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1[[AC:Comic Books]]
2->''"I'm doing mechanics," he says, fingers tapping in unconscious urgency on the sharp edges of a credit-card-sized AI computer brain; same kind of servant-mind you can find in your [[MatterReplicator Maker]], one that comes with the standard chemical scanning gear that checks your food as fit for consumption. Some bastard here's selling mechanics, and he wants some. Not needs. Not yet. Mechanics is -- at least begins as -- a drug, one new enough that we haven't yet developed addiction resistance to it. A drug whose chemical code is also machine code. Make the AI card scan the drug, do the drug yourself, and you [[AIGettingHigh and the machine intelligence]] both get good and fucked up. The drug creates a connection between your mind and the AI. The AI breaks into your head and starts messing around with your DNA. Move a human chemical here, juggle some more there -- and [[CyberneticsEatYourSoul human tissue becomes mineral matter]]. You grow mechanics. The high passes. The mechanics remain.''
3-->-- '''Spider Jerusalem''', ''ComicBook/{{Transmetropolitan}}'', "I Hate it Here"
4
5[[AC:Fan Works]]
6->"It's called Searuby," he said. "It's made from a special kind of coral that grows around [[VideoGame/BioShock2 the old Fontaine Futuristics building]]. It'll take you places weirder than that, believe me."\
7He felt it germane to avoid mentioning that users tended to get rather mobile when visiting these places and usually tended to do things entirely independent of their own conscious minds. The marine biologist who'd sold him his first batch of the drug had mentioned "conscious dream states," "mind/body disconnection," and even "Jekyll and Hyde disorder," all adding up to one of the best commercially-available hallucinogens on the market, so Manny hadn't seen any tangible reason not to sell it -- or add any caveats to his sales pitch, for that matter. True, there'd been a few weird stories about certain users frantically humping the windows in [[BestialityIsDepraved attempts to fuck passing whales]], only to wake up claiming that [[MushroomSamba they'd been sprinting merrily across a labyrinth of chocolate built over a lake of honey]]. And yes, by it was too late to ask his contact about the negative side-effects, given that the poor bastard had [[ReleasedToElsewhere vanished]] about a month after he'd started dealing, but since nobody had cracked down on Manny's business yet, he had to assume that it wasn't due to the coral. At any rate, so long as [[VideoGame/BioShockInfinite this crazy bint]] came back for more, it was all good in his books.
8-->-- ''[[https://www.fanfiction.net/s/13208214/1/After-The-Burial After The Burial]]''
9
10[[AC:Literature]]
11->''In the past, I thought little of selling my blood so a few addicts with [[HookersAndBlow very expensive tastes]] could get high on a touch of [[FunctionalMagic magic]]. It was wildly dangerous to the [[{{Muggles}} unGifted]], who lacked the capacity to control such raw power. It was [[DirtyBusiness one of the few things I truly regretted]], a foul secret I would never share.''
12-->-- ''Literature/TheTraitorGod'', by Cameron Johnston
13
14->''The [[BadGuyBar Korova Milkbar]] was a milk-plus mesto, and you may, O my brothers, have forgotten what those mestos were like, things hanging so skorry these days and everybody very quick to forget, newspapers not being read much neither. Well, what they sold there was milk plus something else. They had no licence for selling liquor, but there was no law yet against prodding some of the new vesches which they used to put into the old moloko, so you could peet it with vellocet or synthemesc or deroncrom or one or two other vesches which would give you a nice quiet horrorshow fifteen minutes [[MushroomSamba admiring Bog And All His Holy Angels and Saints in your left shoe with lights bursting all of your mozg]]. Or you could peet milk with knives in it, as we used to say, and [[PsychoSerum this would sharpen you up and make you ready for a bit of dirty twenty-to-one]], and that was what we were peeting this evening I'm starting off the story with.''
15-->-- ''Literature/AClockworkOrange''
16
17->'''Palmer Eldritch:''' You were wrong. I did ''not'' find God in the Prox system. But I found something better. God promises eternal life. [[BlasphemousBoast I can do better]]; ''I can deliver it.''\
18'''Leo Bulero:''' Deliver it how?\
19'''Palmer Eldritch:''' Through the lichen which we're marketing under the name Chew-Z. It bears little resemblance to your own product, Leo. Can-D is obsolete, because what does it do? [[LotusEaterMachine Provides a few moments of escape, nothing but fantasy]]. Who wants it? Who needs that when they can get [[RealityWarper the genuine thing]] from me?
20-->-- ''Literature/TheThreeStigmataOfPalmerEldritch''
21
22->The DNA made by psychoactive viruses, though, cannot make new viruses, and it is not inserted into the host genome. Instead, it manufactures enzymes which in turn synthesize chemicals that normally present only when the host neurone is activated, [[MushroomSamba enhancing the particular fractional state of consciousness controlled by the infected neurones]]. Because the viruses can't replicate, and because the unbound DNA they make is ephemeral, users have to buy a hit every time they want to turn themselves on. [[MadScientist If you can hack a psychoactive virus]] that targets an interesting component of consciousness's ''Gestalt,'' you can make a lot of money very quickly.
23-->-- ''Literature/{{Fairyland}}'', by Paul J [=McAuley=]
24
25->Bliss was a unique designer drug -- unique for two reasons. The first was that [[BrownNote you could get addicted to Bliss just by looking at it]]. Which made it very hard for the police to carry out drug busts. The second was its effect. [[AGodAmI It made you believe you were God]]. It made you feel as if you were all-seeing, all-knowing, eternal and omnipotent. Which was laughable, really, because when you were high on Bliss, you couldn't even lace your shoes. The Bliss high lasted fifteen minutes; after coming down, the resulting depression lasted fifteen years. Few people could live with it, so they had to take another belt.
26-->-- ''Literature/RedDwarf: Infinity Welcomes Careful Drivers''
27
28->[[DiscussedTrope For those who like it]], the faint insistent sweetness of ''drooz'' may perfume the ways of the city, ''drooz'' which first brings a great lightness and brilliance to the mind and limbs, and then after some hours a dreamy languor, and wonderful visions at last of the very arcana and inmost secrets of the Universe, as well as exciting the pleasure of sex beyond all belief; and it is not habit-forming. [[ZigZaggingTrope For more modest tastes]] I think there ought to be beer.
29-->-- ''Literature/TheOnesWhoWalkAwayFromOmelas''
30
31->The {{spice|OfLife}} [[LongevityTreatment extends life]]. The spice [[HigherUnderstandingThroughDrugs expands consciousness]]. The spice [[ChemicalMessiah is vital to space travel]].
32-->-- ''Literature/{{Dune}}''
33
34[[AC:Video Games]]
35->'''Moniqa:''' Your target is a flower specimen in [[MegaCorp Sumeragi]]'s pharmaceutical lab.\
36'''Gunvolt:''' You want me to kill a flower? That's a new one.\
37'''Moniqa:''' The problem is the drug they produce from it. Ever heard of S.E.E.D.? It's a psychotropic medication used to control things like anxiety. In strong doses, it induces temporary [[PsychicPowers Septimal]] highs and leads to dependence.\
38'''Gunvolt:''' So whoever controls the drug...\
39'''Moniqa:''' Gains leverage over a small army of overpowered, wastoid Adepts.\
40'''Gunvolt:''' Wow... bad flower.
41-->-- ''VideoGame/AzureStrikerGunvolt''
42
43->''"ADAM acts like a benign cancer, destroying native cells and replacing them with [[UnstableGeneticCode unstable stem versions]]. While this very instability is what gives it its [[SuperSerum amazing properties]], it is also what causes the [[BodyHorror cosmetic]] and [[SanitySlippage mental]] damage. [[DescentIntoAddiction You need more and more ADAM just to keep back the tide]]. From a medical standpoint, this is catastrophic. From a business standpoint, well... [[TheBarnum Fontaine]] sees the possibilities."''
44-->-- '''Brigid Tenembaum''', ''VideoGame/BioShock1''
45
46->'''Caller:''' I wanna talk about that SPANK stuff. People say it's bad for you. It's not bad for you at all. [[MotorMouth Why aren't you talking? Oh, you think I'm strange? Am I on the air? Hello? Answer me, you pansy!]]\
47'''Lazlow:''' Er... what's your question?\
48'''Caller:''' [[MadnessMantra SPANK! SPANK SPANK! SPANK!]]
49-->-- ''VideoGame/GrandTheftAutoIII'', "[[Radio/GTARadio Chatterbox FM]]"
50
51->''This drug makes you feel nothing. Use it in a pinch.''
52-->-- '''Item description for [[SuperSerum Joy]]''', ''VideoGame/{{LISA}}''
53
54[[AC:Webcomics]]
55->'''Ch'vorthq:''' Before you dig in, I'dd like to read the ingredients to you.\
56'''Schlock:''' Uh-oh... collateral damage to the conscience.\
57'''Ch'vorthq:''' I'm being serious. Listen to this list... Glucose, fructose, corn syrup solids, concentrated cocoa-bean extract, assorted methylxanthine alkaloids (including caffeine, theobromine, and theophylline), sodium laureth sulfate, Minoxadyl, buckminster fullerene, codeine, hyper-ephedrine, nicotine, with BHA and BHT added to preserve freshness. Sergeant, you will be drinking a very heavy stimulant cocktail cut with shampoo and inert ultra-tensile carbon.\
58'''Schlock:''' I don't drink it. I eat it straight.\
59'''Ch'vorthq:''' And I suspect you're addicted to it.\
60'''Schlock:''' Step away from the tub of happiness.
61-->-- ''Webcomic/SchlockMercenary'', [[https://www.schlockmercenary.com/2001-02-25 "The Tub of Happiness — Bombs Ahoy"]]
62
63[[AC:Web Original]]
64->''"I love how Red Kryptonite apparently works subdermally, then intravenously, eventually rushing to the eyes and the head. Is it basically Kryptonian cocaine? I hope Clark [[HookersAndBlow talks nonstop and goes on and on about his yacht]]."''
65-->-- '''Chris Sims''' and '''David Uzumeri''' [[http://www.comicsalliance.com/smallville-recap-red/ on]] ''Series/{{Smallville}}'', "[[Recap/SmallvilleS02E04Red Red]]"
66
67->''"Along the way, I meet a drug dealer who sells this thing called Zyme. I assume this is one of those fictional drugs created so that the game doesn't have to deal with the ratings problems of real drugs, which is amusing considering [[ConspiracyKitchenSink the sheer number of other RL references to conspiracy stuff]] the game has. Apparently you can say that the US government is evil, but you can't say that there is a drug problem on the streets without making up a fictional drug for that purpose."''
68-->-- '''[[http://forum.rpg.net/showthread.php?603430-Deus-Ex-The-long-playthrough&p=14738667#post14738667 Dkellis]]''' on ''VideoGame/DeusEx''
69
70->'''shattuckl''': Is this where [[GoodBadBugs horse tilt]] anonymous meets?\
71'''Doug''': Look, I can quit horse tilt any time, I don't have a problem. If you have a problem, that's on you.
72-->--'''WebVideo/DougDoug''', ''[[https://youtu.be/yS8JvZTeI8w?si=tUc9xNuj5IXdgf1g Skyrim Speedrun, but I get a RANDOM WEAPON every hit]]''

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