Possible cure for AIDS?:

Total posts: [37]
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WHARRGARBL
Ok, I'm sorry to tell you all, but the whole "guy with leukemia gets bone marrow transplant, is cured of his HIV" thing is pretty old news, and it will never work on a large scale because:

1) This gene is rare, and bone marrow donors with this gene are even rarer. You'd have to wait for a transplant that not only has this gene, but is a match for you... you'll probably die of AIDS faster than you find someone.

2) Bone marrow transplants are extremely risky procedures (10% chance of death, even greater chance of complications) and is only used as a last resort (like if you're in the late stages of leukemia).

Nothing to get excited about here, folks. That one guy was literally just a fluke, nothing more.

Now stem cells, that might be promising, but I haven't seen any studies about that yet.

edited 19th May '11 6:06:44 PM by zoulza

27 Deboss19th May 2011 06:59:34 PM from Awesomeville Texas
I see the Awesomeness.
Couldn't the first one be fixed with genetic engineering? It might not work for anyone infected, but it would immunize future generations.
28 Barkey19th May 2011 08:57:59 PM from Bunker 051 , Relationship Status: [TOP SECRET]
War Profiteer
There's been talk of cloning stem cells and organs, can we clone bone marrow?
The AR-15 is responsible for 95% of all deaths each year. The rest of the deaths are from obesity and drone strikes.
29 Deboss19th May 2011 11:01:48 PM from Awesomeville Texas
I see the Awesomeness.
Hm, I'm not sure. It's been a long ass time since biology, I want to say bone marrow isn't set up like a normal organ and is more more of a goo than an actual organ. On one hand, that would make it easier to copy since you don't have to worry about how the cells are arranged as much, on the other, it's much harder to find active parts to experiment with.
Compulsive Researcher
The CCR 5-delta32 mutation apparently has a negative effect on T cell function, which explains why it isn't universal in the first place (also apparently reduces resistance to West Nile virus), but AIDS reduces T cell function rather a lot more, so this sounds effective . . .

Also, turns out researchers started a clinical trial of taking cells out of the body, modifying them so they carry the delta-32 mutation and putting them back in . . . in 2009. Let's hope it works and is proven safe (or at least safer than having AIDS).

"Human genetic modification" is currently called "gene therapy", and mostly used to treat diseases resulting from single-gene mutations, but it's definitely a thing that happens. It basically consists of what I described above but with other sorts of cells and mutations.
I want Kat's glasses!
Is it possible to make a cell cultivation of bone marrow?
Grandma, what big teeth you have! It would be a shame if anything happened to them.
32 Usht20th May 2011 02:20:17 AM from an arbitrary view point.
Lv. 3 Genasi Wizard
Nice, and this method should be pretty refine-able into a cheap process in the coming years. Good news in general.
The thing about making witty signature lines is that it first needs to actually be witty.
33 Deboss20th May 2011 02:22:28 AM from Awesomeville Texas
34 Usht20th May 2011 02:24:40 AM from an arbitrary view point.
Lv. 3 Genasi Wizard
You've got a person here who's the friend of several med students.

edited 20th May '11 2:36:39 AM by Usht

The thing about making witty signature lines is that it first needs to actually be witty.
35 Barkey20th May 2011 02:30:55 AM from Bunker 051 , Relationship Status: [TOP SECRET]
War Profiteer
Guess it'll have to do.

QUICKLY DEBOSS, FOR SCIENCE!
The AR-15 is responsible for 95% of all deaths each year. The rest of the deaths are from obesity and drone strikes.
36 Deboss20th May 2011 02:38:26 AM from Awesomeville Texas
I see the Awesomeness.
I assume you're proposing dissection. For SCIENCE!

Or possibly some sort of explosion.

edited 20th May '11 2:38:47 AM by Deboss

37 Barkey20th May 2011 02:52:42 AM from Bunker 051 , Relationship Status: [TOP SECRET]
War Profiteer
Sure, long as I get to perform the exploding and the dissection involved high velocity ammunition.
The AR-15 is responsible for 95% of all deaths each year. The rest of the deaths are from obesity and drone strikes.
The system doesn't know you right now, so no post button for you.
You need to Get Known to get one of those.

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