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1* AdaptationDisplacement: While still a fairly niche product, the film is more well known than the novel series it's based on.
2* AlternativeCharacterInterpretation:
3** ''[[BearsAreBadNews The bear]]'', of all things. Fans of the movie are split on whether [[spoiler: its roars being mixed with Shepherd's dying screams is a case of ItCanThink [[VoiceChangeling using her voice to lure in prey]], or if they're the unconscious, uncontrollable vocalizations of a [[FusionDance fused organism]] [[AndIMustScream screaming in agony]], possibly even as a result of Shepherd's mind ''[[FateWorseThanDeath still being alive inside it]]]]''. Or [[TakeAThirdOption some combination of the two.]] Generally, the opinion comes down to whichever the viewer [[RuleOfScary finds the most horrifying.]]
4** Lena, following the ending. [[spoiler: Did she actually survive and escape the Shimmer, albeit with an unknown degree of mutations, and the film as we've been following it is just her trying to remember it as best as she can? Or is she an escaped form of the Humanoid, who pulled a KillAndReplace on Lena and is lying to the Southern Reach about what happened in the Lighthouse?]] Much the same applies to Kane as well, [[spoiler: The fact that the "Kane" who's apparently a clone didn't die with the rest of the Shimmer after Lena destroyed it suggests that at least ''part'' of the Shimmer is still alive within Lena.]]
5*** [[TakeAThirdOption Alternatively]], is she [[spoiler: an escaped form of the Humanoid, but having absorbed Lena's memories, [[TomatoInTheMirror thinks she's the real one?]]]]
6*** Yet another possibility is that [[spoiler:these ''are'' Lena and Kane, but they've had traits of their other squadmates refracted into them by the Shimmer - note that Lena comes home sporting Anya's tattoo, suggesting that the Shimmer isn't even limited to genetic traits in what it refracts. This possibility certainly raises [[{{Transhuman}} interesting implications]] for any children they might have, too]].
7* AwardSnub: The film was completely overlooked at the 2019 UsefulNotes/{{Academy Award}}s, not even receiving nominations in the music, sound, or technical categories.
8* SugarWiki/AwesomeMusic:
9** Crossing over into NightmareFuel, the trailer gives us the Shimmer's own theme song: five notes of somewhat nightmarish, unsettling, alien-sounding music. Just hearing it, one figures this is going to be very iconic in the movie. [[spoiler:And it is significant: it's the sound the Humanoid that copies Lena makes as it manhandles her to do so.]]
10** For more conventional music. the film opens and ends with Crosby, Stills & Nash's [[https://www.youtube.com/watch?v=kyquqw6GeXk Helplessly Hoping]] to GREAT effect.
11* CriticalDissonance: The film has received critical acclaim, but a more mixed response from audiences, having an 88% critic score and a 66% audience score on Rotten Tomatoes, and the film hasn't exactly done well at the box office. The box office returns were not helped by the film being distributed by Netflix outside North America.
12* EnsembleDarkhorse:
13** Anya and Josie are the most popular characters from the film thanks in part to the performances of their actresses (Gina Rodriguez and Tessa Thompson).
14** '''[[BearsAreBadNews THE BEAR]]'''. For a non-sentient animal that only appears briefly in the movie proper, it made an enormous impact on audiences thanks to being absolutely ''[[NightmareFuel horrifying]]'', dangerous, and looks [[SugarWiki/VisualEffectsOfAwesome 100% real.]]
15* EpilepticTrees: Some fans, noticing the rather... ''familiar-looking'' creatures of the Shimmer, are making connections [[https://www.gizmodo.com.au/2018/03/annihilation-is-actually-a-warning-about-how-dangerous-the-world-of-pokmon-really-is/ between this universe and the universe of Pokemon!]] Some are even going as far as to say that the film may as well be a prequel of how the Pokemon universe came to be, albeit darker and more dangerous.
16* {{Fanon}}: A common theory (supported by many fans, including [[WebVideo/HalfInTheBag Mike Stoklasa]]) is that the pair of floral-antlered deer Lena sees right before she finds [[spoiler:Shepherd]]'s body are representations of [[spoiler:Shepherd and her daughter]], and that the transformative effects of the Shimmer caused [[spoiler:Shepherd's mind or body to go into the deer, while her voice went into [[VoiceChangeling the bear.]]]] This one is quite popular among the fans, not just because it fits with the film's themes of [[{{Motifs}} duality, division, and doppelgangers]] but also because it makes [[spoiler:Shepherd]]'s [[KillTheCutie fate]] at least marginally less horrifying.
17* MemeticMutation: ''Annihilation'''s "The Alien" soundtrack has reached memetic levels to even people who don't know the film or the books. The distinct, eerie and absolutely unsettling tone has become a very popular music choice to make things extra creepy.
18* SugarWiki/MostWonderfulSound: In a NightmareFuel way, the aforementioned unsettling alien sound from "The Alien" is CreepyAwesome in audio form.
19* NauseaFuel: The [[BodyHorror unpleasant]]...''[[AmbiguousSituation fate]]'' of the man in Kane's squad. [[spoiler:Kane cuts open his stomach with a combat knife (apparently with the man's consent!) to reveal that his intestines have mutated into grotesque eel-like growths. [[FromBadToWorse Which then start moving around as if alive.]]]]
20* ParanoiaFuel: Given the constant use of cancer as a visual motif and the effect that the shimmer has on the world essentially being a metaphor for cancer, you might feel the urge to have a cancer screening after watching this film.
21** EVERY scene with the bear in it is cause for paranoia fuel. Imagine your close friend screaming for help outside, except when you would go and open the door- you're dead where you stand.
22* SignatureScene: Almost similar to how ''Film/TheRevenant'' built its hype around it, [[spoiler:the mutant bear attack in the cabin]] here has become a MAJOR highlight for many viewers due to the [[spoiler:gruesome concept of a disfigured animal that mimics the death cries of its previous victims, the terrifyingly suspenseful way the scene plays out, and its shockingly brutal conclusion.]]
23* SpiritualSuccessor:
24** Ever wanted an adaptation of Creator/HPLovecraft's ''Literature/TheColourOutOfSpace''? Look no further. It even beat the [[Film/ColorOutOfSpace2020 official adaptation]] by two years.
25** The movie is probably the closest thing we'll get to another ''Film/Stalker1979'' film, though the similarities between the Zone and Area X bring to mind the more aggressive and wild version of the Zone [[spoiler:which may eventually cover the entire planet]] from the [[{{VideoGame/STALKER}} video games.]]
26** A sinister government organization seeking to quarantine a vast anomalous area with bizarre, physics-defying properties and submutations? Mentally assume that Lena and the rest of the team are a Mobile Task Force or D-Class personnel and replace every mention of "Southern Reach" in your mind with "The Foundation", and you pretty much have the best Website/SCPFoundation movie we're ever likely to get.
27** It could also be a sibling-ish adaptation of a TabletopGame/DeltaGreen campaign based around the Hastur Mythos (such as the upcoming Impossible Landscapes campaign book).
28** Or to ''Literature/TheSickLand'', which is about an area that corrupts and warps life in it into hybrid creatures and [[MindScrew mindfucks]] the protagonist that is also expanding.
29** To ''Literature/{{Solaris}}''. A hostile environment that copies whatever things and people coming into it meets a groups of adventurers with personal inner demons. The film and its source material can also be considered to be this or a SpiritualSuccessor to ''Film/Stalker1979'', which is also about a small team of people going into a bizarre EldritchLocation that was warped by an alien visit.
30** To Saul Bass's film ''Film/PhaseIV''. Scientists move in to surveil a region of the United States overtaken by a malignant biological threat. The threat manifests through numerous visually-striking natural anomalies. Characters are killed off. Eventually the biological threat uses its {{Hive Mind}} to transform a man and woman in an underground lair, yielding a bizarre and ambiguous ending which implies mankind is about to be transformed.
31** To some extent, the closest we might get to a film adaptation of ''VideoGame/{{Shin Megami Tensei Strange Journey}}'', which is also about a military team sent to investigate an otherworldly, rapidly growing anomalous space on earth. For the most part the similarities end there though.
32** To ''Webcomic/StandStillStaySilent''. Again, a small group explores an EldritchLocation masquerading as SceneryPorn that infects and mutates those who enter it. Especially noticeable during the bear attack - its design is remarkably similar to some of the comic's monsters, and its [[spoiler: screams for help]] echo a similar scene in the comic.
33** The mutated bear is similar to the 1979 film ''The Prophecy'', which also had a similar monster as its primary antagonist.
34** ''Series/{{Defiance}}''. The Votani terraforming ships crashed on earth and their "cores" would integrate plant and animal life similar to how the Shimmer does.
35** As seen in Epileptic Trees above, some people have discussed how the film could be a sort of StealthPrequel to ''Franchise/{{Pokemon}}'', albeit in a [[DeconstructedTrope Deconstructed]] DarkerAndEdgier fashion.
36** A seaside town with a lighthouse is slowly mutated by an Eldritch Abomination that takes over people, mutates them into creatures and has strange affects on their minds? Oh, and is filled with hazards and is inescapable once you go in? Sounds a lot like ''Manga/{{Uzumaki}}''.
37* SugarWiki/VisualEffectsOfAwesome: Even people who didn't like the movie have admitted that it looks ''incredible'', and despite the relatively low budget (55 million) for a big sci-fi movie, everything about the Shimmer is both unsettlingly disturbing and incredibly beautiful. Then there's the Skull-bear, a creature that looks totally real and convincing (not to mention [[NightmareFuel horrifying]]).

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