- Base-Breaking Character: Lisa in Season 3. Some fans don't mind her change of appearance, while others didn't like how her personality changed from an Adorkable geeky girl to a Dude Magnet.
- Big-Lipped Alligator Moment: The "alternate ending" to the series finale, which consists of an alien invader appearing out of nowhere and the cast attacking him. It used to be available to view on the TeenNick website.
- Bizarro Episode: The Halloween special from the third season.
- Family-Unfriendly Aesop: The "Class Clown" episode. While it is true that being amusing can lighten the tension in a school environment, the episode encourages the viewer to clown around even if it results in you getting in trouble.
- "Funny Aneurysm" Moment: The Halloween episode where Principal Pal is presumed dead after going into the Haunted House. Pal's actor, John Bliss, died a year after the show ended. Ditto as well with Mr. and later on Principle Wright's actor as well.
- Hilarious in Hindsight:
- Cookie's glasses are eerily similar to Google Glass, featuring computing technology and a fully functional web browser five years before Google would bring the idea to the real world.
- "Notebooks" had Cookie recording lectures so he could watch the videos instead of taking notes. By the end of the next decade, many teachers would start recording their lectures for later viewing by their students. However, this generally happens in higher education and is usually so that students who missed the class can catch up, rather than a replacement for class itself like Cookie was doing.
- Ho Yay:
Loomer: Together, Cook, we will rule the dodgeball court!
- Between Loomer and Cookie.
Loomer: (grabs "Simone's" hand) You're special, and I'd like to get to know the real you.Cookie: (nervously) No, you don't!
- Plus Cookie's whole subplot in "Guide to: Girls", when Loomer fell in love with Cookie when he was dressed in drag.
- Memetic Mutation: Cowboy Cookie.
- Retroactive Recognition:
- Christian Serratos (aka Suzie Crabgrass) later appeared in the Twilight movies and played Rosita Espinosa on AMC's The Walking Dead.
- Daniel Curtis Lee (aka Cookie) would later play Kojo on Disney XD's Zeke and Luther.
- One of the Killer Bees was a pre-Big Time Rush Carlos Pena.
- Amy Cassidy, Jock Goldman's ex-girlfriend, was played by Lucy Hale. Hale went on to Pretty Little Liars, on which Lindsey Shaw (Moze) would appear as a supporting character.
- The Andy Warhol-esque art teacher in "Recycling" and "Art Class" was played by future voice acting icon Nolan North.
- Cameron Monaghan, now of Shameless (US) and Gotham fame, played Palmer Noid in three episodes.
- Some Anvils Need to Be Dropped:
- Special Effect Failure:
- The show frequently uses puppets and unconvincing People in Rubber Suits to portray various animals, and sometimes rather obvious dummies representing characters doing painful stunts. It seems that this is largely done on purpose, considering the cartoony nature of the show to begin with.
- In the "Pep Rallies" episode, Cookie jumps onto a powerful trampoline and is launched through the gym's roof and lands outside the school. This was done using a computer model. However, immediately after Cookie crash-landed outside of school the model flipped into an upright position.
- This is actually invoked in one episode where Moze thought she'd knocked out two of Coconut Head's teeth. The "teeth" are obviously pieces of white breath mints that have been cut to resemble teeth. Since audiences were used to the terrible effects, the audience just assumed it was his teeth. Then it was revealed that it really was breath mints in-universe as well.
- Suspiciously Similar Song:
- The first chords of the main theme sound a lot like the main riff of "I Can't Explain" by The Who.
- Crubbs' theme is a knockoff of the Miami Vice theme.
- The disco song that plays during the "School Car Wash" episode is inspired by Rose Royce's "Car Wash".
- The theme that plays during the Talentpalooza is inspired by Van Halen's "Jump".
- The song that plays as Moze tries on new hair styles is very much like Santana's "Smooth".
- Christine the Bad Saw's riff is similar to the famous "Bad to the Bone" riff.
YMMV / Ned's Declassified School Survival Guide