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You should title your video such that it describes the event as accurately as you can without spoilers. It might also be a good idea to place a spoiler warning in the title. To make up an example, a video depicting Emperor Evulz enacting his secret plan to eat The Hero's soul could be titled "Emperor Evulz's Plan In Action (SPOILERS)".
If the thumbnail is spoilery, or if adding a spoiler warning in the thumbnail seems prudent, you can replace it: after uploading your video, edit it from the same place you uploaded it by finding it in the list and clicking the gear ⚙ icon in the corner of the thumbnail. From there, you can upload a non-spoilery thumbnail to use in place of the default one. (You'll have to create the image file yourself.)
Suddenly I'm... still rotating Fallen London in my mind even though I've stopped actively playing it.

if i want to add a video that contains the death of a major character in a series, does it just go unspoilered?