History Main / GeniusSerum

* In the Italian comic ''ComicBook/{{Zannablu}} and the Intelligence Serum'', the protagonist -- a {{Ditz}} from a village of equally ditzy people -- [[AccidentalDiscovery accidentally]] creates an intelligence-enhancing potion when he tries (and fails) to make tea. Since the potion [[NoPlansNoPrototypeNoBackup cannot be remade]], this causes a split in the town -- should the potion be shared equally, making everyone only slightly smarter, or should it be used to make a few select people into geniuses?

* In ''Literature/{{Xenocide}}'', it becomes a major concern of the piqueino species that their intelligence is simply the byproduct of the descoloda virus infecting their world. This especially when the human scientists figure out a way to make a non-lethal version of the virus that would allow the piqueinos to safely leave their potentially doomed planet. [[MeaningfulName Human]] demands his friends remove the virus from his body, suffering in agony as its loss begins to kill him, but crucially remaining lucid and intelligent all the way to his end, proving the pequeinos are a sapient species in their own right.

* The ''WesternAnimation/PhineasAndFerb'' episode "Cranius Maximus" sees the titular characters build an intelligence-enhancing helmet for their BollywoodNerd friend Baljeet at his request. Unfortunately, it also seems to inhibit his morals, seeing as he has no problem creating and using a device that will send Earth's atmosphere to the moon ForScience while wearing it.

* In the ''WesternAnimation/DCSuperHeroGirls'' short "#[=ArtificalIntelligence=]", Doris Zeul (aka Giganta) accidentally injects herself with a serum that boosts her intellect to genius levels instead of her usual growth serum, utilizing her new smarts against the protagonists. She [[NearVillainVictory almost wins]] until the serum wears off at the last minute, causing Doris to forget how to use her machine and winds up blowing herself up.

* ''WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius'' had an episode that saw the title character use a helmet[[note]]initially introduced in an early series episode that invoked TookALevelInDumbass for Jimmy before he ReverseThePolarity of the helmet in the later episode[[/note]] to this effect to make Sheen... less Sheen-like. Unfortunately, the enhanced intelligence seemed to sap Sheen's sense of ethics and he went all EvilOverlord on his friends.