When you find yourself trying to remember a show (or any works) that's on the tip of your tongue but just out of reach, come here - the collective brain of the TVTropes community can probably help. Post all the details you can remember (examples help). If you're looking for a trope, head over to Trope Finder. Have general questions about tropes? Visit Ask The Tropers!
No, I remember that one too. There were a bunch of horror parodies in it, too. Like Frankenstein's Monster being totally normal and not being able to talk due to his mouth being full of peanut butter, his creator being a woman (who the uncle liked?). The uncle was a good guy, too. I think I read it in late grade school or middle school...
Oh man, that's Monster Road, by David Lubar
The main character was always screwing up stuff, so his relatives would always get pissed and hand him over to someone else. The crazy uncle was trying to bring dead things back to life, and they went on the road trip after accidentally reanimating all the corpses in a graveyard. There was a Running Gag that the uncle would forget to watch the road, and nearly drove off because he didn't notice a turn. When he asked why the turn was there, the kid said something like "I guess whoever built the road thought it was a good idea".
And yes, Medusa does make an appearance and is accidentally "killed" when the protagonist picks up a hubcap, just as she was leering over his shoulder. Don't remember rose-tinted glasses in it, unless it's a reference to how ridiculously optimistic the kid and his uncle always were in the weird situations.

This is a children's book that i read probably around 2002. The main character is a kid who none of his relatives wanted to take care of, so they passed him from relative to relative until finally he starts living with this archetypal crazy uncle. And then they have some kind of adventure, and all i remember about it is that they are driving on the road, and look away, almost missing a very sharp turn (that was apparently put there for the purpose of injuring whoever was driving on the road. I think there was a Medusa-like enemy who saw her reflection in a hubcap or something, and rose-tinted glasses were very important to the story, don't ask me how. Also, it was on the Accelerated Reader program in my school, so that might help, maybe.