History BrainwashedAndCrazy / VideoGames

* ''VideoGame/MarvelUltimateAlliance'':
** Towards the end, Dr. Doom does this to several of the {{NPC}}s, turning them against their friends. Thanks to the fact that some of these characters were made playable in the next-gen versions as well as DLC content, namely Colossus, Cyclops, and the Hulk, [[SparedByTheAdaptation this keeps them from getting brainwashed and the evil versions are instead presumably duplicates]].
** ''VideoGame/MarvelUltimateAlliance2'': This is done by [[spoiler:the Fold]]. It seems like the programmers like forcing you to beat the crap out of everyone in the game, regardless of whether they're on your side.
* ''VideoGame/MarvelVsCapcomClashOfTheSuperheroes'': The SecretCharacter known as Shadow Lady is [[Franchise/StreetFighter Chun-Li]] from an AlternateUniverse who was [[UnwillingRoboticization forcibly turned into a brainwashed cyborg]] for Shadaloo. In retaliation for foiling their operations, Shadaloo kidnapped and robotized Chun-Li for the sake of transforming her into M. Bison's [[TheDragon top assassin]]. Unlike Shadow -- a brainwashed Charlie Nash, who escaped shortly after being transformed -- Shadaloo added a RestrainingBolt to Shadow Lady's programming so she would remain fully loyal to them. As Shadow Lady, [[CyberneticsEatYourSoul her formerly cheerful personality was obliterated]], transforming her into an emotionless minion. [[spoiler:In her ending however, Shadow Lady [[HeroicWillpower overcomes Shadaloo's brainwashing]], [[HeelFaceTurn regain her original memories as Chun-Li]], and join forces with Shadow in taking down Shadaloo]].

* ''VideoGame/Splatoon2'':
** [[spoiler:Callie]] is brainwashed by DJ Octavio and his "hypnoshades", complete with an EvilCostumeSwitch. [[spoiler:She comes to her senses after Marie shoots the shades off with her Hero Charger.]]
** [[spoiler:Agent 3 also shares a similar fate in the ''Octo Expansion'' DLC when they are partially sanitized by Commander Tartar, and forced to fight Agent 8.]]

* This is the reason why [[spoiler: Kyo's father Saisyu]] is seen as [[spoiler: TheDragon to Rugal Berstein]] in ''VideoGame/TheKingOfFighters 95''. [[spoiler: You have to fight ''and'' defeat to get him out of such a state.]]
** In the ''KOF: KYO'' manga, this happens [[spoiler: to ''Kyo Kusanagi himself'', as during a fight with Iori he falls in a frenzied state that's actually ''Kyo's own version of the Riot of the Blood''; Athena says he's "entranced by Orochi" and both Mature and Vice confirm this to Iori and Billy, though unlike Iori and Leona's [[AxCrazy completely savage states]], Kyo is in an Orochi-empowered TranquilFury. Saisyu is the one who snaps him out of it via [[WarriorTherapist fighting Kyo on his own]] [[IKnowYoureInThereSomewhereFight and reminding him of his purpose in life]].]]
** In the Tales of Ash saga, this happens to both [[spoiler: Chizuru Kagura]] in ''2003'' and [[spoiler: Rugal's daughter Rose]] in ''XI''. More exactly, [[spoiler: both are controlled as a sort of PeoplePuppets by Botan from Those of the Past. Chizuru is recovering almost at the end of ''2003'', right before the fight against Mukai; Rose remains like this and is freed only at the end of ''XIII''.]]

* This is a rather common plot device in a variety of ''Franchise/FireEmblem'' games, to the point where its overuse has lead to fans to jokingly refer to it as "Kaga's fetish" (despite Shouzou Kaga leaving the series after ''Thracia 776'').

* The main villain of ''VideoGame/PokemonSunAndMoon'', [[spoiler:Lusamine]], gets hit with this ''bad''. [[spoiler:She's infected with the toxin of UB-01 Symbiote, a.k.a. Nihilego, which causes those it infects to become aggressive towards those around them and protective towards the creature itself. The infection, combined with unresolved grief after her husband went missing, caused Lusamine became controlling and abusive towards her children, Lillie and Gladion, until they ran away from home; by the end of the game, her obsession has become so great that she willingly fuses with one of them, [[EldritchAbomination creating one of the most horrifying entities ever seen in the series]]. Oh, and the ending implies that [[AndIMustScream she may have been at least partially conscious throughout all of this]], and that [[MyGodWhatHaveIDone she is horrified by what she did in this state]].]] However, in ''VideoGame/PokemonUltraSunAndUltraMoon'', [[spoiler: this was removed, with Lusamine wanting to defeat Necrozma. Her Mother Beast form is never fought, and the battle is replaced with Necrozma, who subjects Solgaleo/Lunala under Necrozma's control to fuse into Necrozma's new forme. Solgaleo/Lunala comes to its senses after defeating Ultra Necrozma.]]