- Magnificent Bastard:
- Thanos, the Mad Titan and devotee of death, is driven to gain the love of Mistress Death herself. Constantly forming intricate new plans to seize ultimate power, Thanos shows a curious sense of honor, especially to the dying Captain Mar-Vell as he helps guide him to the afterlife. Seizing the Infinity Gauntlet, Thanos erases half the life in the universe before later assisting in undoing his mistakes. Surfacing to manipulate the heroes for the occasional greater good, Thanos later dies in the Annihilation event, but not before leaving a failsafe to help stop the villain Annihilus. Later called back to life in The Thanos Imperative, Thanos arranges the destruction of the monstrous Cancerverse by his clever scheming and later returns again to even defeat his complacent, submissive future self, proclaiming that no matter what happens, only Thanos will ever define his own destiny.
- Doctor Doom has been Marvel's go-to Big Bad since the 1960s, and with good cause. An Evil Sorcerer, Mad Scientist, and tyrannical despot, Doom is respected and feared throughout Marvel's supervillain community, with both a Norse God and the Devil seeing him as someone to step lightly around. While many villains want to Take Over the World, Doom is one of the few who can actually pull it off, and at times he's reached well beyond even that goal, grasping for godhood with both hands. Capable of punching well out of his weight class, Victor Von Doom is the most dangerous man in the Marvel Universe and always bears watching.
- Wilson "The Kingpin" Fisk is Marvel's greatest gangster and a consummate survivor. Having outfought, outwitted, and outlasted everyone who has ever tried to take his place, Fisk has secured his position as both New York's reigning mobster and a fixture in the supervillain community. With the capital to dominate the city and a reach that frequently spans continents, Fisk has developed the psychological torment of heroes like Matt Murdock and Peter Parker into an art form, and has left Matt's life in particular in ruins several times over. Always too stubborn to call it quits, Fisk rolls with or shrugs off everything that Marvel's heroes and villains can throw at him, while repeatedly demonstrating that only the most capable of opponents can do the same when he brings all his resources to bear on them. Having risen, fallen, and risen again, Fisk is never out of the game for long, and is always ready to show off the criminal skill and personal gravitas that made him Kingpin of Crime in the first place.
- Loki himself, Thor's wicked younger brother, is the God of Mischief and frequently forms schemes to embarrass or damage Thor and Asgard itself, which he has repeatedly taken over in some gambit or another. It is later revealed Loki even used time travel to arrange his own adoption at the hands of Odin, murdering his own abusive biological father Laufey, in a clever gambit to get revenge against Asgard in the future. Even when killed, Loki arranges to bring back his younger self and takes him over to return, simultaneously one of Thor's deadliest enemies and beloved brother, rarely lost for his charming smile and a backup plan, who defends Asgard and its people as much as he threatens it.
- Magneto himself is a Holocaust survivor who is hellbent on seeing that no such evil ever befalls the mutants. Becoming a terrorist, Magneto manipulates his followers, allies and enemies alike, constantly waging war to better the lot of mutantkind, even against his best friend Charles Xavier. At one point Magneto even blackmails the world with nuclear weapons to set up a home for Mutants, and even foiled Doctor Doom's attempts at domination at another point. Deciding to protect the world and mutants in his own way, Magneto has returned countless times to commit acts he admits are unscrupulous, but necessary, constantly keeping himself from slipping too far into true evil while protecting his people from all threats.
- Baron Helmut Zemo, heir to the deplorable Heinrich Zemo, eventually rejects his father's fascist ideology. One of captain America's greatest enemies, Zemo led a near perfect defeat of The Avengers in the Siege arc, ending by engaging Captain America himself and coming close to victory. Constantly returning with daring new schemes, Zemo even kidnapped abused and neglected children to give them a loving home with himself and his wife, and later formed the Thunderbolts as heroes specifically to give them cover for more villainous activities. Eventually deciding to save the world by conquering it, Zemo returns time and time again, sometimes as a deadly enemy and other times ready to defeat more evil villains than he himself, proclaiming he could never harm a world he works so hard to save.
- Johann Schmidt, AKA The Red Skull. A murderous Sociopathic Nazi Super-Soldier who basically turned into Hitlers unnoficial successor, The Red skull is one of the most evil, ruthless, cunning, feared and experienced supervillains in the Marvel Universe. Unlike his Nemesis, Captain America, the Red Skull prefers to manipulate others to do his bidding(but if he needs to, he can use his fists and his fighting skills are on par with Cap himself). He doesnt even need mind control to do so, because he can be quite convincing and charismatic when he needs to be. He has convinced and/or manipulated both heroes and villains to do his bidding with high rates of success, which is especially impressive when you consider that all heroes and most villains distrust or hate him and try to stay away from him(because hes a Nazi). He has come very close on several occasions(and in some alternate continuities, has even succeeded) to defeating the superhero community and taking over the world. Most versions of him are always written as having several back-up plans in case his current plan fails and even those that aren't are generally very competent and competitive in widely ranging fields. Typically, he is portrayed as a martial arts master(like his nemesis), dead shot, brilliant military strategist, super-spy, master of disguise, economics expert capable of massive currency manipulations, etc... He also speaks several languages, plays the piano, and can quote more history, philosophy and various obscure lore from one field or another in the sciences and humanities than many of the setting's immortals have amassed. He is both a supergenius with Photographic Memory, and a fanatical Knight Templar who spends almost all the time he isn't engaged in villainous schemes training and studying to improve himself as much as possible. Not to mention that like his nemesis, hes been alive for a long time and has picked up many useful skills along the way. To him, WWII isnt over yet and he will not stop until all of humanity is marching to the tune of the Third Reich. Like Captain America, the Red Skull is also extremely persistent and will never give up his goals, no matter the odds. No matter how many times the heroes foil his plans, the Red Skull will never give up hope that he will succeed and will always fight for the sake of what he considers to be a brighter tommorow...as in a tomorrow where Nazism rules all of humanity with an Iron Fist.
YMMV / Marvel Comics