The short subject dealt with the titular spider befriending a shy little girl but invoking the fearful wrath of the girl's teacher, who sends an exterminator over. The exterminator deploys any means possible to get rid of the spider, only (like Wile E. Coyote) to fail miserably. The TV series resumes the premise, with the girl now named Leslie McRoraty and the teacher Miss Adrienne.
Tropes covered by the short and the series:
- Bug War: Mostly one-sided. Characters try to dispose of Itsy for being a spider and he's just defending himself.
- Determinator: The Exterminator. Santayana would be proud of him.
- Dumb Muscle: The Exterminator is truly no Mensa candidate. His focus—to get rid of Itsy—clouds his ability to think of the best way to do it.
- Kill It with Fire: One of the Exterminator's tools is a flamethrower.
- Meganekko: Leslie. She's sweet in both the short and first season, then undergoes a rather radical change in demeanor in season two.
- Stern Teacher: Adrianne, Leslie's stern teacher. Even when utterly defeated, she gets no sympathy.
Tropes exclusive to the short:
- The Ahnold: The Exterminator after the Robotic Reveal.
- More Dakka: Turned Up to Eleven when the Exterminator pulls out a pair of Gatling guns in his arms after trapping Itsy in a cabinet(with Adrienne's cat) Adrienne, not knowing her pet is in there, pulls out a bunch of guns to get some shots in too. Naturally, Itsy escapes before the first shot is fired.
- No Name Given: Leslie and Adrienne are never identified by name in the short.
- Techno Babble:Music Teacher: What is that?The Exterminator: It's a high-tech microchip thermonuclear light-sensitive radioactive blue-screen laptop computer generator triple decker arachnid detector and Etch-a-Sketch. Any more questions?
Tropes exclusive to the series:
- Lawyer-Friendly Cameo: In one episode the Exterminator kills Expies of Bambi and his mother.
- Negative Continuity: For one thing, the Exterminator is no longer a robot.
- Panty Shot: Leslie has a couple in "State Fair Itsy."
- Universal-Adaptor Cast: Adrienne and the Exterminator show up in different places and roles throughout the series.