Angst? What Angst?: After Hazumu was rejected by the girl she confessed her love to, she gets killed, has her gender permanently switched, both of her parents start treating her differently, and the press begins hounding her about her transformation. She takes most of it in stride.
Big-Lipped Alligator Moment: In the third book, during the preparations for the field games, there is suddenly a page featuring a guy tied upside-down and hanging over a hungry alligator. In the other panels of that page, several other competitors (all male) are being constricted/eaten by snakes. There was no pretext for this, no one who isn't being eaten implies that this is in any way weird, and it is never mentioned again.
The Woobie: Asuta. His best friend is turned into a girl, and he starts becoming attracted to her, but is confused and embarrassed by these feelings so he tries to ignore them. The one time he tries to come clean to Hazumu he gets squashed by a plummeting Nariko. Not to mention Tomari basically treating him as her personal punching bag.