Crosses the Line Twice: Zoe poking Wanda in the eye with a tongue depressor, trying to amputate her, and giving her a shot in the butt while playing Doctor? Terrible. Zoe commenting it means she wins? Hysterical!
Harsher in Hindsight: In a couple early strips, Wanda was shown to be a fan of Mel Gibson (or rather, his buns). Obviously, this was before Gibson's first antisemetic rant incident.
Hilarious in Hindsight: One strip that took place early in Bunny's second pregnancy had her pointing out how big her stomach was getting, and exclaiming "I think it might be twins!" (the joke being that her stomach still looked relatively flat). A few months later, Bunny revealed that she actually was having twins (and then her stomach really did get a lot bigger, much to Wanda and Yolanda's amusement).
The title of the comic's eighth book, "One More and We're Outnumbered!", has become this with the introduction of Wren.
One early strip had Darryl bringing home a large box of crayons and coloring books, only for Wanda to scold him because Zoe (then still a baby) was too young for crayons; the joke being Darryl responding "Who said they were for her?" Nowadays, coloring books marketed specifically for adults are very much a thing.
They Wasted a Perfectly Good Character: The Brewers were introduced as a Happily Married couple who love kids, but are unable to have any of their own due to fertility issues. Through interacting with them, Darryl and Wanda learn that they're perfectly normal, pleasant people instead of "childless yuppie scum." So of course, after Darryl and Wanda learned their lesson, the Brewers quietly disappeared from the strip.
In the early years of the strip, Norm and Cindy/Cyndi were shown to be close friends of Darryl and Wanda, to the point that they were considered candidates to be Zoe's godparents. They haven't been seen since the mid-90s, presumably because they, like the Brewers, were childless.
Unintentionally Unsympathetic: One two-strip story has Wanda getting extremely upset because a young cashier asked her if she worked or was "just" a mom. It's obvious that Wanda's anger is supposed to be seen as justified, since her "job" as a mom isn't easy; however, the way it's presented makes it seem more like Wanda is having a major overreaction over a comment from someone who was, at worst, being Innocently Insensitive. The fact that Wanda's reaction to Darryl trying to comfort her is to snark at him does not help her case.
The series:
Audience-Alienating Premise: Unlike the family-friendly strip, the show was fused with crass humor and language aimed squarely at older audiences, which only seemed to turn off fans of the actual comic, and the show didn't have much of an audience to grab outside of that fanbase.
Awesome Music: Many fans agree that the title song "It's All Been Done" by Barenaked Ladies was the best part about the show.
Broken Base: Some people who weren't familiar with the strip thought it was a decent show in its own right, while others that grew up with the strip disliked it for how much it changed the story to the point where it barely even resembled the original strip.
Ensemble Dark Horse: Despite mixed reactions to the show, Bizzy is a well-liked character. If mostly due to her being voiced by Nicole Sullivan.
In Canada, the show aired on Teletoon Sunday nights at 7:30p.m. in the 2002 Fall Season. It carried a PG rating and was much tamer than what aired post-watershed, though it's still a bit odd.