History BodyHorror / Videogames

* ''BodyHorror/MarvelUniverse''

* ''Franchise/BatmanArkhamSeries'':
** Much like in ''WesternAnimation/BatmanTheAnimatedSeries'', the ''Arkham'' version of Two-Face doesn't just suffer from FacialHorror, but the scars extend to at least his left arm as well. [[spoiler:A hallucination of the Joker in ''VideoGame/BatmanArkhamKnight'' makes a comment that not-subtly questions whether or not Dent's penis also suffers the same scarring.]]
** The Joker in ''VideoGame/BatmanArkhamCity'' certainly counts, as he is covered in a giant red rash due to [[spoiler:the Titan he injected himself with in ''VideoGame/BatmanArkhamAsylum'']] poisoning him. [[spoiler:The Joker hallucination in ''Arkham Knight'' starts out this way, with the twist that the rash slowly gets ''better'' over the course of the game, as each time Batman gets fear-gassed by Scarecrow, the Joker personality is able to exert more and more control. By the end of the game, he is as squeaky clean as he was in ''Asylum''.]]
** Joker's blood also infects several people in ''VideoGame/BatmanArkhamKnight'', bleaching their skin, turning their hair green, and giving them the same nasty "rash" Joker had (as well as giving them a fragment of Joker's personality, but that's another story).

** ''VideoGame/PokemonSwordAndShield'' has its set of Fossil Pokémon, born from the combination of the series's classic prehistoric creature revival system, and the ancient archeological method of mashing incomplete fossils together to make a full "creature". As most of Galar's fossils are missing a lot of parts, you need two to recreate a living Pokémon, and the results are... not pretty. Misshapen, unbalanced, biologically insane (Dracovish most infamously has a dragon ''tail'' for a body, with no explanation on how that even works. It can also only breathe underwater but has a terrestrial animal's legs, meaning it's constantly suffocating as long as it's on land). Arctozolt, the Ice/Electric combination, is so poorly thought out that its head is permanently sick from the low temperatures the Ice-type body generates. Arctovish has its ''head on backwards'', and Dracozolt's upper half is so much thinner than its lower half that it's lower half essentially has its inner flesh constantly exposed to the air.

* ''VideoGame/WorldOfHorror'' has body horror in spades, wearing its inspiration from Creator/JunjiIto on its sleeve. Among the myriad examples you may encounter are a corpse reanimated by a mutant fungus, a mangle of human body parts fused together, and a woman whose face is missing, leaving a gaping hole lined with rib-like bone protrusions. And your player character may suffer a number of dreadful conditions, like [[GlasgowGrin getting their mouth split open]] by a scissor-wielding ghost, or suffering a curse that causes mysterious holes to appear in their flesh.

* ''VideoGame/WorldOfHorror'' has body horror in spades, wearing its inspiration from Creator/JunjiIto on its sleeve. Among the myriad examples you may encounter are a corpse reanimated by a mutant fungus, a mangle of human body parts fused together, and a woman whose face is missing, leaving a gaping hole lined with rib-like bone protrusions.

* ''VideoGame/TraumaCenter'':

* ''Videogame/Splatoon2OctoExpansion'': In the deepsea metro, test subjects who pass all the tests are souped up in a blender. Alive. Their remains are then applied to test subjects who have failed, causing them to become [[MindControl Sanitised]]-In a [[ZombieInfectee zombie-like state]] and able to be mind-controlled, while having no memories.

** Joker's blood also infected several people in ''VideoGame/BatmanArkhamKnight'', bleaching their skin, turning their hair green, and giving them the same nasty "rash" Joker had, as well as giving them a fragment of Joker's personality but that's another story.

* Dark Gaia's OneWingedAngel-form from ''Videogame/SonicUnleashed'' is probably the goriest thing ever shown in a ''[[Franchise/SonicTheHedgehog Sonic]]''-game. [[spoiler:Its jaw splits across its entire head as it roars loudly. It grows two extra pairs of arms, which burst out of its sides with audible cracks and LOTS of AlienBlood. It gains seven more eyes, [[EyesDoNotBelongThere which are all positioned in its mouth]] and surrounded by WAY too many tongues]]. All of this is shown in [[{{Squick}} very gross]] detail.

*** ''Infinite'' has a few very notable varieties of its own, especially since receiving a new Vigor prompts a brief cutscene in which you get a good look at some of its side-effects: for example, "[[PlayingWithFire Devil's Kiss]]" causes your hands to burn from the inside out - right down to the bone; the idle animation to "[[CreepyCrows Murder of Crows]]" has your hand sprouting feathers and your fingernails growing into claws; "Bucking Bronco" shows bloody cracks forming in the skin of your hand, flesh dropping off in petrified clumps; "[[ShockAndAwe Shock Jockey]]" results in electricity-conducting crystals bursting out from under your skin; "[[DeflectorShields Return to Sender]]" slowly peels away the flesh of your hand and coats your finger bones in a black, metallic substance; even the comparatively benign "[[MakingASplash Undertow]]" sees pulsating octopus suckers and barnacles forming on your skin.

** By far one of the most infamous examples is the fate of [[spoiler: Ludwig, the Holy Blade]]. He was once a fairly archtypical horseback KnightInShiningArmor, but the curse fused him with his horse into a gigantic, screeching mass of man and animal flesh, limbs, and features. The fact that during the boss fight, he TurnsRed by [[spoiler: regaining his human sanity and completely changing to act and fight like the sophisticated swordsman he once was, while still looking like a shambling mass of gore, is somehow even more wrong than a shrieking monster in the minds of plenty of players]].

* In ''VideoGame/{{Borderlands}}'', the Badass Psycho has one tiny, almost vestigial left arm, and a heavily overdeveloped right arm. Here's a [[http://fc08.deviantart.net/fs70/f/2014/046/1/7/borderlands__badass_psycho_by_ogloc069-d76ksnt.png pic]].
* The Badass Psycho reappears in ''VideoGame/Borderlands2'', and gains company. A relatively rare enemy called the Lab Rat has been driven insane by medical experiments, gaining glowing eyes from which it can [[EyeBeams shoot lasers]]. More commonly, bandit troops called Goliaths are always seen wearing some sort of headgear; if this is shot off, their face ''peels back over their skull, allowing their spine to elongate and thrust it clear out of their mouth''. A player can actually see their face wobbling around underneath the swaying, gore-coated skull as it scans for victims... not with any great ease, since the Goliath TurnsRed when this happens and goes berserk, drops his guns in favour of GoodOldFisticuffs, and starts beating the hell out of everything in sight, including his former buddies. A Goliath variant called the Caustic Goliath starts vomiting acid in this state as well.

* In ''VideoGame/BreathOfFireDragonQuarter'', when you get your D-Counter to 100% and give up, a game over scene will play in which you get to see Ryu's silhouette on a red background getting brutally, mercilessly torn apart by Odjn [[ChestBurster bursting out of his body ]]all while hearing Ryu's screams of agony. Pretty unusual for a JRPG to actually kill the main character, let alone in such a violent way.

** There is the Devouring Earth, creatures made of plants, stone, and flesh. Their goal is a world without humans. They achieve this by taking humans and mutating them into more Devouring Earth. During the Underground Incarnate trial, you get to see the Praetorian strain of the mutagen at work - people (and robots) with bulbous blue tumors sticking off of them as they begin their transformation into Devoured, gigantic, tentacle-faced, claw-handed monstrosities that, at one point in the game's past, could summon Swarms (essentially, mutated bees) from a hole in their hands.
** Earlier, there is a story arc devoted to helping a woman who has caught the amorous attention of the leader of the Devouring Earth, Hamidon (a four-story tall amoeba). A fair portion of the story arc involves keeping her away from the Devouring Earth to prevent them from infecting her. [[spoiler: The second to last mission is prefaced as a rescue mission, as the Devouring Earth broke into the safehouse where she was being kept. When you find her, she has already begun mutating into Terra, a Devouring Earth broodmother. The final mission has you capturing her, with unfortunately little hope of a cure]].

* ''VideoGame/CliveBarkersJericho'' is utterly rife with this. All of the monsters in this game were [[WasOnceAMAn once human]]: upon becoming [[spoiler:trapped in The Box/The Pyxis and succumbing to death, they are "assimilated" by the Firstborn. Upon returning to life,]] they have transformed into grotesque parodies of their former selves. Some of the more extreme examples include Arnold Leach, who has transformed into a winged creature with ''his eyes being forcefully held open'' by what appears to be thick leather straps punching through his eyelids and scalp; the Crusaders, who have replaced several of their limbs with assorted weaponry and ''nailed'' their own armour to their flesh, and the Corpses Behomoths, who are essentially a ''[[TheWormThatWalks mass of human corpses held together by a collective mind]]'', formed into the shape of huge, crawling creatures, with a metal mask held onto their "faces" via strips of skin, through which they ''spit toxic corpse chunks''.
* In ''VideoGame/CliveBarkersUndying'', Bethany got her final revenge on her brother Aaron by [[spoiler:chaining him inside her private dungeon and letting rats ''eat him alive'', removing his jawbone so he couldn't scream]]. Which also qualifies as ArtisticLicenseBiology, since removing someone's jawbone does not affect his ability to scream - the ''vocal cords'' should be removed for it. As a matter of fact, he could probably do ''nothing but scream''. Whether this makes it better or worse is probably not worth asking.
* ''[[VideoGame/ClockTower Clock Tower: The First Fear]]:'' has a severely deformed ten-year-old named Bobby, a mummified corpse you find in the trophy room, and [[spoiler:a huge, deformed, purple infant-looking thing who is the twin brother of Bobby]].
* In the ''VideoGame/CommandAndConquer'' Tiberium storyline this is what prolonged tiberium exposure has done at some points. It has gone from merely killing infantry, to turning them into [[http://images1.wikia.nocookie.net/__cb20090530124321/cnc/images/4/44/Visceroid_CC1_Art1.png huge moving aggressive meat-blobs]], to [[http://images2.wikia.nocookie.net/__cb20060811103006/cnc/images/thumb/8/8f/Tiberium_Infected_Human.jpg/281px-Tiberium_Infected_Human.jpg crystalizing them while they still live]].
* ''VideoGame/{{Contra}}'' is no stranger to horrendous alien creatures, but ''VideoGame/ContraHardCorps'' goes for this in one route: [[spoiler: Colonel Bahamut ''injects himself'' with the Alien Cell, granting him immense power, but as the fight goes on it becomes clear the cell is taking over him, transforming him into a disturbing twin-headed beast (one head at each end), and then into a beating heart surrounded by spheres with screaming faces on them.]]

** Ceaseless Discharge was originally a boy [[spoiler: and the aforementioned Daughters of Chaos' only brother]] born with a condition that covered his body in sores that constantly bled lava. After he loses a special ring that was made to keep his condition in check, he mutates into an enormous lava golem with fiery tentacles sprouting from his back and whose skin has bled so much he's turned the cave he's in into a LethalLavaLand.

* In ''VideoGame/DarkSoulsIII'' ''The Ringed City'', the Demon In Pain is differentiated from its partner in battle the Demon From Below by its ruined face and chest. [[spoiler:If it becomes the Demon Prince]], its deformities are even ''more'' pronounced.

** For an added extra dosage of sheer WTF: [[ChurchOfHappyology Unitology]] ''worships'' these things! Their whole religion is deifying the instruction manual that humans used to create the Necromorphs in the first place ([[spoiler: the Black Marker was an alien artifact, but humans decoded the information on it and, in a ''Film/{{Species}}'' fashion, the genetic code for the Necromorphs was amongst that info, while the Red Marker was also made by humans using reverse-engineering of the Black Marker]]), treating being turned into a Necromorph as the key to becoming a "divine, immortal being". Needless to say, many of the more sane Unitologists started having doubts about their beliefs when actually confronted with the reality of the Necromorphs.
** The [[spoiler: Brethren Moons are worse in concept than any Necromorph before them, being the final stage of the Necromorph "lifecycle". They are created during the Convergence event. As the name suggests, they are the size of a moon, made by the ''millions upon millions of corpses'' fusing together into one giant corpse planet.]]

* In ''VideoGame/[[DONTLOOKAWAY]]'', if the Entity manages to touch one of the humans, the player is treated a horrifying cutscene as the character's limbs contort and break in a way that quickly kills them.

* In ''VideoGame/Drakengard3'' [[spoiler: [[GenkiGirl Two]] found out that using her [[MagicMusic song powers]], to heal the orphans she had been caring for, inflicted this on them. Turning them into a giant monster that still [[NightmareFuel cries out for her with their voices]]]]. [[spoiler: She]] performs a MercyKill, but the [[MyGodWhatHaveIDone results]] [[BreakTheCutie aren't]] [[DespairEventHorizon pretty]].
* ''VideoGame/DwarfFortress'', being Dwarf Fortress, features this. The most prominent example would be the [[http://www.bay12forums.com/smf/index.php?topic=70899.0 Kitten Rot]], one of the many possible Forgotten Beast syndrome. As the name implies, it causes the skin of the infected to completely rot off, leaving behind a horrible mass of living miasma. In its most basic form. If your medical staff is skilled enough, the afflicted may actually ''survive having their entire skin rotted off''. VideoGame/DwarfFortress players being [[VideogameCrueltyPotential Dwarf Fortress players]], this has been weaponised. Forgotten beast that rots the nervous systems of your dwarves, leaving them completely numb? Well, looks like you've just got a way to make your military immune to pain! (Also, dwarves without eyes are said to make excellent siege operators, since they don't run away from enemies even though they're civilians.)

** [[spoiler: Radagon of the Golden Order has half of his body just crumbled away like he was a hollow ceramic statue, exposing the Elden Ring in his chest.]]
* ''Franchise/TheElderScrolls''

** The previously mentioned process helped to create Springtrap, the BigBad of the third game. You can visibly see human organs when looking at him, further validating the fact that an actual human being has been [[spoiler:''stuck within that suit for at least 30 years'']]. Even worse, [[http://i.imgur.com/YNMEDKB.jpg there's an image clearly showing just what's underneath]] - namely, the chest is ''gone'' and has more or less been crushed into the animatronic torso, the eye sockets and mouth are pulled open, and the eyes appear to have been popped out by those of the animatronic.

--->'''Marine:''' "I...I didn't have a choice...! The L.T...the Sergeant...''they were all infected!'' I could see it crawling...''sliding around beneath their skin!'' (sobs) A-and then they got up...they s-started to talk! Oh, God! Their voices! ''Oh, God! No, make them stop!'' I did them a favor...y-yeah, that's it; [[MercyKill I ]] ''[[MercyKill helped]]'' [[MercyKill them!]] (sobs) Maybe...maybe [[DrivenToSuicide I need to help myself...]](breaks out into sobs)"

* In the ''VideoGame/{{Icescape}}'' series, several dead people turn up mutated in horrific ways, warped as if its flesh was turned inside out. [[spoiler: This is actually the result of a weapon used by [[TheGreys aliens]] nearby, which rewrites the target's DNA with random code.]]

* Poor, poor D-Caf in ''VideoGame/JurassicParkTheGame''. He's bitten by Troodon, which is bad enough, since the venom puts him in a catatonic state. Be sure you can handle the {{Squick}} before checking the following spoiler-tag, even if it's obscured in-game...[[spoiler:they then ''lay their eggs'' in his abdomen, effectively using him as a living nest and food source for the young (a practice done by parasitic wasps in real life). And the worst part? He's still technically '''ALIVE'''.]]

* ''VideoGame/KeroBlaster'': Throughout the course of Normal Mode, Nanao slowly becomes horribly swelled up, deformed, and discolored [[spoiler: as a result of being possessed by one of the "things".]]

** ''VideoGame/KirbyAndTheForgottenLand'' manages to one-up this ''big time'' with [[spoiler: Fecto Forgo, an alien that assimilates the Beast Pack into itself to become a giant blob with deformed, partially digested faces all over it. Even before that happens, the Beast Pack’s leader, Leongar is shown to be possessed by Fecto Forgo, and the whole ordeal is clearly extremely painful for him, as his body language when he fires his [[BreathWeapon laser beam]] resembles a person vomiting.]]

* ''VideoGame/MassEffect1'' has Husks -- organics captured by the Geth are put onto devices that impale them, replaces their organs with cybernetics and they are effectively turned into cyber-zombies. Also, during the final boss fight Saren's [[spoiler:corpse is re-animated into an avatar of Sovereign]] in gruesome detail.
** The [[NightmareFuel vision]] Shepard gets on Eden Prime [[spoiler: shows Proteans being tortured and [[UnwillingRoboticisation merged with machinery]]. [[NothingIsScarier We don't see all that much]], but we hear screaming, [[FateWorseThanDeath lots and lots of screaming]].]]

*** You get to watch in horrifying detail just what has been happening to every one of those abducted colonists - you find a pod in the Collector base and get to watch either a Horizon colonist named Lilith or your very own yeoman, friend, and (possibly) romantic interest Kelly Chambers ''[[NightmareFuel melt]]'' [[NightmareFuel into a bloody mass while screaming in agony]], and there's nothing you can do to save her.

** And then ''VideoGame/MassEffect3'' came out and took the horror of the husks up to eleven. We have Cannibals, batarian husks with human corpses fused on to serve as an ArmCannon. Marauders, turians transformed into husk squad leaders. Brutes, enormous krogan husks with a turian head stapled on to provide intelligence. Ravagers, rachni with two huge artillery cannons bolted on, and covered in sacs filled with baby rachni husks. Harvesters, giant insects transformed into flying Reaper monsters. And the dreaded Banshees, asari with latent Ardat-Yakshi genes, twisted and stretched out into wispy monstrosities. [[http://i.imgur.com/kxb6E.jpg Some of the concept art for Ravagers was even worse]].

* The Harvesters/Ithkul from ''VideoGame/MasterOfOrion 3'' behave similarly to the Zerg, infecting other races and...reconfiguring...their bodies into freakish shapes. [[http://www.moo3.at/strategies/race_picks/lw_strat_guide.php Here]] (most of the way down the page) you can see some Ithkul - two infected humans, and what appears to be an infected Meklar (yes, they ''can infect robots too'')!

* [[spoiler: Inugami]], one of the {{Final Boss}}es of ''VideoGame/MuramasaTheDemonBlade'', provides enough BodyHorror to last the entire game, opening up gaping wounds in reality full of sickle-wielding skeleton arms, contorting his body in disturbing ways as he teleports around, and transforming into an infinitely long maw of teeth as one of his attacks.

* ''VisualNovel/PartTimeJob'' has [[spoiler: Lyra becoming a severed head in a jar, Twilight and Screw Loose being sewn together and given Lyra's body to boot, and Pinkie Pie getting her hind legs replaced with giant alligator legs]]. This isn't really anything ''outstanding'' compared to other examples on this page, but what makes it even more horrifying is that [[spoiler: Fluttershy did this to make them "more interesting" so she could ''sell them to a circus''.]]

*** Quite a few enemies - especially the bosses - are Body Horror galore. Bonus Boss Pandora whose body is vertically split in half and led together by blood-like goo? Was Sugawara whose head has been bloated into a twitching incent-like monster [[AndIMustScream while he's still concious and begging you to kill him from the pain despite being immortal?]] The "stalker" that hunts down Eriko who apparently has no sense of pain and shows up with more injuries and bandages each and every time, not even bothered by his arm breaking? The JOKERS that were ''physically transformed'' to demons? How about the FinalBoss of ''Innocent Sin'' who is a tentacled amalgamation of the fathers of each party member tied up in bondage gear?

** ''VideoGame/HeyPikmin'': The final boss, [[spoiler: the Leech Hydroe, withers at the end of its first phase before sprouting wings to continue the battle]].

** Ever wondered what a video game glitch would look like in reality? Look no further than Porygon-Z - essentially an unlicensed [[GameMod software mod]] of [=Porygon2=], with [[FloatingLimbs its limbs, head and neck disconnected from its body]] and its idle animation consisting of convulsing erratically.

* Villains and protagonist alike of ''VideoGame/{{Prototype}}'' fall into this; the Redlight virus is designed to warp living human flesh into configurations that would be more useful. The protagonist also has the same charming feeding habits as Aptom of ''Manga/{{Guyver}}'': he absorbs beings into himself, preferably ''while'' they're alive, most frequently humans, to heal himself and gain their abilities, their skills, their appearances - and their memories.

** ''VideoGame/QuakeIV'' is positively rife with body horror, from apparently living human chests with computers for heads attached to walls and the Strogg medical facility level, where the player has to watch helplessly - from first-person perspective, no less - as Cpl. Matthew Kane gets a painful-looking injection of steroids, has his ''legs cut off with a buzzsaw'' and new cybernetic legs attached as well as a neural implant stabbed into his brain. The fact that you see all of this happen to another prisoner before you (and hear his screams) does not make it any less horrifying, either. Perhaps the most unsettling sight is that of Kane's bloody leg-stumps quivering after his legs have been amputated. The scene (not for the faint of heart) is [[https://www.youtube.com/watch?v=5HH-MqsB8L4 here]] if you want to see it.

** It's still possible for living humans to be converted into the Draug, as was the case with the unfortunate Joe Slater. [[spoiler: Having been directly exposed to the polluted seas around the Isle of Dead Ships, he's been infected with a dose of the original Filth strain that transformed the first Viking converts; by the time you catch up with him, his left arm has been distorted into massive club of bone and coral, his right arm is covered in wriggling tentacles, and his face is pockmarked with what look like barnacles. According to the Buzzing, his internal organs are being taken over by various species of coral, and forms of sea life are living in his body cavities. Plus, judging by the VaderBreath, he's having trouble breathing on dry land.]]
** The Filth. Dear god, the Filth. Quite apart from being a MysticalPlague derived from the thoughts of {{Eldritch Abomination}}s, the symptoms are nowhere near as simple as the tarry skin and writhing tentacles you commonly see in most infectees: Dr Klein and Dr Schreber have been exposed so long that their bones and skulls are stretching out of shape - the latter looking like a monstrous parody of a gorilla, the former looking like someone tried to crossbreed a human with a [[Film/{{Alien}} Xenomorph]] [[spoiler: probably because he's been injecting the Filth directly into his brain]]. Once again, the Buzzing brings home the goods on other cases, in one case involving a woman covers in boils that explode to reveal new eyes, and another involving a trucker who carved alien runes onto his face, resulting in his head "blossoming into a bouquet of lampreys."

** The Rakshasa are hideously pitiable already, what with all the thorny bindings worked through their flesh and over their eyes... but then you meet the Machine Tyrants - an entire group of Rakshasa [[FusionDance fused into a single giant multi-headed monstrosity]].
** The experiments at the Nursery. Dr Schreber managed to make use of some of the most dangerous phenomena in the Secret World and apply them to ''children.'' There's Filth exposure; there's [[FesteringFungus parasitic fungi]]; there's [[TransformationOfThePossessed demonic possession]]; there's the attempt to make child-lycanthropes into monsters who can transform into ''anything'' - and the giant misshapen [[ComicBook/TheIncredibleHulk Hulk]]-like ''thing'' haunting the forest as a result... and when one of the mutilated kids comes shambling up to [[spoiler: Lilith]] for a hug, you'd be forgiven for wondering if the ensuing NeckSnap counts as a KickTheDog moment or a MercyKill.
** A comparatively mundane example crops up in one of the Halloween 2014 stories, in which a vain woman disfigured by smallpox pesters a Wabanaki shaman for a cure. Having lost his entire family to the same outbreak, the shaman is not pleased at being bothered in his time of mourning - but gives the woman an ointment that he promises will [[ExactWords make her skin smooth]] again. And after applying it to her body, the woman finds too late that the ointment was decidedly acidic. But hey, at least it smoothed out her skin... ''right before the whole thing sloughed off''.

** Speaking of failed fusions, in ''VideoGame/ShinMegamiTenseiIV'' [[spoiler: in a certain room in Camp Ichigaya in Infernal Tokyo, you see a couple of demons talking to each other and find out that one of them is a failed result of making a Demonoid, resulting in a low tier demon that is irreversible. Also during the endgame, Walter fuses with Lucifer to help the later regain his full powers. In the Neutral and Law paths, during the second part of the fight with him, his left gauntlet breaks off revealing that Walter's body had not completely sublimated into Lucifer, leaving a twitching, fetus like tumor]].

* ''Franchise/SilentHill'' games:
** ''VideoGame/SilentHill1'': Doctors, Nurses and [[spoiler: Cybil, when you have to fight her in the Amusement Park]] have all been taken over by some manner of PuppeteerParasite, but the former two have hideous fleshy growths on their backs, resembling massive tumors. Oh, and unlike other monsters in the franchise, they are heavily implied to be real people dragged into the Otherworld and repurposed by Alessa, as opposed to apparitions or creations of Silent Hill made whole cloth.

* Dark Gaia's OneWingedAngel-form from ''Videogame/SonicUnleashed'' is probably the goriest thing ever shown in a ''[[Franchise/SonicTheHedgehog Sonic]]''-game. [[spoiler: Its jaw splits across its entire head as it roars loudly. It grows two extra pairs of arms, which burst out of its sides with audible cracks and LOTS of AlienBlood. It gains seven more eyes, [[EyesDoNotBelongThere which are all positioned in its mouth]] and surrounded by WAY too many tongues]]. All of this is shown in [[{{Squick}} very gross]] detail.
* Despite being a comedy series, ''VideoGame/{{Space Quest IV|Roger Wilco and the Time Rippers}}'' had a terrifying one with the "modified" survivor on Xenon's blighted surface. Wandering in a daze, yellowed skin, clothed in rags, headgear that forces the eyes to never shut, and only able to utter screams. ''VideoGame/{{Space Quest V|The Next Mutation}}'' also had the effects of the Primordial Soup - victims literally erupting in pus-filled boils and their bodies melting into unrecognizable piles of goo if left untreated.
* ''Spirit Hunter'' series:
** All of the spirits in both ''VisualNovel/SpiritHunterDeathMark'' and ''VisualNovel/SpiritHunterNG'' have been hideously warped from their previous humans forms- while most of them still look {{humanoid|Abomination}}, they often have warped, disproportionate limbs and/or non-human traits like arm whips, animal teeth, etc.

* In ''VideoGame/StarFoxAssault'', Pigma undergoes [[spoiler:a horrific transformation at the hands of the Aparoids, in which he is assimilated into a spacecraft, turning his whole body into a giant, mutilated, vaguely cybernetic (but mostly organic-looking) pig's face, kept safe in a metallic cube which can open and close, hiding or revealing said face]]. He then later shows up in ''Command'' in an alternate, still pretty weird form - but fortunately, it's much less creepy (and [[AntiClimaxBoss easier to defeat]]).

** ''VideoGame/ThiefIITheMetalAge'' gives us the Servants. The look like cleverly-built humanoid robots and are sold as such to the City's nobility. Underneath the masks and suits are mutilated vagrants, prostitutes, and others deemed as 'scum' by the villains, forced into servitude by their mechanical masks - you can hear them sobbing and whimpering to themselves. Their existence is so horrific that some of them thank you as they die. Related is the necrotic mutox, also called Rust Gas. It reduces any organic material it touches to something resembling rust, and it will grow until it runs out of organic matter to consume. You never actually witness its effects on a living person... but you do hear them...

*** There are also the remains of the former inmates of the orphanage that was also an insane asylum (simultaneously). They're mummified corpses - but when alive, their hands and heads were locked in wire cages to keep them from harming themselves or anyone else. Now that they're dead, the alien consciousness of the institution puppets them in a freakish, twitching parody of their old lives even as they rot.

** The Damned, a group of hooded, masked men who lurk underground, have, thanks to Sophia's experiments, been left with their flesh constantly rotting - [[AFateWorseThanDeath and immortal, as they discovered when none of their suicide attempts worked]].
** The RX-Tech mine workers have mutated into hideous (and violent) creatures due to the energies from the meteorite. They are among the most unsettling enemies in the game. Then there's [[spoiler: Dr. Willard]]'s boss form...

* In ''VideoGame/TronTwoPointOh'', a User digitized without the necessary safety features or correction algorithims becomes ''horribly'' twisted. Thorne is more or less a living computer virus, and the trio of F-Con execs who decide to take matters into their own hands end up fused into a single, three-headed creature of mix and match parts.

** Ming Xiao, the head of the Los Angeles [[OurVampiresAreDifferent Kuei-Jin]], [[spoiler: turns into a huge red blob with tentacles and then proceeds to beat the shit out of you]].

* In ''VideoGame/XenobladeChronicles1'', the [[spoiler: High Entia]] are subjected to a similar fate as the humans in ''VideoGame/{{Xenogears}}'' when [[spoiler: Zanza]] exposes them to high levels of ether, triggering the genes that cause them to degenerate back into their primordial form of [[spoiler: Telethia]].

%% * ''VideoGame/{{Siren}}'' is rife with examples of this.

* ''VideoGame/TheBindingOfIsaac''. Everything, including the protagonist Isaac, and the enemies he fights. The "power-ups" in this game are indeed power-ups, but they come with a serious price. Burning off one side of his face with toxic chemicals. Injecting himself with dubious substances. Live flies popping out of his body to attack his enemies. Growing giant twisted demon horns and firing a bloody laser beam from your mouth. All this...and Isaac has been confirmed by WordOfGod to be 5 years old...

* The ''VideoGame/{{Fallout}}'' series is all over this trope like it owes it money.

* ''VideoGame/{{Contra}}'' is no stranger to horrendous alien creatures, but ''Hard Corps'' goes for this in one route: [[spoiler: Colonel Bahamut ''injects himself'' with the Alien Cell, granting him immense power, but as the fight goes on it becomes clear the cell is taking over him, transforming him into a disturbing twin-headed beast (one head at each end), and then into a beating heart surrounded by spheres with screaming faces on them.]]