Andrew Glouberman to Nick Birch. While Nick is a late bloomer with puberty, Andrew is an early bloomer, having already started some eighteen months ago, roughly around the start of sixth grade. Nick has a supportive family and high self-esteem, while Andrew comes from a barely-functional family and is a pushover.
Diane and Elliot Birche are direct foils to Jessi's and Andrew's parents.
They are very sex positive and eager to teach their prepubescent son about sex and his body, being extremely open minded, and their sex life is very fulfilling. The Gloubermans, on the other hand, are very awkward about sex, having a hard time or even outright denying to teach or talk with Andrew about sex and have accused him of being a deviant for even being curious about sex and accusing him of being a molester after Missy initiated an unwelcome advance on him, with a sex life that's lukewarm at best.
Diane and Elliot are very much still as in love after all these years together, with Elliot being introduced thanking Diane for the life they have. Their sex life is active and fulfilling, they don't have any fights and are a constant presence in their children's lives. Shannon and Greg's romance died years ago and are stuck with each other now, with Shannon even cheating on Greg with another woman. Their constant fights inevitably cause problems to Jessi, who has to watch the breakdown of her parent's marriage and being in the crossfire of their constant fighting.
Mr. Lizer to Coach Steve. He's less bizarre and clearly a functioning adult, but Steve is a humble and helpful man while Mr. Lizer is a quietly creepy douche-bag.
The Shame Wizard to the Hormone Monsters. While the Hormone Monsters represent the teenage Id, the Shame Wizard represents the teenage Superego.
The Shame Wizard to Coach Steve, with Steve's utter lack of shame confounding the Shame Wizard.
Matthew to Andrew, once we see that Maury is Hormone Monster to both of them. While Andrew seems to have little control over Maury, and by extension his own impulses, Matthew is more self-restrained and is able to refuse Maury's pressure most of the time.
