- Awesome Music:
- "Many Rivers to Cross" by Jimmy Cliff playing at the end of "Resistance" while Ryan walks on the beach, thinking back to all the good times he and Wilfred had when Wilfred was still alive. It truly captures how lost Ryan is.
- "Down in My Heart" as performed by NRBQ in the series finale, "Happiness."
- "Funny Aneurysm" Moment: Amanda is depicted as a Lovable Sex Maniac here. In 2017 and 2018 her actress Allison Mack was revealed to be the second-in-command to a cult that did slavery and sex trafficking, including of children.
- Jerkass Woobie: Kristen grew up with Ryan being the favorite, so it makes sense that she's a bitch towards Ryan, and is most likely a power tripper. But keep in mind that both of their parents are deeply messed up people and she does love her brother and will come through for him. This is especially pronounced in "Responsibility", when Kristen tries to get Catherine recommitted and break up her romance with her psychologist because she can't stand to see her mother happy... because Kristen's own life isn't very happy.
- Wilfred forcing Ryan to smell a homeless mans soiled underwear, causing him to throw up.
- After Spencer gets the impression that he and Ryan are friends, he brings his laptop over to watch some porn with him. Spencer gets rock-hard. A couple minutes later we find out that the porno they watched starred Spencer's transsexual father, who has (according to Spencer) "perfect breasts".
- How about sex with an off-puttingly aggressive Jane Kaczmarek who keeps referring to herself as a "naughty widdle bunny" intercut with footage of Wilfred rimming a plush giraffe? To make matters worse, we soon find out that Wilfred gave Kaczmark's character oral sex after Ryan wasn't up to it. It wasn't vaginal, either.
- Seeing Darryl "preparing" himself with peanut butter to trick Wilfred into licking his testicles.
- Ann is a walking example of this trope, with her ridiculously horrible hygiene. In fact, her only source of income is running a fetish site where perverts can pay to see her being a gross slob. Wilfred makes a habit of eating food remnants off of Ann. He also makes a cologne out of the sweat he wrings from the pits of her clothes.
- The Woobie: Ryan's first act of the series is attempting suicide, and his suffering is just getting started.
YMMV / Wilfred