Lola's life is not easy. She comes from a mildly poor family and routinely has to look after her two baby brothers. But she doesn't care, she has two good friends by her side and that's all she needs. Then comes Virginia, a rich, spoiled brat who always gets her way.
From the moment these two girls meet, they rub each other the wrong way. They're always trying to outdo and each get in each other's way. Lola does the best she can to stop Virginia from ruining other people's fun, but she isn't so innocent herself.
The main characters are:
- Lola: Lola prides herself on trying to help people out. She's bold and adventurous and always looking for ways to make a few extra bucks. She is constantly irritated by Virginia's selfish ways, but has been known to act a bit selfish herself.
- Virginia: Formerly a private school diva, this spoiled rich brat was transferred to public school at the suggestion of her therapist. On the surface, she's a polite girl who routinely gets good grades. But it's just a ruse to hide the selfish, mean-spirited girl underneath. Virginia is ruthless and will do whatever it takes to get her way. On top of that, she considers tormenting Lola to be a personal sport.
- Haide: Haide is Lola's best friend. She's into magic charms, horoscopes and mysticism.
- Poppy: Poppy is Lola's second best friend. A hard-rocking punk tomboy, who's one of the best atheletes in school.
- Beatrice: The school's resident gossip. A consistantly sour girl, Beatrice is Virginia's lackey and possibly her only real friend.
- Charlie: A boy who's into skateboarding. Lola and Virginia both have major crushes on him, but he seems uninterested in their affections.
This series contains examples of:
- Arch-Enemy: The titular characters. It's the show's main plot.
- Attention Whore: Virginia. One episode has her wearing a long dress to school to impress everyone, but only to have her snubbed by her classmates for Lola's hypnotizing T-shirt, and Virginia tries so hard to get their attention by mocking Lola for her T-shirt, but only Beatrice goes along, while the rest are actually still marveled by it.
- Bitch in Sheep's Clothing: Virginia. A polite, good, sweet girl to her parents, teacher, school principal, and her classmates, and a mean, ruthless, insanely spoiled, self-centered girl to Lola and her friends.
- Butt-Monkey: Beatrice. When she isn't suffering the fallout of Virginia's schemes, she's the series resident Chew Toy.
- Black and Gray Morality: Lola is clearly portrayed as the good girl, while Virginia is the bad girl. But Lola is hardly an angel: She routinely gives as good as she gets when it comes to Virginia's schemes. And in one episode, Lola got hold of a bracelet that Charlie was using to cheat at math, there was a chart written on the inside. Does she give it back and tell him to stop using it or give it to the teacher? No, she uses it to blackmail Charlie into kissing her live on a webcam.
- Clothing Damage: In one episode, Lola's dress gets caught in a car door. It gets ripped off, leaving Lola in only her underwear, in public.
- Dub Name Change: Charlie is Carlitos in the original Spanish.
- Fiction 500: There are hints that Virginia comes from not a just a rich family, but a very wealthy family, like how she has the money to turn her public school into an elite private school and to buy the entire five thousand tickets of a brand new amusement park in less than half an hour, just to upset Lola.
- For the Evulz: Some of Virginia and Beatrice's schemes for Lola are actually just done out of pettiness. Like when they try to destroy Lola and Haide's friendship, simply because Virginia bets she can do it within a week and when they expose Lola and her best friends' secrets to the entire school, for the reason as quoted by Lola below:Lola: Poor things, their lives are so boring that the only way they can have fun is by messing things up for everybody else.
- Glass Slipper: In one story, a celebrity is interested in Lola and has no clue to her identity other than the glasses she lost. Virginia tries to pass herself as the glasses' owner but Lola points out Virginia doesn't need glasses. Virginia then tries to walk around with the glasses but can barely walk two steps without hitting something.
- Good Angel, Bad Angel: Lola has them, but they don't appear on her shoulders. Instead they're shown in a fantasy sequence and are completely silent, except for the bad angel chuckling. In the episode "Frozen Hearts", Lola goes to one of Poppy's karate classes and suggests that they arrange a demonstration for Virginia, who has the cheating bracelet. Poppy flatly refuses, stating that karate students don't go around beating people up. Lola says that's not what she had in mind at all. She puts on an innocent smile, but actually changes into the bad angel for a moment.
- Idol Singer: Marco Amore, who is loved by everyone in the cartoon's universe, including Lola and Virginia.
- Informed Ability: Despite being on of the shortest characters on the show, Lola is the captain of the school's girl's basketball team.
- It's All About Me: Virginia. In fact, it's not just part of her personality, she's suffering from it (a strange syndrome called delirium narcissismus, that causes her to think she's the center of the universe), which leads her to transferring to a public school, as a cure.
- Screw the Rules, I Have Money!: Virginia seems to think her money allows her to do anything.
- Slapstick Knows No Gender: Beatrice routinely winds up on the wrong end of Virginia's schemes.
- Swallow the Key: Virginia pulls this in the episode "Uniforms" to keep her self-centered syndrome a secret.
- 30 Minutes, or It's Free!: Lola held this policy during her brief career as a sushi delivery girl. Virginia once tried to stop Lola from making a delivery to her (Virginia's) Dad out of fear he'd compel her to get a part time job.
- Where the Hell Is Springfield?: San Lorenzo, the city where the characters live, its location is unspecified and it's also unknown whether it's in Spain (where the cartoon is originated) or USA, as some episodes use the currency in dollars, some episodes use euros.