How would teens react to a girl's sudden transformation?

My main character is an eighteen year old girl, but due to unintended side effects as a result of the genetic engineering experiment that created her, she resembles an elderly woman. She needs leg braces to walk, can't see well due to cataracts, has gray hair, the works. I'm wondering how other students would see her in the beginning of the story. She's very intelligent, but also painfully shy, with traits of high functioning autism or Asperger syndrome. Physically, she's frail and clumsy. Early on, she volunteers for a corporation's experiment that not only rejuvenates her, but bestows beauty onto her and increases her faculties. How would the students react then? One day, she's an ugly basket case, and the next, she's Supergirl.

Depends on how you want to play it out? Is this a Ugly Betty style comedy with action elements? Or is there something more sinister going on? If nothing else, most will be shocked and amazed that this was the same girl that once needed crutches. They would want details of the supposed medical treatment she received and the boys (maybe girls) would be all over her.

Some would be suspicious and others would even accuse her of faking her disabilities to gain sympathy since apparently she doesn't need them. She'd certainly be the talk of the town for a while.