The series' headliners were crime-solving bears named Hustle, Bump and Boogie (voiced by Daws Butler, Henry Corden and Chuck McCann, respectively). They traveled in a garbage truck and received orders via citizen band radio from their female boss, "Charlie" (voiced seductively by Susan Davis).
Supporting segments in the CB Bears show were:
- Blastoff Buzzard, a cartoon similar to Wile E. Coyote and the Road Runner, and the only H-B cartoon whose soundtrack had no human voices at all;
- Heyyyy, It's the King, an all-animal parody of Happy Days;
- Posse Impossible, a Spin-Off of the series finale of Hong Kong Phooey;
- Shake, Rattle and Roll, in which a trio of ghosts inhabited an abandoned hotel, and
- Undercover Elephant, about a secret-agent pachyderm and his mouse partner.
At mid-season, the show was absorbed into a two-hour block on NBC titled Go Go Globetrotters which included repeats of 1970's The Harlem Globetrotters, 1967's The Herculoids, and 1969's Motormouse & Autocat.
CB Bears provides examples of:
- Amazing Technicolor Wildlife: Clyde is an orange gorilla.
- Animated Anthology
- Aroused by Their Voice: Boogie has this reaction when he hears Charlie.
- Comic-Book Adaptation: The bears, Undercover Elephant and Shake, Rattle and Roll appeared in issues of Marvel's Hanna-Barbera's TV Stars. The C.B. Bears appeared in two stories.
- Comic Trio: The ghosts of Shake, Rattle & Roll.
- And the Bears themselves.
- Does Not Like Spam: In a comic book story, Bump Bear hates cole slaw. This is taken from story writer Mark Evanier's hatred of cole slaw.
- Expy: The King of Heyyyy! It's the King is an expy of Arthur Fonzarelli.
- Forgot I Could Fly: Happened a lot in Blastoff Buzzard shorts. May or may not have been an intentional joke.
- Nice Hats: Especially that trash can lid of Bump's!
- No-Dialogue Episode: All Blastoff Buzzard shorts qualify.
- The One Who Wears Shoes: Boogie and Bump.
- In the Heyyyy! It's the King shorts, Clyde the gorilla fills this role.
- Talking Animal
- Theme Naming: The bears are named for dance styles; the ghosts of Shake, Rattle & Roll are named for a rock song from the 1950s.
- The Voice: Charlie.
- You Gotta Have Blue Hair: Boogie has blue fur.