History ArchEnemy / MarvelUniverse

* [[ComicBook/TheMightyThor Thor]] has Loki, who has long served as CainAndAbel in his conflicts with Thor, though with the debut of the Marvel Cinematic Universe and Loki's move to a more morally ambiguous status as a result the position as Thor's most hated foe is possibly open. Of the possible replacements for Loki, Malekith has made the best showing in the post Cinematic Unvierse age (chopping off Thor's arm and setting off ComicBook/WarOfTheRealms is a solid resume), though if he'll manage to take the position from Loki, or share it with Loki, is to be determined.

** Only one villain has truly rivalled Loki's position as Thor's nemeis, that being [[BreakoutVillain Gorr the God Butcher]] from ''ComicBook/ThorGodOfThunder2012''. A god-slaying atheist turned misotheist and shakespearean tragedy, he hates Thor more than ever other villain has done in Marvel's history while Thor in turn admits Gorr is one of the most despicable and chilling foes he's ever faced, to the extent where he's one of the few things the Prince of Asgard genuinely fears.

* ''Film/SpiderManTrilogy'': [Characters/SpiderManTrilogySpiderMan Spider-Man]] has several over the course of the trilogy.

* ''Film/SpiderManTrilogy'': Spider-Man has several over the course of the trilogy.
** The Green Goblin, the first supervillain who Spider-Man fought, tried to [[WeCanRuleTogether recruit Spider-Man to his side]], and than tried to kill him when he refused. After discovering Spider-Man's SecretIdentity as Peter Parker, the Green Goblin tried to hurt Peter by attacking his aunt May, and later by kidnapping Mary Jane and dropping her off a brige. [[spoiler:Even after the Green Goblin's death, his influence lives on in his son Harry, who seeks [[AvengingTheVillain revenge on Spider-Man for his father's death]]. Goblin returns in ''Film/SpiderManNoWayHome'' just to affirm the fact (after killing MCU Aunt May and forcing her nephew Peter Parker to make everyone forget he exists), no matter what universe the Green Goblin is ''every'' Spider-Man's ArchEnemy.]]
** Doctor Octopus, a scientist who Peter admires before his turn to crime. Spider-Man confronts Doctor Octopus when the latter is in the process of robbing a bank, and Doc Ock takes May as a hostage and drops her. Later in the film, he kidnaps Mary Jane and threatens to kill her to draw Spider-Man out of hiding, and after Doc Ock captures to Spider-Man, he turns Spider-Man over to [[spoiler:Harry Osborn (who wants to kill Spider-Man himself)]], while keeping Mary Jane as a hostage to prevent her from going to the authorities.

** Magneto (Erik Lehnsherr) to Charles Xavier. The two men [[WeUsedToBeFriends were once best friends]] and still have massive respect for each other, often lamenting that their [[FriendlyEnemy friendship]] isn't enough to overcome to diametrically opposed worldviews, as Magneto believes that a war between mutants and humans is inevitable and seeks to commit his own genocide against humankind [[DoUntoOthersBeforeTheyDoUntoUs before]] they have the chance to wipe out the mutants, while Charles believes humanity and mutants can live together in harmony, with the X-Men's primary goal usually being to stop Magneto's Brotherhood of Mutants from killing innocent people.
** Colonel William Stryker to Wolverine. Stryker was the man who recruited Wolverine into Team X and later tricked him into the procedure that gave him his adamantium skeleton in order to turn him into a living weapon before causing Wolverine's amnesia, turning him into the bitter, jaded cynic he is in the present. In ''Film/X2XMenUnited'', Stryker shows disdain for Wolverine's attempts to redeem himself, telling him that he is and always has been an animal, while in ''Film/XMenDaysOfFuturePast'', the mere sight of a younger version of Stryker is enough to send Logan into a HeroicBSOD as he remembers all the pain Stryker will cause him in the future.

** ''Film/{{Deadpool|2016}}'': Francis Freeman/Ajax to Wade Wilson/Deadpool. Ajax is responsible for subjecting Wade to horrific experiments and disfiguring him in order to unlock his mutant powers, before having him tortured purely ForTheEvulz and attempting to sell him into slavery. The entire film revolves around Deadpool's quest for revenge on Ajax, and in the climax, Ajax kidnaps Wade's girlfriend Vanessa and attempts to subject her to the same torture he used on Wade. [[spoiler:When Colossus tries to convince Deadpool that sparing Ajax's life would be the heroic thing to do, Deadpool coldly shoots Ajax in the head and declares that he couldn't care less about being a hero if it means letting monsters like Ajax live]].

!!Comic Books

** ComicBook/{{X 23}} and Kimura: Both were victims of physical and emotional abuse and lost the person who could have helped them recover, but while X chose to heal, Kimura uses it as an excuse to hurt others. Kimura is also physically invulnerable, so Laura is unable to defeat her in a direct fight.

** The Green Goblin, the first supervillain who Spider-Man fought, tried to [[WeCanRuleTogether recruit Spider-Man to his side]], and than tried to kill him when he refused. After discovering Spider-Man's SecretIdentity as Peter Parker, the Green Goblin tried to hurt Peter by attacking his aunt May, and later by kidnapping Mary Jane and dropping her off a brige. [[spoiler:Even after the Green Goblin's death, his influence lives on in his son Harry, who seeks [[AvengingThevillain revenge on Spider-Man for his father's death]]. Goblin returns in ''Film/SpiderManNoWayHome'' just to affirm the fact (after killing MCU Aunt May and forcing her nephew Peter Parker to make everyone forget he exists), no matter what universe the Green Goblin is ''every'' Spider-Man's ArchEnemy.]]

** Venom, an alien symbiote who bonds with Peter, becoming a corrupting influence on him throughout much of the third film. After Peter seperates himself from the symbiote, it bonds with Eddie Brock, a disgraced photagrapher with a vendetta against Peter for [[NeverMyFault costing him his job]] at the ''Daily Bugle'' and for dating Gwen Stacy, who Eddie has a crush on. After bonding with Brock, Venom allies himself with the Sandman, kidnaps Mary Jane, and [[spoiler:mortally wounds a [[HeelFaceTurn redeemed]] Harry.]]
** The New Goblin, a.k.a. [[spoiler:Harry Osborn, Peter's EvilFormerFriend who seeks revenge against Peter, believing that [[YouKilledMyFather he killed Harry's father]]. In order to hurt Peter emotionally, Harry intimidates Mary Jane into breaking up with him.]]

* ComicBook/CaptainAmerica has the ComicBook/RedSkull (one of the oldest villains) and the [[ComicBook/BaronZemo Barons Zemo]] (both the father Heinrich and son Helmut). In ComicBook/UltimateMarvel, he has Herr Kleiser.

** In Deadpool's backstory, Dr. Killebrew used Wade as a human test subject with the sadistic assistance of his [[TheHeavy strongarm]] Francis Fanny aka Ajax [[labelnote:film]]In the first ''[[Film/Deadpool2016 Deadpool]]'' film, he and Dr. Killebrew became the {{composite character}} renamed Francis Freeman aka Ajax[[/labelnote]]. Wade was DrivenToSuicide by the unending medical torture and fell in love with Death herself, but his repeated attempts to "join" her were thwarted to keep him alive for more experiments. Then Wade realized he could provoke "Francis" into killing him. It worked too well; Ajax murdered other patients to torment Wade, then ripped out Wade's heart. Wade's desire for vengeance kept him from Death's embrace; his heart regenerated, but his sanity was broken. Wade became "Deadpool" and seemingly killed Ajax. In Kelly's ''Deadpool'' run, Ajax resurfaces and kills Deadpool-- but Deadpool has PurposeDrivenImmortality to kill Ajax. Wade's [[VengefulGhost old murdered friends]] believe Deadpool's vendetta is their UnfinishedBusiness, and they goad him into dropping his ongoing non-murdering hero attempts so he'll fulfill his destiny and kill Ajax. Years later, Francis comes back ''again'' when Thanos and Deadpool clash over Death.

** ''Film/{{Deadpool}}'': Francis Freeman/Ajax to Wade Wilson/Deadpool. Ajax is responsible for subjecting Wade to horrific experiments and disfiguring him in order to unlock his mutant powers, before having him tortured purely ForTheEvulz and attempting to sell him into slavery. The entire film revolves around Deadpool's quest for revenge on Ajax, and in the climax, Ajax kidnaps Wade's girlfriend Vanessa and attempts to subject her to the same torture he used on Wade. [[spoiler:When Colossus tries to convince Deadpool that sparing Ajax's life would be the heroic thing to do, Deadpool coldly shoots Ajax in the head and declares that he couldn't care less about being a hero if it means letting monsters like Ajax live]].

ArchEnemy in this series.
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!!Comic Books

** A case can also be made for Damon Dran. Who just never stays ''dead''!

* In ''ComicBook/DaredevilEndOfDays'', all of Daredevil's show up, and four of them (Fisk, Bullseye, the Owl, and Killgrave) [[spoiler:wind up gruesomely murdered]]. [[AssholeVictim Your heart bleeds for them.]]

* ''ComicBook/{{Deadpool}}'': T-Ray, Ajax, Dr. Killbrew, Black Swan, and Madcap.

* ''ComicBook/TheIncredibleHulk'': The Hulk has the Leader, the Abomination, Thunderbolt Ross, M.O.D.O.K., the Maestro, Brian Banner, Tyrannus, and the One Below All. One could even make a case about Hulk being [[EnemyWithin Banner's.]]

** M.O.D.O.K. turned Betty Ross into the Harpy, and later, while allied with the Leader, had a hand in [[spoiler:turning Thunderbolt Ross into the Red Hulk, and Betty Ross into the Red She-Hulk.]]

** Tyrannus is a Subterranean EvilOverlord who kidnapped Betty Ross and enslaved the Hulk in his (Tyrannus') first appearance. He later manipulated the Hulk in aiding him in [[EvilVersusEvil his war against the Mole Man]] through his robotic minion Mogol, who the Hulk befriended until discovering Mogol was a robot, after which he destroyed both Mogol and Tyrannus's city.

** Magneto (Erik Lehnsherr) to Charles Xavier. The two men [[WeUsedToBeFriends were once best friends]] and still have massive respect for each other, often lamenting that their [[FriendlyEnemy friendship]] isn't enough to overcome to diametrically opposed worldviews, as Magneto believes that a war between mutants and humans is inevitable and seeks to commit his own genocide against humankind [[DoUntoThemBeforeTheyDoUntoUs before]] they have the chance to wipe out the mutants, while Charles believes humanity and mutants can live together in harmony, with the X-Men's primary goal usually being to stop Magneto's Brotherhood of Mutants from killing innocent people.

** Brian Banner is the Hulk's ArchnemesisDad and his mother's killer. Although Bruce killed him before he ever became the Hulk, his actions left a huge psychologial impact on Bruc. Brian himself was briefly resurrected during the ''Chaos War'', and fought the Hulk during this time. Brian returns as a major antagonist in ''Immortal Hulk'' as an ally for the One Below All.
** Tyrannus is a Subterranean EvilOverlord who kidnapped Betty Ross and enslaved the Hulk in his (Tyrannus') first appearence. He later manipulated the Hulk in aiding him in [[EvilVersusEvil his war against the Mole Man]] through his robotic minion Mogol, who the Hulk befriended until discovering Mogol was a robot, after which he destroyed both Mogol and Tyrannus's city.

** Film/{{Deadpool}}: Francis Freeman/Ajax to Wade Wilson/Deadpool. Ajax is responsible for subjecting Wade to horrific experiments and disfiguring him in order to unlock his mutant powers, before having him tortured purely ForTheEvulz and attempting to sell him into slavery. The entire film revolves around Deadpool's quest for revenge on Ajax, and in the climax, Ajax kidnaps Wade's girlfriend Vanessa and attempts to subject her to the same torture he used on Wade. [[spoiler:When Colossus tries to convince Deadpool that sparing Ajax's life would be the heroic thing to do, Deadpool coldly shoots Ajax in the head and declares that he couldn't care less about being a hero if it means letting monsters like Ajax live]].

* ''Film/XMenFilmSeries''
** Pyro to Bobby, of the WeUsedToBeFriends variety.
** Victor Creed to Wolverine in ''Film/XMenOriginsWolverine'', although the series as a whole places considerably more focus on the animosity between Wolverine and William Stryker.
** Magneto (Erik Lehnsherr) to Charles Xavier. In this case, it's an example of WeUsedToBeFriends.
** Deadpool and Ajax.