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I remember seeing a trailer (or maybe a part of the movie) about a young man who gets cursed somehow, so that he can't feel pain. I'm not sure if he loses other feelings like lust, or the ability to get drunk, as well.
The movie's a college sex comedy trying to capitalize on American Pie and similar films. The main character's a bit of a skinny dork a la Jason Biggs, but he has scruffier, blond hair. Getting the curse both helps him become more popular in college (the one scene I remember has him being hazed pledging for a fraternity, getting paddled and no feeling anything), but ends up getting him into trouble.
I don't remember much more about it, and I'm sure the movie isn't even any good, but I still wanted to try and find it to scratch that itch in my brain.