- Accidental Aesop: While "Nutrition" has an overall message that replacing all food with supplements (in this case, black-hole influence nutrition bars) is bad, the way it's written comes off as "all supplements are bad." Josie even tells Z that she warned Vaughn "[These bars] are bad for you." This moral works for Lucas, who becomes dependent on them for brainpower, which no protein bar is really going to help with. However, it falls flat for Vaughn, an athlete—a wrestler—who trains often and relies on muscle mass/brute strength to compete. He is exactly the person supplements are designed for and they could be helpful for him in his stated goal at the end of the episode: bulk up in order to compete properly in the higher weight class. Maybe just not protein bars influenced by black holes with zero caloric value.
- Anvilicious: Since it is a (somewhat) educational show for children, each episode has a very non-subtle moral that is stated by the limelight character during the climax.
- Best Known for the Fanservice: "Hemispheres" is a great episode. Not only did the actors do a great job acting the complete opposite of their characters, Corrine got the chance to explore her much-neglected creative side. But what does everyone remember from this episode? Marshall's extremely alluring bad boy alter ego.
- Big-Lipped Alligator Moment: In the first episode "Wormhole", Josie visits a forbidden room in Blake Holsey High. She encounters a mysterious woman and her black cat, which screeches at her. Startled, Josie runs out of there. The incident was never brought up again, although it shows how anything can happen at the school.
- Hilarious in Hindsight: This show uses one-word Idiosyncratic Episode Naming for its titles. Executive Producer Bruce Kalish would work on another children's show that does the same exact thing.
- Retroactive Recognition:
- Squick: Josie finding Professor Z completely covered in honey in "Pheromones". The honey looked very sticky and slimey.
YMMV / Black Hole High