Ned and Mitzi are orphans
Their families (sans one aunt living far away) are never shown or discussed, and the Koala Brothers seem to be their guardians, so they could have lost or been separated from their birth families at young ages and given to the brothers to look after.http://tvtropes.org/pmwiki/pmwiki.php/WMG/TheKoalaBrothers
FollowingWMG / The Koala Brothers
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