- Alternative Character Interpretation: Burns snaps at Smithers when the latter explains what dimoxinil is, saying that he already knows about it. While he had done the same thing earlier when Homer tried to explain what fish sticks are (and it's probably a safe bet that fish sticks aren't a part of Burns's diet), it's not too big a leap in logic to think that Burns tried dimoxinil himself at some point, and wasn't quite so lucky as Homer.
- Ensemble Dark Horse: Being one of the few characters to consistently treat Homer with genuine, utmost respect and admiration, Karl is a very memorable one-off character. The moment that has endeared him to many is when he commits career suicide so Homer can keep his job, leading to his surprisingly moving departure.
- Fair for Its Day: Karl is depicted as a possibly-gay man who kisses Homer and pats him on the butt. Nowadays, Karl would be derided as an example of queerbaiting, since Matt Groening has been very evasive about the nature of Karl's sexuality. However, Karl is shown to be an incredibly loyal, helpful, and self-sacrificing assistant to Homer, and his kiss isn't done for a cheap joke, but is taken as a sign of how much Karl cares for Homer. Which is pretty remarkable, considering the episode aired in 1990, when Ambiguously Gay characters had yet to gain recognition in any American media, animation or otherwise.
- Values Resonance: Of all of the episodes to feature any display of homosexuality, this first one is the only one where it's depicted as a complete non-issue, which is still rare today but was controversial at worst and unheard of at best in 1990. Each subsequent episode about the subject ("Homer's Phobia" "Three Gays of the Condo") would have broader and broader gay stereotypes, inversely proportionate to homosexuality becoming less taboo in the United States. It wouldn't be until Patty came out, some 14 seasons later, that the show started to reverse course on this approach.
YMMV / The Simpsons S2 E2 "Simpson and Delilah"