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** On Platform/FimfictionDotNet, the Scootaloo group has an [[https://www.fimfiction.net/group/473/folder/4724/grounded entire folder]] set up for stories about Scootaloo discovering that she will never fly, and having to cope with that. There is also a folder for stories which involve her [[https://www.fimfiction.net/group/473/folder/4723/taking-flight gaining the ability to fly]]. Most of those stick with the original idea that she was just having trouble learning to fly (as Lauren Faust once claimed during her time as showrunner), but some of them present her as disabled and have her fly with the aid of [[Main/ArtificialLimbs prosthetic wings]] or other assistive technology.
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* ''VideoGame/AceCombat3Electrosphere'': The AcePilot Rena Hirose suffers from the "Silverstone disease", meaning that her skins lack any protection from UV sunlight radiation whatsoever. As a result, the only way she has to be outside during daytime is inside the fully-enclosed cockpit of her plane.

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* ''VideoGame/AceCombat3Electrosphere'': The AcePilot Rena Hirose suffers from the "Silverstone disease", meaning that her skins lack skin lacks any protection from UV sunlight radiation whatsoever. As a result, the only way she has to be outside during daytime is inside the fully-enclosed cockpit of her plane.
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* ''WebAnimation/FirstStageProduction'': [[SuccubiAndIncubi Zander Netherbrand]] lost his right wing by using it to shield a past lover from being slain by paladins.
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* Upcoming game ''VideoGame/ToAT'' is about a young boy born with the inability to bend his shoulders and elbows, his arms permanently raised so that his default standing position is a T-pose. The game is about how he navigates his life with such a unique disability, with the support of his friends and family, as well as his uncannily savvy dog. One of the upsides is he discovers a talent for [[HeliCritter twirling so fast that he can take off like a helicopter]].
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** ''Fanfic/OversaturatedWorld'': In ''[[https://www.fimfiction.net/story/323071/2/group-precipitation/launch-error-by-fome Launch Error]]'', it's shown that human Scootaloo can't fly even when she gets the magical wings that let other Pegasus Aspects fly.

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** ''Fanfic/OversaturatedWorld'': In ''[[https://www.fimfiction.net/story/323071/2/group-precipitation/launch-error-by-fome Launch Error]]'', it's shown that human Scootaloo can't fly fly, even when she gets the magical wings that let other Pegasus Aspects fly.



** ''Fanfic/ScootalooAndTheCabinetOfSeers'': Scootaloo worries so much about her possibly being never able to fly that she wants Twilight to consult the greatest {{Seers}} of their world about it.

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** ''Fanfic/ScootalooAndTheCabinetOfSeers'': Scootaloo worries so much about her possibly being never able to fly that she wants Twilight to consult the greatest {{Seers}} {{Seer}}s of their world about it.



** [[AdaptationalMundanity instead of demons which turn people to stone]], [[WesternAnimation/RayaAndTheLastDragon DRUUN]] (Deposit-Rich Un-Uniform Neomineralization) is a horrible disease that causes mineral stones to form throughout the body due to it no longer being able to break down calcium. It's sexually transmitted and currently incurable.
** Equestria is a FictionalCountry in which the population is prone to a disability that makes it very hard to conceive and carry boy babies to term, meaning women outnumber men, and Twilight is chosen as the future ruler partly because she might be able to have a healthy son.

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** [[AdaptationalMundanity instead Instead of demons which turn people to stone]], [[WesternAnimation/RayaAndTheLastDragon DRUUN]] (Deposit-Rich Un-Uniform Neomineralization) is a horrible disease that causes mineral stones to form throughout the body due to it no longer being able to break down calcium. It's sexually transmitted and currently incurable.
** Equestria is a FictionalCountry in which the population is prone to a disability that makes it very hard to conceive and carry boy babies to term, meaning [[GenderRarityValue women outnumber men, and men]]. Twilight is chosen as the future ruler partly because she might be able to have a healthy son.

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->'''Remus Lupin:''' Well, well, Sirius. Looking rather ragged, aren't we? Finally the flesh reflects the madness within.\\
'''Sirius Black:''' Well, you'd know all about the madness within. Wouldn't you, Remus?
-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a [[OurWerewolvesAreDifferent werewolf]], while Sirius [[BoredWithInsanity temporarily]] lost his mind in a TraumaCongaLine after losing his best friends and being wrongly convicted as a {{Fantastic Terrorist|s}})

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->'''Remus Lupin:''' Well, well, Sirius. Looking rather ragged, aren't we? Finally the flesh reflects the madness within.->'''Barrierbot:''' Did your hump just say something?\\
'''Fry:''' Uh... I-I've got talking hump syndrome.
\\
'''Sirius Black:''' Well, you'd know all about the madness within. Wouldn't you, Remus?
-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a [[OurWerewolvesAreDifferent werewolf]], while Sirius [[BoredWithInsanity temporarily]] lost his mind in a TraumaCongaLine after losing his best friends and being wrongly convicted as a {{Fantastic Terrorist|s}})
'''Barrierbot:''' Ah, T.H.S.
-->-- ''WesternAnimation/{{Futurama}}'', "[[Recap/FuturamaS2E10ACloneOfMyOwn A Clone of My Own]]"

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[[folder:Films -- Animation]]

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[[folder:Films -- Animation]]Animated]]


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* ''WesternAnimation/WreckItRalph'': Due to [[spoiler:Turbo haphazardly overwriting her code to remove her from the game]], Vanellope "glitches" frequently, causing her to spasm and change places uncontrollably, making her the subject of bullying and systemic discrimination. To hammer in the metaphor, she refers to it as "pixlexia," a pun on "dyslexia" (though it's not much like dyslexia at all, more closely resembling muscle spasms). Later in the film, she finds a way to control her glitching and use it to her advantage.
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-->'''Nibbler''': The fate of your world -- perhaps all worlds -- rests in his special mind.\\

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-->'''Nibbler''': --->'''Nibbler''': The fate of your world -- perhaps all worlds -- rests in his special mind.\\

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** In "A Clone of My Own," Fry gets away with pretending to be Professor Farnsworth with Cubert in disguise as his hump by claiming he has "Talking Hump Syndrome," which the guards empathize with as a known disability.

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** In "A Clone of My Own," Fry gets away with pretending to be Professor Farnsworth with Cubert in disguise as his hump by claiming he has "Talking Hump Syndrome," which the guards empathize with as a known disability. disability ("Ah, THS.").
** Due to a time paradox in which Fry [[MyOwnGrampa is his own grandfather]], he lacks a trait in the mind known as the "delta brainwave," with his brain being "a random assortment of other brainwaves." While this makes him the only sentient life form impervious to brainwashing and mind-reading, it is also implied to be the root of his mental deficiencies.
-->'''Nibbler''': The fate of your world -- perhaps all worlds -- rests in his special mind.\\
'''Leela''': Now, when you say "''special''"...
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* ''WesternAnimation/{{Futurama}}'x:

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* ''WesternAnimation/{{Futurama}}'x:''WesternAnimation/{{Futurama}}'':
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* ''WesternAnimation/{{Futurama}}'x:
** In "A Clone of My Own," Fry gets away with pretending to be Professor Farnsworth with Cubert in disguise as his hump by claiming he has "Talking Hump Syndrome," which the guards empathize with as a known disability.
** "Leela and the Genestalk" has Leela undergo a mutant-specific genetic disorder known as "squidification," causing her body to mutate into a mass of tentacles. She is later cured with genetic engineering.
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** ''Fanfic/WithPearlAndRubyGlowing'':
*** [[AdaptationalMundanity instead of demons which turn people to stone]], [[WesternAnimation/RayaAndTheLastDragon DRUUN]] (Deposit-Rich Un-Uniform Neomineralization) is a horrible disease that causes mineral stones to form throughout the body due to it no longer being able to break down calcium. It's sexually transmitted and currently incurable.
*** Equestria is a FictionalCountry in which the population is prone to a disability that makes it very hard to conceive and carry boy babies to term, meaning women outnumber men, and Twilight is chosen as the future ruler partly because she might be able to have a healthy son.

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** * ''Fanfic/WithPearlAndRubyGlowing'':
*** ** [[AdaptationalMundanity instead of demons which turn people to stone]], [[WesternAnimation/RayaAndTheLastDragon DRUUN]] (Deposit-Rich Un-Uniform Neomineralization) is a horrible disease that causes mineral stones to form throughout the body due to it no longer being able to break down calcium. It's sexually transmitted and currently incurable.
*** ** Equestria is a FictionalCountry in which the population is prone to a disability that makes it very hard to conceive and carry boy babies to term, meaning women outnumber men, and Twilight is chosen as the future ruler partly because she might be able to have a healthy son.

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* ''Fanfic/WithPearlAndRubyGlowing'':
** [[AdaptationalMundanity instead of demons which turn people to stone]], [[WesternAnimation/RayaAndTheLastDragon DRUUN]] (Deposit-Rich Un-Uniform Neomineralization) is a horrible disease that causes mineral stones to form throughout the body due to it no longer being able to break down calcium. It's sexually transmitted and currently incurable.
** Equestria is a FictionalCountry in which the population is prone to a disability that makes it very hard to conceive and carry boy babies to term, meaning women outnumber men, and Twilight is chosen as the future ruler partly because she might be able to have a healthy son.

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* ** ''Fanfic/WithPearlAndRubyGlowing'':
** *** [[AdaptationalMundanity instead of demons which turn people to stone]], [[WesternAnimation/RayaAndTheLastDragon DRUUN]] (Deposit-Rich Un-Uniform Neomineralization) is a horrible disease that causes mineral stones to form throughout the body due to it no longer being able to break down calcium. It's sexually transmitted and currently incurable.
** *** Equestria is a FictionalCountry in which the population is prone to a disability that makes it very hard to conceive and carry boy babies to term, meaning women outnumber men, and Twilight is chosen as the future ruler partly because she might be able to have a healthy son.son.
* In ''Fanfic/TheMorrigan'', Spontaneous Permetic Growth is a condition where the local AppliedPhlebotinum starts growing on and in the body, causing chronic pain and paralysis. Prospera Mercury has it in both her legs, and is preventing the worst of it with treatments and regular stretches. Nika Nanaura-Fardin has a uniquely benign version in her left arm which doesn't cause her any pain, but permet crystals still have to be filed down regularily for her to be able to move it (a process that is [[FantasticArousal pleasant and often done by her wife, Sabina]]).
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-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a [[OurWerewolvesAreDifferent werewolf]], while Sirius was wrongly convicted as a {{Fantastic Terrorist|s}} and [[BoredWithInsanity temporarily]] lost his mind in the ensuing TraumaCongaLine)

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-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a [[OurWerewolvesAreDifferent werewolf]], while Sirius was wrongly convicted as a {{Fantastic Terrorist|s}} and [[BoredWithInsanity temporarily]] lost his mind in the ensuing TraumaCongaLine)
a TraumaCongaLine after losing his best friends and being wrongly convicted as a {{Fantastic Terrorist|s}})
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-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a [[OurWerewolvesAreDifferent werewolf]], while Sirius is wrongly suspected as AxCrazy after being framed as a FantasticTerrorist and [[BoredWithInsanity temporarily]] losing his mind in the ensuing TraumaCongaLine)

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-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a [[OurWerewolvesAreDifferent werewolf]], while Sirius is was wrongly suspected as AxCrazy after being framed convicted as a FantasticTerrorist {{Fantastic Terrorist|s}} and [[BoredWithInsanity temporarily]] losing lost his mind in the ensuing TraumaCongaLine)
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-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a werewolf, while Sirius is the WhiteSheep of an inbred aristocratic family with a history of mental illness)

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-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a werewolf, [[OurWerewolvesAreDifferent werewolf]], while Sirius is wrongly suspected as AxCrazy after being framed as a FantasticTerrorist and [[BoredWithInsanity temporarily]] losing his mind in the WhiteSheep of an inbred aristocratic family with a history of mental illness)
ensuing TraumaCongaLine)
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->'''Remus:''' Well, well, Sirius. Looking rather ragged, aren't we? Finally the flesh reflects the madness within.\\
'''Sirius:''' Well, you'd know all about the madness within. Wouldn't you, Remus?

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->'''Remus:''' ->'''Remus Lupin:''' Well, well, Sirius. Looking rather ragged, aren't we? Finally the flesh reflects the madness within.\\
'''Sirius:''' '''Sirius Black:''' Well, you'd know all about the madness within. Wouldn't you, Remus?
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->'''Remus:''' Well, well, Sirius. Looking rather ragged, aren't we? Finally the flesh reflects the madness within.\\
'''Sirius:''' Well, you'd know all about the madness within. Wouldn't you, Remus?
-->--''Film/HarryPotterAndThePrisonerOfAzkaban'' (for context, Remus is a werewolf, while Sirius is the WhiteSheep of an inbred aristocratic family with a history of mental illness)
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* ''Literature/HarryPotter'' treats [[OurWerewolvesAreDifferent lycanthropy]] like this. Lupin regularly takes medication to alleviate the worst effects of his condition and required extensive accommodations during his school years. When his wife becomes pregnant, he worries "WhatIfTheBabyIsLikeMe".

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* ''Literature/HarryPotter'' treats [[OurWerewolvesAreDifferent lycanthropy]] like this. Lupin regularly takes medication to alleviate the worst effects of his condition and required extensive accommodations during his school years. When his wife becomes pregnant, he worries "WhatIfTheBabyIsLikeMe"."WhatIfTheBabyIsLikeMe?" Lampshaded in the movie by Sirius Black, whose family has a history of mental illness (not helped by [[RoyalInbreeding aristocratic inbreeding]]) and who turns out to have become BoredWithInsanity during his time in prison:
-->'''Remus:''' Well, well, Sirius. Looking rather ragged, aren't we? Finally the flesh reflects the madness within.\\
'''Sirius:''' Well, you'd know all about the madness within. Wouldn't you, Remus?
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* Starfire in the ''WesternAnimation/TeenTitans'' season one finale is shown to have an allergy to metallic chromium, which for the plot is convenient since the TimeStandsStill bomb device Slade is constructing uses a good deal of it so they can track down its location by Starfire sneezing. As long as the other Titans don't stand too close to her when she sneezes and makes little explosions.

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* Starfire in In the ''WesternAnimation/TeenTitans'' season one finale of ''WesternAnimation/TeenTitans2003'', Starfire is shown to have an allergy to metallic chromium, which for the plot is convenient for the plot since the TimeStandsStill bomb device Slade is constructing uses a good deal of it it, so they can track down its location by Starfire sneezing. As sneezing... as long as the other Titans don't stand too close to her when she sneezes and makes little explosions.
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[[folder:Audio Play]]
* ''AudioPlay/BigFinishDoctorWho'': The renegade Time Lord introduced in "The Eleven" suffers from a condition called "regenerative dissonance", meaning that after [[TheNthDoctor regeneration]], their past selves continue to [[SplitPersonality exist inside their mind]]. [[IHatePastMe None of them get along at all]], and it stated that other Time Lords with the condition have been DrivenToSuicide. The most well known incarnation is the titular Eleven, but we also meet (in person), the Eight, the Nine, the Twelve, and the Union.
[[/folder]]

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