- Hilarious in Hindsight: The Griswold kids complain that there's nothing to do in Vegas, and Ellen worries that Vegas is not place for children. This is right around the time Vegas went through a major re-branding campaign as a family vacation place with tons of safe things for families and kids.
- Memetic Mutation: "I won the money! The money is mine!"
- One-Scene Wonder: Sid Caesar as Mr. Ellis.
- Periphery Demographic: The film is actually quite popular with college males, thanks to the wish fulfillment subplot of a not-yet-gambling-age Rusty sneaking into casinos as "Nick Papagiorgio" and striking it big.
- Squick: Rusty admiring his sister's legs. Also, Eddie telling Vicki to show everyone the stripper move that he taught her.
- Tear Jerker: The fate of Mr. Ellis, the Keno guy. He's spent his entire life playing, has never won once and has no family. Right after he finally wins, he ends up dying. His last act on earth is letting the Griswolds have his ticket, in repayment for letting them be his family for the night.
YMMV / Vegas Vacation