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* The animated film ''WesternAnimation/SupermanDoomsday'' contains an almost amusing example in that even ''Superman'' needed Kryptonite to defeat his clone with identical powers. Admittedly, the real Superman isn't quite at full strength at this point.
--> '''Superman''': You have all my strengths... and weaknesses.

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* The animated film ''WesternAnimation/SupermanDoomsday'' contains an almost amusing example in that even ''Superman'' needed Kryptonite to defeat his clone with identical powers. Admittedly, the real Superman isn't quite at full strength at this point.
--> '''Superman''': -->'''Superman:''' You have all my strengths... and weaknesses.



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* ''Series/LoisAndClark'', setting the tone for most [[Series/{{Smallville}} adaptations]] [[Series/Supergirl2015 after]] it, has red kryptonite affect him mentally instead of the comicverse rules of random one-off effects. Just how dark-side it makes a Kryptonian go depends on the tone of the adaptation, but one thing remains the same: under Red K, Kryptonians are dicks. However, this series also had Red K used to power devices that ''would'' affect him in different ways. You get dickishness out of merely putting a chunk of it near him, though.

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* ''Series/LoisAndClark'', ''Series/LoisAndClarkTheNewAdventuresOfSuperman'', setting the tone for most [[Series/{{Smallville}} adaptations]] [[Series/Supergirl2015 after]] it, has red kryptonite affect him mentally instead of the comicverse rules of random one-off effects. Just how dark-side it makes a Kryptonian go depends on the tone of the adaptation, but one thing remains the same: under Red K, Kryptonians are dicks. However, this series also had Red K used to power devices that ''would'' affect him in different ways. You get dickishness out of merely putting a chunk of it near him, though.



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* In ''WesternAnimation/SupermanTheAnimatedSeries'', it was originally planned that ComicBook/{{Supergirl}}, being in this iteration not from Krypton, but rather the sister-planet of Argos, would not have a weakness to Kryptonite. This is demonstrated in the "Superman Adventures" comic based on the series. By the time of ''WesternAnimation/JusticeLeague Unlimited'', though, the weakness was firmly in place.

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* In ''WesternAnimation/SupermanTheAnimatedSeries'', it was originally planned that ComicBook/{{Supergirl}}, being in this iteration not from Krypton, but rather the sister-planet of Argos, would not have a weakness to Kryptonite. This is demonstrated in the "Superman Adventures" comic based on the series. By the time of ''WesternAnimation/JusticeLeague Unlimited'', though, the weakness was firmly in place.place.
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* ''Film/ManOfSteel'':
** Exposure to Krypton's native environmental conditions weakens and at first even incapacitates Superman.
** Zod's Kryptonians similarly initially lose control of their powers and pass out while trying to adapt to Earth's native atmosphere.

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* *''Franchise/DCExtendedUniverse'':
**
''Film/ManOfSteel'':
** *** Exposure to Krypton's native environmental conditions weakens and at first even incapacitates Superman.
** *** Zod's Kryptonians similarly initially lose control of their powers and pass out while trying to adapt to Earth's native atmosphere.
** ''Film/BatmanVSupermanDawnOfJustice'' has Kryptonite discovered among the wreckage of the [[DoomsdayDevice Kryptonian World Engine]] near India after the events of ''Man of Steel''. It's explained as a radioactive isotope that actively harms Kryptonian cells. Before a large chunk is found in the Indean Ocean, the most they could find was only good for surgical tools. [[AdaptationalWimp In contrast to most portrayals, a small amount has no effect just in proximity.]] [[spoiler:Batman develops Kryptonite-laced gas grenades at his best bet at subduing Superman, with a spear as a FinishingMove.]] This also applies to [[spoiler:Doomsday, who is Kryptonian in origin and just as vulnerable to Kryptonite.]]

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** Something often overlooked is that even ordinary humans are susceptible to Kryptonite radiation, just to a much lesser extent. Additionally, while Kryptonians' natural HealingFactor allows them to recover from radiation sickness almost as soon as they're out of the immediate vicinity of any Kryptonite, exposure in humans is cumulative, as with any radioactive substance. Lex Luthor, who always kept a piece of Kryptonite tucked close to his chest to ensure Superman could never come near him, ends up eventually contracting cancer from it and is forced to build a biomechanical suit to stop it from progressing.
* In Post-Crisis continuity, Gold Kryptonite part is "powerless for 30 seconds", mostly because [[LikeYouWouldReallyDoIt it couldn't credibly be used for much storytelling otherwise]].

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** * Something often overlooked is that even ordinary humans are susceptible to Kryptonite radiation, just to a much lesser extent. Additionally, while Kryptonians' natural HealingFactor allows them to recover from radiation sickness almost as soon as they're out of the immediate vicinity of any Kryptonite, exposure in humans is cumulative, as with any radioactive substance. Lex Luthor, who always kept a piece of Kryptonite tucked close to his chest to ensure Superman could never come near him, ends up eventually contracting cancer from it and is forced to build a biomechanical suit to stop it from progressing.
* In Post-Crisis continuity, Gold Kryptonite part is "powerless for 30 seconds", mostly because [[LikeYouWouldReallyDoIt it couldn't credibly be used for much storytelling otherwise]].otherwise.


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** ''ComicBook/SupergirlAdventuresGirlOfSteel'': Subverted. Kanto tries to stab Kara to death with a Kryptonite knife...which shatters into pieces when it touches her chest because in this continuity -at this point in time- Kara is not Kryptonian but from planet Argo.

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* There are at least six colors of kryptonite, each with its own effects -- including pink Kryptonite in ''ComicBook/ManyHappyReturns'', which can change your sexual orientation.



* ''ComicBook/{{Supergirl}}'' has the same weaknesses as her cousin Superman. Namely: kryptonite, red sunlight, and magic.
* In the ''ComicBook/NewKrypton'' storyline, ''ComicBook/{{Supergirl}}'' faced off against [[ArchEnemy Reactron]], an enemy powered by golden kryptonite which nullified her powers. It becomes a plot point in ''ComicBook/WhoIsSuperwoman'' when the titular villain no-sells Reactron's Kryptonite-fueled blasts, thus revealing she's not Kryptonian.
* In the ''ComicBook/RedDaughterOfKrypton'' arc, Silver Banshee managed to contain Supergirl for a short while when they fought because her sonic attacks are magic, and Kryptonians are vulnerable to magic. Later on, Kara was weakened when she fought [[spoiler:Worldkiller-1]] because Earth's atmosphere was poisoned with kryptonite.
* In the first ''ComicBook/SupergirlRebirth'' story, Red Kryptonite -which is non-lethal but does weird things to Kryptonians- turns a Kryptonian into a werewolf. Supergirl's foster mother Eliza Danvers uses a red solar grenade against Lar-On when she notices he speaks Kryptonian.
* Several times in ''ComicBook/ElseworldsFinestSupergirlAndBatgirl'', Supergirl feels weak and sick without knowing why… until Lex Luthor reveals what Kryptonite is and does to Kryptonians.
* In ''ComicBook/TheSupergirlFromKrypton2004'', Kara Zor-El's pod crash-lands on Earth after spending three decades and a half stuck inside a Kryptonite giant asteroid. Although she survived thanks to her pod's sunlight generators, [[ComicBook/Supergirl2005 she suffered from Kryptonite poisoning for over one year]].
* In ''ComicBook/Supergirl1982'' issue #21, both Super-cousins fight the Kryptonite Man. His power weakens them and hurts them.
-->'''Supergirl:''' Kryptonite... Cutting through me... like a knife.
* Kara is vulnerable to magic because it bypasses her natural invulnerability. In ''ComicBook/DemonSpawn'' Nightflame's attacks hurt her because that villain is a sorcerer.
* Notably PlayedWith regarding ComicBook/PowerGirl. As a Kryptonian from Earth 2 (and in fact, the alternate universe counterpart of Supergirl above), she's vulnerable to the same weaknesses...on Earth 2. Kryptonite from Earth 1, where she now resides, does nothing to her (and likely red sunlight too). Magic still affects her, but as above, its typically more a 'has no immunity to it' rather than something that makes her weaker.
* Notably, during a time where DC were insisting on keeping Superman as the ''only'' Kryptonian, Power Girl was retconned into an Atlantean who had incorrectly believed herself to be Kryptonian, and her powers were now magic in nature. During this time, she was given a weakness to "natural, unprocessed materials" (IE, rocks and trees). Its now explained that this was a result of reality trying to find a 'place' for her after her universe was destroyed, and was attempting to recreate her Kryptonite Factor. Nowadays this period is largely forgotten and ignored.
* Daxamites are descended from ancient Kryptonian colonists who intermingled with the native population of Daxam and have similar weaknesses save for Kryptonite itself, instead they're irrecoverably fatally allergic to lead:
* ''ComicBook/{{Superboy}} (1949)'' #89 story had Superboy meet [[ComicBook/{{Valor}} Mon-El]], an amnesiac with powers like his, who assumed due to this that he was Kryptonian. Near the end of the story, Clark gets suspicious and lobs lead boulders painted to look like Kryptonite at him. Mon-El collapses, and Superboy flies in to accuse him of fakery -- but the trauma has [[EasyAmnesia brought his memory back]]; he's a Daxamite, a member of a race similar to Kryptonians, but with a weakness to lead poisoning instead of Kryptonite. To keep him from dying, Superboy puts him in the PhantomZone, preserving him for a thousand years until the ComicBook/LegionOfSuperHeroes finds a cure. Later retellings have Clark and Mon-El seeing if Mon-El was a Kryptonian (whose memories were slowly coming back) and Mon-El getting sick after Clark takes out a lead box containing some Kryptonite.
* Bizarro and his race are vulnerable to ''blue'' Kryptonite. In ''ComicBook/{{Bizarrogirl}}'', Supergirl and Dr. Light discover they can block Bizarrogirl's powers with light of a K-class star.
-->'''Supergirl:''' Because I just had an interesting conversation with a brilliant scientist I know. Y'see, a yellow sun gives a Kryptonian powers and a red sun takes them away.\\
'''Bizarrogirl:''' Bah! Science am boring!\\
'''Supergirl:''' Ha. You are an imperfect Kryptonian clone, Bizarrogirl, super-powered by a blue sun. Dr. Light theorizes the light of a K-Class star will take your powers away.
* Originally, the blue kryptonite weakness was because Bizarro was a copy of Superman, imperfectly duplicated by a machine. Normal kryptonite had no effect, until Superman thought of using similarly imperfectly duplicated Kryptonite. Just as Bizarro himself has chalk-white skin and a skewed color scheme, the duplicated kryptonite was a different color than the regular stuff.
* ''ComicBook/LastDaughterOfKrypton'': Kara's attempt to retrieve her pod from Simon Tycho's base fails when she gets knocked out by the bits of Kryptonite stuck to the pod's hull.



* ''ComicBook/TheUntoldStoryOfArgoCity'': After being driven crazy by a Kandorian animal's venom, Edna Danvers uses a cache of Kryptonite rocks to attempt to murder Zor-El and Allura.
* Downplayed in ''ComicBook/SupergirlWomanOfTomorrow''. When she travels to Ruthye's homeworld, which revolves around a red star, Kara is weakened and can be hurt, but she is still inhumanly strong and tough. Arrows pierce her skin but they do not reach her muscles or vital organs.



* ''ComicBook/TheHuntForReactron'', the eponymous villain tries to use Golden Kryptonite to depower his Kryptonian enemies in order to destroy them easily, but he is rendered helpless when Flamebird crushes his chunk of rock.
* ''ComicBook/TheGirlWithTheXRayMind'': After giving Lex Luthor powers, the Phantom Zone criminals intend to trick him into retrieving a sample of Golden Kryptonite to remove Superman and Supergirl's powers, as well as Luthor's.
* Subverted in ''ComicBook/TheStrangeRevengeOfLenaLuthor''. Supergirl wakes up in a chamber which supposedly uses high-gravity generators and fluorescent panels which emit red sunlight to nullify her powers by duplicating Krypton's environment. She soon realizes, though, that her kidnappers are gaslighting her and those red lamps have no effect on her.



* Nonetheless, Kryptonite is ''not'' a harmless substance. It's more-or-less a radioactive isotope, and can cause harm to anyone if exposed to it for long periods without the proper protection. In some continuities, Lex Luthor develops cancer or goes crazy thanks to repeated exposure. In ''ComicBook/TheCondemnedLegionnaires'', the female Legionnaires get sick because of involuntary exposure to Red Kryptonite.
* ''ComicBook/WayOfTheWorld'' features Krallian aliens, who are depowered by a substance called Selenite.



* In ''ComicBook/TheSupergirlBatgirlPlot'', Superman believes he cannot be harmed by a meteor thrown by Supergirl until his XRayVision tells him there's Kryptonite inside the rocky outside. The fat that "Supergirl" was not harmed by the Green-K clues him in that he is not fighting his cousin but an impersonator.



* In ''ComicBook/Supergirl1984'', there is not Kryptonite to found anywhere in the story, and magic takes its place as the tool used by the villain to hurt the Kryptonian hero.



* ''ComicBook/TheCondemnedLegionnaires'': Subverted. Supergirl reasons Satan Girl's must be Kryptonian given her powerset, so Kara borrows a box of Kryptonite powder to weaken her; though, Satan Girl shrugs it off completely, and later it is her who dumps a heap of Kryptonite rocks on Supergirl to get rid of her.



* "ComicBook/TheSuperSteedOfSteel": Subverted. Villain Vostar uses a chunk of Kryptonite to murder Supergirl and Comet, unaware that Comet is not from Krypton. Hence, he is downright shocked when Comet remains completely unaffected and flies Supergirl away.

to:


!!Spin-off Comics

!!!Franchise/{{Supergirl}}
* ''ComicBook/{{Supergirl}}'':
** Kara Zor-El has the same weaknesses as her cousin. Namely: kryptonite, red sunlight, and magic.
** In the ''ComicBook/NewKrypton'' storyline, ''Supergirl'' faced off against [[ArchEnemy Reactron]], an enemy powered by golden kryptonite which nullified her powers. It becomes a plot point in ''ComicBook/WhoIsSuperwoman'' when the titular villain no-sells Reactron's Kryptonite-fueled blasts, thus revealing she's not Kryptonian.
** In the ''ComicBook/RedDaughterOfKrypton'' arc, Silver Banshee managed to contain Supergirl for a short while when they fought because her sonic attacks are magic, and Kryptonians are vulnerable to magic. Later on, Kara was weakened when she fought [[spoiler:Worldkiller-1]] because Earth's atmosphere was poisoned with kryptonite.
** In the first ''ComicBook/SupergirlRebirth'' story, Red Kryptonite -which is non-lethal but does weird things to Kryptonians- turns a Kryptonian into a werewolf. Supergirl's foster mother Eliza Danvers uses a red solar grenade against Lar-On when she notices he speaks Kryptonian.
** Several times in ''ComicBook/ElseworldsFinestSupergirlAndBatgirl'', Supergirl feels weak and sick without knowing why… until Lex Luthor reveals what Kryptonite is and does to Kryptonians.
** In ''ComicBook/TheSupergirlFromKrypton2004'', Kara Zor-El's pod crash-lands on Earth after spending three decades and a half stuck inside a Kryptonite giant asteroid. Although she survived thanks to her pod's sunlight generators, [[ComicBook/Supergirl2005 she suffered from Kryptonite poisoning for over one year]].
** In ''ComicBook/Supergirl1982'' issue #21, both Super-cousins fight the Kryptonite Man. His power weakens them and hurts them.
--->'''Supergirl:''' Kryptonite... Cutting through me... like a knife.
** Kara is vulnerable to magic because it bypasses her natural invulnerability. In ''ComicBook/DemonSpawn'' Nightflame's attacks hurt her because that villain is a sorcerer.
** ''ComicBook/LastDaughterOfKrypton'': Kara's attempt to retrieve her pod from Simon Tycho's base fails when she gets knocked out by the bits of Kryptonite stuck to the pod's hull.
** ''ComicBook/TheUntoldStoryOfArgoCity'': After being driven crazy by a Kandorian animal's venom, Edna Danvers uses a cache of Kryptonite rocks to attempt to murder Zor-El and Allura.
** Downplayed in ''ComicBook/SupergirlWomanOfTomorrow''. When she travels to Ruthye's homeworld, which revolves around a red star, Kara is weakened and can be hurt, but she is still inhumanly strong and tough. Arrows pierce her skin but they do not reach her muscles or vital organs.
** ''ComicBook/TheHuntForReactron'', the eponymous villain tries to use Golden Kryptonite to depower his Kryptonian enemies in order to destroy them easily, but he is rendered helpless when Flamebird crushes his chunk of rock.
** ''ComicBook/TheGirlWithTheXRayMind'': After giving Lex Luthor powers, the Phantom Zone criminals intend to trick him into retrieving a sample of Golden Kryptonite to remove Superman and Supergirl's powers, as well as Luthor's.
** Subverted in ''ComicBook/TheStrangeRevengeOfLenaLuthor''. Supergirl wakes up in a chamber which supposedly uses high-gravity generators and fluorescent panels which emit red sunlight to nullify her powers by duplicating Krypton's environment. She soon realizes, though, that her kidnappers are gaslighting her and those red lamps have no effect on her.
** ''ComicBook/WayOfTheWorld'' features Krallian aliens, who are depowered by a substance called Selenite.
** In ''ComicBook/TheSupergirlBatgirlPlot'', Superman believes he cannot be harmed by a meteor thrown by Supergirl until his XRayVision tells him there's Kryptonite inside the rocky outside. The fat that "Supergirl" was not harmed by the Green-K clues him in that he is not fighting his cousin but an impersonator.
** In ''ComicBook/Supergirl1984'', there is not Kryptonite to found anywhere in the story, and magic takes its place as the tool used by the villain to hurt the Kryptonian hero.
**
"ComicBook/TheSuperSteedOfSteel": Subverted. Villain Vostar uses a chunk of Kryptonite to murder Supergirl and Comet, unaware that Comet is not from Krypton. Hence, he is downright shocked when Comet remains completely unaffected and flies Supergirl away.
** PlayedWith regarding ComicBook/PowerGirl. As a Kryptonian from Earth 2, she's vulnerable to the same weaknesses...on Earth 2. Kryptonite from Earth 1, where she now resides, does nothing to her (and likely red sunlight too). Magic still affects her, but as above, its typically more a 'has no immunity to it' rather than something that makes her weaker. During a time where DC were insisting on keeping Superman as the ''only'' Kryptonian, Power Girl was retconned into an Atlantean who had incorrectly believed herself to be Kryptonian, and her powers were now magic in nature. During this time, she was given a weakness to "natural, unprocessed materials" (IE, rocks and trees). ''ComicBook/PowerTrip2005'' explained that this was a result of reality trying to find a 'place' for her after her universe was destroyed, and was attempting to recreate her Kryptonite Factor. Nowadays this period is largely forgotten and ignored.
** There are at least six colors of kryptonite, each with its own effects -- including pink Kryptonite in ''ComicBook/ManyHappyReturns'', which can change your sexual orientation.

!!!Other Spin-off Comics
* ''ComicBook/LegionOfSuperHeroes'':
** Daxamites as Mon-El are descended from ancient Kryptonian colonists who intermingled with the native population of Daxam and have similar weaknesses save for Kryptonite itself, instead they're irrecoverably fatally allergic to lead.
** ''ComicBook/Superboy1949'' #89 story had Superboy meet [[ComicBook/{{Valor}} Mon-El]], an amnesiac with powers like his, who assumed due to this that he was Kryptonian. Near the end of the story, Clark gets suspicious and lobs lead boulders painted to look like Kryptonite at him. Mon-El collapses, and Superboy flies in to accuse him of fakery -- but the trauma has [[EasyAmnesia brought his memory back]]; he's a Daxamite, a member of a race similar to Kryptonians, but with a weakness to lead poisoning instead of Kryptonite. To keep him from dying, Superboy puts him in the PhantomZone, preserving him for a thousand years until the Legion finds a cure in "ComicBook/TheDeathOfLightningLad". Later retellings have Clark and Mon-El seeing if Mon-El was a Kryptonian (whose memories were slowly coming back) and Mon-El getting sick after Clark takes out a lead box containing some Kryptonite.
** Nonetheless, Kryptonite is ''not'' a harmless substance. It's more-or-less a radioactive isotope, and can cause harm to anyone if exposed to it for long periods without the proper protection. In some continuities, Lex Luthor develops cancer or goes crazy thanks to repeated exposure. In ''ComicBook/TheCondemnedLegionnaires'', the female Legionnaires get sick because of involuntary exposure to Red Kryptonite.
** ''ComicBook/TheCondemnedLegionnaires'': Subverted. Supergirl reasons Satan Girl's must be Kryptonian given her powerset, so Kara borrows a box of Kryptonite powder to weaken her; though, Satan Girl shrugs it off completely, and later it is her who dumps a heap of Kryptonite rocks on Supergirl to get rid of her.
* Bizarro and his race are vulnerable to ''blue'' Kryptonite. In ''ComicBook/{{Bizarrogirl}}'', Supergirl and Dr. Light discover they can block Bizarrogirl's powers with light of a K-class star.
-->'''Supergirl:''' Because I just had an interesting conversation with a brilliant scientist I know. Y'see, a yellow sun gives a Kryptonian powers and a red sun takes them away.\\
'''Bizarrogirl:''' Bah! Science am boring!\\
'''Supergirl:''' Ha. You are an imperfect Kryptonian clone, Bizarrogirl, super-powered by a blue sun. Dr. Light theorizes the light of a K-Class star will take your powers away.
* Originally, the blue kryptonite weakness was because Bizarro was a copy of Superman, imperfectly duplicated by a machine. Normal kryptonite had no effect, until Superman thought of using similarly imperfectly duplicated Kryptonite. Just as Bizarro himself has chalk-white skin and a skewed color scheme, the duplicated kryptonite was a different color than the regular stuff.
Is there an issue? Send a MessageReason:
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** Something often overlooked is that even ordinary humans are susceptible to Kryptonite radiation, just to a much lesser extent. Additionally, while Kryptonians' natural HealingFactor allows them to recover from radiation sickness almost as soon as they're out of the immediate vicinity of any Kryptonite, exposure in humans is cumulative. Lex Luthor, who always kept a piece of Kryptonite tucked close to his chest to ensure Superman could never come near him, ends up eventually contracting cancer from it and is forced to build a biomechanical suit to stop it from progressing.

to:

** Something often overlooked is that even ordinary humans are susceptible to Kryptonite radiation, just to a much lesser extent. Additionally, while Kryptonians' natural HealingFactor allows them to recover from radiation sickness almost as soon as they're out of the immediate vicinity of any Kryptonite, exposure in humans is cumulative.cumulative, as with any radioactive substance. Lex Luthor, who always kept a piece of Kryptonite tucked close to his chest to ensure Superman could never come near him, ends up eventually contracting cancer from it and is forced to build a biomechanical suit to stop it from progressing.
Is there an issue? Send a MessageReason:
Updating Link


* ''Franchise/{{Supergirl}}'' has the same weaknesses as her cousin Superman. Namely: kryptonite, red sunlight, and magic.

to:

* ''Franchise/{{Supergirl}}'' ''ComicBook/{{Supergirl}}'' has the same weaknesses as her cousin Superman. Namely: kryptonite, red sunlight, and magic.

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Updating Heading



!!Comic Books
* ''ComicBook/{{Superman}}'' is the {{Trope Namer|s}}, with his weakness to Kryptonite (radioactive GreenRocks from his home planet) established back in the 40's. Since then, he's gained a few other vulnerabilities: he has no particular resistance to magic (DependingOnTheWriter, it may either be a bona fide weakness or that he's just as vulnerable to magic as anyone else, meaning it's a relative weakness for someone immune to almost anything else), red sun radiation can temporarily rob him of his powers, and there's a whole spectrum of colored Kryptonite with varying effects (from Red Kryptonite that causes a random change for 48 hours, to Gold Kryptonite that robs him of his powers ''permanently''). He can still be killed by a huge amount of brute force from a similarly powered being such as Doomsday.

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\n!!Comic Books\nKryptoniteFactor in this franchise.
----
!![[ComicBook/{{Superman}} Comic Books]]
* ''ComicBook/{{Superman}}'' Superman is the {{Trope Namer|s}}, with his weakness to Kryptonite (radioactive GreenRocks from his home planet) established back in the 40's. Since then, he's gained a few other vulnerabilities: he has no particular resistance to magic (DependingOnTheWriter, it may either be a bona fide weakness or that he's just as vulnerable to magic as anyone else, meaning it's a relative weakness for someone immune to almost anything else), red sun radiation can temporarily rob him of his powers, and there's a whole spectrum of colored Kryptonite with varying effects (from Red Kryptonite that causes a random change for 48 hours, to Gold Kryptonite that robs him of his powers ''permanently''). He can still be killed by a huge amount of brute force from a similarly powered being such as Doomsday.



* In ''ComicBook/KryptoniteNevermore'', all Kryptonite on Earth is turned into iron. Comicbook/JimmyOlsen notes magic is still a problem, though.

to:

* In ''ComicBook/KryptoniteNevermore'', all Kryptonite on Earth is turned into iron. Comicbook/JimmyOlsen ComicBook/JimmyOlsen notes magic is still a problem, though.

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None


* ''ComicBook/{{Superman}}'' is the {{Trope Namer|s}}, with his weakness to Kryptonite (radioactive GreenRocks from his home planet) established back in the 40's. Since then, he's gained a few other vulnerabilities: he has no particular resistance to magic (DependingOnTheWriter, it may either be a bona fide weakness or that he's just as vulnerable to magic as anyone else, meaning it's a relative weakness for someone immune to almost anything else), red sun radiation can temporarily rob him of his powers, and there's a whole spectrum of coloured Kryptonite with varying effects (from Red Kryptonite that causes a random change for 48 hours, to Gold Kryptonite that robs him of his powers ''permanently''). He can still be killed by a huge amount of brute force from a similarly powered being such as Doomsday.

to:

* ''ComicBook/{{Superman}}'' is the {{Trope Namer|s}}, with his weakness to Kryptonite (radioactive GreenRocks from his home planet) established back in the 40's. Since then, he's gained a few other vulnerabilities: he has no particular resistance to magic (DependingOnTheWriter, it may either be a bona fide weakness or that he's just as vulnerable to magic as anyone else, meaning it's a relative weakness for someone immune to almost anything else), red sun radiation can temporarily rob him of his powers, and there's a whole spectrum of coloured colored Kryptonite with varying effects (from Red Kryptonite that causes a random change for 48 hours, to Gold Kryptonite that robs him of his powers ''permanently''). He can still be killed by a huge amount of brute force from a similarly powered being such as Doomsday.Doomsday.
** Something often overlooked is that even ordinary humans are susceptible to Kryptonite radiation, just to a much lesser extent. Additionally, while Kryptonians' natural HealingFactor allows them to recover from radiation sickness almost as soon as they're out of the immediate vicinity of any Kryptonite, exposure in humans is cumulative. Lex Luthor, who always kept a piece of Kryptonite tucked close to his chest to ensure Superman could never come near him, ends up eventually contracting cancer from it and is forced to build a biomechanical suit to stop it from progressing.
Is there an issue? Send a MessageReason:
None



to:

* "ComicBook/TheSuperSteedOfSteel": Subverted. Villain Vostar uses a chunk of Kryptonite to murder Supergirl and Comet, unaware that Comet is not from Krypton. Hence, he is downright shocked when Comet remains completely unaffected and flies Supergirl away.



* Interestingly, in ''WesternAnimation/SupermanTheAnimatedSeries'', it was originally planned that ComicBook/{{Supergirl}}, being in this iteration not from Krypton, but rather the sister-planet of Argos, would not have a weakness to Kryptonite. This is demonstrated in the "Superman Adventures" comic based on the series. By the time of ''WesternAnimation/JusticeLeague Unlimited'', though, the weakness was firmly in place.

to:

* Interestingly, in In ''WesternAnimation/SupermanTheAnimatedSeries'', it was originally planned that ComicBook/{{Supergirl}}, being in this iteration not from Krypton, but rather the sister-planet of Argos, would not have a weakness to Kryptonite. This is demonstrated in the "Superman Adventures" comic based on the series. By the time of ''WesternAnimation/JusticeLeague Unlimited'', though, the weakness was firmly in place.
Is there an issue? Send a MessageReason:
None


* ''ComicBook/{{Supergirl}}'' has the same weaknesses as her cousin Superman. Namely: kryptonite, red sunlight, and magic.
* In the ''ComicBook/NewKrypton'' storyline, Supergirl faced off against [[ArchEnemy Reactron]], an enemy powered by golden kryptonite which nullified her powers. It becomes a plot point in ''ComicBook/WhoIsSuperwoman'' when the titular villain no-sells Reactron's Kryptonite-fueled blasts, thus revealing she's not Kryptonian.

to:

* ''ComicBook/{{Supergirl}}'' ''Franchise/{{Supergirl}}'' has the same weaknesses as her cousin Superman. Namely: kryptonite, red sunlight, and magic.
* In the ''ComicBook/NewKrypton'' storyline, Supergirl ''ComicBook/{{Supergirl}}'' faced off against [[ArchEnemy Reactron]], an enemy powered by golden kryptonite which nullified her powers. It becomes a plot point in ''ComicBook/WhoIsSuperwoman'' when the titular villain no-sells Reactron's Kryptonite-fueled blasts, thus revealing she's not Kryptonian.

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!!Films
* ''Film/ManOfSteel'':
** Exposure to Krypton's native environmental conditions weakens and at first even incapacitates Superman.
** Zod's Kryptonians similarly initially lose control of their powers and pass out while trying to adapt to Earth's native atmosphere.

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!!Films
* ''Film/ManOfSteel'':
** Exposure to Krypton's native environmental conditions weakens and at first even incapacitates Superman.
** Zod's Kryptonians similarly initially lose control of their powers and pass out while trying to adapt to Earth's native atmosphere.
!!Films -- Animated


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!!Films -- Live-Action
* ''Film/ManOfSteel'':
** Exposure to Krypton's native environmental conditions weakens and at first even incapacitates Superman.
** Zod's Kryptonians similarly initially lose control of their powers and pass out while trying to adapt to Earth's native atmosphere.
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* PlayedForLaughs in ''ComicBook/BatmanSupermanWorldsFinest'' when while on a date with Robin and waiting for their food Supergirl tries to pass the time by rambling about the different kinds of kryptonite, such as anti-kryptonite which hurts Kryptonians when they're powerless and Bizarro red kryptonite which affects humans instead.
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* Subverted again in ''ComicBook/KingdomCome''. Spending two decades soaking up rays in rural Kansas and not using his powers has supercharged the Big Blue Boyscout to the point where Lex Luthor believes that a kryptonite-doped nuke wouldn't even be able to muss his hair, much less kill him. The only vulnerability he is shown to have is magic, and he gets a shallow cut from Wonder Woman's sword, which was forged by Haphaestus and is, according to her, sharp enough to carve the electrons off an atom.

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* Subverted again in ''ComicBook/KingdomCome''. Spending two decades soaking up rays in rural Kansas and not using his powers has supercharged the Big Blue Boyscout to the point where Lex Luthor believes that a kryptonite-doped nuke wouldn't even be able to muss his hair, much less kill him. The only vulnerability he is shown to have is magic, and he gets a shallow cut from Wonder Woman's sword, which was forged by Haphaestus and is, according to her, sharp enough to carve the electrons off an atom.




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* ''ComicBook/TheKMetalFromKrypton'' was the story which was intended to introduce Kryptonite for the first time (before being rejected by editorial). However, its effects were quite different: Superman merely loses his powers -rather than dying from radioactive poisoning-, and humans gain powers by touching it.
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* ''ComicBook/ThePlanetEaterTrilogy'': When Superman is traversing through the Planet Eater's inner corridors, the humongous machine uses a light cannon powered by red sunlight to weaken him.
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* Though there is a caveat we should mention: Kryptonite is ''not'' a harmless substance. It's more-or-less a radioactive isotope, and can cause harm to anyone if exposed to it for long periods without the proper protection. In some continuities, Lex Luthor develops cancer or goes crazy thanks to repeated exposure.

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* Though there is a caveat we should mention: Nonetheless, Kryptonite is ''not'' a harmless substance. It's more-or-less a radioactive isotope, and can cause harm to anyone if exposed to it for long periods without the proper protection. In some continuities, Lex Luthor develops cancer or goes crazy thanks to repeated exposure. In ''ComicBook/TheCondemnedLegionnaires'', the female Legionnaires get sick because of involuntary exposure to Red Kryptonite.
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* There are at least six colors of kryptonite, each with its own effects -- [[ComicBook/ManyHappyReturns including Pink Kryptonite, which can change your sexual orientation]].

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* There are at least six colors of kryptonite, each with its own effects -- [[ComicBook/ManyHappyReturns including Pink Kryptonite, pink Kryptonite in ''ComicBook/ManyHappyReturns'', which can change your sexual orientation]].orientation.



* Kara is vulnerable to magic because it bypasses her natural invulnerability. In ''Comicbook/DemonSpawn'' Nightflame's attacks hurt her because that villain is a sorcerer.

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* Kara is vulnerable to magic because it bypasses her natural invulnerability. In ''Comicbook/DemonSpawn'' ''ComicBook/DemonSpawn'' Nightflame's attacks hurt her because that villain is a sorcerer.




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* ''ComicBook/TheCondemnedLegionnaires'': Subverted. Supergirl reasons Satan Girl's must be Kryptonian given her powerset, so Kara borrows a box of Kryptonite powder to weaken her; though, Satan Girl shrugs it off completely, and later it is her who dumps a heap of Kryptonite rocks on Supergirl to get rid of her.
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--->'''Supergirl:''' Kryptonite... Cutting through me... like a knife.

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--->'''Supergirl:''' -->'''Supergirl:''' Kryptonite... Cutting through me... like a knife.



--->'''Supergirl:''' Because I just had an interesting conversation with a brilliant scientist I know. Y'see, a yellow sun gives a Kryptonian powers and a red sun takes them away.\\

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--->'''Supergirl:''' -->'''Supergirl:''' Because I just had an interesting conversation with a brilliant scientist I know. Y'see, a yellow sun gives a Kryptonian powers and a red sun takes them away.\\
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* Though there is a caveat we should mention: Kryptonite is ''not'' a harmless substance. It's more-or-less a radioactive isotope, and can cause harm to anyone if exposed to it for long periods without the proper protection. In some continualities Lex Luthor develops cancer, or goes crazy, thanks to repeated exposure.

to:

* Though there is a caveat we should mention: Kryptonite is ''not'' a harmless substance. It's more-or-less a radioactive isotope, and can cause harm to anyone if exposed to it for long periods without the proper protection. In some continualities continuities, Lex Luthor develops cancer, cancer or goes crazy, crazy thanks to repeated exposure.

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* ''[[Series/WonderWoman1975 Wonder Woman]]'':
** Initially, Wonder Woman would lose her superhuman strength if her magic belt was removed from her uniform. Similarly, she possessed no resistance to chloroform, which conveniently made its way into a number of Season 1 episodes. When the show was moved to the 1970s, the former weakness was addressed only once (and only then when she willingly removed her belt, lasso, and bracelets to assure an enemy that she did not wish to fight him), and the chloroform was used far less often.
** There's another, less obvious weakness - Diana Prince needs enough freedom of movement to spin to turn into Wonder Woman. No villains ''deliberately'' exploited this (since very few knew about her secret identity in the first place), but several accidentally used it when they handcuffed Diana to a support beam or something similar.

to:

* ''[[Series/WonderWoman1975 Wonder Woman]]'':
** Initially, Wonder Woman would lose her superhuman strength if her magic belt was removed from her uniform. Similarly, she possessed no resistance to chloroform, which conveniently made its way into a number of Season 1 episodes. When the show was moved to the 1970s, the former weakness was addressed only once (and only then when she willingly removed her belt, lasso, and bracelets to assure an enemy that she did not wish to fight him), and the chloroform was used far less often.
** There's another, less obvious weakness - Diana Prince needs enough freedom of movement to spin to turn into Wonder Woman. No villains ''deliberately'' exploited this (since very few knew about her secret identity in the first place), but several accidentally used it when they handcuffed Diana to a support beam or something similar.
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!''Franchise/{{Superman}}''

!!Comic Books
* ''ComicBook/{{Superman}}'' is the {{Trope Namer|s}}, with his weakness to Kryptonite (radioactive GreenRocks from his home planet) established back in the 40's. Since then, he's gained a few other vulnerabilities: he has no particular resistance to magic (DependingOnTheWriter, it may either be a bona fide weakness or that he's just as vulnerable to magic as anyone else, meaning it's a relative weakness for someone immune to almost anything else), red sun radiation can temporarily rob him of his powers, and there's a whole spectrum of coloured Kryptonite with varying effects (from Red Kryptonite that causes a random change for 48 hours, to Gold Kryptonite that robs him of his powers ''permanently''). He can still be killed by a huge amount of brute force from a similarly powered being such as Doomsday.
* In Post-Crisis continuity, Gold Kryptonite part is "powerless for 30 seconds", mostly because [[LikeYouWouldReallyDoIt it couldn't credibly be used for much storytelling otherwise]].
* He even has at least three villains -- Metallo, Conduit, and [[ManOfKryptonite the Kryptonite Man]] -- possessing powers that boil down to ''being Kryptonite.'' And due to Gold K being {{Nerf}}ed, minor villain Radion was revised into this in ''ComicBook/SupermanUpUpAndAway'' as well.
* Ironically, Superman is infamous for [[FightOffTheKryptonite ignoring Kryptonite]] through sheer HeroicWillpower. The only thing he is always shown as vulnerable to is magic. This has gives [[ComicBook/{{Shazam}} Captain Marvel]] [[SuperHeroSpeciation a firm place]] in Franchise/TheDCU as a valuable ally for the Man of Steel.
* ComicBook/{{Brainiac}} once used a special mix of red and green Kryptonite that gave him a third eye in the back of his head (in ''ComicBook/ActionComics #275''). In order to protect his secret identity, Supes pretended that the kryptonite had addled his brain to make him wear whatever hat is near him.
* ''ComicBook/LetMyPeopleGrow'' proves that; not even Superman can withstand an exploding supernova (he needs to wear a special armor suit, and even so he passes out due to the strain); and Brainiac is able to build Kryptonian-killing weapons.
* There are at least six colors of kryptonite, each with its own effects -- [[ComicBook/ManyHappyReturns including Pink Kryptonite, which can change your sexual orientation]].
* In Bronze Age storyline ''ComicBook/KryptonNoMore'', orange sun radiation can temporarily make Kryptonians blind and cut their powers in half. Superman, Supergirl and ComicBook/{{Krypto|TheSuperdog}} learn this the hard way as they are fighting an alien army.
* In ''ComicBook/SupermanVsTheAmazingSpiderMan'' ComicBook/LexLuthor uses beam weapons powered with red sunlight to destroy Superman.
* In ''ComicBook/WarWorld'', ComicBook/MartianManhunter tries to stop Superman using Kryptonite-tipped missiles.
* In ''ComicBook/KryptoniteNevermore'', all Kryptonite on Earth is turned into iron. Comicbook/JimmyOlsen notes magic is still a problem, though.
* ''ComicBook/{{Supergirl}}'' has the same weaknesses as her cousin Superman. Namely: kryptonite, red sunlight, and magic.
* In the ''ComicBook/NewKrypton'' storyline, Supergirl faced off against [[ArchEnemy Reactron]], an enemy powered by golden kryptonite which nullified her powers. It becomes a plot point in ''ComicBook/WhoIsSuperwoman'' when the titular villain no-sells Reactron's Kryptonite-fueled blasts, thus revealing she's not Kryptonian.
* In the ''ComicBook/RedDaughterOfKrypton'' arc, Silver Banshee managed to contain Supergirl for a short while when they fought because her sonic attacks are magic, and Kryptonians are vulnerable to magic. Later on, Kara was weakened when she fought [[spoiler:Worldkiller-1]] because Earth's atmosphere was poisoned with kryptonite.
* In the first ''ComicBook/SupergirlRebirth'' story, Red Kryptonite -which is non-lethal but does weird things to Kryptonians- turns a Kryptonian into a werewolf. Supergirl's foster mother Eliza Danvers uses a red solar grenade against Lar-On when she notices he speaks Kryptonian.
* Several times in ''ComicBook/ElseworldsFinestSupergirlAndBatgirl'', Supergirl feels weak and sick without knowing why… until Lex Luthor reveals what Kryptonite is and does to Kryptonians.
* In ''ComicBook/TheSupergirlFromKrypton2004'', Kara Zor-El's pod crash-lands on Earth after spending three decades and a half stuck inside a Kryptonite giant asteroid. Although she survived thanks to her pod's sunlight generators, [[ComicBook/Supergirl2005 she suffered from Kryptonite poisoning for over one year]].
* In ''ComicBook/Supergirl1982'' issue #21, both Super-cousins fight the Kryptonite Man. His power weakens them and hurts them.
--->'''Supergirl:''' Kryptonite... Cutting through me... like a knife.
* Kara is vulnerable to magic because it bypasses her natural invulnerability. In ''Comicbook/DemonSpawn'' Nightflame's attacks hurt her because that villain is a sorcerer.
* Notably PlayedWith regarding ComicBook/PowerGirl. As a Kryptonian from Earth 2 (and in fact, the alternate universe counterpart of Supergirl above), she's vulnerable to the same weaknesses...on Earth 2. Kryptonite from Earth 1, where she now resides, does nothing to her (and likely red sunlight too). Magic still affects her, but as above, its typically more a 'has no immunity to it' rather than something that makes her weaker.
* Notably, during a time where DC were insisting on keeping Superman as the ''only'' Kryptonian, Power Girl was retconned into an Atlantean who had incorrectly believed herself to be Kryptonian, and her powers were now magic in nature. During this time, she was given a weakness to "natural, unprocessed materials" (IE, rocks and trees). Its now explained that this was a result of reality trying to find a 'place' for her after her universe was destroyed, and was attempting to recreate her Kryptonite Factor. Nowadays this period is largely forgotten and ignored.
* Daxamites are descended from ancient Kryptonian colonists who intermingled with the native population of Daxam and have similar weaknesses save for Kryptonite itself, instead they're irrecoverably fatally allergic to lead:
* ''ComicBook/{{Superboy}} (1949)'' #89 story had Superboy meet [[ComicBook/{{Valor}} Mon-El]], an amnesiac with powers like his, who assumed due to this that he was Kryptonian. Near the end of the story, Clark gets suspicious and lobs lead boulders painted to look like Kryptonite at him. Mon-El collapses, and Superboy flies in to accuse him of fakery -- but the trauma has [[EasyAmnesia brought his memory back]]; he's a Daxamite, a member of a race similar to Kryptonians, but with a weakness to lead poisoning instead of Kryptonite. To keep him from dying, Superboy puts him in the PhantomZone, preserving him for a thousand years until the ComicBook/LegionOfSuperHeroes finds a cure. Later retellings have Clark and Mon-El seeing if Mon-El was a Kryptonian (whose memories were slowly coming back) and Mon-El getting sick after Clark takes out a lead box containing some Kryptonite.
* Bizarro and his race are vulnerable to ''blue'' Kryptonite. In ''ComicBook/{{Bizarrogirl}}'', Supergirl and Dr. Light discover they can block Bizarrogirl's powers with light of a K-class star.
--->'''Supergirl:''' Because I just had an interesting conversation with a brilliant scientist I know. Y'see, a yellow sun gives a Kryptonian powers and a red sun takes them away.\\
'''Bizarrogirl:''' Bah! Science am boring!\\
'''Supergirl:''' Ha. You are an imperfect Kryptonian clone, Bizarrogirl, super-powered by a blue sun. Dr. Light theorizes the light of a K-Class star will take your powers away.
* Originally, the blue kryptonite weakness was because Bizarro was a copy of Superman, imperfectly duplicated by a machine. Normal kryptonite had no effect, until Superman thought of using similarly imperfectly duplicated Kryptonite. Just as Bizarro himself has chalk-white skin and a skewed color scheme, the duplicated kryptonite was a different color than the regular stuff.
* ''ComicBook/LastDaughterOfKrypton'': Kara's attempt to retrieve her pod from Simon Tycho's base fails when she gets knocked out by the bits of Kryptonite stuck to the pod's hull.
* Subverted in ''ComicBook/TheImmortalSuperman'', where Superman has become invulnerable to Kryptonite after aging several thousands of years.
* In ''ComicBook/TheDeathOfSuperman'', the Eradicator's "Last Son of Krypton" body had an ironic weakness to bright lights. His body, made out of materials from around Superman's tomb, was imperfect and he was unable to see in light. Thus, he is forced to wear a pair of shades to filter the light. In his fight with Steel, Steel is able to punch off Eradicator's glasses, forcing him to flee.
* In ''ComicBook/SupermanVsShazam'', since she is vulnerable to magic, Supergirl gets hurt by [[EvilSorcerer Karmang]]'s fire spells.
* ''ComicBook/TheUntoldStoryOfArgoCity'': After being driven crazy by a Kandorian animal's venom, Edna Danvers uses a cache of Kryptonite rocks to attempt to murder Zor-El and Allura.
* Downplayed in ''ComicBook/SupergirlWomanOfTomorrow''. When she travels to Ruthye's homeworld, which revolves around a red star, Kara is weakened and can be hurt, but she is still inhumanly strong and tough. Arrows pierce her skin but they do not reach her muscles or vital organs.
* In ''ComicBook/TheDeathOfSuperman1961'', Lex Luthor kills Superman by strapping him to one stretcher and exposing him to Kryptonite radiation.
* ''ComicBook/TheHuntForReactron'', the eponymous villain tries to use Golden Kryptonite to depower his Kryptonian enemies in order to destroy them easily, but he is rendered helpless when Flamebird crushes his chunk of rock.
* ''ComicBook/TheGirlWithTheXRayMind'': After giving Lex Luthor powers, the Phantom Zone criminals intend to trick him into retrieving a sample of Golden Kryptonite to remove Superman and Supergirl's powers, as well as Luthor's.
* Subverted in ''ComicBook/TheStrangeRevengeOfLenaLuthor''. Supergirl wakes up in a chamber which supposedly uses high-gravity generators and fluorescent panels which emit red sunlight to nullify her powers by duplicating Krypton's environment. She soon realizes, though, that her kidnappers are gaslighting her and those red lamps have no effect on her.
* Subverted again in ''ComicBook/KingdomCome''. Spending two decades soaking up rays in rural Kansas and not using his powers has supercharged the Big Blue Boyscout to the point where Lex Luthor believes that a kryptonite-doped nuke wouldn't even be able to muss his hair, much less kill him. The only vulnerability he is shown to have is magic, and he gets a shallow cut from Wonder Woman's sword, which was forged by Haphaestus and is, according to her, sharp enough to carve the electrons off an atom.
* Though there is a caveat we should mention: Kryptonite is ''not'' a harmless substance. It's more-or-less a radioactive isotope, and can cause harm to anyone if exposed to it for long periods without the proper protection. In some continualities Lex Luthor develops cancer, or goes crazy, thanks to repeated exposure.
* ''ComicBook/WayOfTheWorld'' features Krallian aliens, who are depowered by a substance called Selenite.
* In ''ComicBook/ThePlagueOfTheAntibioticMan'', Amalak creates a yellow energy cocoon around Green Lantern to nullify his Power Ring, and uses Dr. Light's Kryptonite Light to attempt to kill Superman.
* In ''ComicBook/TheSupergirlBatgirlPlot'', Superman believes he cannot be harmed by a meteor thrown by Supergirl until his XRayVision tells him there's Kryptonite inside the rocky outside. The fat that "Supergirl" was not harmed by the Green-K clues him in that he is not fighting his cousin but an impersonator.
* ''ComicBook/TheLeperFromKrypton'': In at least one instance, though, Kryptonite saved Superman's life. When Kal-El is dying from an incurable disease, two ComicBook/{{Bizarro}}s try to make his demise quicker and less painful by tossing chunks of White Kryptonite at him. The Bizarros are too dumb to understand that white Kryptonite cannot kill Superman because it has no effect on animal lifeforms...but it does destroy other lifeforms, such like the bacteria which was killing him.
* In ''ComicBook/Supergirl1984'', there is not Kryptonite to found anywhere in the story, and magic takes its place as the tool used by the villain to hurt the Kryptonian hero.

!!Films
* ''Film/ManOfSteel'':
** Exposure to Krypton's native environmental conditions weakens and at first even incapacitates Superman.
** Zod's Kryptonians similarly initially lose control of their powers and pass out while trying to adapt to Earth's native atmosphere.
* The animated film ''WesternAnimation/SupermanDoomsday'' contains an almost amusing example in that even ''Superman'' needed Kryptonite to defeat his clone with identical powers. Admittedly, the real Superman isn't quite at full strength at this point.
--> '''Superman''': You have all my strengths... and weaknesses.

!!Live-Action TV
* ''Series/LoisAndClark'', setting the tone for most [[Series/{{Smallville}} adaptations]] [[Series/Supergirl2015 after]] it, has red kryptonite affect him mentally instead of the comicverse rules of random one-off effects. Just how dark-side it makes a Kryptonian go depends on the tone of the adaptation, but one thing remains the same: under Red K, Kryptonians are dicks. However, this series also had Red K used to power devices that ''would'' affect him in different ways. You get dickishness out of merely putting a chunk of it near him, though.
* ''Series/{{Smallville}}'' made use of this so often it could get to ridiculous extremes...though, it ''was'' a JustifiedTrope in-universe: Clark's shuttle arrived alongside a massive Kryptonite meteor shower, and Kryptonite became a super-useful {{Unobtainium}} that provided a MetaOrigin for most villains, with the Kryptonite Factor weakness merely an unknown side-effect. Kryptonite radiation induced metahuman mutations and, until season 4, was seemingly the cause of ''every'' superhuman (ergo, every super-powered threat Clark faced was also armed with his one weakness). It was also a great power-source and wonder-drug for any crazy scheme a villain could have, as well as seemingly able to do ''anything'', including provide ''ink for counterfeit money''.
** Outside of weekly villains, Kryptonite was used as a means to intervene in Clark's relationship with Lana Lang (his original love interest). Yes, Kryptonite wasn't ''just'' used to empower villains and weaken his superpowers, but also ''cock block'' him, too. Lana had a necklace with a piece of Kryptonite on it, and the effect of it made everyone assume Clark just had crush-induced nausea. Later, Lana became a ManOfKryptonite after absorbing a large dose of it to save everyone, forcing the two to separate and never see each other again.
** As for Blue Kryptonite as Bizarro's weakness, Blue K was introduced in the series in a storyline totally unrelated to Bizarro - it was a total off-switch for Kryptonian powers but otherwise harmless. However, when Bizarro appeared, he was no misguided, well-intentioned dimwit - he was a Phantom Zone criminal who could possess others, causing PossessionBurnout, but ended up creating a new, duplicated body when he tried to possess Clark. He was Clark's opposite in every way, including weaknesses - he was hurt by sunlight and fueled by Kryptonite. This means that Blue K, instead of leaving him no power, gave him the opposite - infinite power, more than he could contain, blowing him to smithereens.
* ''Series/Supergirl2015'':
** The DEO revealed early on they have access to actual Kryptonite-based tech, and that general knowledge of it as a Kryptonian weakness is limited. They use it to subdue ComicBook/{{Supergirl}}, and J'onn uses a Kryptonite knife against Astra. In [[Recap/Supergirl2015S1E12Bizarro "Bizarro"]], Bizarrogirl is hurt with blue Kryptonite. Kara can also be hurt by other alien materials. Apparently, Superman and J'onn had a falling out due to the fact that DEO has been stockpiling kryptonite for use against evil Kryptonians. They finally reconcile, after J'onn hands the stockpile over to Superman.
** L-Corp has some synthetic Kryptonite, but it's very unstable and has a tendency to blow up. Lena Luthor and Supergirl have a falling out over this, as Supergirl is absolutely insistent that the Kryptonite be turned over to her, which Lena is not happy about. Supergirl says being exposed to Kryptonite is like being tortured, but Lena says she's just being a hypocrite who doesn't want to be vulnerable. Supergirl later apologizes for her actions, saying that Lena was right, but she feels like she ''can't'' be vulnerable because she has the weight of the world on her shoulders.
** Red sunlight, while not actively harmful, quickly renders Kryptonians as powerless as they were on Krypton. It's one of the DEO's primary weapons against Kryptonians. Flashbacks show that shortly before the start of the series, Lex (who wasn't able to get his hands on Kryptonite) somehow managed to turn Earth's sun red. When Lena insisted that humans can't survive with a red sun, Lex just retorted "neither can Superman."
* In ''Series/SupermanAndLois'', Superman has the usual weakness to green Kryptonite and red sun. The DOD has developed a number of Kryptonite-based weapons that come useful when they end up having to deal with evil Kryptonians. Bizarro, being an inverse of Superman, is strengthened by the red sun and green Kryptonite but is weakened by the yellow sun and X-Kryptonite.
* ''[[Series/WonderWoman1975 Wonder Woman]]'':
** Initially, Wonder Woman would lose her superhuman strength if her magic belt was removed from her uniform. Similarly, she possessed no resistance to chloroform, which conveniently made its way into a number of Season 1 episodes. When the show was moved to the 1970s, the former weakness was addressed only once (and only then when she willingly removed her belt, lasso, and bracelets to assure an enemy that she did not wish to fight him), and the chloroform was used far less often.
** There's another, less obvious weakness - Diana Prince needs enough freedom of movement to spin to turn into Wonder Woman. No villains ''deliberately'' exploited this (since very few knew about her secret identity in the first place), but several accidentally used it when they handcuffed Diana to a support beam or something similar.

!!Western Animation
* Interestingly, in ''WesternAnimation/SupermanTheAnimatedSeries'', it was originally planned that ComicBook/{{Supergirl}}, being in this iteration not from Krypton, but rather the sister-planet of Argos, would not have a weakness to Kryptonite. This is demonstrated in the "Superman Adventures" comic based on the series. By the time of ''WesternAnimation/JusticeLeague Unlimited'', though, the weakness was firmly in place.

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