- Acceptable Targets: As the third segment was a parody of Twilight, critics have given it glowing reviews even if they had given the opening and other two segments negative reviews.
- Heartwarming Moments: Homer realizes Dracula is Not So Different, when the latter shares his concern as a father about his son's welfare. Homer's sacrifice to protect Lisa also qualifies, even if it's undermined by his quick drop and possible death.
- Nightmare Fuel: During the intro, Professor Frink inadvertently spoils the episode with his remote, which he then turns on himself, which ages him until he's reduced to dust. Probably just as well, considering a passing X-ray exposed a Xenomorph fetus in his chest cavity.
- While it's considered one of the Lighter and Softer segments, "War and Pieces" still involves a sequence where Bart thoughtlessly got a trapped Rod and Todd splattered. And there's the ending where, thanks to Milhouse's stupidity, the two were both hanged.
- "Master and Cadaver" revolves around Homer and Marge taking out a man they believe to have murdered the others aboard his ship. However, once it's revealed he hadn't, Homer murders them all to ensure their silence, which drives a guilt-ridden Marge to commit suicide by poison. And the entire segment is revealed as a particularly deranged fantasy of Maggie's, which is arguably the creepiest aspect of the entire thing.
- Shallow Parody: Rather curiously, "Tweenlight" has almost no elements in common with Twilight, aside from just the general idea of being a romance about vampires and a couple of elements from the first film's trailer. Twilight parodies were a very well-trodden ground in the early '10s, which makes it rather obvious when one doesn't include any of the things about Twilight that made it so widely parodied. Doing an extended riff on the car-stopping scene, but not acknowledging that Twilight vampires sparkle in sunlight, is really the sort of thing that only someone who'd only ever seen the first trailer would do.
- What an Idiot!: The ending of "War and Pieces", as noted above. While Milhouse was pretty dumb to guess a number instead of a letter, Bart deciding they should play Hangman around an artifact that brings all games to life is rather bone-headed.
YMMV / The Simpsons S22E4 "Treehouse of Horror XXI"