History Main / OutsideGenreFoe

* Eclipso in ''ComicBook/AmethystPrincessOfGemworld''. Until his arrival, the entire plot of the series revolved around a political struggle between Mordiel and the rest of her family, with most Houses having various positions toward the whole thing. Then this ancient enemy comes back from Earth and proceeds to MindControl two members of the house, essentially becoming the biggest threat and forcing Mordiel into an alliance with her family.

* In the "Burnt Offering" arc of ''ComicBook/CableAndDeadpool'', Cable is kicking the collective asses of Deadpool and the ComicBook/XMen. The authorities call in... the Silver Surfer, whom even Cable didn't expect, resulting in an epic beatdown and [[spoiler:eventual semi-depowering]] (even though Cable breaks the Surfer's board). This is notable since the Fantastic Four and X-Men characters rarely interact, so the Silver Surfer (who rarely intervenes in Earth's affairs even within Fantastic Four storylines) appearing really was a surprise.
* Deadpool himself becomes this in ''ComicBook/DeadpoolKillsTheMarvelUniverse'', as his MediumAwareness gets a boost, letting him subject the whole of the Marvel Universe to a JustShootHim scenario, where PlotArmor no longer applies.
* Fighting (and beating) cosmic beings may now be passé in superhero comics, but in its original context, ''ComicBook/TheComingOfGalactus'' from ''ComicBook/FantasticFour'' fits this. The appearance of an all-powerful "villain" that was beyond good and evil, and who immediately put the protagonists in a literally helpless situation, was unprecedented in superhero stories at the time.

* After ''ComicBook/AgeOfUltron'', Galactus has taken this to another level -- he's been displaced to ComicBook/UltimateMarvel. ''ComicBook/CataclysmTheUltimatesLastStand'' begins with him appearing out of nowhere and vaporizing a chunk of New York without so much as an "I HUNGER." The Ultimates only start to understand what they're dealing with after Tony Stark matches his energy signature to [[ComicBook/SpiderMen 616 Peter Parker]].
* Fenris from ''ComicBook/{{Lucifer}}'' is known, vaguely, by many of the characters, but since the conflict and all of the big hitters are Judeo-Christian in origin very few of them take a minor character from a forgotten religion very seriously. Lucifer himself warns them not to underestimate the guy and still ends up getting outplayed and very nearly killed, and Fenris eventually ends up with the largest major character kill count and a very good claim at being the BigBad.
* One ''Franchise/ANightmareOnElmStreet'' comic has Freddy deal with this, when the teenagers he's after try to destroy him by summoning an ancient Mayan monster that can dwell within dreams like he can.

* The storylines in ''Ramba'' normally dealt with mobsters, drug dealers, mercenaries, etc. In "Vendetta from Hell", Ramba fights a black magic coven that summons a demon in an attempt to kill her. This was the only appearance of the supernatural in the series.
* ''ComicBook/TexWiller'' is usually a straight western series... With a number of villains capable of using magic, hidden cities of Aztecs, Maya and others showing up once in a while, and a story arc including straight-up ''aliens''.

* The story "Wolf Hunt" from Creator/WildStorm's ''Franchise/ResidentEvil'' #3 pitted Jill Valentine against a werewolf that had no apparent connection to the genetic experiments being conducted by the Umbrella Corporation.