up TV show he came up with called "Look What We Can Do With Science" and has him explaining how he thinks human organs can just be either removed or replaced. He then states that they could replace a person's heart with a pacemaker, but Ricky is quick to point out that [[SubvertedTrope they don't really replace the heart with a pacemaker in real life.]]
* Occurs in ''Series/KingdomHospital''. A shady, sleazy, overweight lawyer needs a heart transplant. Otto's dog finds a suitable heart, and Antubis transplants it.
--> '''Antubis''': Out with the old...and in with the new.
--> '''Lawyer''': AAAAAAAAAAAAAAAHHHHHHHHHHHHHHHH!

to:

* Played with in an episode of ''Series/TheRickyGervaisShow''.''Radio/TheRickyGervaisShow''. In the episode, Karl talks about a made-up TV show he came up with called "Look What We Can Do With Science" and has him explaining how he thinks human organs can just be either removed or replaced. He then states that they could replace a person's heart with a pacemaker, but Ricky is quick to point out that [[SubvertedTrope they don't really replace the heart with a pacemaker in real life.]]
* Occurs in ''Series/KingdomHospital''. A shady, sleazy, overweight lawyer needs a heart transplant. Otto's dog finds a suitable heart, and Antubis transplants it.
--> '''Antubis''': Out with the old...and in with the new.
--> '''Lawyer''': AAAAAAAAAAAAAAAHHHHHHHHHHHHHHHH!
]]



* In the ''Series/MissionImpossible'' episode "The Miracle", the IMF team convince a hit man that he's had a heart transplant from a priest, and is no longer able to kill, to get him to betray his boss.

to:

* In the ''Series/MissionImpossible'' episode "The Miracle", the IMF team convince a hit man that he's had a heart transplant from a priest, and is no longer able to kill, to get him to betray his boss.




* In ''Franchise/KingdomHearts'', this is how a GrandTheftMe by BigBad Xehanort is performed.



* ''VideoGame/LegacyOfKain'' features the Heart of Darkness, which is heart of the last ancient vampire Janos Audron, ripped [[BeatStillMyHeart still-beating from his chest by Sarafan vampire hunters]] and christened as such. In the first game, the Heart simply acts as a healing item, but eventually it's revealed that the same heart was used by Mortanius the Necromancer to resurrect Kain, and it's also the only thing that can resurrect Janos himself.
* In ''VideoGame/TeamFortress2'''s "[[https://www.youtube.com/watch?v=36lSzUMBJnc Meet the Medic]]" video, the Medic accidentally destroys the Heavy's heart when trying to attach the Ubercharge device to it. He substitutes a larger heart from a "Mega Baboon" for it instead.
* ''VideoGame/TalesOfVesperia'': Raven's heart was replaced with a modified blastia after [[spoiler: he died during the Great War]], which took place 10 years prior to the events of the game itself. It not only sustains his life, it allows him to unleash the very same power as an offensive weapon; as seen during his Mystic Arte.
* During the ''Old World Blues'' DLC for ''VideoGame/FalloutNewVegas'', the player has his/her heart (and brain, and spine) removed and replaced by a synthetic one. Later on, you have the choice of keeping your powerful synthetic organs or putting your old ones back in (upgraded with a bit of tech, of course). Your upgraded original organs give better boosts to your SPECIAL stats and Damage Threshold, while the synthetic ones give smaller boosts but will also make you immune to poison and being crippled in the head and torso.



* During the ''Old World Blues'' DLC for ''VideoGame/FalloutNewVegas'', the player has his/her heart (and brain, and spine) removed and replaced by a synthetic one. Later on, you have the choice of keeping your powerful synthetic organs or putting your old ones back in (upgraded with a bit of tech, of course). Your upgraded original organs give better boosts to your SPECIAL stats and Damage Threshold, while the synthetic ones give smaller boosts but will also make you immune to poison and being crippled in the head and torso.



* In ''Franchise/KingdomHearts'', this is how a GrandTheftMe by BigBad Xehanort is performed.
* ''VideoGame/LegacyOfKain'' features the Heart of Darkness, which is heart of the last ancient vampire Janos Audron, ripped [[BeatStillMyHeart still-beating from his chest by Sarafan vampire hunters]] and christened as such. In the first game, the Heart simply acts as a healing item, but eventually it's revealed that the same heart was used by Mortanius the Necromancer to resurrect Kain, and it's also the only thing that can resurrect Janos himself.
* In ''VideoGame/TheLegendOfHeroesTrailsOfColdSteel III'', it's revealed that the reason why [[spoiler: Rean has his powers is because his father used his own heart to transplant it to his son. It's revealed in ''Cold Steel IV'' that he can do this because of Ishmelga's powers and that as an Awakener, Osborne cannot be killed by any means. It's also why Crow, Rutger, and the legendary Lianne Sandlot[=/=]Arianrhod are still walking among the living despite dying due to a stab to the heart, a three-day epic duel, and walk around two hundred and fifty years after the previous CivilWar.]]



* In ''VideoGame/TheLegendOfHeroesTrailsOfColdSteel III'', it's revealed that the reason why [[spoiler: Rean has his powers is because his father used his own heart to transplant it to his son. It's revealed in ''Cold Steel IV'' that he can do this because of Ishmelga's powers and that as an Awakener, Osborne cannot be killed by any means. It's also why Crow, Rutger, and the legendary Lianne Sandlot[=/=]Arianrhod are still walking among the living despite dying due to a stab to the heart, a three-day epic duel, and walk around two hundred and fifty years after the previous CivilWar.]]


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* ''VideoGame/TalesOfVesperia'': Raven's heart was replaced with a modified blastia after [[spoiler: he died during the Great War]], which took place 10 years prior to the events of the game itself. It not only sustains his life, it allows him to unleash the very same power as an offensive weapon; as seen during his Mystic Arte.
* In ''VideoGame/TeamFortress2'''s "[[https://www.youtube.com/watch?v=36lSzUMBJnc Meet the Medic]]" video, the Medic accidentally destroys the Heavy's heart when trying to attach the Ubercharge device to it. He substitutes a larger heart from a "Mega Baboon" for it instead.
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* In ''Series/StarTrekTheNextGeneration'', Captain Picard got in a fight with some surly Naausicans as a youth and got stabbed right through the chest. Now he's got an artificial heart. During a near-death experience in a later episode, he was asked by Q if he would like to change that part of his past that lead up to that (and the subsequent malfunction of the artificial heart years later); however, by doing so, he wound up becoming a person who never developed any guts or took any risks.

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* ''Series/StarTrekTheNextGeneration'': In ''Series/StarTrekTheNextGeneration'', "Samaritan Snare", Captain Picard recounts how he got in into a fight with some surly Naausicans Nausicaans as a youth and got stabbed right through the chest. Now he's got an artificial heart. During a near-death experience in a the later episode, episode "Tapestry", he was asked by Q [[SetRightWhatOnceWentWrong if he would like to change that part of his past that lead up to that (and the subsequent malfunction of the artificial heart years later); later)]]; however, by doing so, [[ForWantOfANail he wound up becoming a person who never developed any guts or took any risks.risks]].
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* In the ''Series/MissionImpossible'' episode "The Miracle", the IMF team convince a hit man that he's had a heart transplant from a priest, and is no longer able to kill, to get him to betray his boss.

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