- Harsher in Hindsight: One of the diseases Sheldon names after getting his pimple is monkeypox, which he assures the doctor is a real disease. On the very day the episode first aired, there were reports of outbreaks of monkeypox in Europe and Canada, as well as one confirmed case in Massachusetts and one unconfirmed in New York. (Not to mention, it's actually endemic in parts of West and Central Africa.) In two months time, it would be declared a health emergency by the World Health Organization.
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