The gang tries taking a vacation to Paris, France, but Scooby and Shaggy accidentally get on the wrong plane. Still thinking they're going to Paris, Alphonse LaFleur, a famous French hunter and trapper, plans on capturing the Abominable Snowman, and using Shaggy and Scooby as bait. After locking them up with his equipment, LaFleur drops Shaggy and Scooby off the plane. Realizing they're not going to Paris, Shaggy briefly manages a phone call to Fred before his phone dies.
Fred manages to pinpoint their location with his new phone's GPS, and they head off to the Himalayas. Meanwhile, Shaggy and Scooby land near a small village where they find two men, Professor Jeffries and Pembra. Scooby and Shaggy learn that the only way to call their friends is from a weather station at the top of the mountain, and Jeffries and Pembra agree to accompany them on their mission. And so, they set out to climb the mountain with an Abominable Snowman on the loose.
- Actor Allusion: While stuck at the weather station, Shaggy shows off his "radio voice" which is a nod to his voice actor being a famous DJ.
- Attack of the 50-Foot Whatever: The Abominable Snowman is gigantic.
- Big Brother Bully: It sounds like Pemba may have been this to his sister, Minga, when they were kids. She claims that when she and her brother were little, he used to try scaring her with stories of the Yeti (aka, "Abominable Snowman").
- Big Brother Instinct: While Pemba may be kind of a jerk to Minga, he really does do everything he can to protect his sister and make sure she's safe from the monster. And before it's revealed that Minga was the Yeti and she had seemingly disappeared, Pemba seemed really scared for her safety and went to go look for her.
- Big Eater: Scooby and Shaggy, as always, are depicted with enormous appetites.
- Bigfoot, Sasquatch, and Yeti: The monster this film focuses on is the Abominable Snowman.
- Butt-Monkey: LaFleur becomes this when he attempts to bag the Abominable Snowman, which is karma for all his bragging and for shanghaiing Scooby and Shaggy to use as his hunting bait.
- Continuity Nod: Del Chillman from Scooby-Doo! and the Loch Ness Monster returns, having given up on Nessie and moved to the Himalayas where he became the mountain's DJ, much to Shaggy and Scooby's happy surprise.
- Covers Always Lie: Velma, Daphne, and Freddy never snowboard once in the entire movie — it's Shaggy and Scooby who do so, on improvised snowboards, to escape an avalanche.
- Demoted to Extra: Fred, Daphne and Velma play a much smaller role in this movie compared to previous ones; much of the focus is on Shaggy and Scooby. This would become the norm for the remaining What's New, Scooby-Doo?-based movies.
- Got Me Doing It: After Freddy mispronounces "Abominable" several times, Velma ends up doing the same thing, and grumbles that "Now you've got me all mixed up."
- Here We Go Again!: At the end of the movie, everyone besides Fred is at the same cafe in Paris when they get a phone call — the call turns out to be from Fred, who had gotten on the wrong plane and somehow ended up in the Amazon jungle. The gang runs off to save him while Daphne yells, "For once I'd like to have a vacation that actually stays a vacation."
- Laughing Mad: Professor Jeffries, who's clearly lost it and laughs to himself quite a bit as he tries to get away with one of the crystals from under Shangri-la.
- Not Me This Time: The gang discovers Professor Jeffries stealing one of the crystals from under Shangri-La and assume the culprit in question is also responsible for the Abominable Snowman that's been causing trouble, but the culprit insists they weren't — and then the Snowman shows up.
- Real After All: Played with in a scene where LaFleur shows up alive and claims that his survival is because the real Abominable Snowman saved him.
- The Shangri-La: Shaggy and Scooby end up here after escaping from the Abominable Snowman.
- Shot in the Ass: One of the traps that LaFleur sets up is a device that shoots tranquilizer darts. It ends up hitting him with five right in his butt, rather than the yeti that was his intended target.
- Two Dun It: It turns out the Abominable Snowman is someone completely different from the actual criminal in the film — Minga just wanted to keep Del from leaving, dressing up as the Snowman because she knew he was interested in it, while Professor Jeffries is trying to steal a crystal from under Shangri-La.