- Angst? What Angst?: No Character Development whatsoever regarding Holmes's return to life — he gets nostalgic from time to time and he refuses to accept robo!Watson at first, but this is as far as it goes. One would think he'd have some issues after having died and then returning to life in a completely different century.
- Awesome Ego: Sherlock Holmes and Moriarty both have large egos and boast about themselves, but both are also every bit as smart and competent as they claim to be.
- Awesome Music: The theme song, despite being somewhat repetitive.
- Complete Monster:
- Dr. Martin Fenwick is Professor Moriarty's right-hand man. Assisting Moriarty in his crimes, Fenwick would commit many crimes, but his worst crime is creating a black market organ trafficking ring by tricking homeless citizens into giving him their DNA. He would then clone organs for back-alley transplants that would inevitably fail without warning, and attempt to freeze Holmes and Watson to death when they uncover his scheme. He would exploit the love of a woman named Jill to manipulate her into stealing technology that would allow him to mass produce even more faulty organs for his ring, only to abandon her to save his own skin. Despite being Moriarty's minion, Fenwick proves himself to be even viler than his master.
- "The Adventure of the Deranged Detective": Dr. Culverton Smith is a neurosurgeon turned thief. When Inspector Lestrade finds evidence of his crimes, Smith uses stolen nanobots to turn her into a feral, insane lunatic to destroy the evidence while lighting several buildings full of people on fire, conscious but unable to stop herself. Framing his superior for his crime, he would attempt to drive Holmes insane too when he catches on in order to have him kill Lestrade and then wipe his memory. When Holmes outsmarts him, Smith orders Lestrade to execute a helpless Holmes, smiling as he watches.
- Fan-Preferred Couple: Many fans of the show think Holmes and Lestrade look quite good together.
- Genius Bonus: Many of Sherlock's deductions frequently include these, as befitting from someone as intelligent as him.
- Hilarious in Hindsight: Dr. Watson as a "compudroid" = the WATSON supercomputer that was featured on Jeopardy!.
- Ho Yay: Like any good Sherlock Holmes adaptation, there's plenty of this between Holmes and Watson. Complicated by the Belligerent Sexual Tension between Holmes and Lestrade, though.
- Magnificent Bastard: Professor James Moriarty is a clone of the original created by a Mad Scientist to serve him but ultimately usurped his creator. A Diabolical Mastermind extraordinaire, Moriarty outplays the New Scotland Yard to create a wave of crime unseen for centuries and nearly takes over Earth from the moon with a complex scheme until a resurrected Sherlock Holmes is able to stop him, though Moriarty escapes. Constantly matching wits with Holmes from thereon out, Moriarty shows respect and admiration for his opponent, even when at odds with one another and though his plans are ultimately halted by Holmes, Moriarty ends the series free and still at large.
- Moral Event Horizon: Fenwick crosses this in "The Adventure of the Engineer's Thumb" by mass cloning Black Market organ transplants...which will inevitably fail inside their hosts. Sherlock himself considers this especially heinous and horrible.
- Squick: "The Adventure of the Engineer's Thumb," anyone?
- What Do You Mean, It's for Kids?: The aforementioned "The Adventure of the Engineer's Thumb" (which is notably the only episode to contain blood) is about Black Market organ trafficking. While things are toned down (the organs are grown wholesale from DNA samples, instead of stolen like initially thought) the subject matter is still disturbing, with scenes like the one where Holmes and Watson are sealed in a refrigerated room that turns out to be full of preserved body parts.Sherlock: Organ legging. Illicit trafficking of stolen human body parts. In my day, not even Jack the Ripper stooped so low.
YMMV / Sherlock Holmes in the 22nd Century