- Cult Classic: It came and went in the late 90's before quickly escaping the minds of many a viewer to the point of becoming extremely obscure, but at best, it has a very, very small but dedicated fanbase, even despite its infamously obnoxious theme song.
- Ensemble Dark Horse: Valerina is pretty popular for being in an obscure show.
- Heartwarming Moments:
- In the very first episode "Scared Stiff", Fraz is constantly scared of being doomed and the fortune cookie seems to confirm it. However Fraz jumps into a dangerous pinball machine to save Guapo from getting hurt.
- In "Double Feature" Guapo has everything he wants. But he is not happy because he misses Fraz. He says no matter how huge his ego is he will always care about Fraz because he's his brother. He eventually quits after the movie director insults his brother. At the end, Guapo apologizes to Fraz, who admits his job wasn't the same without him either.
- Hilarious in Hindsight: In the episode "Double Feature", Fraz mentions the movie stars of Movieland having swimming pools in swimming pools. SpongeBob SquarePants, which airs on the same channel, used a similar joke a few years after The Brothers Flub had run its course ("This guy's so rich, he has a swimming pool in a swimming pool!").
- Fraz is very paranoid and a bit of a control freak and is voiced by Scott Menville. Who else is? Teen Titans Go's version of Robin.
- Idiot Plot: "Flubs Overeasy" has Fraz and Guapo tip all of their money to Dot the waitress, forcing them to work at the restaurant since they can't pay their bill otherwise. A good chunk of the episode could easily have been avoided had they just tipped her only a little of their money, or none at all.
- Jerkass Woobie: Fraz is mean to Guapo and causes almost as much trouble as he does. But he does go through a lot of suffering and rarely has a happy ending.
- Never Live It Down: The aforementioned theme song has not helped its reputation in its years of obscurity.
- Self-Fanservice: Some fans draw the titular brothers as attractive human-like aliens.
- The Scrappy:
- Both the titular Brothers, Guapo and Fraz, are seen as this due to their constant arguing. Guapo is mainly disliked due to his ditzy Cloudcuckoolander personality. Fraz is just as hated, as many people find his whiny and cowardly nature annoying, and they don't like his self-proclaimed bragging when he isn't being a whiny coward ("It's all part of my master plan."), simply due to a lot of things go wrong when he acts like that.
- Tarara Boomdeyay is the biggest one because of her Bad Boss personality towards her workers. (Even though Guapo and Fraz somehow see her as "nice" and "special", despite often getting abused by her.)
- So Okay, It's Average: To those who don't mind the annoying theme song, the show isn't all that bad, if not as remarkable as other Nicktoons.
- Tear Jerker: The Crusher/Gerald's sad story of being bullied by Mango in "Wrestlemaniacs".
- They Copied It, So It Sucks!: A lot of people who HAVE seen it have been quick to call it a bad Futurama rip-off, despite the fact that the show premiered two whole months before Futurama did (though production for Futurama dates back to 1996).
- Uncanny Valley: The strange animation and bizarre character designs border on this.
- Vanilla Protagonist: Fraz, who's a boy-next-door workaholic/goody-two-shoes.
- Ugly Cute: The titular brothers.
- The Woobie: Fraz, due to his constant paranoia about being doomed.
YMMV / The Brothers Flub