History Main / TheImmune

* In ''VisualNovel/HigurashiWhenTheyCry'', Rika. [[spoiler:She's immune to Hinamizawa Syndrome and medicine is derived from her blood.]]
* [[spoiler: Marco]] and [[spoiler: Zeus]] are immune to the Medusa Virus in ''Manga/KingOfThorn'' because [[spoiler:they are too confident in themselves for it to find a crack in their psyches to infect.]]
* This is part of the premise of ''Manga/DoubleArts'', in which the world has been decimated by a mysterious plague (a plague with no permanent cure). While there is a small percentage of [[AlwaysFemale young women]] who possess a tolerance to the disease, it is only the protagonist, a young man named Kiri Luchile, who is truly immune to its effects [[spoiler: and even has the capability to nullify the disease when it reaches its final stage; [[HealingHands by physically touching the infected person,]] Kiri can effectively halt the progression of the plague and stave off the infected person's death, but ''only'' so long as he holds on to them. This is a major plot point.]]

* ''Manga/MyHeroAcademia'': Not exactly a plague, but One for All is the only quirk immune to All for One's quirk-stealing abilities, because it can only be transferred between holders willingly. A great deal of All For One's plans revolve around finding a way around this so he ''can'' take One For All for himself.
* ''Manga/MusukoGaKawaikuteShikataganaiMazokuNoHahaoya'': The main reason humans were able to decisively end the war with demonkind was through the creation of a gas that prevents demons using their powers to "Demonify" and make themselves stronger. Part of TheReveal of the identity of baby Gospel's father is that his special ability as a demon is [[spoiler:the creation of a poison that nullifies other demons' abilities, which was used as the basis for the anti-demonification gas]] and that Gospel, as a consequence, [[spoiler:is potentially resistant or immune to the one thing that's maintained peace between the two races]]. When chapter 163 confirms that [[spoiler:Gospel has potential immunity to the A.D. gas]], it causes everyone to panic and work with their doctor to cover it up but, at best, it's only going to buy time before someone notices, at which point the characters fully fear [[spoiler:humanity ''and'' demonkind will start hunting for Gospel]]. The threat ends up coming from the latter direction, however, as [[spoiler:Gospel's doctor, Veronica, is part of Crown's faction and assists in a kidnapping of Gospel when Lorem refuses her offer to join Crown's demon nation]].

* The reason everybody was looking for Ray Palmer in ''ComicBook/CountdownToFinalCrisis''
* This is a plot point in the ''ComicBook/SpiderMan'' arc ''Maximum Clonage'', in which one person survives the test run of the Jackal's virus
* The ''ComicBook/BatmanContagion'' story had a series of these, each typically revealing that [[ThereIsAnother there was one other person]] just before dying (and rendering the antibodies in their blood immediately useless).
* Yorick and Ampersand, the only males to survive the {{Gendercide}} in ''ComicBook/YTheLastMan'', [[spoiler:or so they thought]].

* In ''ComicBook/{{Venomized}}'', the Anti-Venom symbiote proves not only immune to Poison infestation, but [[TouchOfDeath instantly lethal to the smaller Poisons and able to one-shot even the huge ones with effort]]. Unfortunately, it is only immune to ''infestation''; other Poison weapons still work on it - as shown when Anti-Venom starts getting smug about it, and Poison Thanos immediately slams an energy blast into him.
* 1373 Lucifer in ''ComicBook/TheWickedAndTheDivine'' could not contract the plague. However, she may potentially be a TyphoidMary, or at least, she ''believes'' herself to be a TyphoidMary.

* Lelouch becomes this in ''Fanfic/KnightOfDeathAndRebirth'' as he's the only one to [[spoiler:resist and even reverse the effects of demonic energy]].

* Downplayed with Olive, Otto, Oprah, Oscar and Dr. O in ''Fanfic/MyDreamIsYours''. Catching Dream-Transfer-itis makes one automatically immune to the odd disease after they're cured of it, and as such, neither of them can catch it again. Olympia, Otis, Oona and a host of other agents, on the other hand, are not immune because they've never caught the disease before.
* In ''Fanfic/AtTheEdgeOfLasglen'', the Elves are all naturally immune to the [[spoiler:plague that wipes out most of humanity in 2037]]. Around ten percent of humans are immune as well.

* Alice in ''Film/ResidentEvilExtinction''. It doesn't have any actual bearing on the plot, mind; it's just exposited by the White Queen at the end. Given Umbrella bonded her with the T-Virus at the end of ''Film/ResidentEvilApocalypse'', it makes sense that she is immune. She's ''already'' infected.

* The protagonist of ''Film/IAmLegend'' is one of the few humans that are immune to the disease. He spend the next three years trying to synthesise a cure out of his blood for the humans that instead mutated into the feral Darkstalkers. [[note]]In the 2007 film he's not the only immune survivor, in every [[Film/TheLastManOnEarth other]] [[Film/TheOmegaMan adaptation]] of the [[Literature/IAmLegend book]] he is the last uninfected human, ever.[[/note]]
* Not true immunity, but in ''Film/TwentyEightWeeksLater'' both the wife and the son are infected by the Rage Virus, but show no symptoms, instead becoming carriers. It's implied that it has something to do with the fact they have heterochromic eyes.
* In ''Film/{{Skinwalkers}}'' the key to curing lycanthropy are the antigens in a half-werewolf, half-human boy's blood.
* Joanie in ''Film/WarningSign'' is immune to the bio-engineered HatePlague because she's the only pregnant woman in the quarantined facility; the special hormones in her blood is what keeps her safe and is the basis of the cure. WhatDoYouMeanItsNotSymbolic?
* In the SoBadItsGood movie ''Film/RobotMonster'', the only people who are left alive after the alien invasion are the friends and family of a middle aged scientist who'd dosed them all with a cure-all serum. (Initially though, the scientist thinks it's a protective electric barrier he erected that staved off the alien's attack.)
* In ''Film/Contagion2011'' Mitch Emhoff turns out to be naturally immune.
* The doctor's wife in ''Film/{{Blindness}}'' is the only one whose eyesight is retained in the mysterious blinding epidemic.
* ''Franchise/PlanetOfTheApes'':
** Of the few surviving humans in ''Film/DawnOfThePlanetOfTheApes'', it's stated that most are immune to ALZ-113/Simian Flu.
** Though [[Film/WarForThePlanetOfTheApes the sequel]] reveals that they're only immune to the baseline simian flu not to a [[spoiler:mutated strain that robs humans [[TheSpeechless of speech]]]].
* The plot of ''Film/PokemonDetectivePikachu'' involves a gaseous PsychoSerum called R, which temporarily shuts down a Pokémon's higher cognitive functions and drives them into a berserk rage. Detective Pikachu ends up inhaling the stuff at multiple points but is never affected (though the movie never draws direct attention to this). [[spoiler:That's because he's actually a FusionDance of Pikachu and Tim's father Harry. Since his mind isn't that of a Pokémon, it can't affect him.]]
* ''Film/BloodQuantum'': All native people are immune to the zombie virus. Due to this, native Canadians on a reservation fight off the zombies and aid the survivors.

* A big focus of ''Literature/TheAndromedaStrain'' was finding out why two people were immune to the disease when everyone else died. What made it interesting was that they were [[spoiler:immune for similar, yet different reasons. The old man was an alcoholic, so his blood pH was acidic, and the baby was hyperventilating through crying, which made his blood pH alkaline. Turns out the Andromeda Strain could only survive within a narrow pH range]].
* In ''The Changeling Plague'', [=IdahoBlue=] was one of these for a previous disease epidemic (though not the titular one)
* In ''Chasm City'' of Creator/AlastairReynolds' [[Literature/RevelationSpaceSeries Revelation Space]] universe, the cure for the Melding Plague, called Dream Fuel, turns out to be blood harvested from an alien with natural immunity
* Dr. Robert Neville in the book and virtually every adaptation of ''Literature/IAmLegend''. In the book, it's a weird bacteria causing the vampires, but it doesn't affect Neville. (The bacteria is sensitive to sunlight and garlic.)

* Creator/JoseSaramago's ''Literature/{{Blindness}}'' follows the one woman immune to the plague of blindness.
* In ''Literature/OryxAndCrake'', Snowman aka Jimmy believes that he is the only human left in the world after a man-made hemorrhagic virus destroys humanity in a matter of weeks. He inadvertently gained immunity some time before the outbreak of the pandemic via a vaccine created by his friend [[MadScientist Crake]].
* Everyone who lives through the first act of ''Literature/TheStand''. Captain Trips' initial symptoms resemble a cold or flu, so many don't realize how sick they are without a doctor who knows what to look for, meaning the plague rapidly knocks out 99% of humanity.
* Every character in George R. Stewart's ''Literature/EarthAbides'' is immune to the plague for one reason or another - which is only reasonable, since all the non-immunes die within the first few pages.
* In ''Literature/DiarioDeUnZombi'' Paula is immune to the zombie virus, a major plot point since finding out why can save the human race.
* In ''Literature/TheLordOfTheRings'', Tom Bombadil is the only being completely unaffected by the One Ring (it cannot even make him vanish when he puts it on his finger), implied to be because there is nothing he desires in the world that the Ring can tempt him with. The Council of Elrond considers giving the Ring into his keeping because of this, but the problem is that the very cause of this immunity means he wouldn't be a good guardian--he wouldn't be able to appreciate how important the Ring is and would casually toss it aside and forget about it. As Tom doesn't seem to fit anywhere into Middle-Earth's greater cosmology (only really becomes apparent if you read ''Literature/TheSilmarillion'', where the connectedness of everything else is laid out), it's possible that the Ring doesn't work on him because he is somehow ''outside'' its influence.
* ''Literature/TheMazeRunner'': In ''The Death Cure'', it is revealed that most of the kids who were part of WICKED's Trials, along with a very small percentage of the world's population called [[ExactlyWhatItSaysontheTin "Immunes"]], are immune to the Flare. WICKED took them from their families because they wanted to study their brains in the hope that this would eventually lead to a cure. The few among them who are not immune were chosen as control subjects.
* In ''Literature/{{Divergent}}'', [[spoiler:Tris]] is able to resist serums, like most Divergents. [[spoiler:She is notably able to fight off Candor's truth serum in ''Insurgent'' and cannot be killed by the Bureau's death serum in ''Allegiant''. At multiple points, it is mentioned that her ability to resist is beyond that of most Divergents]].
* In ''Literature/{{Peeps}}'', Carriers for some unknown reason get the benefits of the parasite that causes "vampirism" while still managing to remain sane. Night vision, super strength, and long lifespans without the urge to commit cannibalism (just a craving for rare meat and a high libido) or aversion to everything they loved before infection. Unfortunately, they can transmit the parasite with as little as a kiss; those who work as hunters usually start out with their exes.
* ''Literature/TheExpanse'': In ''Cibola Burn'', an alien microbe blinds everyone on Ilus...except for Holden, who consequently ends up doing all the vision-critical jobs around the colony until a cure is found. [[spoiler:It turns out to be his anti-cancer drugs. When they ask if they can borrow his drugs to fix everyone else's vision, which puts him at risk of developing tumors, his response is essentially, "And then I can take a nap?"]]
* ''Literature/TheUnexploredSummonBloodSign'' has a non-physical disease- the [[EldritchAbomination White Queen]]'s influence, which has driven people insane just by seeing her. Everyone has some degree of resistance to it, but Kyousuke [[spoiler:and Shigara]]'s immunity is total. Given time and effort, he can even snap others out of it. Unfortunately, this makes him ''[[HumanPet very interesting]]'' to her.
%% * The ''VideoGame/PerfectDark: Initial Vector'' novel.

** Come to think of it, B'Elanna was also the source of the claimed cure for the Vidiian Phage. Her Klingon half was resistant to the Phage.
* ''Series/{{Heroes}}'': Mohinder's blood carries the cure for the Shanti virus
* A big plot point in the second season of ''Series/DarkAngel'' and the three follow-up novels. The BreedingCult plan to unleash a disease that only they will survive, but Max turns out to possess total immunity
* An episode of ''Series/TheXFiles'' dealt with an oil rig worker who was immune to the alien black oil.
* An episode of ''Series/TerminatorTheSarahConnorChronicles'' revolved around them having to save a woman who will be naturally immune to a disease Skynet engineers to wipe out the Resistance.
* In the BBC series ''{{Series/Survivors}}'' (the 2008 remake/"reimagining"), the last remnants of humanity are those who never caught the "European Flu" or who are naturally immune to it. Abby is the only person to ever develop symptoms but then recover, which causes her to get abducted in the season one finale.
* ''Series/StargateSG1'':
** In "[[Recap/StargateSG1S1E4TheBrocaDivide The Broca Divide]]", [[spoiler:Dr. Fraiser is immune to the virus due to the [[ImprobableAntidote strong antihistamines]] she takes for allergies]]. Daniel Jackson is temporarily immune for the same reasons until he is trapped off-world and no longer has access to his medication.
** In "[[Recap/StargateSG1S3E4Legacy Legacy]]", a contagion that drives Daniel, Jack and Janet insane and threatens Teal'c's life [[spoiler:is treated when it's determined that it was developed to kill Goa'uld in a host, allowing Sam to use the protein marker left by Jolinar to devise a cure]].
* ''Series/TeenWolf'''s Lydia Martin is the only known person who is immune to the bite of a werewolf and the venom of a Kanima. The reason behind this is currently unknown, but it's implied to have something to do with her unexplained ability to sense the supernatural. As of Season 3, we know it's because [[spoiler: she is a Wailing Woman, otherwise known as a banshee]].
* Sam Winchester in ''Series/{{Supernatural}}'' is immune to the [[Recap/SupernaturalS02E09Croatoan Croatoan virus]] (suggested in hindsight to be the result of him possessing demon blood).
* This is part of ''Series/The100'''s backstory. When the nuclear bombs fell, certain people had a natural resistance to radiation, allowing them to survive while the rest of humanity died out. Their radiation immunity was passed on to their descendants, who became the Grounders. This becomes a problem in the second season in particular; the residents of Mount Weather, cut off from the outside world for almost a century, lacked any natural immunity to radiation, and were thus desperate to capture the Grounders or the Ark residents due to their heightened immunity (the Grounders from their time on the surface and the Ark residents through residual exposure to cosmic radiation).
* In ''Series/MyNameIsEarl'', the "Witch Lady" tries to [[SlippingAMickey drug Catalina's tea]], with the intent of storing her in the basement along with all the others she intends to kill [[DisproportionateRetribution for bullying her]]. Catalina gets down into the basement, but explains that she wasn't affected by the drug because [[AcquiredPoisonImmunity so many men have tried to slip her date-rape drugs in the past that she's immune to them]]. She explains that she only pretended to be knocked out and allowed herself to be bagged and tossed in the basement because she felt sorry for the Witch Lady.
* ''Series/TheLastShip'': Most of humanity dies out as a result of a SyntheticPlague, with the eponymous ship going on a mission to develop a cure. In the second season it becomes apparent that a lot more people have a natural immunity than previously thought (around 5% of the population). They start a cult that portrays them as the "chosen people" and set out to kill all non-immunes, led by two immune British brothers who were the only survivors of the nuclear submarine they both served in.
* In ''Series/BeautyAndTheBeast1987'', a Russian immigrant ends up infecting the sewer-dwellers with a deadly disease. Vincent ends up having a natural immunity.
* ''Series/TheBarrier'': Alma, the director of a scientific institute trying to find the cure of the deadly noravirus, is actively keeping an eye out for people who are immune to it. All she's been able to find is [[spoiler:children who have developed antibodies after getting exposed to the virus in the past]].

* ''TabletopGame/DungeonsAndDragons'': Monks and Paladins receive immunity to all diseases once they reach a certain level (which varies depending on the game's edition). Paladins also get the ability to cure non-magical diseases, as well.

* An expensive (and frequently banned) merit in TabletopGame/WerewolfTheApocalypse makes the character immune to contamination by Wyrm taint. The book notes that this will probably lead to some dangerous missions.
* One minor NPC in ''TabletopGame/{{Ravenloft}}'s'' domain of Dementlieu is a man who unknowingly inherited a ''ring of mind shielding''. The mind-controlling villain who secretly controls that nation is aware this man is immune to his powers, and is determined to find out why.

** In this post-apocalyptic "economic horror" RPG, some people are immune to the Blight that causes zombies, and others, called "latents", become carriers after being bitten and become zombies after dying for some other reason. Immunity or latency can be established at character creation or discovered after getting bitten and making a critical success or critical failure on the fort save, respectively.

* ''TabletopGame/{{GURPS}} AfterTheEnd'' offers a possible way to make TheMainCharactersDoEverything in a ZombieApocalypse a JustifiedTrope: Just decree that every PlayerCharacter is immune to the zombie pandemic, thus justifying them being the setting's adventurer.

* ''[[VideoGame/TwelveThirteen 1213]]'': [[spoiler: the protagonist is immune to any disease or poison]], which sets up the horrifying ending.
* ''VideoGame/BlazBlue'' actually downplays this trope. Seithr corruption is a perpetual threat in the world due to the omnipresence of [[{{Magitek}} ars magus]], but seeing as how it is necessary to maintain the current state of the world, nobody sees a problem with it. That said, different individuals process seithr at different rates, so some folks show corruption effects sooner than others. Where this trope comes in is a bit of {{foreshadowing}} in Arcade mode, where precisely one character has their erosion rate measured, and is noteworthy of having it being extremely low: Makoto Nanaya, at 0.2%.
-->'''Hakumen''': So there are still souls in this world as pure as yours. I suggest you cherish this rare commodity, for the sake of us all...
* The four survivors in ''VideoGame/DeadIsland'' are immune to the virus that turns the entire island of Banoi into zombies. [[spoiler:As with ''VideoGame/Left4Dead'' above, it turns out they're just [[TyphoidMary asymptomatic, not immune]].]]
* ''Franchise/DeadRising'': Due to zombie-fighting gameplay of the series, none of the playable protagonists (or even [=NPCs=] to a lesser extent[[note]]they will only turn undead '''after''' being killed by zombies[[/note]]) ever get infected by zombie attacks in-game. In-story, this is explained as some people being more resistant to the zombie virus than others; such resistants include [[spoiler:Frank West and Tyrone King]]. The apparent immunity of Chuck Greene, star of ''VideoGame/DeadRising2'', while unexplained, is a natural step up from that. ''VideoGame/DeadRising3'''s [[TheHero hero]], Nick is immune to zombification because [[spoiler:Carlito inoculated Nick with the cure instead of the zombie virus like the other orphans to ensure that his ZombieApocalypse would not be unstoppable.]]

* In ''VideoGame/DeusEx'', JC Denton tests positive for [[ThePlague Gray Death]], but shows no signs of infection. [[spoiler:It's because the Gray Death is a [[{{Nanotechnology}} artificially created nano-virus]] and JC's [[{{Transhumanism}} nano-augs]] use the same hardware architecture. He's already eyeballs-deep in such nannites. Presumably, his brother Paul is similarly (not) affected]].
* Not so much a plague as a curse, but Adell in ''VideoGame/{{Disgaea 2|CursedMemories}}'' is the only one who doesn't turn demonic under Zenon's influence. [[spoiler:Turns out it was because Adell was a demon to begin with. He never discovers this himself, but it becomes quite obvious to the player.]]
* Carrying into ''VideoGame/{{Disgaea 4|APromiseUnforgotten}}'', [[spoiler:Artina, a.k.a. ]]Vulcanus shows absolutely no signs of A-Virus corruption during Chapter 6, and took a shot meant for Valvatores at the end of Chapter 5. [[spoiler:The blood of angels like her is a panacea for all forms of disease, the A-Virus included. While Valvatores resists through sheer willpower, or so he claims, after winning Chapter 6, she issues blood samples to the demons both to treat the pandemic and simultaneously fill Celestia's coffers]].

* Emeline Shaw in ''VideoGame/TheDivision2'' is an asymptomatic of the [[SyntheticPlague Green Poison]]. Unlike most examples, she doesn’t want to spread her immunity, but instead wants to spread the virus in her body, because she and her fellow immunes were wronged by the government during the outbreak.

* ''VideoGame/TheElderScrollsIIIMorrowind'': It is not given much attention, but this is one of the reasons why the Nerevarine is sent alone into Red Mountain, aside from the prophetic and infiltration aspects -- [[spoiler: earlier in the main quest the Nerevarine gets infected with [[MysticalPlague Corprus]] and then cured of the negative sides, which leaves them immune to ''all'' diseases, including Blight and Corprus.]] Since Red Mountain is the source of the Blight and Corprus...

** Sgt. Johnson was immune to infection by the Flood, either due to "Boren's Syndrome" caused by "overexposure to plasma grenade radiation", or [[spoiler:the ''real'' reason hidden by the previous cover-up - the chemicals that were used to augment Johnson into a Spartan-I]].

** In ''VideoGame/Halo4'': [[spoiler:the Master Chief is exposed to the Libarian's memories, rendering him immune to the Composer.]]
* In ''VideoGame/{{Infected}}'', the main character is not only immune against the zombies, but his/her blood is only thing (short of a nuke) that can kill the zombies. So a scientist makes a gun that shoots his/her blood at zombies, gives them a gun, and tells them to go clean up New York City.
* [[spoiler:Ellie]] in ''VideoGame/TheLastOfUs''. Technically they are Infected, but a random mutation rendered their fungal growths harmless. At the end of the game, [[spoiler:the Fireflies attempt to create a vaccine from her, even though the process will kill her. Unable to accept this, Joel instead kills his way through the Fireflies and escapes with her, thus possibly dooming humanity.]]
* The Green Flu in ''VideoGame/Left4Dead'' is airborne, and the [[PlayerCharacter survivors]] are the few people that happen to be immune to it. Some of the graffiti in the second game and radio chatter near the Bridge Finale suggests [[spoiler:the survivors are actually just [[TyphoidMary asymptomatic carriers]]]]. [[http://www.l4d.com/comic/ A supplementary comic]] explicitly explains that the immunity is genetic, [[spoiler:and confirms the carrier part.]]
* Eve in ''VideoGame/MassEffect3'' wasn't originally unaffected by [[SterilityPlague the genophage]], but was cured by Maelon in ''VideoGame/MassEffect2'', and is now the most important person when it comes to finding a cure.
* Samus in ''VideoGame/MetroidFusion'' becomes immune to the X parasite in the opening. She got infected and some scientists try an experimental cure: cells from the (now dead) baby Metroid. It works, and she gets sent to exterminate the X in the BSL station. The X get smart, though, and ''cold'' X start showing up at a later point in the game (this is because Samus inherited the Metroid's weakness to cold as well as its ability to absorb X). It takes an armor upgrade later on to allow Samus to absorb cold X.
* In ''VideoGame/NinjaBlade'', parasitic hookworms known as "Alpha-worms" end up infesting the whole city and turning them into monsters...except for the ninja protagonist Ken Ogawa, who for some reason seems to be the only one immune to being infested, and can thus safely battle all the enemies. This turns out to be because [[spoiler: he has ''toxic blood'' in him, which is deadly to any parasites that would dare try to infest him. And he has that toxic blood because his father, Kanbe, has it too. So the immunity is genetic]].

** It was eventually explained via subtle RetCon that the T-virus and its variants weren't 100% effective and roughly 10% of humanity was resistant to it to some degree, in comparison to the original games running off the assumption that "your character is just so badass that they never got hit". Furthermore, Umbrella has worked on various antiviruses to the T-virus, most notably seen in ''VideoGame/ResidentEvil3Nemesis''.
** Sherry Birkin is more or less kidnapped by the US Government and put under constant surveillance because, due to the events of ''VideoGame/ResidentEvil2'', she is the sole known source of both the G-Virus and the Devil Vaccine that cured it. [[spoiler:In ''VideoGame/ResidentEvil6'', it's revealed that the Devil only suppressed G and allowed her body to assimilate it, giving her a powerful HealingFactor without losing her mind or turning into a mutant horror]].
** Jill Valentine is implied to be immune to the T-Virus after being cured of her infection in ''VideoGame/ResidentEvil3Nemesis''. [[spoiler:This is confirmed in ''VideoGame/ResidentEvil5'', when it's noted that after she got kidnapped by [[BigBad Albert Wesker]], she turned out to be useless as a test-bed for T-Viral experiments due to her innoculation back in ''3''. However, in the same game, it also works ''against'' her, as the antibodies in her blood were used to improve the Ouroboros virus and this made Wesker decide to brainwash her into serving him as TheDragon rather than just experimenting on her.]]

** Sergei Vladimir is a variant; he's one of the one-in-ten-million who has "total genetic compatibility" with the T-Virus and all its strains, which means that infection doesn't turn him into a TechnicallyLivingZombie, but one of Umbrella's ultimate {{Super Soldier}}s, the Tyrants.
** In ''VideoGame/ResidentEvil7Biohazard'', both Ethan Winters and Zoe Baker are this to a degree, downplaying the trope. [[spoiler:Ethan is heavily resistant to the MindControl aspect of the mutamycete's fungal infection, and so he doesn't start to begin suffering it until the final minutes of the game. Zoe, meanwhile, seems to be completely immune to the MindControl side of the infection, which is why she is TheUnfavorite amongst her infected kin, but this doesn't protect her from Eveline's ability to simply kill off those who are infected with her fungus, even after taking the fungicidal serum. You also later find out that Lucas is ''also'' immune to the MindControl aspects of the infection, but thanks to a serum he was given by The Connections he still has full control of his mind: because he's enough of a PsychopathicManchild (and even was ''before'' his infection) not even Eveline was able to realize he wasn't actually under her control]].

* In ''VideoGame/TheThing'', while your allies have a good chance of being infected by [[TheVirus Things]] just by touching them, your main character Blake can never be infected no matter what. [[spoiler:You find out midway through the game that Blake's cells have a unique resistance to being assimilated or infected by Things which allowed him to resist infection the entire time.]]
* An odd twist can be seen in ''VideoGame/WorldOfWarcraft''; Anyone under the Worgen Curse is immune to the plague of undeath.
* In ''VideoGame/ZombieExodus'' you find out [[spoiler:Devlin]] was bitten but didn't turn.

* In ''Webcomic/WanderingOnes'', this is the reason [[DepopulationBomb Mavon's plague]] didn't completely sterilize the Earth's human population.
* ThePlague in ''Webcomic/StandStillStaySilent'' attacks all mammals, but in every species, some percent is immune. For humans, in Year 90 it's about 7% in Iceland and 48% in the rest of Known World. All cats and non-mammalian species are immune as well. In spite of this, scientists are still looking for a cure, hinting that the discovery of immune people ultimately had limited impact on that particular venture.
** The trope gets an extra degree of deconstruction by having the setting regularly show the reader that the PlagueZombie monsters are still dangerous to those who are immune. In the prologue, immune non-combatants point out that they would die if they went outside the safe areas. Later in the story, an immune character who took a PlagueZombie bite in place of someone who isn't immune develops an infection due to the fact that she got bitten by another (sort of) living being, which carries the same risks as being bitten by an animal in real life, regardless of her incapacity to catch ThePlague.
** Adventure II also reveals [[spoiler:there's a soul affecting only variant of the Rash that affects Finnish mages, and ''not even immune people are safe from it''.]]
* ''Webcomic/{{Uncreation}}'' is about an entire knightly order of them, who stage crusades in the plagued lands on the behalf of TheEmpire.
* In ''Webcomic/ManlyGuysDoingManlyThings'', [[spoiler:Canadian healthcare has rendered Canadian Guy immune to [[{{Bishounen}} Nomura Syndrome]].]] They utilize this to get everyone else cured.
* In ''Webcomic/{{Endtown}}'' there are a few people who seem immune to the mutation virus. The Topsiders refer to them as "Typhoid Mary's" since even if they aren't mutated, still carry the virus, and do even more horrific things to them than normal mutants, who are simply disintegrated or turned into {{Wetware CPU}}s.

* The lice episode of ''WesternAnimation/InvaderZim''. Zim (and Ms. Bitters, actually) are immune to the lice infestation. This leads to Zim being studied, and guess what? His skin, it destroys the lice! This lead to the creation of a [[{{Squick}} Skin Gun]] to take down the "lice Queen". They do eradicate the Queen at least... except [[spoiler:Ms. Bitters just has a higher scratch threshold than most, and ''was'' infected]].

** "Tip of the Day" has Doofenshmirtz invent a Delete-From-My-Mind-inator, which erases whatever he is thinking of from the memories of everyone in the Tri-State Area. However, people who are ''unaware'' of whatever he is thinking of at the moment will be unaffected, so when he unintentionally made everyone forget about [[WhatTheHeckIsAnAglet aglets]] (which was Phineas and Ferb's Big Idea for the episode), only Candace was not affected because she never bothered to learn the name.
** "Cheers for Fears": Doof's Worst-Fear-inator makes whatever is the worst fear of anyone who is zapped by it come to life. However, if the victim is fearless or has no fears at all (Perry for instance), it has no affect on them.
* A ''[[WesternAnimation/TheSimpsons Simpsons]]'' Halloween special had Bart immune to the zombifying effects of the Krusty Burger. The survivors of the outbreak wanted to eat Bart, but they compromised by having Bart taking a bath with their food.
** Another Halloween special featured an illness brought about by Homer eating a radioactive donut that makes everyone it comes into contact with transform into a Homer-like clone. But since the virus works by corrupting people with Homer's DNA, the three Simpson children are automatically immune because they ''already have'' his DNA.
* In ''WesternAnimation/SouthPark'', Cartman and Kyle get infected by HIV, and Cartman vows to find a cure. They go to Magic Johnson's house to figure out why he recovered from HIV. They notice that his bedroom is full of piles of money, because he doesn't trust banks. Sure enough, injecting shredded money into their veins cures them. Then Africa is informed of the good news, all they have to do is roll around in all their money.
* On the ''WesternAnimation/SpongeBobSquarePants'' ChristmasSpecial "WesternAnimation/ItsASpongeBobChristmas", Plankton uses [[{{Unobtanium}} jerktonium]] to make everyone into a jerk. [=SpongeBob=], however, turns out to be immune to its effects due to his [[IncorruptiblePurePureness 100% pure heart]].

* Played with in an episode of ''WesternAnimation/RocketPower''. Sam gets sick with the Fiji Flu... but he recovers from it ''very'' fast. However, every other character (Except the ones who interact with Sam and substitute for the team) get sick.

* Also a plot point in Maximum Clonage arc of Franchise/SpiderMan, where one person survived the test run of the Jackal's virus

* Yorick and Ampersand, the only males to survive the {{Gendercide}} in ''ComicBook/YTheLastMan''. [[spoiler: Or so they thought.]]
* In ''ComicBook/AllStarSuperman'', [[CasanovaWannabe Steve Lombard]] was immune to being turned into a Bizarro. He smugly asks Supes to scan him with his XRayVision and create the antidote, but Franchise/{{Superman}} answers, embarrassed, "I don't think I can recommend your performance enhancers to the rest of the population".

* The ''Franchise/{{Batman}}: Contagion'' story had a series of these, each typically revealing that there was one other person just before dying (and rendering the antibodies in their blood immediately useless).

* Vaccines work on this principal. They in effect train your body's immune system to recognize and destroy a specific virus ''before'' it can propagate within the body. It doesn't necessarily mean the subject will be ''completely'' immune, as it is still possible to suffer some symptoms and even spread the virus during infection, but it also means symptoms will be far less severe, infection will last for much less time, and often reduces what could be a hospitalizing or even fatal experience to common-cold levels of sickness.

** Jill Valentine is implied to be immune to the T-Virus after being cured of her infection in ''VideoGame/ResidentEvil3''. [[spoiler:This is confirmed in ''VideoGame/ResidentEvil5'', when it's noted that after she got kidnapped by [[BigBad Albert Wesker]], she turned out to be useless as a test-bed for T-Viral experiments due to her innoculation back in ''3''. However, in the same game, it also works ''against'' her, as the antibodies in her blood were used to improve the Ouroboros virus and this made Wesker decide to brainwash her into serving him as TheDragon rather than just experimenting on her.]]

** There was a ''Series/StarTrekVoyager'' episode where B'Elanna's unborn baby provided the cure to a Klingon disease.

** From ''Series/StarTrekTheOriginalSeries'', Pavel Chekov in the episode "The Deadly Years." The landing party members age rapidly, except for him, which provides the key to discovering the ImprobableAntidote.

** The episode "The Broca Divide", where [[spoiler:Dr. Fraiser is immune to the virus due to the [[ImprobableAntidote strong antihistamines]] she takes for allergies]]. Daniel Jackson was temporarily immune for the same reasons until he was trapped off-world and no longer had access to his medication.
** In the later episode "Legacy", a contagion that drove Daniel, Jack and Janet insane and threatened Teal'c's life [[spoiler:was treated when it was determined that it was developed to kill Goa'uld in a host, allowing Sam to use the protein marker left by Jolinar to devise a cure]].

* This is part of ''Series/The100''[='s=] backstory. When the nuclear bombs fell, certain people had a natural resistance to radiation, allowing them to survive while the rest of humanity died out. Their radiation immunity was passed on to their descendants, who became the Grounders. This becomes a problem in the second season in particular; the residents of Mount Weather, cut off from the outside world for almost a century, lacked any natural immunity to radiation, and were thus desperate to capture the Grounders or the Ark residents due to their heightened immunity (the Grounders from their time on the surface and the Ark residents through residual exposure to cosmic radiation).
* On ''Series/MyNameIsEarl'', the "Witch Lady" tried to [[SlippingAMickey drug Catalina's tea]], with the intent of storing her in the basement along with all the others she intended to kill [[DisproportionateRetribution for bullying her]]. Catalina gets down into the basement, but explains that she wasn't affected by the drug because [[FridgeHorror so many men have tried to slip her date-rape drugs in the past that she's immune to them]]. She explains that she only pretended to be knocked out and allowed herself to be bagged and tossed in the basement because she felt sorry for the Witch Lady.

* In ''Series/{{Beauty and the Beast|1987}}'', a Russian immigrant ends up infecting the sewer-dwellers with a deadly disease. Vincent ends up having a natural immunity.

* ''VideoGame/TheElderScrollsIIIMorrowind'': It is not given much attention, but this is one of the reasons why the Nerevarine is sent alone into Red Mountain, aside from the prophetic and infiltration aspects -- [[spoiler: earlier in the main quest the Nerevarine gets infected with [[ArtificialPlague Corprus]] and then cured of the negative sides, which leaves them immune to ''all'' diseases, including Blight and Corprus.]] Since Red Mountain is the source of the Blight and Corprus...
* The baby in ''The Pitt'' {{DLC}} of ''VideoGame/Fallout3'' is immune to harmful mutations caused by nuclear radiation. She is also resistant to 'Troglodyte Degeneration Contagion', a condition caused by radiation and industrial toxins that turns humans into sub-human monsters.

** While the Delta 32 mutation is the most famous mutation to grant AIDS resistance, people with this gene are actually the minority of long-term nonprogressor individuals with HIV. Other genes that assist in stopping AIDS progression are various HLA types: HLA-B5701, HLA-B5703, and HLA-B2705.

* ''LightNovel/TheUnexploredSummonBloodSign'' has a non-physical disease- the [[EldritchAbomination White Queen]]'s influence, which has driven people insane just by seeing her. Everyone has some degree of resistance to it, but Kyousuke [[spoiler:and Shigara]]'s immunity is total. Given time and effort, he can even snap others out of it. Unfortunately, this makes him ''[[HumanPet very interesting]]'' to her.

** The episode "Tip of the Day" has Doofenshmirtz invent a Delete-From-My-Mind-inator, which erases whatever he is thinking of from the memories of everyone in the Tri-State Area. However, people who are ''unaware'' of whatever he is thinking of at the moment will be unaffected, so when he unintentionally made everyone forget about [[WhatTheHeckIsAnAglet aglets]] (which was Phineas and Ferb's Big Idea for the episode), only Candace was not affected because she never bothered to learn the name.
** In "Cheers for Fears", Doof's Worst-Fear-inator makes [[YourWorstNightmare whatever is the worst fear of anyone]] who is zapped by it come to life. However, if the victim is fearless or has no fears at all (Perry for instance), it has no affect on them.

* The four survivors in ''VideoGame/DeadIsland'' are immune to the virus that turns the entire island of Banoi into zombies. [[spoiler:As with ''VideoGame/Left4Dead'' above, it turns out they're just [[TyphoidMary asymptotic, not immune]].]]

* The Green Flu in ''VideoGame/Left4Dead'' is airborne, and the [[PlayerCharacter survivors]] are the few people that happen to be immune to it. Some of the graffiti in the second game and radio chatter near the Bridge Finale suggests [[spoiler:the survivors are actually just [[TyphoidMary asymptotic carriers]]]]. [[http://www.l4d.com/comic/ A supplementary comic]] explicitly explains that the immunity is genetic, [[spoiler:and confirms the carrier part.]]

* In ''Literature/TheDeathCure'', it is revealed that most of the kids who were part of WICKED's Trials, along with a very small percentage of the world's population called [[ExactlyWhatItSaysontheTin "Immunes"]], are immune to the Flare. WICKED took them from their families because they wanted to study their brains in the hope that this would eventually lead to a cure. The few among them who are not immune were chosen as control subjects.
* In ''[[Literature/{{Divergent}} The Divergent Trilogy]]'', [[spoiler:Tris]] is able to resist serums, like most Divergents. [[spoiler:She is notably able to fight off Candor's truth serum in ''Insurgent'', and cannot be killed by the Bureau's death serum in ''Allegiant''. At multiple points, it is mentioned that her ability to resist is beyond that of most Divergents]].
* In Scott Westerfeld's ''Literature/{{Peeps}}'' Carriers for some unknown reason get the benefits of the parasite that causes "vampirism" while still managing to remain sane. Night vision, super strength, and long lifespans without the urge to commit cannibalism (just a craving for rare meat and a high libido) or aversion to everything they loved before infection. Unfortunately they can transmit the parasite with as little as a kiss; those who work as hunters usually start out with their exes.
* In ''[[Literature/TheExpanse Cibola Burn]]'', an alien microbe blinds everyone on Ilus...except for Holden, who consequently ends up doing all the vision-critical jobs around the colony until a cure is found. [[spoiler:It turns out to be his anti-cancer drugs. When they ask if they can borrow his drugs to fix everyone else's vision, which puts him at risk of developing tumors, his response is essentially, "And then I can take a nap?"]]

* ''Manga/MyHeroAcademia'': Not exactly a plague, but One for All is the only quirk immune to All for One's quirk-stealing abilities, because it can only be transferred between holders willingly.

* In ''VideoGame/{{Infected}}'', the main character is not only immune against the zombies, but his/her blood is only thing (short of a nuke) that can kill the zombies. So a scientist makes a gun that shoots his/her blood at zombies, gives them a gun, and tells them to go clean up New York City.
* ''Franchise/{{Halo}}'':
** Sgt. Johnson was immune to infection by the Flood, either due to "Boren's Syndrome" caused by "overexposure to plasma grenade radiation", or [[spoiler:the ''real'' reason hidden by the previous cover-up - the chemicals that were used to augment Johnson into a Spartan-I]].
** Due to the physiology of Hunters (they're worm colonies with no central nervous systems), they are immune to direct Flood infection.
** In ''VideoGame/Halo4'': [[spoiler:the Master Chief is exposed to the Libarian's memories, rendering him immune to the Composer.]]
* The Green Flu in ''VideoGame/Left4Dead'' is airborne, and the [[PlayerCharacter survivors]] are the few people that happen to be immune to it. Some of the graffiti in the second game and radio chatter near the Bridge Finale suggests [[spoiler:the survivors are actually just [[TyphoidMary asymptotic carriers]]]]. [[http://www.l4d.com/comic/ A supplementary comic]] explicitly explains that the immunity is genetic, [[spoiler:and confirms the carrier part.]]

** Carrying into [[VideoGame/Disgaea4APromiseUnforgotten the fourth game]], [[spoiler:Artina, a.k.a. ]]Vulcanus shows absolutely no signs of A-Virus corruption during Chapter 6, and took a shot meant for Valvatores at the end of Chapter 5. [[spoiler:The blood of angels like her is a panacea for all forms of disease, the A-Virus included. While Valvatores resists through sheer willpower, or so he claims, after winning Chapter 6, she issues blood samples to the demons both to treat the pandemic and simultaneously fill Celestia's coffers.]]

* ''[[VideoGame/TwelveThirteen 1213]]'': [[spoiler: the protagonist is immune to any disease or poison]], which sets up the horrifying ending.
* Reimi in ''VideoGame/StarOceanTheLastHope''. This is because [[spoiler:as a Seed of Hope, she is genetically engineered for survival on new and unknown worlds]]. Unfortunately, she ended up with a case of SurvivorGuilt when a radiation leak killed off all of her friends except for her. The incident with Stone Sickness on Roak shows that there is an adjustment period while her body adapts to a new ailment, which has [[BodyHorror horrifying implications]] for the radiation incident.
* The four survivors in ''VideoGame/DeadIsland'' are immune to the virus that turns the entire island of Banoi into zombies. [[spoiler:As with ''VideoGame/Left4Dead'' above, it turns out they're just [[TyphoidMary asymptotic, not immune]].]]
* In ''VideoGame/NinjaBlade'', parasitic hookworms known as "Alpha-worms" end up infesting the whole city and turning them into monsters...except for the ninja protagonist Ken Ogawa, who for some reason seems to be the only one immune to being infested, and can thus safely battle all the enemies. This turns out to be because [[spoiler: he has ''toxic blood'' in him, which is deadly to any parasites that would dare try to infest him. And he has that toxic blood because his father, Kanbe, has it too. So the immunity is genetic.]]
* [[spoiler:Ellie]] in ''VideoGame/TheLastOfUs''. Technically they are Infected, but a random mutation rendered their fungal growths harmless. At the end of the game, [[spoiler:the Fireflies attempt to create a vaccine from her, even though the process will kill her. Unable to accept this, Joel instead kills his way through the Fireflies and escapes with her, thus possibly dooming humanity.]]
* In ''VideoGame/ZombieExodus'' you find out [[spoiler:Devlin]] was bitten but didn't turn.

** In ''VideoGame/ResidentEvil7Biohazard'', both Ethan Winters and Zoe Baker are this to a degree, downplaying the trope. [[spoiler:Ethan is heavily resistant to the MindControl aspect of the mutamycete's fungal infection, and so he doesn't start to begin suffering it until the final minutes of the game. Zoe, meanwhile, seems to be completely immune to the MindControl side of the infection, which is why she is TheUnfavorite amongst her infected kin, but this doesn't protect her from Eveline's ability to simply kill off those who are infected with her fungus, even after taking the fungicidal serum. You also later find out that Lucas is ''also'' immune to the MindControl aspects of the infection, but thanks to a serum he was given by The Connections he still has full control of his mind: because he's enough of a PsychopathicManchild (and even was ''before'' his infection) not even Eveline was able to realize he wasn't actually under her control.]]
* Eve in ''VideoGame/MassEffect3'' wasn't originally unaffected by [[SterilityPlague the genophage]], but was cured by Maelon in ''VideoGame/MassEffect2'', and is now the most important person when it comes to finding a cure.
* ''VideoGame/BlazBlue'' actually downplays this trope. Seithr corruption is a perpetual threat in the world due to the omnipresence of [[{{Magitek}} ars magus]], but seeing as how it is necessary to maintain the current state of the world, nobody sees a problem with it. That said, different individuals process seithr at different rates, so some folks show corruption effects sooner than others. Where this trope comes in is a bit of {{foreshadowing}} in Arcade mode, where precisely one character has their erosion rate measured, and is noteworthy of having it being extremely low: Makoto Nanaya, at 0.2%.
-->'''Hakumen''': So there are still souls in this world as pure as yours. I suggest you cherish this rare commodity, for the sake of us all...
* It's not really brought up in the game, but some of the in-game documents in ''VideoGame/{{Dishonored}}'' hint that all Serkonans are immune to the Rat Plague because they are the descendants of survivors of a Rat Plague outbreak on Serkonan who passed on their genetic immunity to their offspring. This would explain why Corvo and Daud, both Serkonans, never contract the Plague despite being exposed to it so often.
* ''Franchise/DragonAge'':
** Meta-example: In ''VideoGame/DragonAgeOrigins'', the entire party is this to the darkspawn taint. Alistair and the player character already ''have'' the taint by virtue of being Grey Wardens, but the others in the party develop an immunity to it purely as a gameplay necessity. It was originally intended that the party members could be put through the Joining ritual to become Grey Wardens, as they would otherwise be dying from the taint toward the end of the game, but this was jettisoned for plot and time reasons. Their immunity is not mentioned in the game.
** This actually serves as a minor plot point in ''VideoGame/DragonAgeInquisition''. A magister researching Leliana, a returning character and former ''Origins'' companion discovers her to have a higher resistance to the taint than any known subject.
** Members of the Seekers of Truth, essentially [[CapeBusters Templar]] InternalAffairs, are immune to mind control and DemonicPossession. It is a benefit of the same initiation ritual that allows them to use special anti-magic powers without [[GreenRocks lyrium]]. [[spoiler:Seekers are made [[EmptyShell Tranquil]] and then immediately cured by having a Spirit of Faith touch the initiate's mind. If successful, the initiate gains the powers and immunity of a Seeker. If unsuccessful, the initiate [[FateWorseThanDeath is left permanently Tranquil]]. At some point, a mage attempted to join the Seekers, seeing it as a solution to fact that Mages are at much higher risk of possession. He failed, and accidentally discovered that Tranquil mages can no longer use magic and become invisible to demons. [[UnwittingInstigatorOfDoom Things spiraled downward from there over the next nine-hundred years]].]]

* In ''VideoGame/DeusEx'', JC Denton tests positive for [[ThePlague Gray Death]], but shows no signs of infection. [[spoiler:It's because the Gray Death is a [[{{Nanotechnology}} artificially created nano-virus]] and JC's [[{{Transhumanism}} nano-augs]] use the same hardware architecture. He's already eyeballs-deep in such nannites. Presumably, his brother Paul is similarly (not) affected.]]
* ''VideoGame/TheElderScrollsIIIMorrowind'': It is not given much attention, but this is one of the reasons why the Nerevarine is sent alone into Red Mountain, aside from the prophetic and infiltration aspects -- [[spoiler: earlier in the main quest the Nerevarine gets infected with [[ArtificialPlague Corprus]] and then cured of the negative sides, which leaves them immune to ''all'' diseases, including Blight and Corprus.]] Since Red Mountain is the source of the Blight and Corprus...
* Emeline Shaw in ''VideoGame/TheDivision2'' is an asymptomatic of the [[SyntheticPlague Green Poison]]. Unlike most examples, she doesn’t want to spread her immunity, but instead wants to spread the virus in her body, because she and her fellow immunes were wronged by the government during the outbreak.
* ''VideoGame/PrayerOfTheFaithless'': Miasma and Fog can transform living beings into monsters, but this doesn't fully apply to all beings.
** Manna and Revenants are a downplayed example. Both are more resistant to Miasma and Fog than humans, but Manna will eventually die from the Fog when they reach the age of 10 while Revenants eventually turn into Hellspawn monsters.
** The Infused play this straight, since they are completely fused with relics that allows them to process the Fog safely. [[spoiler:Since they have the best immunity to the Fog, Vanessa wants to turn as many humans as possible into Infused in order to preserve human civilization. Unfortunately, the Infusion process is unreliable and tends to destroy the subjects' minds, so Vanessa is unlikely to be able to make enough successful Infused to repopulate humanity after the Fog kills them all.]]
* In ''VideoGame/TheThing'', while your allies have a good chance of being infected by [[TheVirus Things]] just by touching them, your main character Blake can never be infected no matter what. [[spoiler:You find out midway through the game that Blake's cells have a unique resistance to being assimilated or infected by Things which allowed him to resist infection the entire time.]]