Since the new You Know That Show doesn't have a Video Games option...

There was a game mentioned on here somewhere that was described as being something like a "Roguelike in Space", where you head farther and farther out into space, upgrading your ship along the way and fighting various opponents and such. I can't find any reference to it anymore, and can't remember the title. Can anyone help?

You can still ask about games on YKTS, it's just a glitch no one bothered to fix.

Could it be Transcendence

That sounds about right, yes.