- Anti-Climax Boss: El Camaleon is shot by a bunch of racist border patrolmen while Machete runs off in another direction, completely forgetting about him.
- Complete Monster: Luther Voz, the founder and head of Voz Tech—"the world's premier space technology and weapons manufacturer"—first shows up in disguise during an arms deal and kills Machete's Love Interest, ICE Agent Sartana Rivera. He's also given a missile to crazed Mexican revolutionary Marcos Mendez, which is attached to a Dead Man's Switch and which Mendez plans to use to destroy Washington, D.C. Voz claims to "have a Mendez everywhere"—including North Korea and Russia—and plans to have them all fire missiles, as he believes the "world must end in order for a more perfect one to emerge"; Voz plans to take his followers and start said perfect world up in space. While the missiles are stopped, saving millions if not more, Voz manages to escape to space with his supporters; Luz, who's frozen in carbonite; as well as surviving members of the Network, who he plans to use for slave labor, along with the current Mexican migrants who are already slaves.
- Hilarious in Hindsight: After Kylo Ren's lightsaber with a laser crossguard in The Force Awakens, a lightsaber machete looks downright practical.
- Ham and Cheese: Mel Gibson is having a ball playing The Heavy for the first time.
- One-Scene Wonder: Walton Goggins as El Camaleón. The other three actors in the role, too.
- Madame Desdemona delivers two awesome speeches (the "house rules" one and the "ball-biter" one), and makes a persuasive case for casting Harley Quinn as a Latina.
- Nausea Fuel: Desdemona talking about how she chewed off her abusive father's balls. It gets gross when she mentions that she went to school the next day with pieces of him stuck in her braces.
- Retroactive Recognition: Corey Burton is credited as "Trailer Voice Guy", after the announcer voice went uncredited in the first Machete, but Burton was credited for Grindhouse.
- Sequelitis: Unlike the original, the film flopped at the box office and got panned by critics.
- What The Hell, Casting Agency?:
YMMV / Machete Kills