- Anticlimax Boss: Once you figure out his attacks, the final boss, Carlos Calaca, isn't very hard at all. His first form doesn't really make any effort to fight you, instead warping in somewhere, doing one attack, and giving you a few seconds to break his shield and get a bit of damage in on him. His second form is gigantic and can do a good amount of damage, but only has four attacks and each one has extremely obvious tells. This is especially true on hard mode, where every other boss has a lengthy, badass fight - especially Jaguar Javier, fought just a bit before Calaca, whose fight is a lengthy test of pure skill.
- Awesome Music: This game has a whole host of cool, appropriately-themed tunes. Of note are the temple themes, appropriately ominous, yet upbeat.
- Best Boss Ever: Jaguar Javier, the closest thing this game has to a Ridley-esque versus-mode-style fight. Unlike the other boss fights, he has no gimmicks — he just attacks fast and aggressively, so you have to be on your toes the entire time. He won't immediately flinch when attacked, so you have to know when to get back after landing a punch and when to press the advantage when he does stagger. He also has his own versions of all of your moves, which makes sense considering his powerful backstory: He has the same master as you. It's a fun and intense fight.
- Demonic Spiders:
- Yellow skeletons, since they're very quick and can dodge your attacks; usually you have to use special techniques just to have a chance of hitting them, let alone setting up a combo. In Hard Mode they become even more of a problem due to how much damage they do in a single hit.
- Hammertime skeletons are a true nightmare to deal with: they have gigantic hammers and not only their attack deal massive damage, even on Normal difficulty, but what makes it worse is that their attack hits a huge area and cannot be dodged. Are you expecting a Mighty Glacier enemy? Nope. They're also frighteningly agile for something of their size.
- The lightning skeletons, which are thankfully only encountered in the final level and bonus areas. They have an attack that shoots a tall column of lightning a considerable distance, and they can pull it off multiple times very quickly. They're extremely tough to deal with in large numbers.
- Any enemy that can dodge your attacks becomes absolutely infuriating in El Infierno's combat challenges. 9 times out of 10 they will spawn in, immediately dodge your first attack, then your combo window runs out.
- Exploders. At first glance, they don't look dangerous. Most of them are just One-Hit-Point Wonder, bloated devils with tiny wings that hover in a fixed position and don't have any attacks. But they have a Catastrophic Countdown over their heads. Upon reaching zero, these bomb-shaped fiends explode with a blast that will hit you wherever you are, regardless of distance or dimension. They always come in packs, they always accompany either large groups of tough enemies or high-difficulty platforming sections (or both), and, more often than not, are shielded, so you need to hit them with the one special move that gets past the shield to defeat them. Simply getting into position to deliver this attack is half of the challenge, the other half is doing it before they explode. There are also Elite Exploders who will instantly annihilate you with their blasts regardless of health and defense, and their countdowns are even shorter than the regular Exploders.
- Ear Worm: LALALAI, LALALAI, LALAAAAAAAAA!!!
- Ensemble Dark Horse: Jaguar Javier. One part Final-Exam Boss one part Best Boss Ever. The fact that he's a Noble Demon is the icing on the cake.
- Evil Is Sexy: X'Tabay.
- Goat Climb lets you run up sheer walls indefinitely. Goat Fly lets you launch off a wall and fly horizontally until you hit another wall (even if the next wall is dozens of screens away.) Together they completely trivialize 90% of the platforming in the game.
- Collecting every mask piece in the game (aside from the one given to you for beating the Final Boss) gives you an infinite jump when in Pollo form, which breaks the platforming even harder.
- Goddamned Bats: Chupacabras love to hover just a little bit too far from your attacks and spit shots which can easily catch you off guard in more hectic combats. They become Demonic Spiders quite easily in Hard Mode, or in El Infierno's combat challenges where they will wreck your combo with those shots.
- That One Puzzle:
- Tule Tree orb is a series of difficult platforming climbing + world swapping you must complete in order to earn the best ending of the game. The window for mistakes in the last set of platforms is almost nonexistent and if you mess up you have to start it all over again.
- El Infierno Challenge 9. Even once you figure out what you have to do, the margin of error is extremely small, even for Silver.
- Unwinnable by Insanity: Or more likely due to ignorance and the lack of game restrictions when it comes to exploring. You can already gain access to the Caverna del Pollo if you have Olmec's Headbutt to destroy the yellow block. The Dashing Derpderp is also required to clear the blue block before the third set of floors. What the game doesn't tell you about the third set of enemy waves is that there is an enemy with a purple barrier than can only be destoryed using the chicken's egg bomb ability (obtained from getting silver medals on El Infierno challenges). You can still beat said enemy if you have the Intenso upgrade that instantly breaks enemy shields. If you don't even have that Intenso upgrade, there's no way that you could beat this purple-shielded mook no matter what you try. Fortunately, the player can just simply exit the game and be teleported back to the nearest checkpoint, but at the expense of losing any newly-collected coins from that unsaved run.
- Woolseyism: As like many videogames translated to Spanish, the games was translated into European Spanish, but only for the menus and the user interface (UI). The game dialogue, due to the fact the game takes place in Mexico, has all the characters speaking in the Mexican dialect, rather than the European one, outside using some misplaced words and slang.
YMMV / Guacamelee!