Unconventional city horror game setting

I am looking for cities that don't have much exposure in media but would allow for good stories and gameplay.

The game itself: 1. The people are under siege by inhuman creatures.( I am hashing some ideas on this front.) 2. The people are also divided into factions that at times cooperate for their survival and at other times are at war with each other.( One idea was very early on part of the city was abandoned by the police allowing an alliance local gangs to take over. The gangs extort those within the area for resources and try to keep the local area clear. Some of the other factions try to get you to create a civil war between the gangs.) 3. The city itself will form a smallish open world sandbox. This includes the suburbs an some rural areas on the outskirts. (Sandboxes are only as good as your ability to traverse them and I plan on keeping the player confined to on-foot.)

These are the aspects I am solid on at this point. Others are still up in the air.

Don't be afraid to bring up any small city or large town from anywhere.

4. Each section of the city should be easy to navigate and be visually district.(I have made a decision to remove GPS, minimaps, and onscreen compasses. The only map will be an old school paper map that you have to pull out and deduct your location and routes manually with. I will also include street names and numbers that can deduced from the environment. I want to encourage learning the city and give a sense of challenge and immersion in navigating the location.)

Sounds really interesting to be honest.