- Accidental Innuendo: Just before the Shocker battle, he says to Spidey, "That's it, webslinger! You've been ridin' me long enough!"
- Awesome Music: The entirety of Michael McCuistion's score for the game, which many would say is just as good as Danny Elfman's music for the films.
- Demonic Spiders: The robotic Oscorp guards.
- Fanon: A popular theory is that the Evil Counterpart Goblin in Harry's storyline is actually a hallucination caused by the Goblin Formula — citing Harry's experiences in the Spider-Man 2 and Spider-Man 3 films.
- Game-Breaker: Advanced Web Gloves + Haymaker performs an One-Hit Kill on all bosses on normal difficulty and below.
- Hilarious in Hindsight: The unlockable story revolves around Harry Osborn taking on the Goblin identity to find out what happened to his father, which becomes pretty hilarious after Spider-Man 3 did the same plotline.
- Narm: J. Jonah Jameson only appears in the XBOX version as part of the exclusive Kraven levels. He sounds absolutely nothing like J.K. Simmons and is completely dead-eyed.
- Nightmare Fuel:
Super Soldier: You're dead. You just don't know it.
- The Game Over music sounds like something straight out of the Batman: Arkham Series.
- "Showdown With Shocker." The first phase puts you in a row of tunnels, faced with his No-Nonsense Nemesis barrage of Advancing Wall of Doom blasts — consequently kicking your Spider Sense into overdrive.
- "Vulture's Lair." Let's see: gothic motif and eerie music, Suicide Attack-happy drones hiding everywhere, and eventual Unexpected Gameplay Change into an Outrun the Fireball section.
- "Corralled" and "Scorpion's Rampage." The first? You have to protect the poor guy from a swarm of similar drones — which are also after you. And the second? He finally snaps from Paranoia and goes Ax-Crazy on you; and while you can't help but pity him, he's nevertheless a Juggernaut That One Boss with all sorts of Madness Mantra quotes. Oh, and he ultimately escapes without a word, making him the only antagonist with no resolution. By the way, enjoy the music in both missions.
- The stealth levels in Oscorp. The first one is very dark with creepy music playing. If the guards or cameras catch you, the entire area goes into alarm mode, sending out the robotic Super Soldiers. If they find you, they will fire at you with everything they've got.
- The unlockable test animation of Vulture getting into position for his heist with Shocker. It's not a very action-filled piece, with Vulture riding a subway train as he inspects a robotic spider drone he's taken from Oscorp, mumbling to himself. But the music combined with the early 2000 visuals makes it feel like a feverish mix of "encountering a sketchy person on an actual subway at night" and "meeting the Tall Man from Phantasm.
- No Problem with Licensed Games: While nowhere as innotative as it's sequel, it's a decent yet fun movie-tie in game with memorable villains and a great voice cast. The combat could be better, since the gameplay is almost the exact same as the PS1 game, and the increased amount of enemies + no real way of dodging makes the game sometimes annoying to play. (Especially on higher difficuly levels.)
- Schizophrenic Difficulty: On harder difficulties, this becomes apparent when you deal with the first few levels. The enemies are capable of dealing damage quickly and there is not a lot of health pick-ups (that may also not respawn.) Spike in Birth of a Hero is also one of the few bosses that you can't exploit with combos due to his shotgun being capable of interrupting your attacks. Contrast; Shocker's goons aren't as tough or threatening with the right skills and later bosses are either easy or very exploitable. The difficulty spikes back up later on but aside from Race Against Time and most instances of Hunter Killers, the game doesn't get much harder.
- Scrappy Mechanic: The combat system works pretty well against single enemies, but if you are surrounded by mooks the awkward dodging system note is practically worthless. This means that the combat on higher difficulties means a lot of hit-and run tactics combined with ranged and aerial attacks.
- Special Effects Failure: Many of the cheats replace Spider-Man's default costume with other characters. This isn't a problem when using another Spidey costume, but swapping into a non-costumed character (like Peter Parker in civilian clothes or Uncle Ben's killer) makes cutscenes awkward since those model's lips don't move at all. Added to that is the Voices Are Mental effect when playing as another character; Tobey Maguire/Spider-Man's voice still comes out their not moving mouths.
- Then there's the most popular and infamous example of this kind, which allows players to play as Mary Jane in her red dress from the Oscorp fair. This video depicts the utter hilarity in seeing Peter transform into his love interest - dress, makeup, hairstyle and all - in cutscenes which would normally see him enter his Spidey costume. This cheat was later taken out of subsequent "Greatest Hits" releases of the game when it became apparent that the Mary Jane cheat heavily changed the ending visual to that of MJ making out with herself.
- That One Attack: The flying Oscorp drones have an attack which, if uninterrupted, literally drain Spidey's health away. It gets especially fun on higher difficulties, where an otherwise perfect run can end after one of the buggers flies next to you and kills you in a couple of seconds.
- That One Boss: Scorpion. He's fast making it very hard to hit him with impact webbing unless he's standing still to use the laser on his tail, and fighting him head on in a fist fight will only get Spider Man killed because Scorpion dishes out far more damage than he takes in return.
- That One Level:
- The "Metal Gear Spidey" stealth levels near the end of the game, in which you have to explore the Oscorp offices without being spotted. If he is, he's usually ripped to pieces by gunfire courtesy of the mechanized Super Soldier guards. And don't think zipping onto the ceiling will save you...
- Oscorp's Ultimate Weapon qualifies, too. What you have to do is destroy 10 control points on a giant robot. Sound easy enough, right? What if we told you that there are turrets and smaller robots constantly firing at you, forcing you to be constantly moving? Tough but manageable. But then you learn that 4 of the control points are in the back of the room, and the robot fires a giant laser if you go over by those control points.
- Vulture's Lair. It's confusing to navigate and the barrage of various explosives near the end can result in a quick death.
- They Wasted a Perfectly Good Plot: Beating the game on Hero or Superhero difficulty earns you the chance to replay the game as Harry Osborn, using the Green Goblin outfits and weapons to find out what happened to his dad. Despite this new storyline, the changes to the basic plot are very minimal and lack the justifications of the regular mode. Worst of all, you never figure out who the other Green Goblin is or what happened to Norman in this version of the game.
- Too Dumb to Live: In Shocker's first level, that single civilian who not only fails to notice that there is a robbery going on, he also misses the fact that the building has been evacuated, and that one of the two masked men fighting is trying to crush him with a giant pillar right above him. Spidey does lampshade this, but still.
YMMV / Spider-Man: The Movie